The Experts below are selected from a list of 15117 Experts worldwide ranked by ideXlab platform
Walter Fratta - One of the best experts on this subject based on the ideXlab platform.
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isradipine inhibits nicotine intravenous self administration in drug naive mice
Pharmacology Biochemistry and Behavior, 1995Co-Authors: M C Martellotta, Alexander Kuzmin, Edvin Zvartau, Gian Luigi Gessa, G Cossu, Walter FrattaAbstract:The effect of isradipine, a dihydropyridine calcium antagonist, on intravenous self-administration of nicotine in naive mice has been investigated. When nicotine injections were made contingent upon nose-poke response by naive mice, they increased their rate of nose poking with respect to animals receiving contingent saline injections or Yoked control animals receiving noncontingent nicotine injections. Pretreatment of mice with mecamylamine (2.4 mg/kg) inhibited self-administration of nicotine contingent upon a nose-poke response. The same effect was observed with isradipine (0.5-1.0 mg/kg) in a dose-related manner and stereospecifically. These data suggest that isradipine suppresses the reinforcing properties of nicotine and might be useful for treatment of nicotine abuse.
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calcium antagonists isradipine and nimodipine suppress cocaine and morphine intravenous self administration in drug naive mice
Pharmacology Biochemistry and Behavior, 1992Co-Authors: Alexander Kuzmin, Edvin Zvartau, Gian Luigi Gessa, Cristina M Martellotta, Walter FrattaAbstract:The effect of isradipine and nimodipine, two dihydropyridine calcium antagonists, on intravenous self-administration of cocaine and morphine in naive mice has been investigated. When morphine or cocaine injections were made contingent upon nose-poke response by naive mice, they increased their rate of nose-poking with respect to animals receiving contingent saline injections or Yoked control animals, receiving noncontingent cocaine or morphine injections. Pretreatment of mice with isradipine (1.0-3.0 mg/kg, SC) or nimodipine (5-20 mg/kg, SC) inhibited in a dose-related manner self-administration both of cocaine and morphine contingent upon a nose-poke response. The ED50 of isradipine against cocaine and morphine self-administration was 1.7 and 2.1 mg/kg, respectively. The relative values for nimodipine were 14.5 and 11.4 mg/kg, respectively. These data suggest that nimodipine and, especially, isradipine suppress the reinforcing properties of morphine and cocaine and may be an effective pharmacotherapy for treatment of cocaine and heroin abuse.
Irma Bowen Historic Clothing G. Collection - One of the best experts on this subject based on the ideXlab platform.
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Housedress, brown printed cotton, c. 1835-1850, back view
University of New Hampshire Scholars\u27 Repository, 2019Co-Authors: Irma Bowen Historic Clothing G. CollectionAbstract:c. 1835-1850. Brown printed cotton floor-length housedress, one piece, open in front and fully lined, with Yoke, dropped shoulders, long full sleeves, and large collar; trimmed with a contrasting print. The housedress is pieced together out of reused printed cotton. The exterior uses the same fabric throughout, though at different stages of fading. The lining has five distinct fabrics present, some likely older than the garment itself. The trim introduces a seventh fabric. This is a loose garment with no shaping or defined waist, and its main body is comprised of a four-piece Yoke and a four-piece skirt. The Yoke is cut close to the neck, and straight across the bottom edge which is finished with narrow piping of the same fabric. It has two panels in front, and two in back with a center-back seam. The left back panel is assembled out of two pieces and the right back panel has a small horizontal piecing at the neck. The Yoke extends onto the upper arm, creating a dropped shoulder line; the shoulder seam joining front and back panels is 21.6 cm / 8.5 in. long. The Yoke is shallow, not quite reaching the bottom of the armscyes, so it has no side seam. The skirt has four 66.7 cm / 26.25 in. wide panels, sewn selvedge to selvedge at the sides and center back. It is gathered evenly to the Yoke in front and back but left flat under the sleeves, where small half-moons, the only piecing present in the skirt, are added in. The front of the housedress is open from throat to hem and is closed with fourteen small buttons. A large collar with points in front, on top of each shoulder, and one at center back is sewn directly to the Yoke’s neck opening. The left front point is pieced. The top edge of the full-length sleeves has piping, sewn on before being joined to the housedress, with the underarm portion of the sleeve extending past the Yoke and into the un-gathered area of the skirt. The sleeve design resembles the banded-down fashions of the late 1830s-1840s, with a smooth, fitted band of fabric at the upper arm to which a wide lower sleeve is added. The bottom of the fitted band incorporates a strip of cording sewn into its hem so as to resemble piping. The full lower sleeve is gathered to the band at the bicep and to a buttoned cuff at the wrist. The sleeves have a single seam construction, but their width is achieved by adding in five pieces of fabric at the back of the arm along the seam. Both sleeves have the same complex pattern of piecing. The left cuff is pieced at the button edge. The housedress is fully lined with the exception of the collar. The lining is constructed to match the shell, including the upper sleeve banding and the underarm gusset, and it is heavily pieced with twenty one individual elements. In addition, not counting the front opening where the outer fabric wraps around to the inside, five different cotton prints are used: one for the sleeves and cuffs, one for the Yoke, one for center back, and two for the skirt. Trim made of strips cut from a fabric printed with stripes and paisleys highlights the collar, sleeve banding, cuffs, and both sides of front opening. Hand-sewn.https://scholars.unh.edu/bowen_collection/1368/thumbnail.jp
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Housedress, brown printed cotton, c. 1835-1850, side view
University of New Hampshire Scholars\u27 Repository, 2019Co-Authors: Irma Bowen Historic Clothing G. CollectionAbstract:c. 1835-1850. Brown printed cotton floor-length housedress, one piece, open in front and fully lined, with Yoke, dropped shoulders, long full sleeves, and large collar; trimmed with a contrasting print. The housedress is pieced together out of reused printed cotton. The exterior uses the same fabric throughout, though at different stages of fading. The lining has five distinct fabrics present, some likely older than the garment itself. The trim introduces a seventh fabric. This is a loose garment with no shaping or defined waist, and its main body is comprised of a four-piece Yoke and a four-piece skirt. The Yoke is cut close to the neck, and straight across the bottom edge which is finished with narrow piping of the same fabric. It has two panels in front, and two in back with a center-back seam. The left back panel is assembled out of two pieces and the right back panel has a small horizontal piecing at the neck. The Yoke extends onto the upper arm, creating a dropped shoulder line; the shoulder seam joining front and back panels is 21.6 cm / 8.5 in. long. The Yoke is shallow, not quite reaching the bottom of the armscyes, so it has no side seam. The skirt has four 66.7 cm / 26.25 in. wide panels, sewn selvedge to selvedge at the sides and center back. It is gathered evenly to the Yoke in front and back but left flat under the sleeves, where small half-moons, the only piecing present in the skirt, are added in. The front of the housedress is open from throat to hem and is closed with fourteen small buttons. A large collar with points in front, on top of each shoulder, and one at center back is sewn directly to the Yoke’s neck opening. The left front point is pieced. The top edge of the full-length sleeves has piping, sewn on before being joined to the housedress, with the underarm portion of the sleeve extending past the Yoke and into the un-gathered area of the skirt. The sleeve design resembles the banded-down fashions of the late 1830s-1840s, with a smooth, fitted band of fabric at the upper arm to which a wide lower sleeve is added. The bottom of the fitted band incorporates a strip of cording sewn into its hem so as to resemble piping. The full lower sleeve is gathered to the band at the bicep and to a buttoned cuff at the wrist. The sleeves have a single seam construction, but their width is achieved by adding in five pieces of fabric at the back of the arm along the seam. Both sleeves have the same complex pattern of piecing. The left cuff is pieced at the button edge. The housedress is fully lined with the exception of the collar. The lining is constructed to match the shell, including the upper sleeve banding and the underarm gusset, and it is heavily pieced with twenty one individual elements. In addition, not counting the front opening where the outer fabric wraps around to the inside, five different cotton prints are used: one for the sleeves and cuffs, one for the Yoke, one for center back, and two for the skirt. Trim made of strips cut from a fabric printed with stripes and paisleys highlights the collar, sleeve banding, cuffs, and both sides of front opening. Hand-sewn.https://scholars.unh.edu/bowen_collection/1367/thumbnail.jp
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Housedress, brown printed cotton, c. 1835-1850, detail of front lining
University of New Hampshire Scholars\u27 Repository, 2019Co-Authors: Irma Bowen Historic Clothing G. CollectionAbstract:c. 1835-1850. Brown printed cotton floor-length housedress, one piece, open in front and fully lined, with Yoke, dropped shoulders, long full sleeves, and large collar; trimmed with a contrasting print. The housedress is pieced together out of reused printed cotton. The exterior uses the same fabric throughout, though at different stages of fading. The lining has five distinct fabrics present, some likely older than the garment itself. The trim introduces a seventh fabric. This is a loose garment with no shaping or defined waist, and its main body is comprised of a four-piece Yoke and a four-piece skirt. The Yoke is cut close to the neck, and straight across the bottom edge which is finished with narrow piping of the same fabric. It has two panels in front, and two in back with a center-back seam. The left back panel is assembled out of two pieces and the right back panel has a small horizontal piecing at the neck. The Yoke extends onto the upper arm, creating a dropped shoulder line; the shoulder seam joining front and back panels is 21.6 cm / 8.5 in. long. The Yoke is shallow, not quite reaching the bottom of the armscyes, so it has no side seam. The skirt has four 66.7 cm / 26.25 in. wide panels, sewn selvedge to selvedge at the sides and center back. It is gathered evenly to the Yoke in front and back but left flat under the sleeves, where small half-moons, the only piecing present in the skirt, are added in. The front of the housedress is open from throat to hem and is closed with fourteen small buttons. A large collar with points in front, on top of each shoulder, and one at center back is sewn directly to the Yoke’s neck opening. The left front point is pieced. The top edge of the full-length sleeves has piping, sewn on before being joined to the housedress, with the underarm portion of the sleeve extending past the Yoke and into the un-gathered area of the skirt. The sleeve design resembles the banded-down fashions of the late 1830s-1840s, with a smooth, fitted band of fabric at the upper arm to which a wide lower sleeve is added. The bottom of the fitted band incorporates a strip of cording sewn into its hem so as to resemble piping. The full lower sleeve is gathered to the band at the bicep and to a buttoned cuff at the wrist. The sleeves have a single seam construction, but their width is achieved by adding in five pieces of fabric at the back of the arm along the seam. Both sleeves have the same complex pattern of piecing. The left cuff is pieced at the button edge. The housedress is fully lined with the exception of the collar. The lining is constructed to match the shell, including the upper sleeve banding and the underarm gusset, and it is heavily pieced with twenty one individual elements. In addition, not counting the front opening where the outer fabric wraps around to the inside, five different cotton prints are used: one for the sleeves and cuffs, one for the Yoke, one for center back, and two for the skirt. Trim made of strips cut from a fabric printed with stripes and paisleys highlights the collar, sleeve banding, cuffs, and both sides of front opening. Hand-sewn.https://scholars.unh.edu/bowen_collection/1372/thumbnail.jp
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Housedress, brown printed cotton, c. 1835-1850, detail of all lining fabrics
University of New Hampshire Scholars\u27 Repository, 2019Co-Authors: Irma Bowen Historic Clothing G. CollectionAbstract:c. 1835-1850. Brown printed cotton floor-length housedress, one piece, open in front and fully lined, with Yoke, dropped shoulders, long full sleeves, and large collar; trimmed with a contrasting print. The housedress is pieced together out of reused printed cotton. The exterior uses the same fabric throughout, though at different stages of fading. The lining has five distinct fabrics present, some likely older than the garment itself. The trim introduces a seventh fabric. This is a loose garment with no shaping or defined waist, and its main body is comprised of a four-piece Yoke and a four-piece skirt. The Yoke is cut close to the neck, and straight across the bottom edge which is finished with narrow piping of the same fabric. It has two panels in front, and two in back with a center-back seam. The left back panel is assembled out of two pieces and the right back panel has a small horizontal piecing at the neck. The Yoke extends onto the upper arm, creating a dropped shoulder line; the shoulder seam joining front and back panels is 21.6 cm / 8.5 in. long. The Yoke is shallow, not quite reaching the bottom of the armscyes, so it has no side seam. The skirt has four 66.7 cm / 26.25 in. wide panels, sewn selvedge to selvedge at the sides and center back. It is gathered evenly to the Yoke in front and back but left flat under the sleeves, where small half-moons, the only piecing present in the skirt, are added in. The front of the housedress is open from throat to hem and is closed with fourteen small buttons. A large collar with points in front, on top of each shoulder, and one at center back is sewn directly to the Yoke’s neck opening. The left front point is pieced. The top edge of the full-length sleeves has piping, sewn on before being joined to the housedress, with the underarm portion of the sleeve extending past the Yoke and into the un-gathered area of the skirt. The sleeve design resembles the banded-down fashions of the late 1830s-1840s, with a smooth, fitted band of fabric at the upper arm to which a wide lower sleeve is added. The bottom of the fitted band incorporates a strip of cording sewn into its hem so as to resemble piping. The full lower sleeve is gathered to the band at the bicep and to a buttoned cuff at the wrist. The sleeves have a single seam construction, but their width is achieved by adding in five pieces of fabric at the back of the arm along the seam. Both sleeves have the same complex pattern of piecing. The left cuff is pieced at the button edge. The housedress is fully lined with the exception of the collar. The lining is constructed to match the shell, including the upper sleeve banding and the underarm gusset, and it is heavily pieced with twenty one individual elements. In addition, not counting the front opening where the outer fabric wraps around to the inside, five different cotton prints are used: one for the sleeves and cuffs, one for the Yoke, one for center back, and two for the skirt. Trim made of strips cut from a fabric printed with stripes and paisleys highlights the collar, sleeve banding, cuffs, and both sides of front opening. Hand-sewn.https://scholars.unh.edu/bowen_collection/1375/thumbnail.jp
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Housedress, brown printed cotton, c. 1835-1850, detail of Yoke and sleeve piping, trim, gathers, and sleeve piecing
University of New Hampshire Scholars\u27 Repository, 2019Co-Authors: Irma Bowen Historic Clothing G. CollectionAbstract:c. 1835-1850. Brown printed cotton floor-length housedress, one piece, open in front and fully lined, with Yoke, dropped shoulders, long full sleeves, and large collar; trimmed with a contrasting print. The housedress is pieced together out of reused printed cotton. The exterior uses the same fabric throughout, though at different stages of fading. The lining has five distinct fabrics present, some likely older than the garment itself. The trim introduces a seventh fabric. This is a loose garment with no shaping or defined waist, and its main body is comprised of a four-piece Yoke and a four-piece skirt. The Yoke is cut close to the neck, and straight across the bottom edge which is finished with narrow piping of the same fabric. It has two panels in front, and two in back with a center-back seam. The left back panel is assembled out of two pieces and the right back panel has a small horizontal piecing at the neck. The Yoke extends onto the upper arm, creating a dropped shoulder line; the shoulder seam joining front and back panels is 21.6 cm / 8.5 in. long. The Yoke is shallow, not quite reaching the bottom of the armscyes, so it has no side seam. The skirt has four 66.7 cm / 26.25 in. wide panels, sewn selvedge to selvedge at the sides and center back. It is gathered evenly to the Yoke in front and back but left flat under the sleeves, where small half-moons, the only piecing present in the skirt, are added in. The front of the housedress is open from throat to hem and is closed with fourteen small buttons. A large collar with points in front, on top of each shoulder, and one at center back is sewn directly to the Yoke’s neck opening. The left front point is pieced. The top edge of the full-length sleeves has piping, sewn on before being joined to the housedress, with the underarm portion of the sleeve extending past the Yoke and into the un-gathered area of the skirt. The sleeve design resembles the banded-down fashions of the late 1830s-1840s, with a smooth, fitted band of fabric at the upper arm to which a wide lower sleeve is added. The bottom of the fitted band incorporates a strip of cording sewn into its hem so as to resemble piping. The full lower sleeve is gathered to the band at the bicep and to a buttoned cuff at the wrist. The sleeves have a single seam construction, but their width is achieved by adding in five pieces of fabric at the back of the arm along the seam. Both sleeves have the same complex pattern of piecing. The left cuff is pieced at the button edge. The housedress is fully lined with the exception of the collar. The lining is constructed to match the shell, including the upper sleeve banding and the underarm gusset, and it is heavily pieced with twenty one individual elements. In addition, not counting the front opening where the outer fabric wraps around to the inside, five different cotton prints are used: one for the sleeves and cuffs, one for the Yoke, one for center back, and two for the skirt. Trim made of strips cut from a fabric printed with stripes and paisleys highlights the collar, sleeve banding, cuffs, and both sides of front opening. Hand-sewn.https://scholars.unh.edu/bowen_collection/1369/thumbnail.jp
Alexander Kuzmin - One of the best experts on this subject based on the ideXlab platform.
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isradipine inhibits nicotine intravenous self administration in drug naive mice
Pharmacology Biochemistry and Behavior, 1995Co-Authors: M C Martellotta, Alexander Kuzmin, Edvin Zvartau, Gian Luigi Gessa, G Cossu, Walter FrattaAbstract:The effect of isradipine, a dihydropyridine calcium antagonist, on intravenous self-administration of nicotine in naive mice has been investigated. When nicotine injections were made contingent upon nose-poke response by naive mice, they increased their rate of nose poking with respect to animals receiving contingent saline injections or Yoked control animals receiving noncontingent nicotine injections. Pretreatment of mice with mecamylamine (2.4 mg/kg) inhibited self-administration of nicotine contingent upon a nose-poke response. The same effect was observed with isradipine (0.5-1.0 mg/kg) in a dose-related manner and stereospecifically. These data suggest that isradipine suppresses the reinforcing properties of nicotine and might be useful for treatment of nicotine abuse.
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calcium antagonists isradipine and nimodipine suppress cocaine and morphine intravenous self administration in drug naive mice
Pharmacology Biochemistry and Behavior, 1992Co-Authors: Alexander Kuzmin, Edvin Zvartau, Gian Luigi Gessa, Cristina M Martellotta, Walter FrattaAbstract:The effect of isradipine and nimodipine, two dihydropyridine calcium antagonists, on intravenous self-administration of cocaine and morphine in naive mice has been investigated. When morphine or cocaine injections were made contingent upon nose-poke response by naive mice, they increased their rate of nose-poking with respect to animals receiving contingent saline injections or Yoked control animals, receiving noncontingent cocaine or morphine injections. Pretreatment of mice with isradipine (1.0-3.0 mg/kg, SC) or nimodipine (5-20 mg/kg, SC) inhibited in a dose-related manner self-administration both of cocaine and morphine contingent upon a nose-poke response. The ED50 of isradipine against cocaine and morphine self-administration was 1.7 and 2.1 mg/kg, respectively. The relative values for nimodipine were 14.5 and 11.4 mg/kg, respectively. These data suggest that nimodipine and, especially, isradipine suppress the reinforcing properties of morphine and cocaine and may be an effective pharmacotherapy for treatment of cocaine and heroin abuse.
H Yano - One of the best experts on this subject based on the ideXlab platform.
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effects of geomagnetism and residual magnetism on single sheet testers for amorphous magnetic material
Journal of Magnetism and Magnetic Materials, 1996Co-Authors: T Nakata, M Nakano, Koji Fujiwara, K Muramatsu, H L Zhu, H YanoAbstract:Abstract The effects of geomagnetism and residual magnetism in various types of single sheet testers (SST) on magnetic characteristics, such as the power loss of amorphous magnetic material, have been investigated. It has been clarified that the measured accuracy is affected significantly by the directions of the Yoke. The single-Yoke types show unfavorable performance when used outside a magnetic shielding room (MSR). If the Yoke is not demagnetized, the horizontal double-Yoke type requires a MSR. However, the performance of the vertical double-Yoke type is acceptable even in the case without a MSR.
Jin Kook Kim - One of the best experts on this subject based on the ideXlab platform.
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design and manufacture of an automotive hybrid aluminum composite drive shaft
Composite Structures, 2004Co-Authors: Dai Gil Lee, Jong Woon Kim, Jin Kook KimAbstract:Substituting composite structures for conventional metallic structures has many advantages because of higher specific stiffness and higher specific strength of composite materials. In this work, one-piece automotive hybrid aluminum/composite drive shaft was developed with a new manufacturing method, in which a carbon fiber epoxy composite layer was co-cured on the inner surface of an aluminum tube rather than wrapping on the outer surface to prevent the composite layer from being damaged by external impact and absorption of moisture. The optimal stacking sequence of the composite layer was determined considering the thermal residual stresses of interface between the aluminum tube and the composite layer calculated by finite element analysis. Press fitting method for the joining of the aluminum/composite tube and steel Yokes was devised to improve reliability and to reduce manufacturing cost, compared to other joining methods such as adhesively bonded, bolted or riveted and welded joints. Protrusion shapes on the inner surface of steel Yoke were created to increase the torque capability of the press fitted joint. From experimental results, it was found that the developed one-piece automotive hybrid aluminum/composite drive shaft had 75% mass reduction, 160% increase in torque capability compared with a conventional two-piece steel drive shaft. It also had 9390 rpm of natural frequency which was higher than the design specification of 9200 rpm.
