18 Hydroxycorticosterone

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Shinpei Morimoto - One of the best experts on this subject based on the ideXlab platform.

  • Lack of enhanced responsiveness of plasma 18-Hydroxycorticosterone and aldosterone to adrenocorticotropin as well as to angiotensin-II during moderate sodium depletion in type II diabetic subjects with normoreninemia.
    The Journal of clinical endocrinology and metabolism, 1991
    Co-Authors: Toshikazu Kigoshi, Kenzo Uchida, Ryoji Iwasaki, Sadahide Azukizawa, Mihoko Kaneko, Shigeru Nakano, Shinpei Morimoto
    Abstract:

    ABSTRACT Responses of plasma aldosterone (PA) and its precursor steroids to αACTH-(1-24) (85.2 nmol, iv) injection and graded angiotensin-II (All) infusions (3.90 and 7.80 pmol/kg·min for 30 min at each dose) on both 170 and 100 mmol sodium intakes were assessed in 25 type II diabeticsubjects with normoreninemia and 11 age-matched normal subjects. The diabetic subjects and the normal subjects did not differ in mean blood pressure, serum electrolytes, and creatinine clearance, except for an increase in fasting plasma glucose (P < 0.001) in the diabetic subjects. A 100-mmol sodium intake for 4 days produced an increase in basal plasma reninactivity (P / 0.01), plasma 18-Hydroxycorticosterone (18-OHB; P < 0.05), and PA (P < 0.05), and a decrease in urinary sodium excretion (P < 0.001) in the two groups. These parameters were similar in the two groups. ACTH injection produced significant increases in plasma cortisol, plasma corticosterone, plasma 18-OHB, and PA (P < 0.005 or P < 0.001), and graded All infusio...

Carl-joachim Partsch - One of the best experts on this subject based on the ideXlab platform.

  • Chromatographic system for the simultaneous measurement of plasma 18-hydroxy-11-deoxycorticosterone and 18-Hydroxycorticosterone by radioimmunoassay: reference data for neonates and infants and its application in aldosterone-synthase deficiency
    Journal of chromatography. B Analytical technologies in the biomedical and life sciences, 2003
    Co-Authors: Felix G. Riepe, Nils Krone, Michael Peter, Carl-joachim Partsch
    Abstract:

    Abstract A new chromatographic system for the steroid precursor separation and a sensitive radioimmunoassay system for the subsequent measurement of 18-hydroxy-11-deoxycorticosterone and 18-Hydroxycorticosterone has been developed. 18-Hydroxy-11-deoxycorticosterone and 18-Hydroxycorticosterone were extracted with methylene chloride and separated from cross-reacting steroids by Sephadex LH-20 column chromatography. Anti-18-hydroxy-11-deoxycorticosterone and anti-18-Hydroxycorticosterone antibodies raised in rabbits were used. The lower detection limit of the assay is 0.03 nmol/l and 0.128 nmol/l for 18-hydroxy-11-deoxycorticosterone and 18-Hydroxycorticosterone, respectively. Normal values for this assay in 128 healthy neonates and infants aged 0–5 months were established as a basis for the early hormonal diagnosis of aldosterone synthase deficiency types I and II. Its application for the diagnosis of aldosterone synthase deficiency is demonstrated in two patients with homozygous mutation/deletion in the encoding CYP11B2 gene.

Clayton K. Trimmer - One of the best experts on this subject based on the ideXlab platform.

  • BRIEF REPORT Measurement of 18-Hydroxycorticosterone during Adrenal Vein Sampling for Primary Aldosteronism
    The Journal of clinical endocrinology and metabolism, 2007
    Co-Authors: Richard J. Auchus, Donald W. Chandler, Sarita Singeetham, Neema Chokshi, Fiemu E. Nwariaku, Bart Dolmatch, Shelby A. Holt, Frank H. Wians, Shellie C. Josephs, Clayton K. Trimmer
    Abstract:

    Context: In primary aldosteronism, elevated serum 18-Hydroxycorticosterone (18OHB) suggests aldosterone-producing adenoma (APA) rather than bilateral, idiopathic hyperaldosteronism (IHA), but little is known about the relative production of 18OHB and aldosterone (A) in APAs compared with IHA. Objectives: We measured 18OHB, A, and cortisol (F) in blood from adrenal vein sampling (AVS) studies. We compared the discriminatory power of gradients in 18OHB/A and 18OHB/F ratios with A/F ratio gradients for distinguishing APA from IHA. Design, Setting, and Subjects: We measured 18OHB and A in excess serum from 23 AVS studies performed at our university hospitals. Main Outcome Measures: We calculated the ratios 18OHB/A, 18OHB/F, and A/F for all specimens, and determined the adrenal vein gradients for these ratios. Results: The 18OHB/A ratios were much lower in blood draining APAs (2.17 ± 0.62) than in blood draining the contralateral adrenals (12.96 ± 12.76; P < 0.001) but similar to blood draining IHA adrenals (4...

Toshikazu Kigoshi - One of the best experts on this subject based on the ideXlab platform.

  • Lack of enhanced responsiveness of plasma 18-Hydroxycorticosterone and aldosterone to adrenocorticotropin as well as to angiotensin-II during moderate sodium depletion in type II diabetic subjects with normoreninemia.
    The Journal of clinical endocrinology and metabolism, 1991
    Co-Authors: Toshikazu Kigoshi, Kenzo Uchida, Ryoji Iwasaki, Sadahide Azukizawa, Mihoko Kaneko, Shigeru Nakano, Shinpei Morimoto
    Abstract:

    ABSTRACT Responses of plasma aldosterone (PA) and its precursor steroids to αACTH-(1-24) (85.2 nmol, iv) injection and graded angiotensin-II (All) infusions (3.90 and 7.80 pmol/kg·min for 30 min at each dose) on both 170 and 100 mmol sodium intakes were assessed in 25 type II diabeticsubjects with normoreninemia and 11 age-matched normal subjects. The diabetic subjects and the normal subjects did not differ in mean blood pressure, serum electrolytes, and creatinine clearance, except for an increase in fasting plasma glucose (P < 0.001) in the diabetic subjects. A 100-mmol sodium intake for 4 days produced an increase in basal plasma reninactivity (P / 0.01), plasma 18-Hydroxycorticosterone (18-OHB; P < 0.05), and PA (P < 0.05), and a decrease in urinary sodium excretion (P < 0.001) in the two groups. These parameters were similar in the two groups. ACTH injection produced significant increases in plasma cortisol, plasma corticosterone, plasma 18-OHB, and PA (P < 0.005 or P < 0.001), and graded All infusio...

Taisen Iguchi - One of the best experts on this subject based on the ideXlab platform.

  • subchapter 95b 18 Hydroxycorticosterone
    Handbook of Hormones#R##N#Comparative Endocrinology for Basic and Clinical Research, 2016
    Co-Authors: Yoshinao Katsu, Taisen Iguchi
    Abstract:

    18-Hydroxycorticosterone (18-OHB), which has a weak electrolyte action, is a derivative of corticosterone. Corticosterone is converted into 18-OHB by two steps, 18-hydroxylation and 18-oxidation. These two steps are catalyzed by CYP11B2. There is no difference between the sexes in the concentration of this 18-OHT; however, ACTH stimulation increases the plasma concentration of 18-OHT, while dexamethasone decreases this steroid. Very little is known about the physiological function of 18-OHT. In adrenalectomized rats, a physiological dose of 18-OHT has a positive effect on the brush border Na+/K+ exchanger. In sodium-replete patients with low-renin essential hypertension, 18-OHT seems to be a better marker than aldosterone.

  • Subchapter 95B – 18-Hydroxycorticosterone
    Handbook of Hormones, 2016
    Co-Authors: Yoshinao Katsu, Taisen Iguchi
    Abstract:

    18-Hydroxycorticosterone (18-OHB), which has a weak electrolyte action, is a derivative of corticosterone. Corticosterone is converted into 18-OHB by two steps, 18-hydroxylation and 18-oxidation. These two steps are catalyzed by CYP11B2. There is no difference between the sexes in the concentration of this 18-OHT; however, ACTH stimulation increases the plasma concentration of 18-OHT, while dexamethasone decreases this steroid. Very little is known about the physiological function of 18-OHT. In adrenalectomized rats, a physiological dose of 18-OHT has a positive effect on the brush border Na+/K+ exchanger. In sodium-replete patients with low-renin essential hypertension, 18-OHT seems to be a better marker than aldosterone.