The Experts below are selected from a list of 3 Experts worldwide ranked by ideXlab platform
Aidar T. Gubaidullin - One of the best experts on this subject based on the ideXlab platform.
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Synthesis, crystal structure, and absolute configuration of the enantiomers of chiral drug Xibenolol hydrochloride
Tetrahedron: Asymmetry, 2017Co-Authors: Alexander A. Bredikhin, Zemfira A. Bredikhina, Alexey V. Kurenkov, Aidar T. GubaidullinAbstract:Abstract Based on the features of its crystallization, racemic 3-(2,3-dimethylphenoxy)propane-1,2-diol 2 , the synthetic precursor of the chiral drug Xibenolol 1 , was resolved into pure enantiomers by the direct method of entrainment. The enantiomers of diol 2 through a Mitsunobu reaction were converted into the nonracemic 1,2-epoxy-3-(2,3-dimethylphenoxy)propanes ( S )- and ( R )- 3 , and then into the Xibenolol enantiomers. Single crystals of (+)- and (−)- 1 ·HCl were studied by X-ray diffraction. On the basis of the Flack parameter, the absolute ( R )- and ( S )-configurations were assigned to these compounds and to the other intermediate chiral substances.
Alexander A. Bredikhin - One of the best experts on this subject based on the ideXlab platform.
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Synthesis, crystal structure, and absolute configuration of the enantiomers of chiral drug Xibenolol hydrochloride
Tetrahedron: Asymmetry, 2017Co-Authors: Alexander A. Bredikhin, Zemfira A. Bredikhina, Alexey V. Kurenkov, Aidar T. GubaidullinAbstract:Abstract Based on the features of its crystallization, racemic 3-(2,3-dimethylphenoxy)propane-1,2-diol 2 , the synthetic precursor of the chiral drug Xibenolol 1 , was resolved into pure enantiomers by the direct method of entrainment. The enantiomers of diol 2 through a Mitsunobu reaction were converted into the nonracemic 1,2-epoxy-3-(2,3-dimethylphenoxy)propanes ( S )- and ( R )- 3 , and then into the Xibenolol enantiomers. Single crystals of (+)- and (−)- 1 ·HCl were studied by X-ray diffraction. On the basis of the Flack parameter, the absolute ( R )- and ( S )-configurations were assigned to these compounds and to the other intermediate chiral substances.
Zemfira A. Bredikhina - One of the best experts on this subject based on the ideXlab platform.
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Synthesis, crystal structure, and absolute configuration of the enantiomers of chiral drug Xibenolol hydrochloride
Tetrahedron: Asymmetry, 2017Co-Authors: Alexander A. Bredikhin, Zemfira A. Bredikhina, Alexey V. Kurenkov, Aidar T. GubaidullinAbstract:Abstract Based on the features of its crystallization, racemic 3-(2,3-dimethylphenoxy)propane-1,2-diol 2 , the synthetic precursor of the chiral drug Xibenolol 1 , was resolved into pure enantiomers by the direct method of entrainment. The enantiomers of diol 2 through a Mitsunobu reaction were converted into the nonracemic 1,2-epoxy-3-(2,3-dimethylphenoxy)propanes ( S )- and ( R )- 3 , and then into the Xibenolol enantiomers. Single crystals of (+)- and (−)- 1 ·HCl were studied by X-ray diffraction. On the basis of the Flack parameter, the absolute ( R )- and ( S )-configurations were assigned to these compounds and to the other intermediate chiral substances.
Alexey V. Kurenkov - One of the best experts on this subject based on the ideXlab platform.
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Synthesis, crystal structure, and absolute configuration of the enantiomers of chiral drug Xibenolol hydrochloride
Tetrahedron: Asymmetry, 2017Co-Authors: Alexander A. Bredikhin, Zemfira A. Bredikhina, Alexey V. Kurenkov, Aidar T. GubaidullinAbstract:Abstract Based on the features of its crystallization, racemic 3-(2,3-dimethylphenoxy)propane-1,2-diol 2 , the synthetic precursor of the chiral drug Xibenolol 1 , was resolved into pure enantiomers by the direct method of entrainment. The enantiomers of diol 2 through a Mitsunobu reaction were converted into the nonracemic 1,2-epoxy-3-(2,3-dimethylphenoxy)propanes ( S )- and ( R )- 3 , and then into the Xibenolol enantiomers. Single crystals of (+)- and (−)- 1 ·HCl were studied by X-ray diffraction. On the basis of the Flack parameter, the absolute ( R )- and ( S )-configurations were assigned to these compounds and to the other intermediate chiral substances.
