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Patrick Dupuy - One of the best experts on this subject based on the ideXlab platform.
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quality of life in patients with uraemic Xerosis and pruritus
Acta Dermato-venereologica, 2011Co-Authors: Jacek C. Szepietowski, Elias V Balaskas, Klausmichael Taube, Alain Taberly, Patrick DupuyAbstract:A total of 334 end-stage renal disease patients with moderate-to-severe uraemic Xerosis were surveyed for quality of life assessment, using the generic Short-Form (SF-12) scale and the Dermatology Life Quality Index (DLQI). In parallel, the intensity of Xerosis at four sites (the two lower legs, chest, forearm without arterio-venous shunt) was assessed, using a five-point lesional intensity score. Pruritus was auto-assessed by the patients, using a 100-mm visual analogue scale. Uraemic Xerosis patients had a marked deterioration in the Physical Component Summary of SF-12 (mean ± SD: 34.92 ± 9.98) and DLQI (5.06 ± 4.73). Younger age (r = -0.20), Xerosis intensity (r = 0.14), and the presence of pruritus (p < 0.0001) and its intensity (r = 0.50) were shown to be significant worsening factors of DLQI. Because a low, but significant, correlation between the intensity of Xerosis and pruritus was also demonstrated (r = 0.18), the direct contribution of age, Xerosis and pruritus on DLQI was analysed in a multiple linear regression model. Age and pruritus intensity, but not Xerosis intensity, were found to be independent contributors to DLQI deterioration (p < 0.0005). On the other hand, uraemic Xerosis without associated pruritus still resulted in DLQI alteration (3.24 ± 3.99). It was concluded that young age and intensity of uraemic pruritus compromise quality of life in uraemic Xerosis patients. Some characteristics of uraemic Xerosis other than Xerosis intensity may also be involved in quality of life alteration.
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Randomized, Double-blind Study with Glycerol and Paraffin in Uremic Xerosis
Clinical journal of the American Society of Nephrology : CJASN, 2011Co-Authors: Elias V Balaskas, Jacek C. Szepietowski, Alain Taberly, Didier Bessis, Dimitrios Ioannides, Claudio Ponticelli, Corinne Ghienne, Patrick DupuyAbstract:Summary Background and objectives Uremic Xerosis is a bothersome condition that is poorly responsive to moisturizing and emollient therapy. Design, setting, participants, & measurements A randomized, double-blind, intraindividual (left versus right comparison), multicentric clinical study was performed on 100 patients with moderate to severe uremic Xerosis for 7 days, during which the patients applied twice daily an emulsion combining glycerol and paraffin (test product) on one allocated lower leg, and the emulsion alone (comparator) on the other lower leg. This was followed by an open-labeled use of the test product on all of the xerotic areas for 49 days. The main efficacy parameter was treatment response on each lower leg, as defined by a reduction from baseline of at least two grades in a five-point clinical score on day 7. Results Among the 99 patients analyzed, the test product was highly effective with a treatment response in 72 patients (73%), whereas 44 patients (44%) responded to the comparator ( P P P Conclusions Uremic Xerosis can be managed successfully when an appropriate emollient therapy is used.
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Quality of life in patients with uraemic Xerosis and pruritus.
Acta dermato-venereologica, 2011Co-Authors: Jacek C. Szepietowski, Elias V Balaskas, Klausmichael Taube, Alain Taberly, Patrick DupuyAbstract:A total of 334 end-stage renal disease patients with moderate-to-severe uraemic Xerosis were surveyed for quality of life assessment, using the generic Short-Form (SF-12) scale and the Dermatology Life Quality Index (DLQI). In parallel, the intensity of Xerosis at four sites (the two lower legs, chest, forearm without arterio-venous shunt) was assessed, using a five-point lesional intensity score. Pruritus was auto-assessed by the patients, using a 100-mm visual analogue scale. Uraemic Xerosis patients had a marked deterioration in the Physical Component Summary of SF-12 (mean ± SD: 34.92 ± 9.98) and DLQI (5.06 ± 4.73). Younger age (r = -0.20), Xerosis intensity (r = 0.14), and the presence of pruritus (p
Roberto Montes De Oca-jiménez - One of the best experts on this subject based on the ideXlab platform.
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Identification and molecular characterization of Corynebacterium Xerosis isolated from a sheep cutaneous abscess: first case report in Mexico
BMC research notes, 2016Co-Authors: Fernando Hernández-león, Jorge Acosta-dibarrat, Juan Carlos Vázquez-chagoyán, Pomposo Fernández Rosas, Roberto Montes De Oca-jiménezAbstract:Background Corynebacterium Xerosis is a commensal organism found in skin and mucous membranes of humans. It is considered an unusual pathogen, and it is rarely found in human and animal clinical samples. Here we describe the isolation of C. Xerosis from a 4-months-old Pelifolk lamb located in Tesistan, central western Mexico. This microorganism should be considered for differential diagnosis in cutaneous abscessed lesions in sheep, as it represents a zoonotic risk factor for human infection in sheep farms.
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Identification and molecular characterization of Corynebacterium Xerosis isolated from a sheep cutaneous abscess: first case report in Mexico
BMC Research Notes, 2016Co-Authors: Fernando Hernández-león, Jorge Acosta-dibarrat, Juan Carlos Vázquez-chagoyán, Pomposo Fernández Rosas, Roberto Montes De Oca-jiménezAbstract:Background Corynebacterium Xerosis is a commensal organism found in skin and mucous membranes of humans. It is considered an unusual pathogen, and it is rarely found in human and animal clinical samples. Here we describe the isolation of C. Xerosis from a 4-months-old Pelifolk lamb located in Tesistán, central western Mexico. This microorganism should be considered for differential diagnosis in cutaneous abscessed lesions in sheep, as it represents a zoonotic risk factor for human infection in sheep farms. Case presentation The animal exhibited a hard-consistency, 5 cm diameter abscess, without drainage, in the neck. The presumptive clinical diagnosis was caseous lymphadenitis, caused by Corynebacterium pseudotuberculosis . Samples were obtained by puncture and cultured in 8 % sheep blood agar under microaerophilic conditions. Colonies were non-haemolytic, brown-yellowish and showed microscopic and biochemical features similar to C. pseudotuberculosis , except for the urea test. A multiplex-PCR for the amplification of partial sequences of the pld , rpoB and intergenic fragment from 16S to 23S genes suggested that isolate could be C. Xerosis, which was later confirmed by sequencing analysis of the rpoB gene. Conclusions This study shows for the first time isolation and molecular characterization of C. Xerosis from a clinical sample of an ovine cutaneous abscess in Mexico. This finding highlights the need for differential diagnosis of this pathogen in ovine skin abscesses, as well as epidemiological and control studies of this pathogen in sheep farms.
Jacek C. Szepietowski - One of the best experts on this subject based on the ideXlab platform.
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quality of life in patients with uraemic Xerosis and pruritus
Acta Dermato-venereologica, 2011Co-Authors: Jacek C. Szepietowski, Elias V Balaskas, Klausmichael Taube, Alain Taberly, Patrick DupuyAbstract:A total of 334 end-stage renal disease patients with moderate-to-severe uraemic Xerosis were surveyed for quality of life assessment, using the generic Short-Form (SF-12) scale and the Dermatology Life Quality Index (DLQI). In parallel, the intensity of Xerosis at four sites (the two lower legs, chest, forearm without arterio-venous shunt) was assessed, using a five-point lesional intensity score. Pruritus was auto-assessed by the patients, using a 100-mm visual analogue scale. Uraemic Xerosis patients had a marked deterioration in the Physical Component Summary of SF-12 (mean ± SD: 34.92 ± 9.98) and DLQI (5.06 ± 4.73). Younger age (r = -0.20), Xerosis intensity (r = 0.14), and the presence of pruritus (p < 0.0001) and its intensity (r = 0.50) were shown to be significant worsening factors of DLQI. Because a low, but significant, correlation between the intensity of Xerosis and pruritus was also demonstrated (r = 0.18), the direct contribution of age, Xerosis and pruritus on DLQI was analysed in a multiple linear regression model. Age and pruritus intensity, but not Xerosis intensity, were found to be independent contributors to DLQI deterioration (p < 0.0005). On the other hand, uraemic Xerosis without associated pruritus still resulted in DLQI alteration (3.24 ± 3.99). It was concluded that young age and intensity of uraemic pruritus compromise quality of life in uraemic Xerosis patients. Some characteristics of uraemic Xerosis other than Xerosis intensity may also be involved in quality of life alteration.
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Randomized, Double-blind Study with Glycerol and Paraffin in Uremic Xerosis
Clinical journal of the American Society of Nephrology : CJASN, 2011Co-Authors: Elias V Balaskas, Jacek C. Szepietowski, Alain Taberly, Didier Bessis, Dimitrios Ioannides, Claudio Ponticelli, Corinne Ghienne, Patrick DupuyAbstract:Summary Background and objectives Uremic Xerosis is a bothersome condition that is poorly responsive to moisturizing and emollient therapy. Design, setting, participants, & measurements A randomized, double-blind, intraindividual (left versus right comparison), multicentric clinical study was performed on 100 patients with moderate to severe uremic Xerosis for 7 days, during which the patients applied twice daily an emulsion combining glycerol and paraffin (test product) on one allocated lower leg, and the emulsion alone (comparator) on the other lower leg. This was followed by an open-labeled use of the test product on all of the xerotic areas for 49 days. The main efficacy parameter was treatment response on each lower leg, as defined by a reduction from baseline of at least two grades in a five-point clinical score on day 7. Results Among the 99 patients analyzed, the test product was highly effective with a treatment response in 72 patients (73%), whereas 44 patients (44%) responded to the comparator ( P P P Conclusions Uremic Xerosis can be managed successfully when an appropriate emollient therapy is used.
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Quality of life in patients with uraemic Xerosis and pruritus.
Acta dermato-venereologica, 2011Co-Authors: Jacek C. Szepietowski, Elias V Balaskas, Klausmichael Taube, Alain Taberly, Patrick DupuyAbstract:A total of 334 end-stage renal disease patients with moderate-to-severe uraemic Xerosis were surveyed for quality of life assessment, using the generic Short-Form (SF-12) scale and the Dermatology Life Quality Index (DLQI). In parallel, the intensity of Xerosis at four sites (the two lower legs, chest, forearm without arterio-venous shunt) was assessed, using a five-point lesional intensity score. Pruritus was auto-assessed by the patients, using a 100-mm visual analogue scale. Uraemic Xerosis patients had a marked deterioration in the Physical Component Summary of SF-12 (mean ± SD: 34.92 ± 9.98) and DLQI (5.06 ± 4.73). Younger age (r = -0.20), Xerosis intensity (r = 0.14), and the presence of pruritus (p
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efficacy and tolerance of the cream containing structured physiological lipids with endocannabinoids in the treatment of uremic pruritus a preliminary study
Acta Dermatovenerologica Croatica, 2005Co-Authors: Jacek C. Szepietowski, Tomasz Szepietowski, Adam ReichAbstract:®® ) and endogenous cannabinoids in controlling pruritus in patients on maintenance hemodialysis. Twenty-one subjects with uremic pruritus completed the trial. All patients applied the tested cream twice daily for a period of three weeks. Pruritus was evaluated using two pruritus scoring methods: standard visual analog scale (VAS) and a questionnaire method. Moreover, all patients had dry skin scored according to the 5-point scale. Global pruritus and Xerosis were examined before the trial, on study visits at weekly intervals, and on follow-up visit performed two weeks of study discontinuation. After 3-week therapy pruritus was completely eliminated in 8 (38.1%) patients. Pruritus evaluation by both scales revealed significant reduction of pruritus scores (p<0.0001) during the tested product application. At the beginning of the trial there was no significant correlation between the intensity of dry skin and severity of pruritus. The 3-week treatment period resulted in complete reduction of Xerosis in 17 (81%) patients, while Xerosis scores were significantly reduced (p=0.0001) throughout the study period. The test product was very well tolerated by all patients.The test product appeared to be effective in reducing both pruritus and Xerosis in hemodialysis patients. It is very probable that the observed decrease of pruritus with the test product therapy was not only the result of dry skin improvement but that the addition of endocannabinoids may have also played a role. These preliminary results are encouraging, however, additional controlled studies are needed to clarify the exact usefulness of this product in therapy of uremic pruritus.
Elias V Balaskas - One of the best experts on this subject based on the ideXlab platform.
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quality of life in patients with uraemic Xerosis and pruritus
Acta Dermato-venereologica, 2011Co-Authors: Jacek C. Szepietowski, Elias V Balaskas, Klausmichael Taube, Alain Taberly, Patrick DupuyAbstract:A total of 334 end-stage renal disease patients with moderate-to-severe uraemic Xerosis were surveyed for quality of life assessment, using the generic Short-Form (SF-12) scale and the Dermatology Life Quality Index (DLQI). In parallel, the intensity of Xerosis at four sites (the two lower legs, chest, forearm without arterio-venous shunt) was assessed, using a five-point lesional intensity score. Pruritus was auto-assessed by the patients, using a 100-mm visual analogue scale. Uraemic Xerosis patients had a marked deterioration in the Physical Component Summary of SF-12 (mean ± SD: 34.92 ± 9.98) and DLQI (5.06 ± 4.73). Younger age (r = -0.20), Xerosis intensity (r = 0.14), and the presence of pruritus (p < 0.0001) and its intensity (r = 0.50) were shown to be significant worsening factors of DLQI. Because a low, but significant, correlation between the intensity of Xerosis and pruritus was also demonstrated (r = 0.18), the direct contribution of age, Xerosis and pruritus on DLQI was analysed in a multiple linear regression model. Age and pruritus intensity, but not Xerosis intensity, were found to be independent contributors to DLQI deterioration (p < 0.0005). On the other hand, uraemic Xerosis without associated pruritus still resulted in DLQI alteration (3.24 ± 3.99). It was concluded that young age and intensity of uraemic pruritus compromise quality of life in uraemic Xerosis patients. Some characteristics of uraemic Xerosis other than Xerosis intensity may also be involved in quality of life alteration.
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Randomized, Double-blind Study with Glycerol and Paraffin in Uremic Xerosis
Clinical journal of the American Society of Nephrology : CJASN, 2011Co-Authors: Elias V Balaskas, Jacek C. Szepietowski, Alain Taberly, Didier Bessis, Dimitrios Ioannides, Claudio Ponticelli, Corinne Ghienne, Patrick DupuyAbstract:Summary Background and objectives Uremic Xerosis is a bothersome condition that is poorly responsive to moisturizing and emollient therapy. Design, setting, participants, & measurements A randomized, double-blind, intraindividual (left versus right comparison), multicentric clinical study was performed on 100 patients with moderate to severe uremic Xerosis for 7 days, during which the patients applied twice daily an emulsion combining glycerol and paraffin (test product) on one allocated lower leg, and the emulsion alone (comparator) on the other lower leg. This was followed by an open-labeled use of the test product on all of the xerotic areas for 49 days. The main efficacy parameter was treatment response on each lower leg, as defined by a reduction from baseline of at least two grades in a five-point clinical score on day 7. Results Among the 99 patients analyzed, the test product was highly effective with a treatment response in 72 patients (73%), whereas 44 patients (44%) responded to the comparator ( P P P Conclusions Uremic Xerosis can be managed successfully when an appropriate emollient therapy is used.
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Quality of life in patients with uraemic Xerosis and pruritus.
Acta dermato-venereologica, 2011Co-Authors: Jacek C. Szepietowski, Elias V Balaskas, Klausmichael Taube, Alain Taberly, Patrick DupuyAbstract:A total of 334 end-stage renal disease patients with moderate-to-severe uraemic Xerosis were surveyed for quality of life assessment, using the generic Short-Form (SF-12) scale and the Dermatology Life Quality Index (DLQI). In parallel, the intensity of Xerosis at four sites (the two lower legs, chest, forearm without arterio-venous shunt) was assessed, using a five-point lesional intensity score. Pruritus was auto-assessed by the patients, using a 100-mm visual analogue scale. Uraemic Xerosis patients had a marked deterioration in the Physical Component Summary of SF-12 (mean ± SD: 34.92 ± 9.98) and DLQI (5.06 ± 4.73). Younger age (r = -0.20), Xerosis intensity (r = 0.14), and the presence of pruritus (p
Fernando Hernández-león - One of the best experts on this subject based on the ideXlab platform.
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Identification and molecular characterization of Corynebacterium Xerosis isolated from a sheep cutaneous abscess: first case report in Mexico
BMC research notes, 2016Co-Authors: Fernando Hernández-león, Jorge Acosta-dibarrat, Juan Carlos Vázquez-chagoyán, Pomposo Fernández Rosas, Roberto Montes De Oca-jiménezAbstract:Background Corynebacterium Xerosis is a commensal organism found in skin and mucous membranes of humans. It is considered an unusual pathogen, and it is rarely found in human and animal clinical samples. Here we describe the isolation of C. Xerosis from a 4-months-old Pelifolk lamb located in Tesistan, central western Mexico. This microorganism should be considered for differential diagnosis in cutaneous abscessed lesions in sheep, as it represents a zoonotic risk factor for human infection in sheep farms.
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Identification and molecular characterization of Corynebacterium Xerosis isolated from a sheep cutaneous abscess: first case report in Mexico
BMC Research Notes, 2016Co-Authors: Fernando Hernández-león, Jorge Acosta-dibarrat, Juan Carlos Vázquez-chagoyán, Pomposo Fernández Rosas, Roberto Montes De Oca-jiménezAbstract:Background Corynebacterium Xerosis is a commensal organism found in skin and mucous membranes of humans. It is considered an unusual pathogen, and it is rarely found in human and animal clinical samples. Here we describe the isolation of C. Xerosis from a 4-months-old Pelifolk lamb located in Tesistán, central western Mexico. This microorganism should be considered for differential diagnosis in cutaneous abscessed lesions in sheep, as it represents a zoonotic risk factor for human infection in sheep farms. Case presentation The animal exhibited a hard-consistency, 5 cm diameter abscess, without drainage, in the neck. The presumptive clinical diagnosis was caseous lymphadenitis, caused by Corynebacterium pseudotuberculosis . Samples were obtained by puncture and cultured in 8 % sheep blood agar under microaerophilic conditions. Colonies were non-haemolytic, brown-yellowish and showed microscopic and biochemical features similar to C. pseudotuberculosis , except for the urea test. A multiplex-PCR for the amplification of partial sequences of the pld , rpoB and intergenic fragment from 16S to 23S genes suggested that isolate could be C. Xerosis, which was later confirmed by sequencing analysis of the rpoB gene. Conclusions This study shows for the first time isolation and molecular characterization of C. Xerosis from a clinical sample of an ovine cutaneous abscess in Mexico. This finding highlights the need for differential diagnosis of this pathogen in ovine skin abscesses, as well as epidemiological and control studies of this pathogen in sheep farms.
