Zirconium Zr

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Nadim J Hallab - One of the best experts on this subject based on the ideXlab platform.

  • orthopedic implant cobalt alloy particles produce greater toxicity and inflammatory cytokines than titanium alloy and Zirconium alloy based particles in vitro in human osteoblasts fibroblasts and macrophages
    Journal of Biomedical Materials Research Part A, 2012
    Co-Authors: Ali Dalal, Vivek Pawar, Kyron Mcallister, Carolyn Weaver, Nadim J Hallab
    Abstract:

    The performance of total joint arthroplasty (TJA) depends on the size/shape, material, and amounts of implant debris. Much remains unknown in terms of which types of debris are most reactive. We compared the responses of human periimplant cells, osteoblasts, fibroblasts, and macrophages, exposed to particles of different metal-based particles (i.e., cobalt-chromium-molybdenum (CoCrMo) alloy, titanium (Ti) alloy, Zirconium (Zr) oxide, and Zr alloy. CoCrMo-alloy particles were by far the most toxic (p 50% at a dose of only 50 particles per cell. All particle types induced the production of interleukin (IL)-6, tumor necrosis factor (TNF)-α, and IL-8 by osteoblasts, fibroblasts, and monocytes/macrophages. However, the greatest cytokine responses of macrophages were to CoCrMo alloy (TNF-α and IL-8) and Ti alloy (IL-1β). Likewise, the greatest responses of fibroblasts and osteoblasts were to CoCrMo alloy (IL-6 and TNF-α) (i.e., IL-6 300 pg/mL; 30-fold max, TNF-α 150 pg/mL; 15-fold max) versus controls. For macrophages, CoCrMo particles induced IL-8 (> 2000 pg/mL; approx 100-fold max) above controls and were also significantly elevated above levels produced by Zr-based particles. Submicron sized (0.2-0.9 μm) Zr-based particles (originally presumed to be more reactive) induced less toxicity and inflammatory responses when compared with larger (approx 1 μm) CoCrMo-alloy and Ti-alloy particles.

  • orthopedic implant cobalt alloy particles produce greater toxicity and inflammatory cytokines than titanium alloy and Zirconium alloy based particles in vitro in human osteoblasts fibroblasts and macrophages
    Journal of Biomedical Materials Research Part A, 2012
    Co-Authors: Ali Dalal, Vivek Pawar, Kyron Mcallister, Carolyn Weaver, Nadim J Hallab
    Abstract:

    The performance of total joint arthroplasty (TJA) depends on the size/shape, material, and amounts of implant debris. Much remains unknown in terms of which types of debris are most reactive. We compared the responses of human periimplant cells, osteoblasts, fibroblasts, and macrophages, exposed to particles of different metal-based particles (i.e., cobalt-chromium-molybdenum (CoCrMo) alloy, titanium (Ti) alloy, Zirconium (Zr) oxide, and Zr alloy. CoCrMo-alloy particles were by far the most toxic (p 50% at a dose of only 50 particles per cell. All particle types induced the production of interleukin (IL)-6, tumor necrosis factor (TNF)-α, and IL-8 by osteoblasts, fibroblasts, and monocytes/macrophages. However, the greatest cytokine responses of macrophages were to CoCrMo alloy (TNF-α and IL-8) and Ti alloy (IL-1β). Likewise, the greatest responses of fibroblasts and osteoblasts were to CoCrMo alloy (IL-6 and TNF-α) (i.e., IL-6 300 pg/mL; 30-fold max, TNF-α 150 pg/mL; 15-fold max) versus controls. For macrophages, CoCrMo particles induced IL-8 (> 2000 pg/mL; approx 100-fold max) above controls and were also significantly elevated above levels produced by Zr-based particles. Submicron sized (0.2-0.9 μm) Zr-based particles (originally presumed to be more reactive) induced less toxicity and inflammatory responses when compared with larger (approx 1 μm) CoCrMo-alloy and Ti-alloy particles. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2012.

Ali Dalal - One of the best experts on this subject based on the ideXlab platform.

  • orthopedic implant cobalt alloy particles produce greater toxicity and inflammatory cytokines than titanium alloy and Zirconium alloy based particles in vitro in human osteoblasts fibroblasts and macrophages
    Journal of Biomedical Materials Research Part A, 2012
    Co-Authors: Ali Dalal, Vivek Pawar, Kyron Mcallister, Carolyn Weaver, Nadim J Hallab
    Abstract:

    The performance of total joint arthroplasty (TJA) depends on the size/shape, material, and amounts of implant debris. Much remains unknown in terms of which types of debris are most reactive. We compared the responses of human periimplant cells, osteoblasts, fibroblasts, and macrophages, exposed to particles of different metal-based particles (i.e., cobalt-chromium-molybdenum (CoCrMo) alloy, titanium (Ti) alloy, Zirconium (Zr) oxide, and Zr alloy. CoCrMo-alloy particles were by far the most toxic (p 50% at a dose of only 50 particles per cell. All particle types induced the production of interleukin (IL)-6, tumor necrosis factor (TNF)-α, and IL-8 by osteoblasts, fibroblasts, and monocytes/macrophages. However, the greatest cytokine responses of macrophages were to CoCrMo alloy (TNF-α and IL-8) and Ti alloy (IL-1β). Likewise, the greatest responses of fibroblasts and osteoblasts were to CoCrMo alloy (IL-6 and TNF-α) (i.e., IL-6 300 pg/mL; 30-fold max, TNF-α 150 pg/mL; 15-fold max) versus controls. For macrophages, CoCrMo particles induced IL-8 (> 2000 pg/mL; approx 100-fold max) above controls and were also significantly elevated above levels produced by Zr-based particles. Submicron sized (0.2-0.9 μm) Zr-based particles (originally presumed to be more reactive) induced less toxicity and inflammatory responses when compared with larger (approx 1 μm) CoCrMo-alloy and Ti-alloy particles.

  • orthopedic implant cobalt alloy particles produce greater toxicity and inflammatory cytokines than titanium alloy and Zirconium alloy based particles in vitro in human osteoblasts fibroblasts and macrophages
    Journal of Biomedical Materials Research Part A, 2012
    Co-Authors: Ali Dalal, Vivek Pawar, Kyron Mcallister, Carolyn Weaver, Nadim J Hallab
    Abstract:

    The performance of total joint arthroplasty (TJA) depends on the size/shape, material, and amounts of implant debris. Much remains unknown in terms of which types of debris are most reactive. We compared the responses of human periimplant cells, osteoblasts, fibroblasts, and macrophages, exposed to particles of different metal-based particles (i.e., cobalt-chromium-molybdenum (CoCrMo) alloy, titanium (Ti) alloy, Zirconium (Zr) oxide, and Zr alloy. CoCrMo-alloy particles were by far the most toxic (p 50% at a dose of only 50 particles per cell. All particle types induced the production of interleukin (IL)-6, tumor necrosis factor (TNF)-α, and IL-8 by osteoblasts, fibroblasts, and monocytes/macrophages. However, the greatest cytokine responses of macrophages were to CoCrMo alloy (TNF-α and IL-8) and Ti alloy (IL-1β). Likewise, the greatest responses of fibroblasts and osteoblasts were to CoCrMo alloy (IL-6 and TNF-α) (i.e., IL-6 300 pg/mL; 30-fold max, TNF-α 150 pg/mL; 15-fold max) versus controls. For macrophages, CoCrMo particles induced IL-8 (> 2000 pg/mL; approx 100-fold max) above controls and were also significantly elevated above levels produced by Zr-based particles. Submicron sized (0.2-0.9 μm) Zr-based particles (originally presumed to be more reactive) induced less toxicity and inflammatory responses when compared with larger (approx 1 μm) CoCrMo-alloy and Ti-alloy particles. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2012.

Vivek Pawar - One of the best experts on this subject based on the ideXlab platform.

  • orthopedic implant cobalt alloy particles produce greater toxicity and inflammatory cytokines than titanium alloy and Zirconium alloy based particles in vitro in human osteoblasts fibroblasts and macrophages
    Journal of Biomedical Materials Research Part A, 2012
    Co-Authors: Ali Dalal, Vivek Pawar, Kyron Mcallister, Carolyn Weaver, Nadim J Hallab
    Abstract:

    The performance of total joint arthroplasty (TJA) depends on the size/shape, material, and amounts of implant debris. Much remains unknown in terms of which types of debris are most reactive. We compared the responses of human periimplant cells, osteoblasts, fibroblasts, and macrophages, exposed to particles of different metal-based particles (i.e., cobalt-chromium-molybdenum (CoCrMo) alloy, titanium (Ti) alloy, Zirconium (Zr) oxide, and Zr alloy. CoCrMo-alloy particles were by far the most toxic (p 50% at a dose of only 50 particles per cell. All particle types induced the production of interleukin (IL)-6, tumor necrosis factor (TNF)-α, and IL-8 by osteoblasts, fibroblasts, and monocytes/macrophages. However, the greatest cytokine responses of macrophages were to CoCrMo alloy (TNF-α and IL-8) and Ti alloy (IL-1β). Likewise, the greatest responses of fibroblasts and osteoblasts were to CoCrMo alloy (IL-6 and TNF-α) (i.e., IL-6 300 pg/mL; 30-fold max, TNF-α 150 pg/mL; 15-fold max) versus controls. For macrophages, CoCrMo particles induced IL-8 (> 2000 pg/mL; approx 100-fold max) above controls and were also significantly elevated above levels produced by Zr-based particles. Submicron sized (0.2-0.9 μm) Zr-based particles (originally presumed to be more reactive) induced less toxicity and inflammatory responses when compared with larger (approx 1 μm) CoCrMo-alloy and Ti-alloy particles.

  • orthopedic implant cobalt alloy particles produce greater toxicity and inflammatory cytokines than titanium alloy and Zirconium alloy based particles in vitro in human osteoblasts fibroblasts and macrophages
    Journal of Biomedical Materials Research Part A, 2012
    Co-Authors: Ali Dalal, Vivek Pawar, Kyron Mcallister, Carolyn Weaver, Nadim J Hallab
    Abstract:

    The performance of total joint arthroplasty (TJA) depends on the size/shape, material, and amounts of implant debris. Much remains unknown in terms of which types of debris are most reactive. We compared the responses of human periimplant cells, osteoblasts, fibroblasts, and macrophages, exposed to particles of different metal-based particles (i.e., cobalt-chromium-molybdenum (CoCrMo) alloy, titanium (Ti) alloy, Zirconium (Zr) oxide, and Zr alloy. CoCrMo-alloy particles were by far the most toxic (p 50% at a dose of only 50 particles per cell. All particle types induced the production of interleukin (IL)-6, tumor necrosis factor (TNF)-α, and IL-8 by osteoblasts, fibroblasts, and monocytes/macrophages. However, the greatest cytokine responses of macrophages were to CoCrMo alloy (TNF-α and IL-8) and Ti alloy (IL-1β). Likewise, the greatest responses of fibroblasts and osteoblasts were to CoCrMo alloy (IL-6 and TNF-α) (i.e., IL-6 300 pg/mL; 30-fold max, TNF-α 150 pg/mL; 15-fold max) versus controls. For macrophages, CoCrMo particles induced IL-8 (> 2000 pg/mL; approx 100-fold max) above controls and were also significantly elevated above levels produced by Zr-based particles. Submicron sized (0.2-0.9 μm) Zr-based particles (originally presumed to be more reactive) induced less toxicity and inflammatory responses when compared with larger (approx 1 μm) CoCrMo-alloy and Ti-alloy particles. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2012.

Kyron Mcallister - One of the best experts on this subject based on the ideXlab platform.

  • orthopedic implant cobalt alloy particles produce greater toxicity and inflammatory cytokines than titanium alloy and Zirconium alloy based particles in vitro in human osteoblasts fibroblasts and macrophages
    Journal of Biomedical Materials Research Part A, 2012
    Co-Authors: Ali Dalal, Vivek Pawar, Kyron Mcallister, Carolyn Weaver, Nadim J Hallab
    Abstract:

    The performance of total joint arthroplasty (TJA) depends on the size/shape, material, and amounts of implant debris. Much remains unknown in terms of which types of debris are most reactive. We compared the responses of human periimplant cells, osteoblasts, fibroblasts, and macrophages, exposed to particles of different metal-based particles (i.e., cobalt-chromium-molybdenum (CoCrMo) alloy, titanium (Ti) alloy, Zirconium (Zr) oxide, and Zr alloy. CoCrMo-alloy particles were by far the most toxic (p 50% at a dose of only 50 particles per cell. All particle types induced the production of interleukin (IL)-6, tumor necrosis factor (TNF)-α, and IL-8 by osteoblasts, fibroblasts, and monocytes/macrophages. However, the greatest cytokine responses of macrophages were to CoCrMo alloy (TNF-α and IL-8) and Ti alloy (IL-1β). Likewise, the greatest responses of fibroblasts and osteoblasts were to CoCrMo alloy (IL-6 and TNF-α) (i.e., IL-6 300 pg/mL; 30-fold max, TNF-α 150 pg/mL; 15-fold max) versus controls. For macrophages, CoCrMo particles induced IL-8 (> 2000 pg/mL; approx 100-fold max) above controls and were also significantly elevated above levels produced by Zr-based particles. Submicron sized (0.2-0.9 μm) Zr-based particles (originally presumed to be more reactive) induced less toxicity and inflammatory responses when compared with larger (approx 1 μm) CoCrMo-alloy and Ti-alloy particles.

  • orthopedic implant cobalt alloy particles produce greater toxicity and inflammatory cytokines than titanium alloy and Zirconium alloy based particles in vitro in human osteoblasts fibroblasts and macrophages
    Journal of Biomedical Materials Research Part A, 2012
    Co-Authors: Ali Dalal, Vivek Pawar, Kyron Mcallister, Carolyn Weaver, Nadim J Hallab
    Abstract:

    The performance of total joint arthroplasty (TJA) depends on the size/shape, material, and amounts of implant debris. Much remains unknown in terms of which types of debris are most reactive. We compared the responses of human periimplant cells, osteoblasts, fibroblasts, and macrophages, exposed to particles of different metal-based particles (i.e., cobalt-chromium-molybdenum (CoCrMo) alloy, titanium (Ti) alloy, Zirconium (Zr) oxide, and Zr alloy. CoCrMo-alloy particles were by far the most toxic (p 50% at a dose of only 50 particles per cell. All particle types induced the production of interleukin (IL)-6, tumor necrosis factor (TNF)-α, and IL-8 by osteoblasts, fibroblasts, and monocytes/macrophages. However, the greatest cytokine responses of macrophages were to CoCrMo alloy (TNF-α and IL-8) and Ti alloy (IL-1β). Likewise, the greatest responses of fibroblasts and osteoblasts were to CoCrMo alloy (IL-6 and TNF-α) (i.e., IL-6 300 pg/mL; 30-fold max, TNF-α 150 pg/mL; 15-fold max) versus controls. For macrophages, CoCrMo particles induced IL-8 (> 2000 pg/mL; approx 100-fold max) above controls and were also significantly elevated above levels produced by Zr-based particles. Submicron sized (0.2-0.9 μm) Zr-based particles (originally presumed to be more reactive) induced less toxicity and inflammatory responses when compared with larger (approx 1 μm) CoCrMo-alloy and Ti-alloy particles. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2012.

Carolyn Weaver - One of the best experts on this subject based on the ideXlab platform.

  • orthopedic implant cobalt alloy particles produce greater toxicity and inflammatory cytokines than titanium alloy and Zirconium alloy based particles in vitro in human osteoblasts fibroblasts and macrophages
    Journal of Biomedical Materials Research Part A, 2012
    Co-Authors: Ali Dalal, Vivek Pawar, Kyron Mcallister, Carolyn Weaver, Nadim J Hallab
    Abstract:

    The performance of total joint arthroplasty (TJA) depends on the size/shape, material, and amounts of implant debris. Much remains unknown in terms of which types of debris are most reactive. We compared the responses of human periimplant cells, osteoblasts, fibroblasts, and macrophages, exposed to particles of different metal-based particles (i.e., cobalt-chromium-molybdenum (CoCrMo) alloy, titanium (Ti) alloy, Zirconium (Zr) oxide, and Zr alloy. CoCrMo-alloy particles were by far the most toxic (p 50% at a dose of only 50 particles per cell. All particle types induced the production of interleukin (IL)-6, tumor necrosis factor (TNF)-α, and IL-8 by osteoblasts, fibroblasts, and monocytes/macrophages. However, the greatest cytokine responses of macrophages were to CoCrMo alloy (TNF-α and IL-8) and Ti alloy (IL-1β). Likewise, the greatest responses of fibroblasts and osteoblasts were to CoCrMo alloy (IL-6 and TNF-α) (i.e., IL-6 300 pg/mL; 30-fold max, TNF-α 150 pg/mL; 15-fold max) versus controls. For macrophages, CoCrMo particles induced IL-8 (> 2000 pg/mL; approx 100-fold max) above controls and were also significantly elevated above levels produced by Zr-based particles. Submicron sized (0.2-0.9 μm) Zr-based particles (originally presumed to be more reactive) induced less toxicity and inflammatory responses when compared with larger (approx 1 μm) CoCrMo-alloy and Ti-alloy particles.

  • orthopedic implant cobalt alloy particles produce greater toxicity and inflammatory cytokines than titanium alloy and Zirconium alloy based particles in vitro in human osteoblasts fibroblasts and macrophages
    Journal of Biomedical Materials Research Part A, 2012
    Co-Authors: Ali Dalal, Vivek Pawar, Kyron Mcallister, Carolyn Weaver, Nadim J Hallab
    Abstract:

    The performance of total joint arthroplasty (TJA) depends on the size/shape, material, and amounts of implant debris. Much remains unknown in terms of which types of debris are most reactive. We compared the responses of human periimplant cells, osteoblasts, fibroblasts, and macrophages, exposed to particles of different metal-based particles (i.e., cobalt-chromium-molybdenum (CoCrMo) alloy, titanium (Ti) alloy, Zirconium (Zr) oxide, and Zr alloy. CoCrMo-alloy particles were by far the most toxic (p 50% at a dose of only 50 particles per cell. All particle types induced the production of interleukin (IL)-6, tumor necrosis factor (TNF)-α, and IL-8 by osteoblasts, fibroblasts, and monocytes/macrophages. However, the greatest cytokine responses of macrophages were to CoCrMo alloy (TNF-α and IL-8) and Ti alloy (IL-1β). Likewise, the greatest responses of fibroblasts and osteoblasts were to CoCrMo alloy (IL-6 and TNF-α) (i.e., IL-6 300 pg/mL; 30-fold max, TNF-α 150 pg/mL; 15-fold max) versus controls. For macrophages, CoCrMo particles induced IL-8 (> 2000 pg/mL; approx 100-fold max) above controls and were also significantly elevated above levels produced by Zr-based particles. Submicron sized (0.2-0.9 μm) Zr-based particles (originally presumed to be more reactive) induced less toxicity and inflammatory responses when compared with larger (approx 1 μm) CoCrMo-alloy and Ti-alloy particles. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2012.