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C Kelley Vincent - One of the best experts on this subject based on the ideXlab platform.
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Studies of 17-Hydroxycorticosteroids in children. II. Response of blood levels to the injection of certain hormones.
The Journal of Pediatrics, 2006Co-Authors: Richard B. Raile, S Ely Robert, C Kelley VincentAbstract:Summary 1. The response of 17-Hydroxycorticosteroid plasma levels to the administration of ACTH, cortisone, and epinephrine is reported both in well and in sick children. 2. The injection of ACTH causes a prompt but transient elevation of 17-Hydroxycorticosteroid levels. Cortisone administered orally likewise causes a prompt and transient elevation of these levels but cortisone administered intramuscularly in a single dose results in a somewhat variable response. 3. The injection of epinephrine results in no consistent pattern of response of 17-Hydroxycorticosteroid plasma levels. On the basis of these data the validity of the previously postulated mechanism of action of epinephrine is questioned. 4. The preliminary data concerning responses of 17-Hydroxycorticosteroid plasma levels to these three stimulating agents do not show major differences in the groups of children reported here.
Ph. D - One of the best experts on this subject based on the ideXlab platform.
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Intercorrelations Between Affect, Urinary 17-Hydroxycorticosteroid Levels, and Epileptic Convulsions
2014Co-Authors: Jack Raher, Frank M. Ganis, Ph. D, John W. ShafferAbstract:In a longitudinal study of an epileptic, serial measurements were made of affect and urinary 17-Hydroxycorticosteroid (17-OHCS) levels. During an 8-month period of hospitalization, a rising trend in 17-OHCS level was noted on the day prior to seizure activity and a significantly positive rise on the day of seizure activity. These observations were seen as supporting evidence for the hypothesis that elevated 17-OHCS levels may be associated with a lowered seizure threshold. Depression showed a positive linear correlation with both seizure activity and 17-OHCS levels. o BSERVATIONS from experimental ani-mal investigations1 and from clinical studies- support the idea that the ad-renocortical hormones effect cerebral ex-citability and thus play a role in the occurrence of epileptic convulsions. The specific hormonal substances most strong-ly implicated in affecting the threshold of excitability are 17-hydroxycortico
Richard B. Raile - One of the best experts on this subject based on the ideXlab platform.
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Studies of 17-Hydroxycorticosteroids in children. II. Response of blood levels to the injection of certain hormones.
The Journal of Pediatrics, 2006Co-Authors: Richard B. Raile, S Ely Robert, C Kelley VincentAbstract:Summary 1. The response of 17-Hydroxycorticosteroid plasma levels to the administration of ACTH, cortisone, and epinephrine is reported both in well and in sick children. 2. The injection of ACTH causes a prompt but transient elevation of 17-Hydroxycorticosteroid levels. Cortisone administered orally likewise causes a prompt and transient elevation of these levels but cortisone administered intramuscularly in a single dose results in a somewhat variable response. 3. The injection of epinephrine results in no consistent pattern of response of 17-Hydroxycorticosteroid plasma levels. On the basis of these data the validity of the previously postulated mechanism of action of epinephrine is questioned. 4. The preliminary data concerning responses of 17-Hydroxycorticosteroid plasma levels to these three stimulating agents do not show major differences in the groups of children reported here.
C. F. A. Van Bezooijen - One of the best experts on this subject based on the ideXlab platform.
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cortisol production rate and the urinary excretion of 17 Hydroxycorticosteroids free cortisol and 6β hydroxycortisol in healthy elderly men and women
The Journals of Gerontology, 1993Co-Authors: R N Barton, A N Sakkee, M.a. Horan, N A Roberts, Johan W H Weijers, C. F. A. Van BezooijenAbstract:BACKGROUND: Although many workers have tested adrenal function in the elderly, few have studied the effect of aging on cortisol production rate or urinary free cortisol or 6 beta-hydroxycortisol excretion, and none have published comparisons of these variables between old people of defined health status and young people. METHODS: We have measured cortisol production rate and the urinary excretion of free cortisol, 6 beta-hydroxycortisol, 17-Hydroxycorticosteroids (Porter-Silber chromogens) and creatinine in elderly men and women screened by the SENIEUR protocol and in young men; 17-Hydroxycorticosteroid and 6 beta-hydroxycortisol excretion were also measured in young women. The period of measurement was 24 h or, usually, 48 h. RESULTS: Only 6 beta-hydroxycortisol excretion was affected by aging; it was lower in the elderly men and women than in their younger counterparts. Urinary free cortisol excretion was lower in the elderly women than in the elderly men. There were no significant differences between groups in cortisol production rate or 17-Hydroxycorticosteroid excretion. Excretion and (over the first 24 h) clearance of creatinine were lower in the old women than in the old men. The cortisol-related variables tended to be positively correlated with each other and with the relevant creatinine-related variables in the elderly subjects; over the first but not the second 24 h, most of the correlations were significant in the men and women combined. CONCLUSIONS: With the exception of 6 beta-hydroxycortisol, the data agree with measurements of plasma cortisol and the results of adrenal function tests in showing little change in hypothalamic-pituitary-adrenal function with aging in healthy people.
S Ely Robert - One of the best experts on this subject based on the ideXlab platform.
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Studies of 17-Hydroxycorticosteroids in children. II. Response of blood levels to the injection of certain hormones.
The Journal of Pediatrics, 2006Co-Authors: Richard B. Raile, S Ely Robert, C Kelley VincentAbstract:Summary 1. The response of 17-Hydroxycorticosteroid plasma levels to the administration of ACTH, cortisone, and epinephrine is reported both in well and in sick children. 2. The injection of ACTH causes a prompt but transient elevation of 17-Hydroxycorticosteroid levels. Cortisone administered orally likewise causes a prompt and transient elevation of these levels but cortisone administered intramuscularly in a single dose results in a somewhat variable response. 3. The injection of epinephrine results in no consistent pattern of response of 17-Hydroxycorticosteroid plasma levels. On the basis of these data the validity of the previously postulated mechanism of action of epinephrine is questioned. 4. The preliminary data concerning responses of 17-Hydroxycorticosteroid plasma levels to these three stimulating agents do not show major differences in the groups of children reported here.