The Experts below are selected from a list of 36 Experts worldwide ranked by ideXlab platform
Masutaka Furue - One of the best experts on this subject based on the ideXlab platform.
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blood levels of pcdds pcdfs and coplanar pcbs in Yusho mothers and their descendants association with fetal Yusho Disease
Chemosphere, 2013Co-Authors: Kiyomi Tsukimori, Hiroshi Uchi, Shoji Tokunaga, Fumiko Yasukawa, Takahito Chiba, Junboku Kajiwara, Teruaki Hirata, Masutaka FurueAbstract:Abstract Maternal exposure to polychlorinated dibenzo- p -dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and polychlorinated biphenyls (PCBs) may result in adverse health effects in their children. In Japan in 1968, an accidental human exposure to rice oil contaminated with PCDDs, PCDFs, and PCBs, led to the development of Yusho Disease. Yusho mothers delivered descendants with low birth weights and hyperpigmented skin and mucosa, which are characteristic of fetal Yusho Disease (FYD). The Yusho cohort was used to evaluate the effect of maternal exposure to PCDDs, PCDFs, and PCBs on the development of FYD. Blood samples, obtained from 64 Yusho mothers (117 descendants: 10 with FYD and 107 without FYD), were analyzed for congeners of seven PCDDs, 10 PCDFs, and four coplanar PCBs. We investigated the association between the maternal estimated blood levels of dioxins at delivery and the risk of fetal Yusho Disease. We also studied the differences in dioxin blood levels in 24 mother–descendant pairs (5 with FYD and 19 without FYD). The estimated levels of total PCDD TEQ, total PCDF TEQ, total coplanar PCB TEQ, and total TEQ in the maternal blood at delivery were associated with significantly increased risk of FYD. The odds ratios, which present the risk of FYD for a 10-fold increase in blood dioxin, were largest for 1,2,3,6,7,8-HexaCDD (odds ratio = 28.6, 95% confidence interval = 1.67–489.9, p = 0.02). The levels of 1,2,3,6,7,8-HexaCDD in both the Yusho mothers and their descendants with FYD were higher than the levels in those without FYD. These findings suggest that 1,2,3,6,7,8-HexaCDD is the most important causative congener for the development of FYD.
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relationships between concentrations of dioxin isomers and symptoms and among concentrations and half lives of dioxin isomers in patients with Yusho Disease
Hukuoka acta medica, 2013Co-Authors: Shinya Matsumoto, Hiroshi Uchi, Masutaka Furue, Manabu Akahane, Yoshiyuki Kanagawa, Jumboku Kajiwara, Tomoaki ImamuraAbstract:The relationships among dioxin isomers are not well understood. This study aimed to clarify the relationships among isomers using two methods. First, the relationships between isomers and symptoms were analyzed by analysis of variance. Second, concentrations and half-lives were determined for each isomer in each patient, and correlation coefficients for the concentrations and half-lives among isomers were calculated. Two isomers very similar to 2, 3, 4, 7, 8-pentachlorodibenzofuran (2, 3, 4, 7, 8-PeCDF) were correlated with symptoms of Yusho Disease. The correlation coefficients among three isomers similar to 2, 3, 4, 7, 8-PeCDF were very high at 0.98, indicating that there may be a mechanism which maintains constant ratios among these isomers.
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infundibular cyst with seborrheic verruca like cyst walls in a patient with Yusho Disease exposed to dioxins
European Journal of Dermatology, 2012Co-Authors: Hiroshi Uchi, Fumiko Yasukawa, Hiromaro Kiryu, Ken Hashimoto, Masutaka FurueAbstract:ejd.2012.1805 Auteur(s) : Hiroshi Uchi1 uchihir@dermatol.med.kyushu-u.ac.jp, Fumiko Yasukawa1, Hiromaro Kiryu2, Ken Hashimoto3, Masutaka Furue1 1 Department of Dermatology, Kyushu University, 3-1-1, Maidashi Higashi-ku, Fukuoka 812-8582, Japan 2 Fukuoka Institute for Dermatopathology, Fukuoka, Japan, 3 Department of Dermatology, Wayne State School of Medicine, Dearborn MI 48124, USA Infundibular cysts with seborrheic verruca-like cyst walls, originally reported as epidermoid cysts with seborrheic verruca-like [...]
Hiroshi Uchi - One of the best experts on this subject based on the ideXlab platform.
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blood levels of pcdds pcdfs and coplanar pcbs in Yusho mothers and their descendants association with fetal Yusho Disease
Chemosphere, 2013Co-Authors: Kiyomi Tsukimori, Hiroshi Uchi, Shoji Tokunaga, Fumiko Yasukawa, Takahito Chiba, Junboku Kajiwara, Teruaki Hirata, Masutaka FurueAbstract:Abstract Maternal exposure to polychlorinated dibenzo- p -dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and polychlorinated biphenyls (PCBs) may result in adverse health effects in their children. In Japan in 1968, an accidental human exposure to rice oil contaminated with PCDDs, PCDFs, and PCBs, led to the development of Yusho Disease. Yusho mothers delivered descendants with low birth weights and hyperpigmented skin and mucosa, which are characteristic of fetal Yusho Disease (FYD). The Yusho cohort was used to evaluate the effect of maternal exposure to PCDDs, PCDFs, and PCBs on the development of FYD. Blood samples, obtained from 64 Yusho mothers (117 descendants: 10 with FYD and 107 without FYD), were analyzed for congeners of seven PCDDs, 10 PCDFs, and four coplanar PCBs. We investigated the association between the maternal estimated blood levels of dioxins at delivery and the risk of fetal Yusho Disease. We also studied the differences in dioxin blood levels in 24 mother–descendant pairs (5 with FYD and 19 without FYD). The estimated levels of total PCDD TEQ, total PCDF TEQ, total coplanar PCB TEQ, and total TEQ in the maternal blood at delivery were associated with significantly increased risk of FYD. The odds ratios, which present the risk of FYD for a 10-fold increase in blood dioxin, were largest for 1,2,3,6,7,8-HexaCDD (odds ratio = 28.6, 95% confidence interval = 1.67–489.9, p = 0.02). The levels of 1,2,3,6,7,8-HexaCDD in both the Yusho mothers and their descendants with FYD were higher than the levels in those without FYD. These findings suggest that 1,2,3,6,7,8-HexaCDD is the most important causative congener for the development of FYD.
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relationships between concentrations of dioxin isomers and symptoms and among concentrations and half lives of dioxin isomers in patients with Yusho Disease
Hukuoka acta medica, 2013Co-Authors: Shinya Matsumoto, Hiroshi Uchi, Masutaka Furue, Manabu Akahane, Yoshiyuki Kanagawa, Jumboku Kajiwara, Tomoaki ImamuraAbstract:The relationships among dioxin isomers are not well understood. This study aimed to clarify the relationships among isomers using two methods. First, the relationships between isomers and symptoms were analyzed by analysis of variance. Second, concentrations and half-lives were determined for each isomer in each patient, and correlation coefficients for the concentrations and half-lives among isomers were calculated. Two isomers very similar to 2, 3, 4, 7, 8-pentachlorodibenzofuran (2, 3, 4, 7, 8-PeCDF) were correlated with symptoms of Yusho Disease. The correlation coefficients among three isomers similar to 2, 3, 4, 7, 8-PeCDF were very high at 0.98, indicating that there may be a mechanism which maintains constant ratios among these isomers.
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infundibular cyst with seborrheic verruca like cyst walls in a patient with Yusho Disease exposed to dioxins
European Journal of Dermatology, 2012Co-Authors: Hiroshi Uchi, Fumiko Yasukawa, Hiromaro Kiryu, Ken Hashimoto, Masutaka FurueAbstract:ejd.2012.1805 Auteur(s) : Hiroshi Uchi1 uchihir@dermatol.med.kyushu-u.ac.jp, Fumiko Yasukawa1, Hiromaro Kiryu2, Ken Hashimoto3, Masutaka Furue1 1 Department of Dermatology, Kyushu University, 3-1-1, Maidashi Higashi-ku, Fukuoka 812-8582, Japan 2 Fukuoka Institute for Dermatopathology, Fukuoka, Japan, 3 Department of Dermatology, Wayne State School of Medicine, Dearborn MI 48124, USA Infundibular cysts with seborrheic verruca-like cyst walls, originally reported as epidermoid cysts with seborrheic verruca-like [...]
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maternal exposure to high levels of dioxins in relation to birth weight in women affected by Yusho Disease
Environment International, 2012Co-Authors: Kiyomi Tsukimori, Hiroshi Uchi, Fumiko Yasukawa, Takahito Chiba, Junboku Kajiwara, Teruaki Hirata, Chikage Mitoma, Takashi Todaka, Takesumi Yoshimura, Kotaro FukushimaAbstract:Abstract Background Studies on the association of maternal exposure to polychlorinated dibenzo- p -dioxin (PCDDs), polychlorinated dibenzofurans (PCDFs), and polychlorinated biphenyls (PCBs) with decreased birth weight in humans have produced conflicting results. In Japan in 1968, an accidental human exposure to rice oil contaminated with PCDDs, PCDFs, and PCBs, led to the development of Yusho Disease. Objective The Yusho cohort was used to evaluate the effect of maternal exposure to PCDDs, PCDFs, and PCBs on birth weight. Methods Blood samples, obtained from 101 Yusho women (190 births) who gave birth after exposure, were analyzed for congeners of seven PCDDs, ten PCDFs, and four non- ortho PCBs. Results Total PCDD TEQ (adjusted beta = − 161.9 g; 95% CI, −265.3 to − 58.6), total PCDF TEQ (adjusted beta = − 105.9 g; 95% CI, −179.5 to − 32.2), and total non- ortho PCBs (adjusted beta = − 178.4 g; 95% CI, −318.3 to − 38.5) levels were inversely associated with birth weight. Significant inverse associations with birth weight were also found for total PCDD TEQ, total PCDF TEQ, and total non- ortho PCB TEQ levels among male, but not female, infants. Significant inverse associations with birth weight were also found for nine congeners among all infants; the adjusted beta coefficients were largest for 1,2,3,6,7,8-HxCDD and smallest for 2,3,4,7,8-PeCDF. Conclusion In the setting of exposure to high levels of dioxins, maternal blood levels of PCDDs, PCDFs and PCBs are associated with lower birth weight in Yusho patients. The association exhibited gender-specific differences, as male infants are more susceptible than females to growth restriction induced by in utero dioxin exposures.
Yasunobu Aoki - One of the best experts on this subject based on the ideXlab platform.
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polychlorinated biphenyls polychloronated dibenzo p dioxins and polychlorinated dibenzofurans as endocrine disrupters what we have learned from Yusho Disease
Environmental Research, 2001Co-Authors: Yasunobu AokiAbstract:Abstract Polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins, and polychlorinated dibenzofurans (PCDFs) are persistent environmental pollutants. In some areas wildlife reproduction has been affected by these compounds, which are recognized as endocrine disrupters. In 1968 in northern Kyushu in Japan about 2000 people were poisoned by PCBs and PCDFs (pyrolysis products of PCBs) which contaminated rice oil. Their condition was named “Yusho” Disease. A similar poisoning by PCBs in Taiwan was named “Yu-Cheng” Disease. The major symptoms of Yusho Disease were dermal and ocular lesions, but some of the symptoms, such as irregular menstrual cycles and altered immune responses, were notable with respect to the endocrine disrupting activities of PCBs and related compounds. Several important observations relevant to the mechanisms of Yusho have been made from animal studies. For example, a coplanar PCB congener was shown to cause atrophy of the thymus and PCB administration was thought to alter androgen metabolism. The most tragic aspect of Yusho and Yu-Cheng Diseases was the exposure of children to PCBs. In the case of Yu-Cheng, children exposed to PCBs in utero and lactationally were reported to have poor cognitive development. Intellectual impairment was also observed in children born to women who had eaten fish contaminated with PCBs in the United States. From animal studies, alterations in thyroid hormone status, modulation of protein kinase C, and changes in dopamine levels, etc. were proposed as the possible mechanisms for the adverse effects of PCBs on brain development. Whereas coplanar PCB and related congeners, e.g., 2,3,7,8-tetrachlorodibenzo-p-dioxin, induce gene expression via a ligand-dependent transactivating factor, the arylhydrocarbon receptor, alternative pathways for gene expression, e.g., c-Src and cross talk with the MAP kinase pathway, are also reviewed with respect to understanding the toxic mechanisms of these compounds. Finally, the “precautionary principle” is discussed for prevention of the health hazards caused by exposure to endocrine disrupters.
Kiyomi Tsukimori - One of the best experts on this subject based on the ideXlab platform.
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blood levels of pcdds pcdfs and coplanar pcbs in Yusho mothers and their descendants association with fetal Yusho Disease
Chemosphere, 2013Co-Authors: Kiyomi Tsukimori, Hiroshi Uchi, Shoji Tokunaga, Fumiko Yasukawa, Takahito Chiba, Junboku Kajiwara, Teruaki Hirata, Masutaka FurueAbstract:Abstract Maternal exposure to polychlorinated dibenzo- p -dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and polychlorinated biphenyls (PCBs) may result in adverse health effects in their children. In Japan in 1968, an accidental human exposure to rice oil contaminated with PCDDs, PCDFs, and PCBs, led to the development of Yusho Disease. Yusho mothers delivered descendants with low birth weights and hyperpigmented skin and mucosa, which are characteristic of fetal Yusho Disease (FYD). The Yusho cohort was used to evaluate the effect of maternal exposure to PCDDs, PCDFs, and PCBs on the development of FYD. Blood samples, obtained from 64 Yusho mothers (117 descendants: 10 with FYD and 107 without FYD), were analyzed for congeners of seven PCDDs, 10 PCDFs, and four coplanar PCBs. We investigated the association between the maternal estimated blood levels of dioxins at delivery and the risk of fetal Yusho Disease. We also studied the differences in dioxin blood levels in 24 mother–descendant pairs (5 with FYD and 19 without FYD). The estimated levels of total PCDD TEQ, total PCDF TEQ, total coplanar PCB TEQ, and total TEQ in the maternal blood at delivery were associated with significantly increased risk of FYD. The odds ratios, which present the risk of FYD for a 10-fold increase in blood dioxin, were largest for 1,2,3,6,7,8-HexaCDD (odds ratio = 28.6, 95% confidence interval = 1.67–489.9, p = 0.02). The levels of 1,2,3,6,7,8-HexaCDD in both the Yusho mothers and their descendants with FYD were higher than the levels in those without FYD. These findings suggest that 1,2,3,6,7,8-HexaCDD is the most important causative congener for the development of FYD.
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maternal exposure to high levels of dioxins in relation to birth weight in women affected by Yusho Disease
Environment International, 2012Co-Authors: Kiyomi Tsukimori, Hiroshi Uchi, Fumiko Yasukawa, Takahito Chiba, Junboku Kajiwara, Teruaki Hirata, Chikage Mitoma, Takashi Todaka, Takesumi Yoshimura, Kotaro FukushimaAbstract:Abstract Background Studies on the association of maternal exposure to polychlorinated dibenzo- p -dioxin (PCDDs), polychlorinated dibenzofurans (PCDFs), and polychlorinated biphenyls (PCBs) with decreased birth weight in humans have produced conflicting results. In Japan in 1968, an accidental human exposure to rice oil contaminated with PCDDs, PCDFs, and PCBs, led to the development of Yusho Disease. Objective The Yusho cohort was used to evaluate the effect of maternal exposure to PCDDs, PCDFs, and PCBs on birth weight. Methods Blood samples, obtained from 101 Yusho women (190 births) who gave birth after exposure, were analyzed for congeners of seven PCDDs, ten PCDFs, and four non- ortho PCBs. Results Total PCDD TEQ (adjusted beta = − 161.9 g; 95% CI, −265.3 to − 58.6), total PCDF TEQ (adjusted beta = − 105.9 g; 95% CI, −179.5 to − 32.2), and total non- ortho PCBs (adjusted beta = − 178.4 g; 95% CI, −318.3 to − 38.5) levels were inversely associated with birth weight. Significant inverse associations with birth weight were also found for total PCDD TEQ, total PCDF TEQ, and total non- ortho PCB TEQ levels among male, but not female, infants. Significant inverse associations with birth weight were also found for nine congeners among all infants; the adjusted beta coefficients were largest for 1,2,3,6,7,8-HxCDD and smallest for 2,3,4,7,8-PeCDF. Conclusion In the setting of exposure to high levels of dioxins, maternal blood levels of PCDDs, PCDFs and PCBs are associated with lower birth weight in Yusho patients. The association exhibited gender-specific differences, as male infants are more susceptible than females to growth restriction induced by in utero dioxin exposures.
Fumiko Yasukawa - One of the best experts on this subject based on the ideXlab platform.
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blood levels of pcdds pcdfs and coplanar pcbs in Yusho mothers and their descendants association with fetal Yusho Disease
Chemosphere, 2013Co-Authors: Kiyomi Tsukimori, Hiroshi Uchi, Shoji Tokunaga, Fumiko Yasukawa, Takahito Chiba, Junboku Kajiwara, Teruaki Hirata, Masutaka FurueAbstract:Abstract Maternal exposure to polychlorinated dibenzo- p -dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and polychlorinated biphenyls (PCBs) may result in adverse health effects in their children. In Japan in 1968, an accidental human exposure to rice oil contaminated with PCDDs, PCDFs, and PCBs, led to the development of Yusho Disease. Yusho mothers delivered descendants with low birth weights and hyperpigmented skin and mucosa, which are characteristic of fetal Yusho Disease (FYD). The Yusho cohort was used to evaluate the effect of maternal exposure to PCDDs, PCDFs, and PCBs on the development of FYD. Blood samples, obtained from 64 Yusho mothers (117 descendants: 10 with FYD and 107 without FYD), were analyzed for congeners of seven PCDDs, 10 PCDFs, and four coplanar PCBs. We investigated the association between the maternal estimated blood levels of dioxins at delivery and the risk of fetal Yusho Disease. We also studied the differences in dioxin blood levels in 24 mother–descendant pairs (5 with FYD and 19 without FYD). The estimated levels of total PCDD TEQ, total PCDF TEQ, total coplanar PCB TEQ, and total TEQ in the maternal blood at delivery were associated with significantly increased risk of FYD. The odds ratios, which present the risk of FYD for a 10-fold increase in blood dioxin, were largest for 1,2,3,6,7,8-HexaCDD (odds ratio = 28.6, 95% confidence interval = 1.67–489.9, p = 0.02). The levels of 1,2,3,6,7,8-HexaCDD in both the Yusho mothers and their descendants with FYD were higher than the levels in those without FYD. These findings suggest that 1,2,3,6,7,8-HexaCDD is the most important causative congener for the development of FYD.
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infundibular cyst with seborrheic verruca like cyst walls in a patient with Yusho Disease exposed to dioxins
European Journal of Dermatology, 2012Co-Authors: Hiroshi Uchi, Fumiko Yasukawa, Hiromaro Kiryu, Ken Hashimoto, Masutaka FurueAbstract:ejd.2012.1805 Auteur(s) : Hiroshi Uchi1 uchihir@dermatol.med.kyushu-u.ac.jp, Fumiko Yasukawa1, Hiromaro Kiryu2, Ken Hashimoto3, Masutaka Furue1 1 Department of Dermatology, Kyushu University, 3-1-1, Maidashi Higashi-ku, Fukuoka 812-8582, Japan 2 Fukuoka Institute for Dermatopathology, Fukuoka, Japan, 3 Department of Dermatology, Wayne State School of Medicine, Dearborn MI 48124, USA Infundibular cysts with seborrheic verruca-like cyst walls, originally reported as epidermoid cysts with seborrheic verruca-like [...]
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maternal exposure to high levels of dioxins in relation to birth weight in women affected by Yusho Disease
Environment International, 2012Co-Authors: Kiyomi Tsukimori, Hiroshi Uchi, Fumiko Yasukawa, Takahito Chiba, Junboku Kajiwara, Teruaki Hirata, Chikage Mitoma, Takashi Todaka, Takesumi Yoshimura, Kotaro FukushimaAbstract:Abstract Background Studies on the association of maternal exposure to polychlorinated dibenzo- p -dioxin (PCDDs), polychlorinated dibenzofurans (PCDFs), and polychlorinated biphenyls (PCBs) with decreased birth weight in humans have produced conflicting results. In Japan in 1968, an accidental human exposure to rice oil contaminated with PCDDs, PCDFs, and PCBs, led to the development of Yusho Disease. Objective The Yusho cohort was used to evaluate the effect of maternal exposure to PCDDs, PCDFs, and PCBs on birth weight. Methods Blood samples, obtained from 101 Yusho women (190 births) who gave birth after exposure, were analyzed for congeners of seven PCDDs, ten PCDFs, and four non- ortho PCBs. Results Total PCDD TEQ (adjusted beta = − 161.9 g; 95% CI, −265.3 to − 58.6), total PCDF TEQ (adjusted beta = − 105.9 g; 95% CI, −179.5 to − 32.2), and total non- ortho PCBs (adjusted beta = − 178.4 g; 95% CI, −318.3 to − 38.5) levels were inversely associated with birth weight. Significant inverse associations with birth weight were also found for total PCDD TEQ, total PCDF TEQ, and total non- ortho PCB TEQ levels among male, but not female, infants. Significant inverse associations with birth weight were also found for nine congeners among all infants; the adjusted beta coefficients were largest for 1,2,3,6,7,8-HxCDD and smallest for 2,3,4,7,8-PeCDF. Conclusion In the setting of exposure to high levels of dioxins, maternal blood levels of PCDDs, PCDFs and PCBs are associated with lower birth weight in Yusho patients. The association exhibited gender-specific differences, as male infants are more susceptible than females to growth restriction induced by in utero dioxin exposures.
