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Patrick M Cherveny - One of the best experts on this subject based on the ideXlab platform.

  • femoral rotational alignment using the tibial shaft axis in total knee arthroplasty
    Clinical Orthopaedics and Related Research, 1996
    Co-Authors: James B Stiehl, Patrick M Cherveny
    Abstract:

    The capability of determining femoral component rotation by using a posterior femoral condyle resection made perpendicular to the longitudinal tibial shaft axis in posterior cruciate retaining total knee arthroplasty was evaluated. From 100 consecutive cases, 54 used the femoral posterior condyle axis and 46 used an extramedullary alignment rod based on the tibial shaft axis. Seventy-two percent of total knee arthroplasties using the posterior condyle axis required lateral release versus 28% using the tibial shaft axis. Patellar fracture occurred in 7% using the posterior condyle axis versus none using the tibial shaft axis. Two patients had both techniques in opposite knees. Using computed tomography, the posterior condyle axis method gave a posterior condyle angle of 5' and 4' compared with the transepicondylar axis, whereas the tibial shaft axis technique measured 0' and lo. The posterior condyle resection using the tibial shaft axis restores the anatomic patellofemoral relationships, minimizing patellofemoral complications.

  • femoral rotational alignment using the tibial shaft axis in total knee arthroplasty
    Clinical Orthopaedics and Related Research, 1996
    Co-Authors: James B Stiehl, Patrick M Cherveny
    Abstract:

    The capability of determining femoral component rotation by using a posterior femoral condyle resection made perpendicular to the longitudinal tibial shaft axis in posterior cruciate retaining total knee arthroplasty was evaluated. From 100 consecutive cases, 54 used the femoral posterior condyle axis and 46 used an extramedullary alignment rod based on the tibial shaft axis. Seventy-two percent of total knee arthroplasties using the posterior condyle axis required lateral release versus 28% using the tibial shaft axis. Patellar fracture occurred in 7% using the posterior condyle axis versus none using the tibial shaft axis. Two patients had both techniques in opposite knees. Using computed tomography, the posterior condyle axis method gave a posterior condyle angle of 5 degrees and 4 degrees compared with the transepicondylar axis, whereas the tibial shaft axis technique measured 0 degrees and 1 degree. The posterior condyle resection using the tibial shaft axis restores the anatomic patellofemoral relationships, minimizing patellofemoral complications.

Nobuaki Shime - One of the best experts on this subject based on the ideXlab platform.

  • long axis in plane approach versus short axis out of plane approach for ultrasound guided central venous catheterization in pediatric patients a randomized controlled trial
    Pediatric Critical Care Medicine, 2020
    Co-Authors: Jun Takeshita, Kazuya Tachibana, Yasufumi Nakajima, Gaku Nagai, Ai Fujiwara, Hirofumi Hamaba, Hideki Matsuura, Tomonori Yamashita, Nobuaki Shime
    Abstract:

    Objectives The aim of this study was to compare the occurrence of posterior wall puncture between the long-axis in-plane and the short-axis out-of-plane approaches in a randomized controlled trial of pediatric patients who underwent cardiovascular surgery under general anesthesia. Design Prospective randomized controlled trial. Setting Operating room of Osaka Women's and Children's Hospital. Patients Pediatric patients less than 5 years old who underwent cardiovascular surgery. Interventions Ultrasound-guided central venous catheterization using the long-axis in-plane approach and short-axis out-of-plane approach. Measurements and main results The occurrence of posterior wall puncture was compared between the long-axis in-plane and short-axis out-of-plane approaches for ultrasound-guided central venous catheterization. Patients were randomly allocated to a long-axis group or a short-axis group and underwent ultrasound-guided central venous catheterization in the internal jugular vein using either the long-axis in-plane approach (long-axis group) or the short-axis out-of-plane approach (short-axis group). After exclusion, 97 patients were allocated to the long-axis (n = 49) or short-axis (n = 48) groups. Posterior wall puncture rates were 8.2% (4/49) and 39.6% (19/48) in the long-axis and short-axis groups, respectively (relative risk, 0.21; 95% CI, 0.076-0.56; p = 0.0003). First attempt success rates were 67.3% (33/49) and 64.6% (31/48) in the long-axis and short-axis groups, respectively (relative risk, 1.04; 95% CI, 0.78-1.39; p = 0.77). Overall success rates within 20 minutes were 93.9% (46/49) and 93.8% (45/48) in the long-axis and short-axis groups, respectively (relative risk, 0.99; 95% CI, 0.90-1.11; p = 0.98). Conclusions The long-axis in-plane approach for ultrasound-guided central venous catheterization is a useful technique for avoiding posterior wall puncture in pediatric patients, compared with the short-axis out-of-plane approach.

  • combined approach versus 2 conventional approaches in ultrasound guided central venous catheterization a randomized controlled trial
    Journal of Cardiothoracic and Vascular Anesthesia, 2019
    Co-Authors: Jun Takeshita, Kei Nishiyama, Atsushi Fukumoto, Nobuaki Shime
    Abstract:

    Objective The authors compared the occurrence of posterior wall puncture using the short-axis out-of-plane and long-axis in-plane approaches with that using the combined short-axis-and-long-axis approach that the authors previously showed to be effective in observational and manikin studies. Design Randomized controlled study. Setting Single tertiary institution. Participants One hundred twenty patients who underwent cardiac or vascular surgery under general anesthesia. Interventions The patients were divided randomly into combined short-axis-and-long-axis (n = 40), short-axis out-of-plane (SA-OOP) (n = 40), and long-axis in-plane (LA-IP) (n = 40) groups and received ultrasound-guided central venous catheterization at the right internal jugular vein. Measurements and Main Results Successful guidewire insertion without posterior wall puncture was performed in 40 patients (100%) in the combined short-axis-and-long-axis approach group, 28 (70%) in the short-axis out-of-plane approach group, and 38 (95%) in the LA-IP approach group (combined short-axis-and-long-axis v SA-OOP, p = 0.0002 [relative risk = 1.43; 95% CI: 1.17-1.75]; combined short-axis-and-long-axis v LA-IP, p = 0.49 [relative risk = 1.05; 95% CI: 0.98-1.13]). Procedure durations were 28.5 (24.1-36.4) seconds in the combined short-axis-and-long-axis group, 31.7 (24.4-40.6) seconds in the SA-OOP group, and 24.3 (20.8-32.1) seconds in the long-axis in-plane group (combined short-axis-and-long-axis v SA-OOP, p = 0.53; combined short-axis-and-long-axis v LA-IP, p = 0.044). Conclusion The combined short-axis-and-long-axis approach for ultrasound-guided central venous catheterization had a lower posterior wall puncture rate than the SA-OOP approach, but there was no significant difference with the long-axis in-plane approach.

James B Stiehl - One of the best experts on this subject based on the ideXlab platform.

  • femoral rotational alignment using the tibial shaft axis in total knee arthroplasty
    Clinical Orthopaedics and Related Research, 1996
    Co-Authors: James B Stiehl, Patrick M Cherveny
    Abstract:

    The capability of determining femoral component rotation by using a posterior femoral condyle resection made perpendicular to the longitudinal tibial shaft axis in posterior cruciate retaining total knee arthroplasty was evaluated. From 100 consecutive cases, 54 used the femoral posterior condyle axis and 46 used an extramedullary alignment rod based on the tibial shaft axis. Seventy-two percent of total knee arthroplasties using the posterior condyle axis required lateral release versus 28% using the tibial shaft axis. Patellar fracture occurred in 7% using the posterior condyle axis versus none using the tibial shaft axis. Two patients had both techniques in opposite knees. Using computed tomography, the posterior condyle axis method gave a posterior condyle angle of 5' and 4' compared with the transepicondylar axis, whereas the tibial shaft axis technique measured 0' and lo. The posterior condyle resection using the tibial shaft axis restores the anatomic patellofemoral relationships, minimizing patellofemoral complications.

  • femoral rotational alignment using the tibial shaft axis in total knee arthroplasty
    Clinical Orthopaedics and Related Research, 1996
    Co-Authors: James B Stiehl, Patrick M Cherveny
    Abstract:

    The capability of determining femoral component rotation by using a posterior femoral condyle resection made perpendicular to the longitudinal tibial shaft axis in posterior cruciate retaining total knee arthroplasty was evaluated. From 100 consecutive cases, 54 used the femoral posterior condyle axis and 46 used an extramedullary alignment rod based on the tibial shaft axis. Seventy-two percent of total knee arthroplasties using the posterior condyle axis required lateral release versus 28% using the tibial shaft axis. Patellar fracture occurred in 7% using the posterior condyle axis versus none using the tibial shaft axis. Two patients had both techniques in opposite knees. Using computed tomography, the posterior condyle axis method gave a posterior condyle angle of 5 degrees and 4 degrees compared with the transepicondylar axis, whereas the tibial shaft axis technique measured 0 degrees and 1 degree. The posterior condyle resection using the tibial shaft axis restores the anatomic patellofemoral relationships, minimizing patellofemoral complications.

Sergei Y Sokol - One of the best experts on this subject based on the ideXlab platform.

  • axis determination in xenopus involves biochemical interactions of axin glycogen synthase kinase 3 and β catenin
    Current Biology, 1998
    Co-Authors: Keiji Itoh, Valery E Krupnik, Sergei Y Sokol
    Abstract:

    Abstract Signaling by the Wnt family of extracellular proteins is critical in a variety of developmental processes in which cell and tissue polarity are established [1–5]. Wnt signal transduction has been studied mostly by the genetic approach in Drosophila and Caenorhabditis elegans [1,2,5], but the biochemical mechanisms involved remain to be elucidated. The Wnt pathway also operates during axis determination in vertebrates [3,5]. Frizzled receptors transduce a signal to Dishevelled, leading to inactivation of glycogen synthase kinase 3 (GSK3) and regulation of gene expression by the complex of β -catenin with LEF/TCF (lymphocyte enhancer factor/T-cell factor) transcription factors [3,5]. Axin is a negative regulator of Wnt signaling and dorsal axial development in vertebrates [6]. Here, we demonstrate that axin is associated with GSK3 in the Xenopus embryo and we localize the GSK3-binding domain to a short region of axin. Binding of GSK3 correlates with the ability of axin to inhibit axial development and with the axis-inducing activity of its dominant-negative form ( Δ RGS). We also find that wild-type axin, but not Δ RGS, forms a complex with β -catenin. Thus, axin may act as a docking station mediating negative regulation of β -catenin by GSK3 during dorsoventral axis determination in vertebrate embryos.

Akira Kikuchi - One of the best experts on this subject based on the ideXlab platform.

  • axil a member of the axin family interacts with both glycogen synthase kinase 3β and β catenin and inhibits axis formation of xenopus embryos
    Molecular and Cellular Biology, 1998
    Co-Authors: Hideki Yamamoto, Satoshi Ikeda, Shosei Kishida, Takaaki Uochi, Shinya Koyama, Makoto Asashima, Akira Kikuchi
    Abstract:

    Using a yeast two-hybrid method, we identified a novel protein which interacts with glycogen synthase kinase 3β (GSK-3β). This protein had 44% amino acid identity with Axin, a negative regulator of the Wnt signaling pathway.We designated this protein Axil for Axin like. Like Axin, Axil ventralized Xenopus embryos and inhibited Xwnt8-induced Xenopus axis duplication. Axil was phosphorylated by GSK-3β. Axil bound not only to GSK-3β but also to β-catenin, and the GSK-3β-binding site of Axil was distinct from the β-catenin-binding site. Furthermore, Axil enhanced GSK-3β-dependent phosphorylation of β-catenin. These results indicate that Axil negatively regulates the Wnt signaling pathway by mediating GSK-3β-dependent phosphorylation of β-catenin, thereby inhibiting axis formation.