17 Hydroxycorticosteroid

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C Kelley Vincent - One of the best experts on this subject based on the ideXlab platform.

Ph. D - One of the best experts on this subject based on the ideXlab platform.

  • Intercorrelations Between Affect, Urinary 17-Hydroxycorticosteroid Levels, and Epileptic Convulsions
    2014
    Co-Authors: Jack Raher, Frank M. Ganis, Ph. D, John W. Shaffer
    Abstract:

    In a longitudinal study of an epileptic, serial measurements were made of affect and urinary 17-Hydroxycorticosteroid (17-OHCS) levels. During an 8-month period of hospitalization, a rising trend in 17-OHCS level was noted on the day prior to seizure activity and a significantly positive rise on the day of seizure activity. These observations were seen as supporting evidence for the hypothesis that elevated 17-OHCS levels may be associated with a lowered seizure threshold. Depression showed a positive linear correlation with both seizure activity and 17-OHCS levels. o BSERVATIONS from experimental ani-mal investigations1 and from clinical studies- support the idea that the ad-renocortical hormones effect cerebral ex-citability and thus play a role in the occurrence of epileptic convulsions. The specific hormonal substances most strong-ly implicated in affecting the threshold of excitability are 17-hydroxycortico

Richard B. Raile - One of the best experts on this subject based on the ideXlab platform.

C. F. A. Van Bezooijen - One of the best experts on this subject based on the ideXlab platform.

  • cortisol production rate and the urinary excretion of 17 Hydroxycorticosteroids free cortisol and 6β hydroxycortisol in healthy elderly men and women
    The Journals of Gerontology, 1993
    Co-Authors: R N Barton, A N Sakkee, M.a. Horan, N A Roberts, Johan W H Weijers, C. F. A. Van Bezooijen
    Abstract:

    BACKGROUND: Although many workers have tested adrenal function in the elderly, few have studied the effect of aging on cortisol production rate or urinary free cortisol or 6 beta-hydroxycortisol excretion, and none have published comparisons of these variables between old people of defined health status and young people. METHODS: We have measured cortisol production rate and the urinary excretion of free cortisol, 6 beta-hydroxycortisol, 17-Hydroxycorticosteroids (Porter-Silber chromogens) and creatinine in elderly men and women screened by the SENIEUR protocol and in young men; 17-Hydroxycorticosteroid and 6 beta-hydroxycortisol excretion were also measured in young women. The period of measurement was 24 h or, usually, 48 h. RESULTS: Only 6 beta-hydroxycortisol excretion was affected by aging; it was lower in the elderly men and women than in their younger counterparts. Urinary free cortisol excretion was lower in the elderly women than in the elderly men. There were no significant differences between groups in cortisol production rate or 17-Hydroxycorticosteroid excretion. Excretion and (over the first 24 h) clearance of creatinine were lower in the old women than in the old men. The cortisol-related variables tended to be positively correlated with each other and with the relevant creatinine-related variables in the elderly subjects; over the first but not the second 24 h, most of the correlations were significant in the men and women combined. CONCLUSIONS: With the exception of 6 beta-hydroxycortisol, the data agree with measurements of plasma cortisol and the results of adrenal function tests in showing little change in hypothalamic-pituitary-adrenal function with aging in healthy people.

S Ely Robert - One of the best experts on this subject based on the ideXlab platform.