The Experts below are selected from a list of 21 Experts worldwide ranked by ideXlab platform
G. Brookes - One of the best experts on this subject based on the ideXlab platform.
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Treatment of cervical dystonia hand spasms and laryngeal dystonia with botulinum toxin
Journal of Neurology, 1992Co-Authors: A. J. Lees, N. Turjanski, J. Rivest, R. Whurr, M. Lorch, G. BrookesAbstract:One hundred and twenty-six patients with different forms of focal dystonia (89 with cervical dystonia, 12 with hand Cramps and 25 with laryngeal dystonia) were treated with localised injections of botulinum toxin. Mean doses per muscle were 200 mouse units (m.u.) for treating cervical dystonia, 40–120 m.u. for forearm muscles in Writers' Cramp and 3.7 m. u. for the thyroarytenoid muscle in laryngeal dystonia. Responder rates have been above 80% in all patient groups and beneficial effects could be reproduced over follow-up periods of up to 4 years. The commonest side-effects were dysphagia after treatment of spasmodic torticollis, weakness of neighbouring muscles after injections for hand Cramps and breathiness and hypophonia following laryngeal injections. All these were transient and generally well tolerated. It is concluded that botulinum toxin injections are a safe and effective treatment in all three types of focal dystonia.
A. J. Lees - One of the best experts on this subject based on the ideXlab platform.
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Treatment of cervical dystonia hand spasms and laryngeal dystonia with botulinum toxin
Journal of Neurology, 1992Co-Authors: A. J. Lees, N. Turjanski, J. Rivest, R. Whurr, M. Lorch, G. BrookesAbstract:One hundred and twenty-six patients with different forms of focal dystonia (89 with cervical dystonia, 12 with hand Cramps and 25 with laryngeal dystonia) were treated with localised injections of botulinum toxin. Mean doses per muscle were 200 mouse units (m.u.) for treating cervical dystonia, 40–120 m.u. for forearm muscles in Writers' Cramp and 3.7 m. u. for the thyroarytenoid muscle in laryngeal dystonia. Responder rates have been above 80% in all patient groups and beneficial effects could be reproduced over follow-up periods of up to 4 years. The commonest side-effects were dysphagia after treatment of spasmodic torticollis, weakness of neighbouring muscles after injections for hand Cramps and breathiness and hypophonia following laryngeal injections. All these were transient and generally well tolerated. It is concluded that botulinum toxin injections are a safe and effective treatment in all three types of focal dystonia.
Tricia Wong - One of the best experts on this subject based on the ideXlab platform.
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differences in physical characteristics and response to rehabilitation for patients with hand dystonia musicians Cramp compared to Writers Cramp
Journal of Hand Therapy, 2009Co-Authors: Alison Mckenzie, Sarah B Goldman, Cindy Barrango, Maria Shrime, Tricia WongAbstract:Abstract Study Design Pre-Post, Mixed Factorial Trial. Introduction Focal hand dystonia is a challenging movement disorder to rehabilitate in musicians and Writers. Purpose of the Study To compare the neuromusculoskeletal characteristics of those with Writers' Cramp (WC) and musicians' Cramp (MC), and evaluate responsiveness to learning-based sensorimotor training. Methods Twenty-seven individuals (14 musicians, 13 Writers) participated in 8 weeks of supervised therapy supplemented with a home program. Between-group differences on measures of musculoskeletal (physical), sensory, and motor performance were evaluated at baseline and post-intervention. Results Subjects with MC had a higher level of functional independence and better range of motion, but less strength in the affected upper limb than those of subjects with WC. Subjects with MC demonstrated greater accuracy on graphesthesia, kinesthesia, and localization at baseline. No between-group differences in motor performance were noted at baseline or post-intervention. Following individually adapted learning-based sensorimotor training, both groups improved in musculoskeletal (physical) parameters, sensory processing, and motor control; however, improvements on certain subtests differed by group. At follow-up, differences in posture, ROM, strength, graphesthesia, and kinesthesia persisted between the groups. Conclusions Subjects with WC have different physical and performance risk factors compared with those of subjects with MC. Intervention paradigms are efficacious, but variable responses to rehabilitation occur. Level of Evidence 4.
France Woimant - One of the best experts on this subject based on the ideXlab platform.
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Inhibitory rTMS applied on somatosensory cortex in Wilson’s disease patients with hand dystonia
Journal of Neural Transmission, 2017Co-Authors: Pierre Lozeron, Aurélia Poujois, Elodie Meppiel, Sana Masmoudi, Thierry Peron Magnan, Eric Vicaut, Emmanuel Houdart, Jean-pierre Guichard, Jean-marc Trocello, France WoimantAbstract:Hand dystonia is a common complication of Wilson’s disease (WD), responsible for handwriting difficulties and disability. Alteration of sensorimotor integration and overactivity of the somatosensory cortex have been demonstrated in dystonia. This study investigated the immediate after effect of an inhibitory repetitive transcranial magnetic stimulation (rTMS) applied over the somatosensory cortex on the writing function in WD patients with hand dystonia. We performed a pilot prospective randomized double-blind sham-controlled crossover rTMS study. A 20-min 1-Hz rTMS session, stereotaxically guided, was applied over the left somatosensory cortex in 13 WD patients with right dystonic writer’s Cramp. After 3 days, each patient was crossed-over to the alternative treatment. Patients were clinically evaluated before and immediately after each rTMS session with the Unified Wilson’s Disease rating scale (UWDRS), the Writers’ Cramp Rating Scale (WCRS), a specifically designed scale for handwriting difficulties in Wilson’s disease patients (FAR, flow, accuracy, and rhythmicity evaluation), and a visual analog scale (VAS) for handwriting discomfort. No significant change in UWDRS, WCRS, VAS, or FAR scores was observed in patients treated with somatosensory inhibitory rTMS compared to the sham protocol. The FAR negatively correlated with UWDRS ( r = −0.6; P = 0.02), but not with the WCRS score, disease duration, MRI diffusion lesions, or with atrophy scores. In our experimental conditions, a single inhibitory rTMS session applied over somatosensory cortex did not improve dystonic writer Cramp in WD patients.
N. Turjanski - One of the best experts on this subject based on the ideXlab platform.
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Treatment of cervical dystonia hand spasms and laryngeal dystonia with botulinum toxin
Journal of Neurology, 1992Co-Authors: A. J. Lees, N. Turjanski, J. Rivest, R. Whurr, M. Lorch, G. BrookesAbstract:One hundred and twenty-six patients with different forms of focal dystonia (89 with cervical dystonia, 12 with hand Cramps and 25 with laryngeal dystonia) were treated with localised injections of botulinum toxin. Mean doses per muscle were 200 mouse units (m.u.) for treating cervical dystonia, 40–120 m.u. for forearm muscles in Writers' Cramp and 3.7 m. u. for the thyroarytenoid muscle in laryngeal dystonia. Responder rates have been above 80% in all patient groups and beneficial effects could be reproduced over follow-up periods of up to 4 years. The commonest side-effects were dysphagia after treatment of spasmodic torticollis, weakness of neighbouring muscles after injections for hand Cramps and breathiness and hypophonia following laryngeal injections. All these were transient and generally well tolerated. It is concluded that botulinum toxin injections are a safe and effective treatment in all three types of focal dystonia.
