The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Saik Bang - One of the best experts on this subject based on the ideXlab platform.
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negative pressure Wound Dressings to secure split thickness skin grafts in the perineum
International Wound Journal, 2014Co-Authors: Jaikyong Pyon, Kap Sung Oh, Saik BangAbstract:: Several researches have shown that negative-pressure Wound Dressings can secure split-thickness skin grafts and improve graft survival. However, in anatomically difficult body regions such as the perineum it is questionable whether these Dressings have similar beneficial effects. In this study, we evaluated the effects of negative-pressure Wound Dressings on split-thickness skin grafts in the perineum by comparing Wound healing rate and complication rate with that of tie-over Dressings. A retrospective chart review was performed for the patients who underwent a split-thickness skin graft to reconstruct perineal skin defects between January 2007 and December 2011. After grafting, the surgeon selected patients to receive either a negative-pressure dressing or a tie-over dressing. In both groups, the initial dressing was left unchanged for 5 days, then changed to conventional wet gauze dressing. Graft success was assessed 2 weeks after surgery by a single clinician. A total of 26 patients were included in this study. The mean age was 56·6 years and the mean Wound size was 273·1 cm(2). Among them 14 received negative-pressure Dressings and 12 received tie-over Dressings. Negative-pressure dressing group had higher graft taken rate (P = 0·036) and took shorter time to complete healing (P = 0·01) than tie-over dressing group. The patients with negative-pressure Dressings had a higher rate of graft success and shorter time to complete healing, which has statistical significance. Negative-pressure Wound dressing can be a good option for effective management of skin grafts in the perineum.
Nosratollah Zarghami - One of the best experts on this subject based on the ideXlab platform.
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an overview on application of natural substances incorporated with electrospun nanofibrous scaffolds to development of innovative Wound Dressings
Mini-reviews in Medicinal Chemistry, 2017Co-Authors: Younes Pilehvarsoltanahmadi, Mehdi Dadashpour, Abbas Mohajeri, Amir Fattahi, Roghayeh Sheervalilou, Nosratollah ZarghamiAbstract:Conventional Dressings are cost-effective and highly absorbent, but not effectual enough to promote hemostasis, adherence and in holding a moist Wound bed. Thanks to the developments in the field of nanotechnology and bioengineering, one of the promising current trends is to move progress of innovative Wound Dressings, merging the application of traditional healing agents and modern products/ practices, such as hydrocolloids, hydrogels, films and nanofibers. This review surveys on potentials of electrospun nanofibrous mats for Wound dressing applications. Furthermore, loading of bioactive molecules and therapeutic agents into the nanofibrous mats especially natural compounds with the aim of fabrication novel bioactive electrospun nanofibrous mats for skin substitutes and Wound Dressings are discussed. Systematic literature search was conducted to review all recent progress toward the potential of natural substances incorporated with electrospun nanofibrous scaffolds for Wound dressing applications. The electrospun nanofibers webs can provide the essential parameters require for Wound dressing to heal Wounds including absorptivity, oxygen permeability, and non-adherence to the healing tissue, barrier to bacteria, bioactivity and occlusivity. The modern Wound Dressings materials made of electrospun nanofibers contain various traditional healing agents such as plant derived compounds could be beneficial to the healing of Wounds. Natural substances have been used in skin Wound care for many years because of their therapeutic properties, including antimicrobial, antioxidant, anti-inflammatory and mitogenic activities. A screening of natural substances with plant or animal sources having high Wound healer activities and cooperating with electrospun nanofiber are an important step toward producing innovative bioactive Wound Dressings.
Jaikyong Pyon - One of the best experts on this subject based on the ideXlab platform.
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negative pressure Wound Dressings to secure split thickness skin grafts in the perineum
International Wound Journal, 2014Co-Authors: Jaikyong Pyon, Kap Sung Oh, Saik BangAbstract:: Several researches have shown that negative-pressure Wound Dressings can secure split-thickness skin grafts and improve graft survival. However, in anatomically difficult body regions such as the perineum it is questionable whether these Dressings have similar beneficial effects. In this study, we evaluated the effects of negative-pressure Wound Dressings on split-thickness skin grafts in the perineum by comparing Wound healing rate and complication rate with that of tie-over Dressings. A retrospective chart review was performed for the patients who underwent a split-thickness skin graft to reconstruct perineal skin defects between January 2007 and December 2011. After grafting, the surgeon selected patients to receive either a negative-pressure dressing or a tie-over dressing. In both groups, the initial dressing was left unchanged for 5 days, then changed to conventional wet gauze dressing. Graft success was assessed 2 weeks after surgery by a single clinician. A total of 26 patients were included in this study. The mean age was 56·6 years and the mean Wound size was 273·1 cm(2). Among them 14 received negative-pressure Dressings and 12 received tie-over Dressings. Negative-pressure dressing group had higher graft taken rate (P = 0·036) and took shorter time to complete healing (P = 0·01) than tie-over dressing group. The patients with negative-pressure Dressings had a higher rate of graft success and shorter time to complete healing, which has statistical significance. Negative-pressure Wound dressing can be a good option for effective management of skin grafts in the perineum.
Chetna Dhand - One of the best experts on this subject based on the ideXlab platform.
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bio inspired crosslinking and matrix drug interactions for advanced Wound Dressings with long term antimicrobial activity
Biomaterials, 2017Co-Authors: Chetna Dhand, Mayandi Venkatesh, Veluchami Amutha Barathi, Sriram Harini, Samiran Bairagi, Eunice Goh Tze Leng, Nandhakumar Muruganandham, Kenny Zhi Wei Low, Mobashar Hussain Urf Turabe Fazil, Xian Jun LohAbstract:There is a growing demand for durable advanced Wound Dressings for the management of persistent infections after deep burn injuries. Herein, we demonstrated the preparation of durable antimicrobial nanofiber mats, by taking advantage of strong interfacial interactions between polyhydroxy antibiotics (with varying number of OH groups) and gelatin and their in-situ crosslinking with polydopamine (pDA) using ammonium carbonate diffusion method. Polydopamine crosslinking did not interfere with the antimicrobial efficacy of the loaded antibiotics. Interestingly, incorporation of antibiotics containing more number of alcoholic OH groups (NOH ≥ 5) delayed the release kinetics with complete retention of antimicrobial activity for an extended period of time (20 days). The antimicrobials-loaded mats displayed superior mechanical and thermal properties than gelatin or pDA-crosslinked gelatin mats. Mats containing polyhydroxy antifungals showed enhanced aqueous stability and retained nanofibrous morphology under aqueous environment for more than 4 weeks. This approach can be expanded to produce mats with broad spectrum antimicrobial properties by incorporating the combination of antibacterial and antifungal drugs. Direct electrospinning of vancomycin-loaded electrospun nanofibers onto a bandage gauze and subsequent crosslinking produced non-adherent durable advanced Wound Dressings that could be easily applied to the injured sites and readily detached after treatment. In a partial thickness burn injury model in piglets, the drug-loaded mats displayed comparable Wound closure to commercially available silver-based Dressings. This prototype Wound dressing designed for easy handling and with long-lasting antimicrobial properties represents an effective option for treating life-threatening microbial infections due to thermal injuries.
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insight into membrane selectivity of linear and branched polyethylenimines and their potential as biocides for advanced Wound Dressings
Acta Biomaterialia, 2016Co-Authors: Mobashar Hussain Urf Turabe Fazil, Chetna Dhand, Mayandi Venkatesh, Sriram Harini, Christo Eugene, Seeram Ramakrishna, Shyam S Chaurasia, Roger W Beuerman, Chandra S VermaAbstract:Abstract We report here structure-property relationship between linear and branched polyethylene imines by examining their antimicrobial activities against wide range of pathogens. Both the polymers target the cytoplasmic membrane of bacteria and yeasts, eliciting rapid microbicidal properties. Using multiscale molecular dynamic simulations, we showed that, in both fully or partially protonated forms LPEI discriminates between mammalian and bacterial model membranes whereas BPEI lacks selectivity for both the model membranes. Simulation results suggest that LPEI forms weak complex with the zwitterionic lipids whereas the side chain amino groups of BPEI sequester the zwitterionic lipids by forming tight complex. Consistent with these observations, label-free cell impedance measurements, cell viability assays and high content analysis indicate that BPEI is cytotoxic to human epithelial and fibroblasts cells. Crosslinking of BPEI onto electrospun gelatin mats attenuate the cytotoxicity for fibroblasts while retaining the antimicrobial activity against Gram-positive and yeasts strains. PEI crosslinked gelatin mats elicit bactericidal activity by contact-mediated killing and durable to leaching for 7 days. The potent antimicrobial activity combined with enhanced selectivity of the crosslinked ES gelatin mats would expand the arsenel of biocides in the management of superficial skin infections. The contact-mediated microbicidal properties may avert antimicrobial resistance and expand the diversity of applications to prevent microbial contamination. Statement of Significance Current commercially available advanced Wound Dressings are either impregnated with metallic silver or silver salts which have side effects or may not avert antimicrobial resistance. In this article, we have used multidisciplinary approach comprising of computational, chemical and biological methods to understand the antimicrobial properties and biocompatibility of linear (LPEI) and branched (BPEI) polyethylenimines. We then applied this knowledge to develop dual purpose Wound Dressings containing these polymers, which encourages healing while maintain antimicrobial activity. In addition, the approach can be expanded to rationalize the antimicrobial vs. cytotoxicity of other cationic polymers and the method of crosslinking would enhance their potentials as biocides for advanced materials.
Edward V Maytin - One of the best experts on this subject based on the ideXlab platform.
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thread size and polymer composition of 3d printed and electrospun Wound Dressings affect Wound healing outcomes in an excisional Wound rat model
Biomacromolecules, 2020Co-Authors: Nicholas Nun, Megan A Cruz, Tanmay Jain, Yenming Tseng, Josh Menefee, Samreen Jatana, Pritam S Patil, Nic D Leipzig, Christine Mcdonald, Edward V MaytinAbstract:Thread size and polymer composition are critical properties to consider for achieving a positive healing outcome with a Wound dressing. Three-dimensional (3D) printed scaffolds and electrospun mats both offer distinct advantages as replaceable Wound Dressings. This research aims to determine if the thread size and polymer compositions of the scaffolds affect skin Wound healing outcomes, an aspect that has not been adequately explored. Using a modular polymer platform, four polyester direct-write 3D printed scaffolds and electrospun mats were fabricated into Wound Dressings. The Dressings were applied to splinted, full thickness skin Wounds in an excisional Wound rat model and evaluated against control Wounds to which no dressing was applied. Wound closure rates and reduction of the Wound bed width were not affected by the thread size or polymer composition. However, epidermal thickness was larger in Wounds treated with electrospun Dressings and was slightly affected by the polymer composition. Two of the four tested polymer compositions lead to delayed reorganization of granulation tissues. Moreover, enhanced angiogenesis was seen in Wounds treated with 3D printed Dressings compared to those treated with electrospun Dressings. The results from this study can be used to inform the choice of dressing architecture and polymer compositions to achieve positive Wound healing outcomes.
