The Experts below are selected from a list of 9 Experts worldwide ranked by ideXlab platform
Arumugam Sudalai - One of the best experts on this subject based on the ideXlab platform.
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NaIO4/LiBr-mediated Diastereoselective Dihydroxylation of Olefins: A Catalytic Approach to the Prevost−Woodward Reaction
Organic letters, 2005Co-Authors: Lourdusamy Emmanuvel, Tanveer Mahammad Ali Shaikh, Arumugam SudalaiAbstract:LiBr catalyzes efficiently the dihydroxylation of alkenes to afford syn and anti diols with excellent diastereoselectivity depending upon the use of NaIO4 (30 mol %) or PhI(OAc)2 (1 equiv), respectively, as the oxidants. The oxidation of non-benzylic halides has been achieved for the first time to afford the corresponding diols in excellent yields.
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naio4 libr mediated diastereoselective dihydroxylation of olefins a catalytic approach to the prevost Woodward Reaction
Organic Letters, 2005Co-Authors: Lourdusamy Emmanuvel, Tanveer Mahammad Ali Shaikh, Arumugam SudalaiAbstract:LiBr catalyzes efficiently the dihydroxylation of alkenes to afford syn and anti diols with excellent diastereoselectivity depending upon the use of NaIO4 (30 mol %) or PhI(OAc)2 (1 equiv), respectively, as the oxidants. The oxidation of non-benzylic halides has been achieved for the first time to afford the corresponding diols in excellent yields.
Lourdusamy Emmanuvel - One of the best experts on this subject based on the ideXlab platform.
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NaIO4/LiBr-mediated Diastereoselective Dihydroxylation of Olefins: A Catalytic Approach to the Prevost−Woodward Reaction
Organic letters, 2005Co-Authors: Lourdusamy Emmanuvel, Tanveer Mahammad Ali Shaikh, Arumugam SudalaiAbstract:LiBr catalyzes efficiently the dihydroxylation of alkenes to afford syn and anti diols with excellent diastereoselectivity depending upon the use of NaIO4 (30 mol %) or PhI(OAc)2 (1 equiv), respectively, as the oxidants. The oxidation of non-benzylic halides has been achieved for the first time to afford the corresponding diols in excellent yields.
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naio4 libr mediated diastereoselective dihydroxylation of olefins a catalytic approach to the prevost Woodward Reaction
Organic Letters, 2005Co-Authors: Lourdusamy Emmanuvel, Tanveer Mahammad Ali Shaikh, Arumugam SudalaiAbstract:LiBr catalyzes efficiently the dihydroxylation of alkenes to afford syn and anti diols with excellent diastereoselectivity depending upon the use of NaIO4 (30 mol %) or PhI(OAc)2 (1 equiv), respectively, as the oxidants. The oxidation of non-benzylic halides has been achieved for the first time to afford the corresponding diols in excellent yields.
Tanveer Mahammad Ali Shaikh - One of the best experts on this subject based on the ideXlab platform.
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NaIO4/LiBr-mediated Diastereoselective Dihydroxylation of Olefins: A Catalytic Approach to the Prevost−Woodward Reaction
Organic letters, 2005Co-Authors: Lourdusamy Emmanuvel, Tanveer Mahammad Ali Shaikh, Arumugam SudalaiAbstract:LiBr catalyzes efficiently the dihydroxylation of alkenes to afford syn and anti diols with excellent diastereoselectivity depending upon the use of NaIO4 (30 mol %) or PhI(OAc)2 (1 equiv), respectively, as the oxidants. The oxidation of non-benzylic halides has been achieved for the first time to afford the corresponding diols in excellent yields.
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naio4 libr mediated diastereoselective dihydroxylation of olefins a catalytic approach to the prevost Woodward Reaction
Organic Letters, 2005Co-Authors: Lourdusamy Emmanuvel, Tanveer Mahammad Ali Shaikh, Arumugam SudalaiAbstract:LiBr catalyzes efficiently the dihydroxylation of alkenes to afford syn and anti diols with excellent diastereoselectivity depending upon the use of NaIO4 (30 mol %) or PhI(OAc)2 (1 equiv), respectively, as the oxidants. The oxidation of non-benzylic halides has been achieved for the first time to afford the corresponding diols in excellent yields.
Mikael Bols - One of the best experts on this subject based on the ideXlab platform.
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Synthesis of 1-azagalactofagomine, a potent galactosidase inhibitor
Journal of the Chemical Society Perkin Transactions 1, 2001Co-Authors: Henrik H. Jensen, Mikael BolsAbstract:1-Azagalactofagomine [(+)-(3R,4S,5R)-4,5-Dihydroxy-3-(hydroxymethyl)hexahydropyridazine, 2] was synthesised from achiral starting materials in a chemoenzymic synthesis. The racemic Diels–Alder adduct (2-hydroxymethyl-8-methyl-1,6,8-triazabicyclo[4.3.0]non-3-ene-7,9-dione, 5) from addition of pentadienol to 4-methyl-1,2,4-triazoline-3,5-dione was resolved using lipase R-catalysed acetylation. The acetate [(S)-2-acetoxymethyl-8-methyl-1,6,8-triazabicyclo[4.3.0]non-3-ene-7,9-dione, 6] was saponified and treated with MCPBA to give a majority of the syn epoxide [(2R,3S,4R)-3,4-epoxy-2-hydroxymethyl-8-methyl-1,6,8-triazabicyclo[4.3.0]nonane-7,9-dione, 7]. This isomer was subjected to epoxide opening with HI followed by a Woodward Reaction-like displacement of the iodide with water and peracetylation to give an all-syn triacetate [(2R,3S,4R)-3,4-diacetoxy-2-acetoxymethyl-1,6,8-triazabicyclo[4.3.0]nonane-7,9-dione, 11]. Finally deacetylation and hydrazinolysis gave 2. The pKa of 2 was determined to be 5.7. 1-Azagalactofagomine was found to be a potent competitive galactosidase inhibitor. The inhibition constants, Ki, were 40, 300 and 7800 nM versus β-galactosidase from Aspergillusoryzae, Eschinchia coli and Saccharomyces fragilis, respectively, and 280 nM vs. α-galactosidase from green coffee beans.
Henrik H. Jensen - One of the best experts on this subject based on the ideXlab platform.
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Synthesis of 1-azagalactofagomine, a potent galactosidase inhibitor
Journal of the Chemical Society Perkin Transactions 1, 2001Co-Authors: Henrik H. Jensen, Mikael BolsAbstract:1-Azagalactofagomine [(+)-(3R,4S,5R)-4,5-Dihydroxy-3-(hydroxymethyl)hexahydropyridazine, 2] was synthesised from achiral starting materials in a chemoenzymic synthesis. The racemic Diels–Alder adduct (2-hydroxymethyl-8-methyl-1,6,8-triazabicyclo[4.3.0]non-3-ene-7,9-dione, 5) from addition of pentadienol to 4-methyl-1,2,4-triazoline-3,5-dione was resolved using lipase R-catalysed acetylation. The acetate [(S)-2-acetoxymethyl-8-methyl-1,6,8-triazabicyclo[4.3.0]non-3-ene-7,9-dione, 6] was saponified and treated with MCPBA to give a majority of the syn epoxide [(2R,3S,4R)-3,4-epoxy-2-hydroxymethyl-8-methyl-1,6,8-triazabicyclo[4.3.0]nonane-7,9-dione, 7]. This isomer was subjected to epoxide opening with HI followed by a Woodward Reaction-like displacement of the iodide with water and peracetylation to give an all-syn triacetate [(2R,3S,4R)-3,4-diacetoxy-2-acetoxymethyl-1,6,8-triazabicyclo[4.3.0]nonane-7,9-dione, 11]. Finally deacetylation and hydrazinolysis gave 2. The pKa of 2 was determined to be 5.7. 1-Azagalactofagomine was found to be a potent competitive galactosidase inhibitor. The inhibition constants, Ki, were 40, 300 and 7800 nM versus β-galactosidase from Aspergillusoryzae, Eschinchia coli and Saccharomyces fragilis, respectively, and 280 nM vs. α-galactosidase from green coffee beans.
