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Jong Hoon Ryu - One of the best experts on this subject based on the ideXlab platform.

  • the ameliorating effect of oroxylin a on scopolamine induced memory impairment in mice
    Neurobiology of Learning and Memory, 2007
    Co-Authors: Donghyun Kim, Ji Wook Jung, Seungjoo Lee, Byung Hoon Yoon, Jae Hoon Cheong, Su Jin Jeon, Kun Ho Son, Jongju Lee, Youngwuk Cho, Jong Hoon Ryu
    Abstract:

    Oroxylin A is a flavonoid and was originally isolated from the root of Scutellaria baicalensis Georgi., one of the most important medicinal herbs in traditional Chinese medicine. The aim of this study was to investigate the ameliorating effects of oroxylin A on memory impairment using the passive avoidance Test, the Y-Maze Test, and the Morris water maze Test in mice. Drug-induced amnesia was induced by administering scopolamine (1 mg/kg, i.p.) or diazepam (1 mg/kg, i.p.). Oroxylin A (5 mg/kg) significantly reversed cognitive impairments in mice by passive avoidance and the Y-Maze Testing (P<.05). Oroxylin A also improved escape latencies in training trials and increased swimming times and distances within the target zone of the Morris water maze (P<.05). Moreover, the ameliorating effects of oroxylin A were antagonized by both muscimol and diazepam (0.25 mg/kg, i.p., respectively), which are GABA(A) receptor agonists. Furthermore, oroxylin A (100 microM) was found to inhibit GABA-induced inward Cl(-) current in a single cortical neuron. These results suggest that oroxylin A may be useful for the treatment of cognitive impairments induced by cholinergic dysfunction via the GABAergic nervous system.

  • nodakenin a coumarin compound ameliorates scopolamine induced memory disruption in mice
    Life Sciences, 2007
    Co-Authors: Donghyun Kim, Ji Wook Jung, Seungjoo Lee, Byung Hoon Yoon, Jae Hoon Cheong, Do Yoon Kim, Young Choong Kim, Yeong Shik Kim, Sam Sik Kang, Jong Hoon Ryu
    Abstract:

    Nodakenin is a coumarin compound initially isolated from the roots of Angelica gigas. In the present study, we investigated the effects of nodakenin on learning and memory impairments induced by scopolamine (1 mg/kg, i.p.) using the passive avoidance Test, the Y-Maze Test, and the Morris water maze Test in mice. Nodakenin (10 mg/kg, p.o.) administration significantly reversed scopolamine-induced cognitive impairments in the passive avoidance Test and the Y-Maze Test (P<0.05), and also reduced escape latency during training in the Morris water maze Test (P<0.05). Moreover, swimming times and distances within the target zone of the Morris water maze were greater in the nodakenin-treated group than in the scopolamine-treated group (P<0.05). In an in vitro study, nodakenin was found to inhibit acetylcholinesterase activity in a dose-dependent manner (IC(50)=84.7 microM). In addition, nodakenin was also found to inhibit acetylcholinesterase activity for 6 h in an ex-vivo study. These results suggest that nodakenin may be a useful for the treatment of cognitive impairment, and that its beneficial effects are mediated, in part, via the enhancement of cholinergic signaling.

  • gomisin a improves scopolamine induced memory impairment in mice
    European Journal of Pharmacology, 2006
    Co-Authors: Donghyun Kim, Tran Manh Hung, Kihwan Bae, Ji Wook Jung, Seungjoo Lee, Byung Hoon Yoon, Jae Hoon Cheong, Jong Hoon Ryu
    Abstract:

    Gomisin A is a component of the fruits of Schizandra chinesis which are widely used as a tonic in traditional Chinese medicine. In the present study, we assessed the effect of gomisin A on the learning and memory impairments induced by scopolamine. The cognition-enhancing effect of gomisin A was investigated using a passive avoidance Test, the Y-Maze Test, and the Morris water maze Test in mice. Drug-induced amnesia was induced by treating animals with scopolamine (1 mg/kg, i.p.). Gomisin A (5 mg/kg, p.o.) administration significantly reversed scopolamine-induced cognitive impairments in mice by the passive avoidance Test and the Y-Maze Test (P<0.05), and also improved escape latency in the Morris water maze Test at 5 mg/kg (P<0.05). Moreover, in an in vitro study, gomisin A was found to inhibit acetylcholinesterase activity in a dose-dependent manner (IC50 value; 15.5 microM). These results suggest that gomisin A may be a useful cognitive impairment treatment, and its beneficial effects are mediated, in part, via enhancing the cholinergic nervous system.

Donghyun Kim - One of the best experts on this subject based on the ideXlab platform.

  • the ameliorating effect of oroxylin a on scopolamine induced memory impairment in mice
    Neurobiology of Learning and Memory, 2007
    Co-Authors: Donghyun Kim, Ji Wook Jung, Seungjoo Lee, Byung Hoon Yoon, Jae Hoon Cheong, Su Jin Jeon, Kun Ho Son, Jongju Lee, Youngwuk Cho, Jong Hoon Ryu
    Abstract:

    Oroxylin A is a flavonoid and was originally isolated from the root of Scutellaria baicalensis Georgi., one of the most important medicinal herbs in traditional Chinese medicine. The aim of this study was to investigate the ameliorating effects of oroxylin A on memory impairment using the passive avoidance Test, the Y-Maze Test, and the Morris water maze Test in mice. Drug-induced amnesia was induced by administering scopolamine (1 mg/kg, i.p.) or diazepam (1 mg/kg, i.p.). Oroxylin A (5 mg/kg) significantly reversed cognitive impairments in mice by passive avoidance and the Y-Maze Testing (P<.05). Oroxylin A also improved escape latencies in training trials and increased swimming times and distances within the target zone of the Morris water maze (P<.05). Moreover, the ameliorating effects of oroxylin A were antagonized by both muscimol and diazepam (0.25 mg/kg, i.p., respectively), which are GABA(A) receptor agonists. Furthermore, oroxylin A (100 microM) was found to inhibit GABA-induced inward Cl(-) current in a single cortical neuron. These results suggest that oroxylin A may be useful for the treatment of cognitive impairments induced by cholinergic dysfunction via the GABAergic nervous system.

  • nodakenin a coumarin compound ameliorates scopolamine induced memory disruption in mice
    Life Sciences, 2007
    Co-Authors: Donghyun Kim, Ji Wook Jung, Seungjoo Lee, Byung Hoon Yoon, Jae Hoon Cheong, Do Yoon Kim, Young Choong Kim, Yeong Shik Kim, Sam Sik Kang, Jong Hoon Ryu
    Abstract:

    Nodakenin is a coumarin compound initially isolated from the roots of Angelica gigas. In the present study, we investigated the effects of nodakenin on learning and memory impairments induced by scopolamine (1 mg/kg, i.p.) using the passive avoidance Test, the Y-Maze Test, and the Morris water maze Test in mice. Nodakenin (10 mg/kg, p.o.) administration significantly reversed scopolamine-induced cognitive impairments in the passive avoidance Test and the Y-Maze Test (P<0.05), and also reduced escape latency during training in the Morris water maze Test (P<0.05). Moreover, swimming times and distances within the target zone of the Morris water maze were greater in the nodakenin-treated group than in the scopolamine-treated group (P<0.05). In an in vitro study, nodakenin was found to inhibit acetylcholinesterase activity in a dose-dependent manner (IC(50)=84.7 microM). In addition, nodakenin was also found to inhibit acetylcholinesterase activity for 6 h in an ex-vivo study. These results suggest that nodakenin may be a useful for the treatment of cognitive impairment, and that its beneficial effects are mediated, in part, via the enhancement of cholinergic signaling.

  • gomisin a improves scopolamine induced memory impairment in mice
    European Journal of Pharmacology, 2006
    Co-Authors: Donghyun Kim, Tran Manh Hung, Kihwan Bae, Ji Wook Jung, Seungjoo Lee, Byung Hoon Yoon, Jae Hoon Cheong, Jong Hoon Ryu
    Abstract:

    Gomisin A is a component of the fruits of Schizandra chinesis which are widely used as a tonic in traditional Chinese medicine. In the present study, we assessed the effect of gomisin A on the learning and memory impairments induced by scopolamine. The cognition-enhancing effect of gomisin A was investigated using a passive avoidance Test, the Y-Maze Test, and the Morris water maze Test in mice. Drug-induced amnesia was induced by treating animals with scopolamine (1 mg/kg, i.p.). Gomisin A (5 mg/kg, p.o.) administration significantly reversed scopolamine-induced cognitive impairments in mice by the passive avoidance Test and the Y-Maze Test (P<0.05), and also improved escape latency in the Morris water maze Test at 5 mg/kg (P<0.05). Moreover, in an in vitro study, gomisin A was found to inhibit acetylcholinesterase activity in a dose-dependent manner (IC50 value; 15.5 microM). These results suggest that gomisin A may be a useful cognitive impairment treatment, and its beneficial effects are mediated, in part, via enhancing the cholinergic nervous system.

Seungjoo Lee - One of the best experts on this subject based on the ideXlab platform.

  • the ameliorating effect of oroxylin a on scopolamine induced memory impairment in mice
    Neurobiology of Learning and Memory, 2007
    Co-Authors: Donghyun Kim, Ji Wook Jung, Seungjoo Lee, Byung Hoon Yoon, Jae Hoon Cheong, Su Jin Jeon, Kun Ho Son, Jongju Lee, Youngwuk Cho, Jong Hoon Ryu
    Abstract:

    Oroxylin A is a flavonoid and was originally isolated from the root of Scutellaria baicalensis Georgi., one of the most important medicinal herbs in traditional Chinese medicine. The aim of this study was to investigate the ameliorating effects of oroxylin A on memory impairment using the passive avoidance Test, the Y-Maze Test, and the Morris water maze Test in mice. Drug-induced amnesia was induced by administering scopolamine (1 mg/kg, i.p.) or diazepam (1 mg/kg, i.p.). Oroxylin A (5 mg/kg) significantly reversed cognitive impairments in mice by passive avoidance and the Y-Maze Testing (P<.05). Oroxylin A also improved escape latencies in training trials and increased swimming times and distances within the target zone of the Morris water maze (P<.05). Moreover, the ameliorating effects of oroxylin A were antagonized by both muscimol and diazepam (0.25 mg/kg, i.p., respectively), which are GABA(A) receptor agonists. Furthermore, oroxylin A (100 microM) was found to inhibit GABA-induced inward Cl(-) current in a single cortical neuron. These results suggest that oroxylin A may be useful for the treatment of cognitive impairments induced by cholinergic dysfunction via the GABAergic nervous system.

  • nodakenin a coumarin compound ameliorates scopolamine induced memory disruption in mice
    Life Sciences, 2007
    Co-Authors: Donghyun Kim, Ji Wook Jung, Seungjoo Lee, Byung Hoon Yoon, Jae Hoon Cheong, Do Yoon Kim, Young Choong Kim, Yeong Shik Kim, Sam Sik Kang, Jong Hoon Ryu
    Abstract:

    Nodakenin is a coumarin compound initially isolated from the roots of Angelica gigas. In the present study, we investigated the effects of nodakenin on learning and memory impairments induced by scopolamine (1 mg/kg, i.p.) using the passive avoidance Test, the Y-Maze Test, and the Morris water maze Test in mice. Nodakenin (10 mg/kg, p.o.) administration significantly reversed scopolamine-induced cognitive impairments in the passive avoidance Test and the Y-Maze Test (P<0.05), and also reduced escape latency during training in the Morris water maze Test (P<0.05). Moreover, swimming times and distances within the target zone of the Morris water maze were greater in the nodakenin-treated group than in the scopolamine-treated group (P<0.05). In an in vitro study, nodakenin was found to inhibit acetylcholinesterase activity in a dose-dependent manner (IC(50)=84.7 microM). In addition, nodakenin was also found to inhibit acetylcholinesterase activity for 6 h in an ex-vivo study. These results suggest that nodakenin may be a useful for the treatment of cognitive impairment, and that its beneficial effects are mediated, in part, via the enhancement of cholinergic signaling.

  • gomisin a improves scopolamine induced memory impairment in mice
    European Journal of Pharmacology, 2006
    Co-Authors: Donghyun Kim, Tran Manh Hung, Kihwan Bae, Ji Wook Jung, Seungjoo Lee, Byung Hoon Yoon, Jae Hoon Cheong, Jong Hoon Ryu
    Abstract:

    Gomisin A is a component of the fruits of Schizandra chinesis which are widely used as a tonic in traditional Chinese medicine. In the present study, we assessed the effect of gomisin A on the learning and memory impairments induced by scopolamine. The cognition-enhancing effect of gomisin A was investigated using a passive avoidance Test, the Y-Maze Test, and the Morris water maze Test in mice. Drug-induced amnesia was induced by treating animals with scopolamine (1 mg/kg, i.p.). Gomisin A (5 mg/kg, p.o.) administration significantly reversed scopolamine-induced cognitive impairments in mice by the passive avoidance Test and the Y-Maze Test (P<0.05), and also improved escape latency in the Morris water maze Test at 5 mg/kg (P<0.05). Moreover, in an in vitro study, gomisin A was found to inhibit acetylcholinesterase activity in a dose-dependent manner (IC50 value; 15.5 microM). These results suggest that gomisin A may be a useful cognitive impairment treatment, and its beneficial effects are mediated, in part, via enhancing the cholinergic nervous system.

Jae Hoon Cheong - One of the best experts on this subject based on the ideXlab platform.

  • the ameliorating effect of oroxylin a on scopolamine induced memory impairment in mice
    Neurobiology of Learning and Memory, 2007
    Co-Authors: Donghyun Kim, Ji Wook Jung, Seungjoo Lee, Byung Hoon Yoon, Jae Hoon Cheong, Su Jin Jeon, Kun Ho Son, Jongju Lee, Youngwuk Cho, Jong Hoon Ryu
    Abstract:

    Oroxylin A is a flavonoid and was originally isolated from the root of Scutellaria baicalensis Georgi., one of the most important medicinal herbs in traditional Chinese medicine. The aim of this study was to investigate the ameliorating effects of oroxylin A on memory impairment using the passive avoidance Test, the Y-Maze Test, and the Morris water maze Test in mice. Drug-induced amnesia was induced by administering scopolamine (1 mg/kg, i.p.) or diazepam (1 mg/kg, i.p.). Oroxylin A (5 mg/kg) significantly reversed cognitive impairments in mice by passive avoidance and the Y-Maze Testing (P<.05). Oroxylin A also improved escape latencies in training trials and increased swimming times and distances within the target zone of the Morris water maze (P<.05). Moreover, the ameliorating effects of oroxylin A were antagonized by both muscimol and diazepam (0.25 mg/kg, i.p., respectively), which are GABA(A) receptor agonists. Furthermore, oroxylin A (100 microM) was found to inhibit GABA-induced inward Cl(-) current in a single cortical neuron. These results suggest that oroxylin A may be useful for the treatment of cognitive impairments induced by cholinergic dysfunction via the GABAergic nervous system.

  • nodakenin a coumarin compound ameliorates scopolamine induced memory disruption in mice
    Life Sciences, 2007
    Co-Authors: Donghyun Kim, Ji Wook Jung, Seungjoo Lee, Byung Hoon Yoon, Jae Hoon Cheong, Do Yoon Kim, Young Choong Kim, Yeong Shik Kim, Sam Sik Kang, Jong Hoon Ryu
    Abstract:

    Nodakenin is a coumarin compound initially isolated from the roots of Angelica gigas. In the present study, we investigated the effects of nodakenin on learning and memory impairments induced by scopolamine (1 mg/kg, i.p.) using the passive avoidance Test, the Y-Maze Test, and the Morris water maze Test in mice. Nodakenin (10 mg/kg, p.o.) administration significantly reversed scopolamine-induced cognitive impairments in the passive avoidance Test and the Y-Maze Test (P<0.05), and also reduced escape latency during training in the Morris water maze Test (P<0.05). Moreover, swimming times and distances within the target zone of the Morris water maze were greater in the nodakenin-treated group than in the scopolamine-treated group (P<0.05). In an in vitro study, nodakenin was found to inhibit acetylcholinesterase activity in a dose-dependent manner (IC(50)=84.7 microM). In addition, nodakenin was also found to inhibit acetylcholinesterase activity for 6 h in an ex-vivo study. These results suggest that nodakenin may be a useful for the treatment of cognitive impairment, and that its beneficial effects are mediated, in part, via the enhancement of cholinergic signaling.

  • gomisin a improves scopolamine induced memory impairment in mice
    European Journal of Pharmacology, 2006
    Co-Authors: Donghyun Kim, Tran Manh Hung, Kihwan Bae, Ji Wook Jung, Seungjoo Lee, Byung Hoon Yoon, Jae Hoon Cheong, Jong Hoon Ryu
    Abstract:

    Gomisin A is a component of the fruits of Schizandra chinesis which are widely used as a tonic in traditional Chinese medicine. In the present study, we assessed the effect of gomisin A on the learning and memory impairments induced by scopolamine. The cognition-enhancing effect of gomisin A was investigated using a passive avoidance Test, the Y-Maze Test, and the Morris water maze Test in mice. Drug-induced amnesia was induced by treating animals with scopolamine (1 mg/kg, i.p.). Gomisin A (5 mg/kg, p.o.) administration significantly reversed scopolamine-induced cognitive impairments in mice by the passive avoidance Test and the Y-Maze Test (P<0.05), and also improved escape latency in the Morris water maze Test at 5 mg/kg (P<0.05). Moreover, in an in vitro study, gomisin A was found to inhibit acetylcholinesterase activity in a dose-dependent manner (IC50 value; 15.5 microM). These results suggest that gomisin A may be a useful cognitive impairment treatment, and its beneficial effects are mediated, in part, via enhancing the cholinergic nervous system.

Ji Wook Jung - One of the best experts on this subject based on the ideXlab platform.

  • the ameliorating effect of oroxylin a on scopolamine induced memory impairment in mice
    Neurobiology of Learning and Memory, 2007
    Co-Authors: Donghyun Kim, Ji Wook Jung, Seungjoo Lee, Byung Hoon Yoon, Jae Hoon Cheong, Su Jin Jeon, Kun Ho Son, Jongju Lee, Youngwuk Cho, Jong Hoon Ryu
    Abstract:

    Oroxylin A is a flavonoid and was originally isolated from the root of Scutellaria baicalensis Georgi., one of the most important medicinal herbs in traditional Chinese medicine. The aim of this study was to investigate the ameliorating effects of oroxylin A on memory impairment using the passive avoidance Test, the Y-Maze Test, and the Morris water maze Test in mice. Drug-induced amnesia was induced by administering scopolamine (1 mg/kg, i.p.) or diazepam (1 mg/kg, i.p.). Oroxylin A (5 mg/kg) significantly reversed cognitive impairments in mice by passive avoidance and the Y-Maze Testing (P<.05). Oroxylin A also improved escape latencies in training trials and increased swimming times and distances within the target zone of the Morris water maze (P<.05). Moreover, the ameliorating effects of oroxylin A were antagonized by both muscimol and diazepam (0.25 mg/kg, i.p., respectively), which are GABA(A) receptor agonists. Furthermore, oroxylin A (100 microM) was found to inhibit GABA-induced inward Cl(-) current in a single cortical neuron. These results suggest that oroxylin A may be useful for the treatment of cognitive impairments induced by cholinergic dysfunction via the GABAergic nervous system.

  • nodakenin a coumarin compound ameliorates scopolamine induced memory disruption in mice
    Life Sciences, 2007
    Co-Authors: Donghyun Kim, Ji Wook Jung, Seungjoo Lee, Byung Hoon Yoon, Jae Hoon Cheong, Do Yoon Kim, Young Choong Kim, Yeong Shik Kim, Sam Sik Kang, Jong Hoon Ryu
    Abstract:

    Nodakenin is a coumarin compound initially isolated from the roots of Angelica gigas. In the present study, we investigated the effects of nodakenin on learning and memory impairments induced by scopolamine (1 mg/kg, i.p.) using the passive avoidance Test, the Y-Maze Test, and the Morris water maze Test in mice. Nodakenin (10 mg/kg, p.o.) administration significantly reversed scopolamine-induced cognitive impairments in the passive avoidance Test and the Y-Maze Test (P<0.05), and also reduced escape latency during training in the Morris water maze Test (P<0.05). Moreover, swimming times and distances within the target zone of the Morris water maze were greater in the nodakenin-treated group than in the scopolamine-treated group (P<0.05). In an in vitro study, nodakenin was found to inhibit acetylcholinesterase activity in a dose-dependent manner (IC(50)=84.7 microM). In addition, nodakenin was also found to inhibit acetylcholinesterase activity for 6 h in an ex-vivo study. These results suggest that nodakenin may be a useful for the treatment of cognitive impairment, and that its beneficial effects are mediated, in part, via the enhancement of cholinergic signaling.

  • gomisin a improves scopolamine induced memory impairment in mice
    European Journal of Pharmacology, 2006
    Co-Authors: Donghyun Kim, Tran Manh Hung, Kihwan Bae, Ji Wook Jung, Seungjoo Lee, Byung Hoon Yoon, Jae Hoon Cheong, Jong Hoon Ryu
    Abstract:

    Gomisin A is a component of the fruits of Schizandra chinesis which are widely used as a tonic in traditional Chinese medicine. In the present study, we assessed the effect of gomisin A on the learning and memory impairments induced by scopolamine. The cognition-enhancing effect of gomisin A was investigated using a passive avoidance Test, the Y-Maze Test, and the Morris water maze Test in mice. Drug-induced amnesia was induced by treating animals with scopolamine (1 mg/kg, i.p.). Gomisin A (5 mg/kg, p.o.) administration significantly reversed scopolamine-induced cognitive impairments in mice by the passive avoidance Test and the Y-Maze Test (P<0.05), and also improved escape latency in the Morris water maze Test at 5 mg/kg (P<0.05). Moreover, in an in vitro study, gomisin A was found to inhibit acetylcholinesterase activity in a dose-dependent manner (IC50 value; 15.5 microM). These results suggest that gomisin A may be a useful cognitive impairment treatment, and its beneficial effects are mediated, in part, via enhancing the cholinergic nervous system.