The Experts below are selected from a list of 48 Experts worldwide ranked by ideXlab platform
Richard L. Goldberg - One of the best experts on this subject based on the ideXlab platform.
-
Effects of tryptophan and serotonin uptake inhibitors on behavior in male transgenic transforming growth factor α mice
European Journal of Pharmacology, 1993Co-Authors: Leena Hilakivi-clarke, Richard L. GoldbergAbstract:Abstract Our findings have implicated that transgenic male mice overexpressing human growth factor α (TGF α exhibit lengthened immobility in the swim test and elevated levels of aggression in the resident-intruder test. Further, these animals have a reduced ratio between the metabolite of serotonin (5-HT), and 5-HT in the brain. The present study investigated whether pharmacological manipulations of serotonergic transmission affect the altered behavioral patterns of the male TGF α mice. For that purpose, we used tryptophan (0, 50 or 100 mg/kg), a precursor substance to 5-HT, and 5-HT uptake inhibitors, Zimelidine (0, 12.5 or 25 mg/kg) and clomipramine (0, 10 or 20 mg/kg). Administration of tryptophan or Zimelidine significantly shortened immobility in the swim test in the TGF α male mice. Tryptophan or clomipramine did not influence the male non-transgenic CD-1 mice, and Zimelidine significantly lengthened their immobility. High levels of aggression were completely reversed by Zimelidine or clomipramine in the transgenic male mice. Neither of these compounds altered behavior of the control mice in the resident-intruder test. Tryptophan failed to affect aggressive behavior in the TGF α or control male mice. These results suggest that TGF α may influence behavior by affecting the uptake of 5-HT in neurons.
J. Vlainić - One of the best experts on this subject based on the ideXlab platform.
-
Zimelidine decreases seizure susceptibility in stressed mice
Journal of Neural Transmission, 2006Co-Authors: D. Peričić, D. Š. Štrac, J. VlainićAbstract:To further evaluate whether selective serotonin reuptake inhibitors (SSRIs) have pro- or anticonvulsant properties and whether these properties will be modified by stress, we studied the effect of Zimelidine on the convulsions produced by picrotoxin, a GABA_A receptor antagonist, in unstressed and swim stressed mice. Zimelidine potentiated the ability of swim stress to enhance the threshold doses of intravenously administered picrotoxin producing convulsant signs and death, without having an effect in unstressed mice. The anticonvulsant effect of Zimelidine was counteracted with mianserin, the antagonist of 5-HT_2A/2C, and diminished with WAY-100635, a selective antagonist of 5-HT_1A receptors. In stressed mice, WAY-100635 prevented the anticonvulsant effect of 8-OH-DPAT, a 5-HT_1A receptor agonist. SB-269970 and ketanserin, the antagonists of 5-HT_7 and 5-HT_2A receptors, respectively, failed to reduce the effect of Zimelidine. The results suggest the involvement of 5-HT_2C and 5-HT_1A receptors in the anticonvulsant effects of Zimelidine and possibly other SSRIs in stress.
Leena Hilakivi-clarke - One of the best experts on this subject based on the ideXlab platform.
-
Effects of tryptophan and serotonin uptake inhibitors on behavior in male transgenic transforming growth factor α mice
European Journal of Pharmacology, 1993Co-Authors: Leena Hilakivi-clarke, Richard L. GoldbergAbstract:Abstract Our findings have implicated that transgenic male mice overexpressing human growth factor α (TGF α exhibit lengthened immobility in the swim test and elevated levels of aggression in the resident-intruder test. Further, these animals have a reduced ratio between the metabolite of serotonin (5-HT), and 5-HT in the brain. The present study investigated whether pharmacological manipulations of serotonergic transmission affect the altered behavioral patterns of the male TGF α mice. For that purpose, we used tryptophan (0, 50 or 100 mg/kg), a precursor substance to 5-HT, and 5-HT uptake inhibitors, Zimelidine (0, 12.5 or 25 mg/kg) and clomipramine (0, 10 or 20 mg/kg). Administration of tryptophan or Zimelidine significantly shortened immobility in the swim test in the TGF α male mice. Tryptophan or clomipramine did not influence the male non-transgenic CD-1 mice, and Zimelidine significantly lengthened their immobility. High levels of aggression were completely reversed by Zimelidine or clomipramine in the transgenic male mice. Neither of these compounds altered behavior of the control mice in the resident-intruder test. Tryptophan failed to affect aggressive behavior in the TGF α or control male mice. These results suggest that TGF α may influence behavior by affecting the uptake of 5-HT in neurons.
D. Peričić - One of the best experts on this subject based on the ideXlab platform.
-
Zimelidine decreases seizure susceptibility in stressed mice
Journal of Neural Transmission, 2006Co-Authors: D. Peričić, D. Š. Štrac, J. VlainićAbstract:To further evaluate whether selective serotonin reuptake inhibitors (SSRIs) have pro- or anticonvulsant properties and whether these properties will be modified by stress, we studied the effect of Zimelidine on the convulsions produced by picrotoxin, a GABA_A receptor antagonist, in unstressed and swim stressed mice. Zimelidine potentiated the ability of swim stress to enhance the threshold doses of intravenously administered picrotoxin producing convulsant signs and death, without having an effect in unstressed mice. The anticonvulsant effect of Zimelidine was counteracted with mianserin, the antagonist of 5-HT_2A/2C, and diminished with WAY-100635, a selective antagonist of 5-HT_1A receptors. In stressed mice, WAY-100635 prevented the anticonvulsant effect of 8-OH-DPAT, a 5-HT_1A receptor agonist. SB-269970 and ketanserin, the antagonists of 5-HT_7 and 5-HT_2A receptors, respectively, failed to reduce the effect of Zimelidine. The results suggest the involvement of 5-HT_2C and 5-HT_1A receptors in the anticonvulsant effects of Zimelidine and possibly other SSRIs in stress.
Reidun Ursin - One of the best experts on this subject based on the ideXlab platform.
-
The 5-HT1A antagonist (-)-alprenolol fails to modify sleep or zimeldine-induced sleep-waking effects in rats.
Pharmacology biochemistry and behavior, 1992Co-Authors: Bjørn Bjorvatn, Dag Neckelmann, Reidun UrsinAbstract:Sleep and waking in rats were studied for 8 h following administration of a selective 5-hydroxytryptamine (5-HT) reuptake inhibitor (zimeldine), a putative 5-HT1A antagonist {L(−)-alprenolol hydrogene tartrate monohydrate [(−)-alprenolol]} and a combination of (−)-alprenolol and zimeldine. Consistent with earlier findings, zimeldine gave a biphasic effect on sleep and waking. Waking was increased during the first 3 h, followed by a small decrease. Deep slow-wave sleep (SWS-2) showed the opposite trend. An initial decrease in SWS-2 was followed by an increase after around 3 h. Rapid eye movement sleep was markedly suppressed and latencies to sleep increased after zimeldine. (−)-Alprenolol had no effects on the different sleep and waking stages or latencies to sleep. The 5-HT1A antagonist also failed to modify the effects of zimeldine administration. The behavioral syndrome induced by a selective 5-HT1A agonist [8-hydroxy-2-(di-n-propyl-amino)-tetralin (8-OH-DPAT)] was clearly antagonized by administration of (−)-alprenolol, indicating that (−)-alprenolol was an efficient 5-HT1A blocker. The data indicate that the sleep-waking effects of zimeldine cannot easily be explained by stimulation of 5-HT1A receptors.
