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Tibor Kurtan - One of the best experts on this subject based on the ideXlab platform.
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xylomolones a d from the thai mangrove Xylocarpus moluccensis assignment of absolute stereostructures and unveiling a convergent strategy for limonoid biosynthesis
Journal of Organic Chemistry, 2019Co-Authors: Attila Mandi, Junjun Liu, Li Shen, Tibor KurtanAbstract:Two new 9,10- seco limonoids with a central 3,4-dihydro-2 H-pyran motif, named xylomolones A and B (1 and 2, respectively), possessing identical absolute configurations but reversed alignments of ring A, compared to the tricyclic core of rings B-D, were obtained from seeds of the Thai mangrove Xylocarpus moluccensis, together with a highly modified 1,2- seco limonoid, named xylomolone C (3), containing a novel 3-oxabicyclo[3.2.1]octane-2,7-dione motif, and a new C11-terpenic acid methyl ester (4). The relative and absolute configurations of 1-4 were evidenced by extensive nuclear magnetic resonance (NMR) investigations combined with density functional theory and time-dependent density functional theory calculations of electronic circular dichroism, specific optical rotation, and 13C NMR data. The co-isolation of 1-4 allowed us to propose a novel convergent strategy for limonoid biosynthesis for the first time. This study demonstrates that mangroves of the genus Xylocarpus harbor new limonoid biosynthetic routes.
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bioactive rearranged limonoids from the chinese mangrove Xylocarpus granatum koenig
ChemInform, 2015Co-Authors: Zhen Fang Zhou, Attila Mandi, Tibor Kurtan, Wen Zhang, Attila Benyei, Jia Li, Orazio TaglialatelascafatiAbstract:Two new pyridine-containing limonoids, xylogranatopyridines A (I) and B (II) and their formal precursor, prexylogranatopyridine (III), are isolated and evaluated for their protein tyrosine phosphatase 1B (PTP1B) activity.
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bioactive rearranged limonoids from the chinese mangrove Xylocarpus granatum koenig
Tetrahedron, 2014Co-Authors: Zhen Fang Zhou, Attila Mandi, Tibor Kurtan, Wen Zhang, Attila Benyei, Jia Li, Orazio TaglialatelascafatiAbstract:Abstract Two new pyridine-containing limonoids, xylogranatopyridines A and B ( 1 and 2 ) and their formal precursor, prexylogranatopyridine ( 3 ) were isolated from the twigs and leaves of the Chinese mangrove, Xylocarpus granatum . Xylogranatopyridine B ( 2 ) possesses an unprecedented rearranged B-ring together with a seco-ring A, supporting the biogenetic connection of 1 – 2 with 3 . The chemical structures were elucidated by means of detailed spectroscopic analysis and X-ray single-crystal diffraction. The absolute configurations were assigned using electronic solid-state circular dichroism (ECD) supported by time-dependent density functional theory (TDDFT) ECD calculations and X-ray analysis. Xylogranatopyridine A ( 1 ) exhibited a significant inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) with an IC 50 value of 22.9 μM. This is the first report of PTP1B inhibitory activity of limonoids.
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four phragmalin orthoesters from the chinese mangrove Xylocarpus granatum
Planta Medica, 2014Co-Authors: Zhen Fang Zhou, Attila Mandi, Tibor Kurtan, Lingyi Kong, Haili Liu, Yuewei GuoAbstract:Four new 8,9,30-phragmalin orthoesters (1–4), along with six related known compounds, namely xyloccensins O–S (5–9) and V (10), were isolated and characterized from the twigs and leaves of the Chinese mangrove Xylocarpus granatum. The structures of the new compounds were determined on the basis of extensive spectroscopic analysis and by comparison with those of related known compounds in the literature. The absolute configuration of xyloccensin Q (7) was revised as its enantiomer by X-ray diffraction analysis employing graphite monochromated Cu Kα radiation (λ = 1.54 178 A) with a Flack parameter of − 0.04 and was further secured by a time-dependent density functional theory electronic circular dichroism (TDDFT ECD) calculation. Consequently, the absolute configurations of xyloccensins O (5), P (6), R (8), S (9), and V (10) were all corrected as their corresponding enantiomers, respectively. Xyloccensin S (9) exhibited inhibitory activity against protein tyrosine phosphatase 1B, a potential drug target for the treatment of type II diabetes and obesity, with an IC50 value of 8.72 µg/mL.
Baderan D. K. - One of the best experts on this subject based on the ideXlab platform.
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Struktur Vegetasi dan Zonasi Mangrove di Wilayah Pesisir Kecamatan Kwandang Kabupaten Gorontalo Utara Provinsi Gorontalo
'Hasanuddin University Faculty of Law', 2019Co-Authors: Baderan D. K.Abstract:Ekosistem hutan mangrove bersifat kompleks dan dinamis, namun juga labil. Dikatakan kompleks karena ekosistemnya dipenuhi oleh vegetasi mangrove, juga merupakan habitat berbagai satwa dan biota perairan. Ekosistem mangrove adalah suatu sistem di alam tempat berlangsungnya kehidupan yang mencerminkan hubungan timbal Balik antara makhluk hidup dengan lingkungannya dan diantara makhluk hidup itu sendiri, terdapat pada wilayah pesisir, terpengaruh pasang surut air laut, dan didominasi oleh spesies pohon atau semak yang khas dan mampu tumbuh dalam perairan asin/payau. Penelitian ini bertujuan untuk mengetahui struktur vegetasi dan zonasi mangrove di wilayah pesisir Kecamatan Kwandang Kabupaten Gorontalo Utara Provinsi Gorontalo. Pengambilan data struktur vegetasi mangrove dengan cara membuat transek segi empat dengan panjang transek dibuat dengan ukuran 30 m x30 m (total transek sebanyak 31 transek).Hasil penelitian menemukan 16 spesies yang mendiami hutan mangrove di wilayah pesisir Kecamatan Kwandang Kabupaten Gorontalo Utara yakni spesies Rhizophora mucronata Blume, Rhizophora Apiculata Lamk, Ceriops decandra (Griff.) Ding Hou, Ceriops tagal (Perr.) C.B.Rob, Brugueira gymnorrhiza (L) Lamk, Bruguiera paviflora (Roxb) W&A, Sonneratia alba J.E. Smith, Soneratia caseolaris (L) Eng, Xylocarpus mulocensis (Lamk) Roem, Xylocarpus granatum Koen (niri), Avecennia alba Blume, Avecennia marina (Forsk) Vierh, Avicennia officinalis (L) Lamk, Acanthus ilicifolius L, Heritiera littoralis Dryand. Ex W.Ait, Aegiceras corniculatum (L.) Blanco.Profil zonasi di wilayah ini masuk pada zonasi sederhana (satu zonasi atau zonasi campuran) dimana dari pinggir pantai sampai pedalaman daratan setiap spesies saling berasosiasi dalam satu lapisan. Profil zonasi di wilayah pesisir Kecamatan Kwandang tidak terdiri atas beberapa zonasi, karena tidak ada zonasi yang murni satu genus saja, yang ditemukan hanya satu zonasi yang merupakan campuran (mixel), dimana setiap spesies tumbuh berulang sampai kearah daratan, dan tumbuh saling bercampur antara 16 spesies tersebut.Keseluruhan spesies yang ditemukan terdapat spesies Ceriops decandra yang merupakan spesies langka secara global sehingga diperlukan perhatian khusus dalam pengelolaan hutan mangrove di wilayah pesisir Kecamatan Kwandang
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STRUKTUR VEGETASI DAN ZONASI MANGROVE DI WILAYAH PESISIR KECAMATAN KWANDANG KABUPATEN GORONTALO UTARA PROVINSI GORONTALO
'Hasanuddin University Faculty of Law', 2019Co-Authors: Baderan D. K.Abstract:Ekosistem hutan mangrove bersifat kompleks dan dinamis, namun juga labil. Dikatakan kompleks karena ekosistemnya dipenuhi oleh vegetasi mangrove, juga merupakan habitat berbagai satwa dan biota perairan. Ekosistem mangrove adalah suatu sistem di alam tempat berlangsungnya kehidupan yang mencerminkan hubungan timbal balik antara makhluk hidup dengan lingkungannya dan diantara makhluk hidup itu sendiri, terdapat pada wilayah pesisir, terpengaruh pasang surut air laut, dan didominasi oleh spesies pohon atau semak yang khas dan mampu tumbuh dalam perairan asin/payau. Penelitian ini bertujuan untuk mengetahui struktur vegetasi dan zonasi mangrove di wilayah pesisir Kecamatan Kwandang Kabupaten Gorontalo Utara Provinsi Gorontalo. Pengambilan data struktur vegetasi mangrove dengan cara membuat transek segi empat dengan panjang transek dibuat dengan ukuran 30 m x30 m (total transek sebanyak 31 transek).Hasil penelitian menemukan 16 spesies yang mendiami hutan mangrove di wilayah pesisir Kecamatan Kwandang Kabupaten Gorontalo Utara yakni spesies Rhizophora mucronata Blume, Rhizophora Apiculata Lamk, Ceriops decandra (Griff.) Ding Hou, Ceriops tagal (Perr.) C.B.Rob, Brugueira gymnorrhiza (L) Lamk, Bruguiera paviflora (Roxb) W&A, Sonneratia alba J.E. Smith, Soneratia caseolaris (L) Eng, Xylocarpus mulocensis (Lamk) Roem, Xylocarpus granatum Koen (niri), Avecennia alba Blume, Avecennia marina (Forsk) Vierh, Avicennia officinalis (L) Lamk, Acanthus ilicifolius L, Heritiera littoralis Dryand. Ex W.Ait, Aegiceras corniculatum (L.) Blanco.Profil zonasi di wilayah ini masuk pada zonasi sederhana (satu zonasi atau zonasi campuran) dimana dari pinggir pantai sampai pedalaman daratan setiap spesies saling berasosiasi dalam satu lapisan. Profil zonasi di wilayah pesisir Kecamatan Kwandang tidak terdiri atas beberapa zonasi, karena tidak ada zonasi yang murni satu genus saja, yang ditemukan hanya satu zonasi yang merupakan campuran (mixel), dimana setiap spesies tumbuh berulang sampai kearah daratan, dan tumbuh saling bercampur antara 16 spesies tersebut.Keseluruhan spesies yang ditemukan terdapat spesies Ceriops decandra yang merupakan spesies langka secara global sehingga diperlukan perhatian khusus dalam pengelolaan hutan mangrove di wilayah pesisir Kecamatan Kwandang.Kata Kunci : Struktur Vegetasi, Zonasi, Spesies Mangrove
Attila Mandi - One of the best experts on this subject based on the ideXlab platform.
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xylomolones a d from the thai mangrove Xylocarpus moluccensis assignment of absolute stereostructures and unveiling a convergent strategy for limonoid biosynthesis
Journal of Organic Chemistry, 2019Co-Authors: Attila Mandi, Junjun Liu, Li Shen, Tibor KurtanAbstract:Two new 9,10- seco limonoids with a central 3,4-dihydro-2 H-pyran motif, named xylomolones A and B (1 and 2, respectively), possessing identical absolute configurations but reversed alignments of ring A, compared to the tricyclic core of rings B-D, were obtained from seeds of the Thai mangrove Xylocarpus moluccensis, together with a highly modified 1,2- seco limonoid, named xylomolone C (3), containing a novel 3-oxabicyclo[3.2.1]octane-2,7-dione motif, and a new C11-terpenic acid methyl ester (4). The relative and absolute configurations of 1-4 were evidenced by extensive nuclear magnetic resonance (NMR) investigations combined with density functional theory and time-dependent density functional theory calculations of electronic circular dichroism, specific optical rotation, and 13C NMR data. The co-isolation of 1-4 allowed us to propose a novel convergent strategy for limonoid biosynthesis for the first time. This study demonstrates that mangroves of the genus Xylocarpus harbor new limonoid biosynthetic routes.
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bioactive rearranged limonoids from the chinese mangrove Xylocarpus granatum koenig
ChemInform, 2015Co-Authors: Zhen Fang Zhou, Attila Mandi, Tibor Kurtan, Wen Zhang, Attila Benyei, Jia Li, Orazio TaglialatelascafatiAbstract:Two new pyridine-containing limonoids, xylogranatopyridines A (I) and B (II) and their formal precursor, prexylogranatopyridine (III), are isolated and evaluated for their protein tyrosine phosphatase 1B (PTP1B) activity.
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bioactive rearranged limonoids from the chinese mangrove Xylocarpus granatum koenig
Tetrahedron, 2014Co-Authors: Zhen Fang Zhou, Attila Mandi, Tibor Kurtan, Wen Zhang, Attila Benyei, Jia Li, Orazio TaglialatelascafatiAbstract:Abstract Two new pyridine-containing limonoids, xylogranatopyridines A and B ( 1 and 2 ) and their formal precursor, prexylogranatopyridine ( 3 ) were isolated from the twigs and leaves of the Chinese mangrove, Xylocarpus granatum . Xylogranatopyridine B ( 2 ) possesses an unprecedented rearranged B-ring together with a seco-ring A, supporting the biogenetic connection of 1 – 2 with 3 . The chemical structures were elucidated by means of detailed spectroscopic analysis and X-ray single-crystal diffraction. The absolute configurations were assigned using electronic solid-state circular dichroism (ECD) supported by time-dependent density functional theory (TDDFT) ECD calculations and X-ray analysis. Xylogranatopyridine A ( 1 ) exhibited a significant inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) with an IC 50 value of 22.9 μM. This is the first report of PTP1B inhibitory activity of limonoids.
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four phragmalin orthoesters from the chinese mangrove Xylocarpus granatum
Planta Medica, 2014Co-Authors: Zhen Fang Zhou, Attila Mandi, Tibor Kurtan, Lingyi Kong, Haili Liu, Yuewei GuoAbstract:Four new 8,9,30-phragmalin orthoesters (1–4), along with six related known compounds, namely xyloccensins O–S (5–9) and V (10), were isolated and characterized from the twigs and leaves of the Chinese mangrove Xylocarpus granatum. The structures of the new compounds were determined on the basis of extensive spectroscopic analysis and by comparison with those of related known compounds in the literature. The absolute configuration of xyloccensin Q (7) was revised as its enantiomer by X-ray diffraction analysis employing graphite monochromated Cu Kα radiation (λ = 1.54 178 A) with a Flack parameter of − 0.04 and was further secured by a time-dependent density functional theory electronic circular dichroism (TDDFT ECD) calculation. Consequently, the absolute configurations of xyloccensins O (5), P (6), R (8), S (9), and V (10) were all corrected as their corresponding enantiomers, respectively. Xyloccensin S (9) exhibited inhibitory activity against protein tyrosine phosphatase 1B, a potential drug target for the treatment of type II diabetes and obesity, with an IC50 value of 8.72 µg/mL.
Li Shen - One of the best experts on this subject based on the ideXlab platform.
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xylomolones a d from the thai mangrove Xylocarpus moluccensis assignment of absolute stereostructures and unveiling a convergent strategy for limonoid biosynthesis
Journal of Organic Chemistry, 2019Co-Authors: Attila Mandi, Junjun Liu, Li Shen, Tibor KurtanAbstract:Two new 9,10- seco limonoids with a central 3,4-dihydro-2 H-pyran motif, named xylomolones A and B (1 and 2, respectively), possessing identical absolute configurations but reversed alignments of ring A, compared to the tricyclic core of rings B-D, were obtained from seeds of the Thai mangrove Xylocarpus moluccensis, together with a highly modified 1,2- seco limonoid, named xylomolone C (3), containing a novel 3-oxabicyclo[3.2.1]octane-2,7-dione motif, and a new C11-terpenic acid methyl ester (4). The relative and absolute configurations of 1-4 were evidenced by extensive nuclear magnetic resonance (NMR) investigations combined with density functional theory and time-dependent density functional theory calculations of electronic circular dichroism, specific optical rotation, and 13C NMR data. The co-isolation of 1-4 allowed us to propose a novel convergent strategy for limonoid biosynthesis for the first time. This study demonstrates that mangroves of the genus Xylocarpus harbor new limonoid biosynthetic routes.
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Xylomolones A–D from the Thai Mangrove Xylocarpus moluccensis: Assignment of Absolute Stereostructures and Unveiling a Convergent Strategy for Limonoid Biosynthesis
2019Co-Authors: Attila Mándi, Junjun Liu, Li Shen, Tibor KurtánAbstract:Two new 9,10-seco limonoids with a central 3,4-dihydro-2H-pyran motif, named xylomolones A and B (1 and 2, respectively), possessing identical absolute configurations but reversed alignments of ring A, compared to the tricyclic core of rings B–D, were obtained from seeds of the Thai mangrove Xylocarpus moluccensis, together with a highly modified 1,2-seco limonoid, named xylomolone C (3), containing a novel 3-oxabicyclo[3.2.1]octane-2,7-dione motif, and a new C11-terpenic acid methyl ester (4). The relative and absolute configurations of 1–4 were evidenced by extensive nuclear magnetic resonance (NMR) investigations combined with density functional theory and time-dependent density functional theory calculations of electronic circular dichroism, specific optical rotation, and 13C NMR data. The co-isolation of 1–4 allowed us to propose a novel convergent strategy for limonoid biosynthesis for the first time. This study demonstrates that mangroves of the genus Xylocarpus harbor new limonoid biosynthetic routes
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Twenty-Nine New Limonoids with Skeletal Diversity from the Mangrove Plant, Xylocarpus moluccensis
MDPI AG, 2018Co-Authors: Jianzhi Zhang, Yiguo Dai, Li ShenAbstract:Twenty-nine new limonoids—named xylomolins A1–A7, B1–B2, C1–C2, D–F, G1–G5, H–I, J1–J2, K1–K2, L1–L2, and M–N, were isolated from the seeds of the mangrove plant, Xylocarpus moluccensis. Compounds 1–13 are mexicanolides with one double bond or two conjugated double bonds, while 14 belongs to a small group of mexicanolides with an oxygen bridge between C1 and C8. Compounds 15–19 are khayanolides containing a Δ8,14 double bond, whereas 20 and 21 are rare khayanolides containing a Δ14,15 double bond and Δ8,9, Δ14,15 conjugated double bonds, respectively. Compounds 22 and 23 are unusual limonoids possessing a (Z)-bicyclo[5.2.1]dec-3-en-8-one motif, while 24 and 25 are 30-ketophragmalins with Δ8,9, Δ14,15 conjugated double bonds. Compounds 26 and 27 are phragmalin 8,9,30-ortho esters, whereas 28 and 29 are azadirone and andirobin derivatives, respectively. The structures of these compounds, including absolute configurations of 15–19, 21–23, and 26, were established by HRESIMS, extensive 1D and 2D NMR investigations, and the comparison of experimental electronic circular dichroism (ECD) spectra. The absolute configuration of 1 was unequivocally established by single-crystal X-ray diffraction analysis, obtained with Cu Kα radiation. The diverse cyclization patterns of 1–29 reveal the strong flexibility of skeletal plasticity in the limonoid biosynthesis of X. moluccensis. Compound 23 exhibited weak antitumor activity against human triple-negative breast MD-MBA-231 cancer cells with an IC50 value of 37.7 μM. Anti-HIV activities of 1, 3, 8, 10, 11, 14, 20, 23–25, and 27 were tested in vitro. However, no compounds showed potent inhibitory activity
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Mangrove Tirucallane- and Apotirucallane-Type Triterpenoids: Structure Diversity of the C-17 Side-Chain and Natural Agonists of Human Farnesoid/Pregnane–X–Receptor
'MDPI AG', 2018Co-Authors: Zhong-ping Jiang, Qun Zhang, Zhi-lin Luan, Ruo-xi Liu, Li ShenAbstract:Ten new triterpenoid compounds with structure diversity of the C-17 side-chain, including nine tirucallanes, named xylocarpols A⁻E (1⁻5) and agallochols A⁻D (6⁻9), and an apotirucallane, named 25-dehydroxy protoxylogranatin B (10), were isolated from the mangrove plants Xylocarpus granatum, Xylocarpus moluccensis, and Excoecaria agallocha. The structures of these compounds were established by HR-ESIMS and extensive one-dimensional (1D) and two-dimensional (2D) NMR investigations. The absolute configurations of 1 and 2 were unequivocally determined by single-crystal X-ray diffraction analyses, conducted with Cu Kα radiation; whereas those of 4, 6⁻8 were assigned by a modified Mosher’s method and the comparison of experimental electronic circular dichroism (ECD) spectra. Most notably, 5, 6, 7, and 9 displayed potent activation effects on farnesoid⁻X⁻receptor (FXR) at the concentration of 10.0 μM; 10 exhibited very significant agonistic effects on pregnane⁻X⁻receptor (PXR) at the concentration of 10.0 nM
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Krishnolides A–D: New 2-Ketokhayanolides from the Krishna Mangrove, Xylocarpus moluccensis
MDPI AG, 2017Co-Authors: Qun Zhang, Tirumani Satyanandamurty, Li ShenAbstract:Four new khayanolide-type limonoids with a 2-carbonyl group, named krishnolides A–D (1–4), were isolated from the seeds of an Indian mangrove, Xylocarpus moluccensis, collected in the mangrove swamp of Krishna estuary, Andhra Pradesh. The relative and absolute configurations of these compounds were established by HR-ESIMS, extensive NMR investigations, single-crystal X-ray diffraction analysis with CuKα radiation, and experimental electronic circular dichroism (ECD) spectra. Krishnolides A–D are unusual khayanolides containing two large ester substituents of five or four carbon atoms at the C-3 and C-30 positions, respectively. Krishnolide A, containing an 8,14-epoxy group, exhibited moderate anti-Human Immunodeficiency Virus (HIV) activity with an IC50 value of 17.45 ± 1.65 μM and a CC50 value of 78.45 ± 1.69 μM, respectively. This is not only the first report of natural khayanolides from Indian mangroves of the genus Xylocarpus, but also the first report of the anti-HIV activity of khayanolide
Tirumani Satyanandamurty - One of the best experts on this subject based on the ideXlab platform.
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Krishnolides A–D: New 2-Ketokhayanolides from the Krishna Mangrove, Xylocarpus moluccensis
MDPI AG, 2017Co-Authors: Qun Zhang, Tirumani Satyanandamurty, Li ShenAbstract:Four new khayanolide-type limonoids with a 2-carbonyl group, named krishnolides A–D (1–4), were isolated from the seeds of an Indian mangrove, Xylocarpus moluccensis, collected in the mangrove swamp of Krishna estuary, Andhra Pradesh. The relative and absolute configurations of these compounds were established by HR-ESIMS, extensive NMR investigations, single-crystal X-ray diffraction analysis with CuKα radiation, and experimental electronic circular dichroism (ECD) spectra. Krishnolides A–D are unusual khayanolides containing two large ester substituents of five or four carbon atoms at the C-3 and C-30 positions, respectively. Krishnolide A, containing an 8,14-epoxy group, exhibited moderate anti-Human Immunodeficiency Virus (HIV) activity with an IC50 value of 17.45 ± 1.65 μM and a CC50 value of 78.45 ± 1.69 μM, respectively. This is not only the first report of natural khayanolides from Indian mangroves of the genus Xylocarpus, but also the first report of the anti-HIV activity of khayanolide
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Moluccensins R–Y, Limonoids from the Seeds of a Mangrove, Xylocarpus moluccensis
2016Co-Authors: Gang Feng, Jing Zhang, Maarit Karonen, Jari Sinkkonen, Tirumani SatyanandamurtyAbstract:Eight limonoids, named moluccensins R–Y (1, 2, 5–10), and six known compounds, including 6-hydroxymexicanolide (3), were isolated from the seeds of an Indian mangrove, Xylocarpus moluccensis, collected in the estuaries of Andhra Pradesh. The absolute configuration of moluccensin V (7) was confirmed by means of single-crystal X-ray diffraction analysis. The 1H and 13C NMR data for 6-hydroxymexicanolide (3) was assigned for the first time, and the 6R absolute configuration established by single-crystal X-ray diffraction analysis. Moluccensin R (1), 6R-hydroxymexicanolide (3), and 2-hydroxyfissinolide (4) exhibited marked antifeedant activity against the third-instar larvae of Brontispa longissima at a concentration of 1 mg/mL. The most potent compound tested was 2-hydroxyfissinolide (4), with an AFC50 (concentration for 50% antifeedant activity) value of 94 μg/mL at 24 h
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godavarin k a new limonoid with an oxygen bridge between c 1 and c 29 from the godavari mangrove Xylocarpus moluccensis
Helvetica Chimica Acta, 2011Co-Authors: Tirumani SatyanandamurtyAbstract:Godavarin K (1), a new limonoid with an oxygen bridge between C(1) and C(29), was obtained from seeds of an Indian mangrove, Xylocarpus moluccensis, together with a known tetranortriterpene, 6-de(acetyloxy)-7-deacetylchisocheton compound E (=(5α,7α,13α,17α)-7-hydroxy-4,4,8-trimethyl-3-oxocarda-1,14-dienolide; 2). The structure of godavarin K was established on the basis of spectroscopic data. In addition, the confusion of 1H- and 13C-NMR data for compound 2 in previous literature was clarified.
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moluccensins a g phragmalins with a conjugated c 30 carbonyl group from a krishna mangrove Xylocarpus moluccensis
Journal of Natural Products, 2009Co-Authors: Minyi Li, Shengxin Yang, Tirumani Satyanandamurty, Qiang Xiao, Jun WuAbstract:Seven new phragmalins with a C-30 carbonyl moiety, named moluccensins A-G (1-7), among which moluccensins A-F, possessing a Delta(8,14) double bond, and moluccensin G (7), containing conjugated Delta(8,9) and Delta(14,15) double bonds, were isolated from the seeds of an Indian mangrove, Xylocarpus moluccensis. The structures of these compounds were established on the basis of single-crystal X-ray diffraction analysis and spectroscopic data. This is the first report of phragmalins with a conjugated C-30 carbonyl group.
