Wuchereria bancrofti

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  • macrofilaricidal effect of 4 weeks of treatment with doxycycline on Wuchereria bancrofti
    Tropical Medicine & International Health, 2007
    Co-Authors: Sabine Mand, Linda Batsa, Yeboah Marfodebrekyei, Marcelle Buttner, Alexander Yaw Debrah, Ohene Adjei, Kenneth Pfarr, Dietrich W Buttner, Achim Hoerauf
    Abstract:

    Summary Objective  To evaluate the efficacy of doxycycline as a macrofilaricidal agent against Wuchereria bancrofti. Method  In the Western Region of Ghana, 18 patients infected with W. bancrofti were recruited and treated with 200 mg doxycycline per day for 4 weeks. Seven untreated patients served as controls. Four months after doxycycline treatment, all patients received 150 μg/kg ivermectin. Patients were monitored for Wolbachia and microfilaria loads, antigenaemia and filarial dance sign (FDS). Results  Four months after doxycycline treatment, cases had a significantly lower Wolbachia load than controls; and 24 months after treatment, microfilaraemia, antigenaemia and frequency of FDS were significantly lower in cases than controls. Most importantly, 4 weeks of doxycycline killed 80% of macrofilariae, which is comparable with the results of a 6-week regimen. Circulating filarial antigenaemia and FDS were strongly correlated. Conclusion  A 4-week regimen of doxycycline seems sufficient to kill adult W. bancrofti and could be advantageous for the treatment of individual patients, e.g. in outpatient clinics. Activite macrofilaricide de la doxycycline apres 4 semaines de traitement du Wuchereria bancrofti Objectif:  Evaluer l’efficacite de la doxycycline comme agent macrofilaricide contre Wuchereria bancrofti. Methode:  Dans la region ouest du Ghana, 18 patients atteints du W. bancrofti ont ete recrutes et traites avec la doxycycline a 200 mg par jour pendant quatre semaines et sept patients non traites ont servis de controles. Quatre mois apres le traitement a la doxycycline, tous les patients ont recu 150 mg/kg d’ivermectine. Les patients ont ete suivis pour les taux de Wolbachia et de microfilaire, l’antigenemie et le signe de la danse filariale (FDS). Resultats:  Quatre mois apres le traitement a la doxycycline, les cas avaient un taux de Wolbachia significativement plus faible que les controles et 24 mois apres le traitement, la microfilaremie, l’antigenemie et la frequence du FDS etaient sensiblement plus faibles chez les cas que chez les controles. De facon plus importante, quatre semaines de doxycycline avaient comme consequence un effet macrofilaricide de 80%, ce qui est comparable aux resultats d’un regime de six semaines. L’antigenemie filariale circulante et le FDS etaient fortement associes. Conclusion:  Un regime de quatre semaines de doxycycline semble suffisant pour obtenir une activite macrofilaricide sur W. bancrofti et pourrait etre avantageux dans le traitement individuel des patients, par exemple dans des cliniques de patients ambulants. Actividad macrofilaricida despues de 4 semanas del tratamiento con doxyciclina de Wuchereria bancrofti Objetivo:  Evaluar la eficacia de la doxiciclina como agente macrofilaricida frente a Wuchereria bancrofti. Metodo:  En la region de Ghana occidental, se reclutaron 18 pacientes infectados con W. bancrofti y fueron tratados con 200 mg de doxiciclina por dia durante cuatro semanas. Siete pacientes no tratados sirvieron como controles. Cuatro meses despues del tratamiento con doxiciclina, todos los pacientes recibieron 150μg/kg de ivermectina. Los pacientes fueron monitorizados para cargas de Wolbachia y microfilaria, antigenemia, y signos de movimiento filarial (filarial dance signs - FDS). Resultados:  Cuatro meses despues del tratamiento con doxiciclina, los casos tenian una carga de Wolbachia significativamente menor que los controles. Veinticuatro meses despues del tratamiento, la microfilaremia, antigenemia, y la frecuencia de FDS eran significativamente menores en los casos que en los controles. Mas importante aun, cuatro semanas de doxiciclina tuvieron un efecto macrofilaricida del 80%, lo cual es comparable con los resultados de un regimen de seis semanas. La antigenemia filarial circulante (AFC) y FDS estaban altamente correlacionadas. Conclusion:  Un regimen de cuatro semanas de doxiciclina parece ser suficiente para alcanzar una actividad macrofilaricida frente a W. bancrofti, y podria ser ventajoso para el tratamiento de pacientes individuales, por ejemplo en consulta externa.

  • reliable and frequent detection of adult Wuchereria bancrofti in ghanaian women by ultrasonography
    Tropical Medicine & International Health, 2004
    Co-Authors: Sabine Mand, Linda Batsa, Alexander Yaw Debrah, Ohene Adjei, Achim Hoerauf
    Abstract:

    Detection of adult Wuchereria bancrofti by ultrasonography of the scrotal region in men is a suitable diagnostic tool for lymphatic filariasis, whereas there are only a few case reports of adult filariae observed by ultrasonography in women. We examined 35 microfilaraemic women ultrasonographically in sites of the body suspected as locations for worm nests. In 15 women the 'filaria dance sign' (FDS) was detected in various locations, some being novel, such as adult worms within lymphatic vessels between muscular fibres of the thighs. The surprisingly high number of worm nests detectable in microfilaraemic women recommends ultrasonography for diagnosis and treatment efficacy monitoring of female patients infected with W. bancrofti.

James W Kazura - One of the best experts on this subject based on the ideXlab platform.

Alexander Yaw Debrah - One of the best experts on this subject based on the ideXlab platform.

  • macrofilaricidal effect of 4 weeks of treatment with doxycycline on Wuchereria bancrofti
    Tropical Medicine & International Health, 2007
    Co-Authors: Sabine Mand, Linda Batsa, Yeboah Marfodebrekyei, Marcelle Buttner, Alexander Yaw Debrah, Ohene Adjei, Kenneth Pfarr, Dietrich W Buttner, Achim Hoerauf
    Abstract:

    Summary Objective  To evaluate the efficacy of doxycycline as a macrofilaricidal agent against Wuchereria bancrofti. Method  In the Western Region of Ghana, 18 patients infected with W. bancrofti were recruited and treated with 200 mg doxycycline per day for 4 weeks. Seven untreated patients served as controls. Four months after doxycycline treatment, all patients received 150 μg/kg ivermectin. Patients were monitored for Wolbachia and microfilaria loads, antigenaemia and filarial dance sign (FDS). Results  Four months after doxycycline treatment, cases had a significantly lower Wolbachia load than controls; and 24 months after treatment, microfilaraemia, antigenaemia and frequency of FDS were significantly lower in cases than controls. Most importantly, 4 weeks of doxycycline killed 80% of macrofilariae, which is comparable with the results of a 6-week regimen. Circulating filarial antigenaemia and FDS were strongly correlated. Conclusion  A 4-week regimen of doxycycline seems sufficient to kill adult W. bancrofti and could be advantageous for the treatment of individual patients, e.g. in outpatient clinics. Activite macrofilaricide de la doxycycline apres 4 semaines de traitement du Wuchereria bancrofti Objectif:  Evaluer l’efficacite de la doxycycline comme agent macrofilaricide contre Wuchereria bancrofti. Methode:  Dans la region ouest du Ghana, 18 patients atteints du W. bancrofti ont ete recrutes et traites avec la doxycycline a 200 mg par jour pendant quatre semaines et sept patients non traites ont servis de controles. Quatre mois apres le traitement a la doxycycline, tous les patients ont recu 150 mg/kg d’ivermectine. Les patients ont ete suivis pour les taux de Wolbachia et de microfilaire, l’antigenemie et le signe de la danse filariale (FDS). Resultats:  Quatre mois apres le traitement a la doxycycline, les cas avaient un taux de Wolbachia significativement plus faible que les controles et 24 mois apres le traitement, la microfilaremie, l’antigenemie et la frequence du FDS etaient sensiblement plus faibles chez les cas que chez les controles. De facon plus importante, quatre semaines de doxycycline avaient comme consequence un effet macrofilaricide de 80%, ce qui est comparable aux resultats d’un regime de six semaines. L’antigenemie filariale circulante et le FDS etaient fortement associes. Conclusion:  Un regime de quatre semaines de doxycycline semble suffisant pour obtenir une activite macrofilaricide sur W. bancrofti et pourrait etre avantageux dans le traitement individuel des patients, par exemple dans des cliniques de patients ambulants. Actividad macrofilaricida despues de 4 semanas del tratamiento con doxyciclina de Wuchereria bancrofti Objetivo:  Evaluar la eficacia de la doxiciclina como agente macrofilaricida frente a Wuchereria bancrofti. Metodo:  En la region de Ghana occidental, se reclutaron 18 pacientes infectados con W. bancrofti y fueron tratados con 200 mg de doxiciclina por dia durante cuatro semanas. Siete pacientes no tratados sirvieron como controles. Cuatro meses despues del tratamiento con doxiciclina, todos los pacientes recibieron 150μg/kg de ivermectina. Los pacientes fueron monitorizados para cargas de Wolbachia y microfilaria, antigenemia, y signos de movimiento filarial (filarial dance signs - FDS). Resultados:  Cuatro meses despues del tratamiento con doxiciclina, los casos tenian una carga de Wolbachia significativamente menor que los controles. Veinticuatro meses despues del tratamiento, la microfilaremia, antigenemia, y la frecuencia de FDS eran significativamente menores en los casos que en los controles. Mas importante aun, cuatro semanas de doxiciclina tuvieron un efecto macrofilaricida del 80%, lo cual es comparable con los resultados de un regimen de seis semanas. La antigenemia filarial circulante (AFC) y FDS estaban altamente correlacionadas. Conclusion:  Un regimen de cuatro semanas de doxiciclina parece ser suficiente para alcanzar una actividad macrofilaricida frente a W. bancrofti, y podria ser ventajoso para el tratamiento de pacientes individuales, por ejemplo en consulta externa.

  • reliable and frequent detection of adult Wuchereria bancrofti in ghanaian women by ultrasonography
    Tropical Medicine & International Health, 2004
    Co-Authors: Sabine Mand, Linda Batsa, Alexander Yaw Debrah, Ohene Adjei, Achim Hoerauf
    Abstract:

    Detection of adult Wuchereria bancrofti by ultrasonography of the scrotal region in men is a suitable diagnostic tool for lymphatic filariasis, whereas there are only a few case reports of adult filariae observed by ultrasonography in women. We examined 35 microfilaraemic women ultrasonographically in sites of the body suspected as locations for worm nests. In 15 women the 'filaria dance sign' (FDS) was detected in various locations, some being novel, such as adult worms within lymphatic vessels between muscular fibres of the thighs. The surprisingly high number of worm nests detectable in microfilaraemic women recommends ultrasonography for diagnosis and treatment efficacy monitoring of female patients infected with W. bancrofti.

Christopher L King - One of the best experts on this subject based on the ideXlab platform.

Sabine Mand - One of the best experts on this subject based on the ideXlab platform.

  • macrofilaricidal effect of 4 weeks of treatment with doxycycline on Wuchereria bancrofti
    Tropical Medicine & International Health, 2007
    Co-Authors: Sabine Mand, Linda Batsa, Yeboah Marfodebrekyei, Marcelle Buttner, Alexander Yaw Debrah, Ohene Adjei, Kenneth Pfarr, Dietrich W Buttner, Achim Hoerauf
    Abstract:

    Summary Objective  To evaluate the efficacy of doxycycline as a macrofilaricidal agent against Wuchereria bancrofti. Method  In the Western Region of Ghana, 18 patients infected with W. bancrofti were recruited and treated with 200 mg doxycycline per day for 4 weeks. Seven untreated patients served as controls. Four months after doxycycline treatment, all patients received 150 μg/kg ivermectin. Patients were monitored for Wolbachia and microfilaria loads, antigenaemia and filarial dance sign (FDS). Results  Four months after doxycycline treatment, cases had a significantly lower Wolbachia load than controls; and 24 months after treatment, microfilaraemia, antigenaemia and frequency of FDS were significantly lower in cases than controls. Most importantly, 4 weeks of doxycycline killed 80% of macrofilariae, which is comparable with the results of a 6-week regimen. Circulating filarial antigenaemia and FDS were strongly correlated. Conclusion  A 4-week regimen of doxycycline seems sufficient to kill adult W. bancrofti and could be advantageous for the treatment of individual patients, e.g. in outpatient clinics. Activite macrofilaricide de la doxycycline apres 4 semaines de traitement du Wuchereria bancrofti Objectif:  Evaluer l’efficacite de la doxycycline comme agent macrofilaricide contre Wuchereria bancrofti. Methode:  Dans la region ouest du Ghana, 18 patients atteints du W. bancrofti ont ete recrutes et traites avec la doxycycline a 200 mg par jour pendant quatre semaines et sept patients non traites ont servis de controles. Quatre mois apres le traitement a la doxycycline, tous les patients ont recu 150 mg/kg d’ivermectine. Les patients ont ete suivis pour les taux de Wolbachia et de microfilaire, l’antigenemie et le signe de la danse filariale (FDS). Resultats:  Quatre mois apres le traitement a la doxycycline, les cas avaient un taux de Wolbachia significativement plus faible que les controles et 24 mois apres le traitement, la microfilaremie, l’antigenemie et la frequence du FDS etaient sensiblement plus faibles chez les cas que chez les controles. De facon plus importante, quatre semaines de doxycycline avaient comme consequence un effet macrofilaricide de 80%, ce qui est comparable aux resultats d’un regime de six semaines. L’antigenemie filariale circulante et le FDS etaient fortement associes. Conclusion:  Un regime de quatre semaines de doxycycline semble suffisant pour obtenir une activite macrofilaricide sur W. bancrofti et pourrait etre avantageux dans le traitement individuel des patients, par exemple dans des cliniques de patients ambulants. Actividad macrofilaricida despues de 4 semanas del tratamiento con doxyciclina de Wuchereria bancrofti Objetivo:  Evaluar la eficacia de la doxiciclina como agente macrofilaricida frente a Wuchereria bancrofti. Metodo:  En la region de Ghana occidental, se reclutaron 18 pacientes infectados con W. bancrofti y fueron tratados con 200 mg de doxiciclina por dia durante cuatro semanas. Siete pacientes no tratados sirvieron como controles. Cuatro meses despues del tratamiento con doxiciclina, todos los pacientes recibieron 150μg/kg de ivermectina. Los pacientes fueron monitorizados para cargas de Wolbachia y microfilaria, antigenemia, y signos de movimiento filarial (filarial dance signs - FDS). Resultados:  Cuatro meses despues del tratamiento con doxiciclina, los casos tenian una carga de Wolbachia significativamente menor que los controles. Veinticuatro meses despues del tratamiento, la microfilaremia, antigenemia, y la frecuencia de FDS eran significativamente menores en los casos que en los controles. Mas importante aun, cuatro semanas de doxiciclina tuvieron un efecto macrofilaricida del 80%, lo cual es comparable con los resultados de un regimen de seis semanas. La antigenemia filarial circulante (AFC) y FDS estaban altamente correlacionadas. Conclusion:  Un regimen de cuatro semanas de doxiciclina parece ser suficiente para alcanzar una actividad macrofilaricida frente a W. bancrofti, y podria ser ventajoso para el tratamiento de pacientes individuales, por ejemplo en consulta externa.

  • reliable and frequent detection of adult Wuchereria bancrofti in ghanaian women by ultrasonography
    Tropical Medicine & International Health, 2004
    Co-Authors: Sabine Mand, Linda Batsa, Alexander Yaw Debrah, Ohene Adjei, Achim Hoerauf
    Abstract:

    Detection of adult Wuchereria bancrofti by ultrasonography of the scrotal region in men is a suitable diagnostic tool for lymphatic filariasis, whereas there are only a few case reports of adult filariae observed by ultrasonography in women. We examined 35 microfilaraemic women ultrasonographically in sites of the body suspected as locations for worm nests. In 15 women the 'filaria dance sign' (FDS) was detected in various locations, some being novel, such as adult worms within lymphatic vessels between muscular fibres of the thighs. The surprisingly high number of worm nests detectable in microfilaraemic women recommends ultrasonography for diagnosis and treatment efficacy monitoring of female patients infected with W. bancrofti.

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