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Philip R. Cohen - One of the best experts on this subject based on the ideXlab platform.
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Vegas (Verruciform Genital-Associated) Xanthoma: A Comprehensive Literature Review
Dermatology and Therapy, 2017Co-Authors: Katherine M. Stiff, Philip R. CohenAbstract:Introduction Verruciform Xanthoma is a wart-like benign lesion. The classic histologic appearance consists of foamy histiocytes within elongated dermal papillae and epithelial acanthosis. The lesion most commonly occurs in the oral cavity, but has been reported in extra-oral sites such as the penis, scrotum, and vulva. The clinical and histologic characteristics of verruciform genital-associated (Vegas) Xanthomas of the penis, scrotum, and vulva are reviewed. Methods PubMed was used to search the following term: verruciform Xanthoma. The relevant papers were obtained and reviewed. Results There have been 193 cases of genital-associated verruciform Xanthomas. There were 164 in men and 29 in women. Similar to verruciform Xanthomas of the oral mucosa, they presented as asymptomatic lesions, demonstrated foam cells in the dermal papillae, and were typically managed successfully with surgical excision. Conclusion Verruciform Xanthoma is a benign lesion characterized by a wart-like growth that is most commonly seen in the oral mucosa. Verruciform Xanthomas of the genital region have been coined Vegas Xanthomas. Vegas Xanthomas have been reported in association with a variety of diseases, as well as in healthy individuals. Biopsy is required for diagnosis, and complete surgical excision is typically curative.
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vegas verruciform genital associated Xanthoma a comprehensive literature review
Dermatologic Therapy, 2017Co-Authors: Katherine M. Stiff, Philip R. CohenAbstract:Introduction Verruciform Xanthoma is a wart-like benign lesion. The classic histologic appearance consists of foamy histiocytes within elongated dermal papillae and epithelial acanthosis. The lesion most commonly occurs in the oral cavity, but has been reported in extra-oral sites such as the penis, scrotum, and vulva. The clinical and histologic characteristics of verruciform genital-associated (Vegas) Xanthomas of the penis, scrotum, and vulva are reviewed.
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Verruciform Genital-Associated (Vegas) Xanthoma: report of a patient with verruciform Xanthoma of the scrotum and literature review.
Dermatology online journal, 2015Co-Authors: Bryce D. Beutler, Philip R. CohenAbstract:Background: Verruciform Xanthoma is a benign verrucous lesion characterized by epithelial acanthosis and lipid-laden foamy histiocytes in the connective tissue papillae. It typically presents as a papillomatous, polypoid, or sessile lesion. Verruciform Xanthoma is most commonly observed within the oral cavity. However, albeit less frequently, it develops on the penis, scrotum, or vulva. Purpose: We describe the clinical and pathologic findings of a man who developed a verruciform Xanthoma on his scrotum. We also summarize the associated conditions, the differential diagnosis, the postulated pathogenesis, and the treatment options for this tumor. Materials and methods: The features of a man with a scrotal verruciform Xanthoma are presented. Using PubMed, the following terms were searched and relevant citations assessed: anogenital, foam cells, penis, scrotum, verruciform, verruciform Xanthoma, vulva, and Xanthoma. In addition, the literature on verruciform Xanthoma is reviewed. Results: Our patient developed an asymptomatic, exophytic, red filiform papule on his scrotum. A shave biopsy, attempting to remove the entire lesion, was performed. Based on correlation of the clinical presentation and histopathologic findings, a diagnosis of verruciform Xanthoma was established. The patient applied mupirocin 2% ointment to the biopsy site, which subsequently healed without complication or recurrence. Conclusion: Verruciform Xanthoma is a benign tumor commonly located within the oral cavity and characterized by the development of a small verrucous, papillomatous, polypoid, or sessile growth. Extraoral sites of verruciform Xanthoma often include the penis, scrotum, or vulva; we introduce the term 'Vegas' (Verruciform Genital-Associated) Xanthoma for these lesions. The lesions are often mistaken for viral warts or malignancies. Although the mechanism of pathogenesis is unknown, verruciform Xanthoma may have a multifactorial etiology involving inflammation, local immunosuppression, and/or metabolic dysfunction. It has also been postulated that verruciform Xanthoma is a secondary reaction to trauma-induced epithelial damage or degeneration. A biopsy for histopathologic examination is required to diagnose verruciform Xanthoma. The treatment of verruciform Xanthoma typically involves simple surgical excision.
Katherine M. Stiff - One of the best experts on this subject based on the ideXlab platform.
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Vegas (Verruciform Genital-Associated) Xanthoma: A Comprehensive Literature Review
Dermatology and Therapy, 2017Co-Authors: Katherine M. Stiff, Philip R. CohenAbstract:Introduction Verruciform Xanthoma is a wart-like benign lesion. The classic histologic appearance consists of foamy histiocytes within elongated dermal papillae and epithelial acanthosis. The lesion most commonly occurs in the oral cavity, but has been reported in extra-oral sites such as the penis, scrotum, and vulva. The clinical and histologic characteristics of verruciform genital-associated (Vegas) Xanthomas of the penis, scrotum, and vulva are reviewed. Methods PubMed was used to search the following term: verruciform Xanthoma. The relevant papers were obtained and reviewed. Results There have been 193 cases of genital-associated verruciform Xanthomas. There were 164 in men and 29 in women. Similar to verruciform Xanthomas of the oral mucosa, they presented as asymptomatic lesions, demonstrated foam cells in the dermal papillae, and were typically managed successfully with surgical excision. Conclusion Verruciform Xanthoma is a benign lesion characterized by a wart-like growth that is most commonly seen in the oral mucosa. Verruciform Xanthomas of the genital region have been coined Vegas Xanthomas. Vegas Xanthomas have been reported in association with a variety of diseases, as well as in healthy individuals. Biopsy is required for diagnosis, and complete surgical excision is typically curative.
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vegas verruciform genital associated Xanthoma a comprehensive literature review
Dermatologic Therapy, 2017Co-Authors: Katherine M. Stiff, Philip R. CohenAbstract:Introduction Verruciform Xanthoma is a wart-like benign lesion. The classic histologic appearance consists of foamy histiocytes within elongated dermal papillae and epithelial acanthosis. The lesion most commonly occurs in the oral cavity, but has been reported in extra-oral sites such as the penis, scrotum, and vulva. The clinical and histologic characteristics of verruciform genital-associated (Vegas) Xanthomas of the penis, scrotum, and vulva are reviewed.
Natasha Mirza - One of the best experts on this subject based on the ideXlab platform.
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extensive intracranial Xanthoma associated with type ii hyperlipidemia
American Journal of Neuroradiology, 2000Co-Authors: Gabrielle R Bonhomme, Laurie A Loevner, David M Yen, Daniel A Deems, Douglas C Bigelow, Natasha MirzaAbstract:Xanthomas are associated with a spectrum of medical conditions, most commonly disorders of lipid storage and lipid metabolism. They occur primarily in the subcutaneous tissues, especially along the Achilles tendon and the extensor tendons of the hands. Intracranial Xanthomas are extremely rare. We present a case of an extensive Xanthoma of the temporal bone in a patient with hyperlipidemia.
Akira Tsutsumi - One of the best experts on this subject based on the ideXlab platform.
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Xanthoma of the temporal bone case report
Neurosurgery, 2000Co-Authors: Toshihiko Kuroiwa, Tomio Ohta, Akira TsutsumiAbstract:OBJECTIVE AND IMPORTANCE: Xanthomas of the cranium that are not accompanied by endocrine or metabolic abnormalities are extremely rare. It is very important to understand the pathological features of this disease, for differential diagnosis from other diseases. CLINICAL PRESENTATION: A 62-year-old woman presented to the hospital with headaches. Cranial x-rays revealed bone destruction in the right temporal bone, with osteosclerosis in the area surrounding the lesion. In computed tomographic scans, the bone cortex was intact and the diploe was dilated because of the large mass of the lesion. T1-weighted magnetic resonance imaging findings were heterogeneous, with areas of hypo- and isointensity; T2-weighted magnetic resonance imaging findings were also heterogeneous, with areas of hypo- and hyperintensity. INTERVENTION: Total removal of the tumor was performed, followed by cranioplasty using artificial bone. DIAGNOSIS: Histologically, lipid-containing foamy cells were dense and a cholesterin granuloma was observed. There was no reason to infer other diseases, and a diagnosis of Xanthoma of the temporal bone was reached. CONCLUSION: Xanthomatous lesions are observed in various pathological conditions, including malignant diseases. Xanthomas are benign lesions and the prognoses for patients with these lesions are satisfactory, even after partial excision. Therefore, it is quite important to distinguish Xanthomas from other diseases that produce Xanthomatous lesions.
Jonathan I Epstein - One of the best experts on this subject based on the ideXlab platform.
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Xanthoma of the prostate a mimicker of high grade prostate adenocarcinoma
The American Journal of Surgical Pathology, 2007Co-Authors: Ai Ying Chuang, Jonathan I EpsteinAbstract:Prostatic Xanthoma may mimic high-grade prostatic adenocarcinoma or prostate cancer treated with hormone therapy. From 1995 to 2006, 40 cases of prostatic Xanthoma were diagnosed at The Johns Hopkins Hospital. Thirty-four cases were received in consultation from outside institutions. Hematoxylin and eosin-stained or unstained slides were available in 27 cases (24 consultation cases; 3 in-house cases). Xanthoma was found on needle biopsy in 25 cases, with 2 cases noted on transurethral resection of prostate. Twenty-six cases contained only 1 focus of prostatic Xanthoma with 1 case having 3 foci on the same core biopsy specimen. In 21 Xanthomas, the lesions were small measuring 1 mm with the largest one measuring 2.5 mm. Xanthoma cells had small uniform, benign-appearing nuclei, small inconspicuous nucleoli, and abundant vacuolated foamy cytoplasm. No mitoses were identified. Focal necrosis was identified in 1 case. Most Xanthomas were arranged in circumscribed solid nodular pattern (17 cases). Ten Xanthomas consisted of cords and individual cells infiltrating the prostatic stroma, further mimicking high-grade prostate carcinoma. Two Xanthomas contained a mixed circumscribed nodular pattern and infiltrating pattern. Of cases with the lesion still present on slides for immunohistochemistry, CD68 was diffusely strongly positive in 18/19 (94.7%) and CAM5.2 was positive in none of the cases 0/14 (0%). One of 15 (6.7%), 2/17 (11.8%), and 1/12 (8.3%) cases were positive for prostate-specific antigen, prostate-specific acid phosphatase, and alpha-methylacyl-CoA racemase, respectively. Careful attention to morphology with adjunctive use of CD68 and CAM5.2 immunohistochemical stains are helpful in the diagnosis of prostatic Xanthoma, especially in difficult cases with an infiltrative pattern.
