Wound Infection

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Hester Vermeulen - One of the best experts on this subject based on the ideXlab platform.

  • topical silver for preventing Wound Infection
    Cochrane Database of Systematic Reviews, 2010
    Co-Authors: Marja N Stormversloot, Dirk T Ubbink, Hester Vermeulen
    Abstract:

    Background Silver-containing treatments are popular and used in Wound treatments to combat a broad spectrum of pathogens, but evidence of their effectiveness in preventing Wound Infection or promoting healing is lacking. Objectives To establish the effects of silver-containing Wound dressings and topical agents in preventing Wound Infection and healing of Wounds. Search methods We searched the Cochrane Wounds Group Specialised Register (6 May 2009); The Cochrane Central Register of Controlled Trials (CENTRAL) (2009 Issue 2); Ovid MEDLINE (1950 to April Week 4 2009); Ovid EMBASE (1980 to 2009 Week 18); EBSCO CINAHL (1982 to April Week 4 2009) and Digital Dissertations (to May 2009) for relevant trials. We contacted manufacturers and distributors. Selection criteria Randomised controlled trials (RCTs) comparing silver-containing Wound dressings and topical agents with silver-containing and non silver-containing comparators on uninfected Wounds. Data collection and analysis Two authors independently selected trials, assessed risk of bias, and extracted data. Main results We identified 26 RCTs (2066 patients). Heterogeneity of treatments and outcomes precluded meta-analysis. We grouped results according to Wound type, and silver preparation. Burns Thirteen trials compared topical silver (in a variety of formulations - including silver sulphadiazine (SSD) cream) with non-silver dressings. One trial showed fewer Infections with silver nitrate when compared with a non-silver dressing, but three trials showed significantly more Infection with SSD than with the non-silver dressing. Six trials compared SSD cream with silver-containing dressings. One showed significantly fewer Infections with the silver-containing dressing (Hydron AgSD) compared with SSD, the remaining five found no evidence of a difference. One trial compared two silver-containing dressings, and showed a significantly lower Infection rate with silver-coated gauze (Acticoat®) than with silver nitrate gauze. Other Wounds Six trials compared SSD/silver-containing dressings with non-silver dressings (nine dressings in total). Most comparisons (seven) found no significant differences in Infection rates; one trial in a variety of Wounds exhibited significantly fewer Infections with SSD/hydrocolloid, but another, in acute Wounds, found significantly more Infections with SSD. Only one comparison showed a significant reduction in healing time associated with a silver-containing hydrofibre dressing in diabetic foot ulcers.  Authors' conclusions There is insufficient evidence to establish whether silver-containing dressings or topical agents promote Wound healing or prevent Wound Infection; some poor quality evidence for SSD suggests the opposite.

Yiannis Tselentis - One of the best experts on this subject based on the ideXlab platform.

  • surgical Wound Infection caused by rahnella aquatilis
    Journal of Clinical Microbiology, 1994
    Co-Authors: Sofia Maraki, E Marnelakis, George Samonis, Yiannis Tselentis
    Abstract:

    Rahnella aquatilis is a water-residing gram-negative rod, a member of the family Enterobacteriaceae, isolated rarely from clinical specimens of immunocompromised patients. A case of a surgical Wound Infection caused by R. aquatilis in a patient who underwent a prosthetic surgical intervention is reported. The presence of inducible beta-lactamase was suggested by the disk induction test and the conventional agar dilution assay. Literature on R. aquatilis Infections in humans is reviewed. Images

Marja N Stormversloot - One of the best experts on this subject based on the ideXlab platform.

  • topical silver for preventing Wound Infection
    Cochrane Database of Systematic Reviews, 2010
    Co-Authors: Marja N Stormversloot, Dirk T Ubbink, Hester Vermeulen
    Abstract:

    Background Silver-containing treatments are popular and used in Wound treatments to combat a broad spectrum of pathogens, but evidence of their effectiveness in preventing Wound Infection or promoting healing is lacking. Objectives To establish the effects of silver-containing Wound dressings and topical agents in preventing Wound Infection and healing of Wounds. Search methods We searched the Cochrane Wounds Group Specialised Register (6 May 2009); The Cochrane Central Register of Controlled Trials (CENTRAL) (2009 Issue 2); Ovid MEDLINE (1950 to April Week 4 2009); Ovid EMBASE (1980 to 2009 Week 18); EBSCO CINAHL (1982 to April Week 4 2009) and Digital Dissertations (to May 2009) for relevant trials. We contacted manufacturers and distributors. Selection criteria Randomised controlled trials (RCTs) comparing silver-containing Wound dressings and topical agents with silver-containing and non silver-containing comparators on uninfected Wounds. Data collection and analysis Two authors independently selected trials, assessed risk of bias, and extracted data. Main results We identified 26 RCTs (2066 patients). Heterogeneity of treatments and outcomes precluded meta-analysis. We grouped results according to Wound type, and silver preparation. Burns Thirteen trials compared topical silver (in a variety of formulations - including silver sulphadiazine (SSD) cream) with non-silver dressings. One trial showed fewer Infections with silver nitrate when compared with a non-silver dressing, but three trials showed significantly more Infection with SSD than with the non-silver dressing. Six trials compared SSD cream with silver-containing dressings. One showed significantly fewer Infections with the silver-containing dressing (Hydron AgSD) compared with SSD, the remaining five found no evidence of a difference. One trial compared two silver-containing dressings, and showed a significantly lower Infection rate with silver-coated gauze (Acticoat®) than with silver nitrate gauze. Other Wounds Six trials compared SSD/silver-containing dressings with non-silver dressings (nine dressings in total). Most comparisons (seven) found no significant differences in Infection rates; one trial in a variety of Wounds exhibited significantly fewer Infections with SSD/hydrocolloid, but another, in acute Wounds, found significantly more Infections with SSD. Only one comparison showed a significant reduction in healing time associated with a silver-containing hydrofibre dressing in diabetic foot ulcers.  Authors' conclusions There is insufficient evidence to establish whether silver-containing dressings or topical agents promote Wound healing or prevent Wound Infection; some poor quality evidence for SSD suggests the opposite.

Michihiko Miyazaki - One of the best experts on this subject based on the ideXlab platform.

  • Efficacy of skin closure with subcuticular sutures for preventing Wound Infection after resection of colorectal cancer: a propensity score–matched analysis
    Langenbeck's Archives of Surgery, 2015
    Co-Authors: Yusuke Yamaoka, Masataka Ikeda, Masakazu Ikenaga, Naotsugu Haraguchi, Masakazu Miyake, Kazuyoshi Yamamoto, Tadafumi Asaoka, Kazuhiro Nishikawa, Atsushi Miyamoto, Michihiko Miyazaki
    Abstract:

    Purpose The purpose of this study was to examine the efficacy of skin closure with subcuticular sutures for the prevention of Wound Infection after colorectal cancer resection. Methods Medical records of 1008 patients with colorectal cancer who underwent resection between 2006 and 2013 were reviewed. Patients were divided into two groups based on skin closure method: the subcuticular suture group ( n  = 323) and the staple group ( n  = 685). The incidence of Wound Infection was compared with and without propensity score matching, and multivariate analysis was performed to identify risk factors for Wound Infection. Results The incidence of Wound Infection was 3.1 % (10/323) in the subcuticular suture group and 10.4 % (71/685) in the staple group. After propensity score matching, the incidence of Wound Infection was significantly lower in the subcuticular suture group (4.6 %, 9/197) than in the staple group (12.2 %, 24/197) ( p  = 0.004). In the propensity score–matched cohort, multivariate analysis identified advanced age (odds ratio [OR], 1.07; 95 % confidence interval [CI], 1.03–1.12), higher preoperative body mass index (OR, 1.19; 95 % CI, 1.07–1.33), lower preoperative serum albumin (OR, 0.45; 95 % CI, 0.22–0.91), open surgery (OR, 3.28; 95 % CI, 1.38–8.49), and skin closure with staples (OR, 3.21; 95 % CI, 1.43–7.81) as independent risk factors for Wound Infection. Conclusions Our results suggest that subcuticular suturing could be beneficial after colorectal cancer surgery.

Dirk T Ubbink - One of the best experts on this subject based on the ideXlab platform.

  • topical silver for preventing Wound Infection
    Cochrane Database of Systematic Reviews, 2010
    Co-Authors: Marja N Stormversloot, Dirk T Ubbink, Hester Vermeulen
    Abstract:

    Background Silver-containing treatments are popular and used in Wound treatments to combat a broad spectrum of pathogens, but evidence of their effectiveness in preventing Wound Infection or promoting healing is lacking. Objectives To establish the effects of silver-containing Wound dressings and topical agents in preventing Wound Infection and healing of Wounds. Search methods We searched the Cochrane Wounds Group Specialised Register (6 May 2009); The Cochrane Central Register of Controlled Trials (CENTRAL) (2009 Issue 2); Ovid MEDLINE (1950 to April Week 4 2009); Ovid EMBASE (1980 to 2009 Week 18); EBSCO CINAHL (1982 to April Week 4 2009) and Digital Dissertations (to May 2009) for relevant trials. We contacted manufacturers and distributors. Selection criteria Randomised controlled trials (RCTs) comparing silver-containing Wound dressings and topical agents with silver-containing and non silver-containing comparators on uninfected Wounds. Data collection and analysis Two authors independently selected trials, assessed risk of bias, and extracted data. Main results We identified 26 RCTs (2066 patients). Heterogeneity of treatments and outcomes precluded meta-analysis. We grouped results according to Wound type, and silver preparation. Burns Thirteen trials compared topical silver (in a variety of formulations - including silver sulphadiazine (SSD) cream) with non-silver dressings. One trial showed fewer Infections with silver nitrate when compared with a non-silver dressing, but three trials showed significantly more Infection with SSD than with the non-silver dressing. Six trials compared SSD cream with silver-containing dressings. One showed significantly fewer Infections with the silver-containing dressing (Hydron AgSD) compared with SSD, the remaining five found no evidence of a difference. One trial compared two silver-containing dressings, and showed a significantly lower Infection rate with silver-coated gauze (Acticoat®) than with silver nitrate gauze. Other Wounds Six trials compared SSD/silver-containing dressings with non-silver dressings (nine dressings in total). Most comparisons (seven) found no significant differences in Infection rates; one trial in a variety of Wounds exhibited significantly fewer Infections with SSD/hydrocolloid, but another, in acute Wounds, found significantly more Infections with SSD. Only one comparison showed a significant reduction in healing time associated with a silver-containing hydrofibre dressing in diabetic foot ulcers.  Authors' conclusions There is insufficient evidence to establish whether silver-containing dressings or topical agents promote Wound healing or prevent Wound Infection; some poor quality evidence for SSD suggests the opposite.