1H-Benzimidazole

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Vukic Soskic - One of the best experts on this subject based on the ideXlab platform.

  • synthesis dopamine d2 receptor binding studies and docking analysis of 5 3 4 arylpiperazin 1 yl propyl 1h benzimidazole 5 2 4 arylpiperazin 1 yl ethoxy 1h benzimidazole and their analogs
    European Journal of Medicinal Chemistry, 2005
    Co-Authors: Vladimir Sukalovic, Deana Andric, Goran Roglic, Sladjana Kosticrajacic, Andre Schrattenholz, Vukic Soskic
    Abstract:

    Abstract 5-[3-(4-Arylpiperazin-1-yl)propyl]-1 H -benzimidazoles and 5-[2-(4-arylpiperazin-1-yl)ethoxy]-1 H -benzimidazoles were synthesized and their affinity for the D 1 , D 2 and 5-HT 1A receptors examined. They expressed a rather high affinity for the D 2 dopamine receptor. The main features of ligand–D 2 receptor interactions revealed by docking analyses were: salt bridge between piperazine ring protonated N 1 and Asp 86, hydrogen bonds of ligand bezimidazole part with Ser 141, Ser 122 and His 189, edge-to-face interactions of arylpiperazine aromatic ring with Phe 178, Tyr 216 and Trp 182 and hydrogen bond between ethereal oxygen in ethylenoxy ligands and hydrogen of Phe 185 or Trp 115. The most active 5-{2-[4-(2-methoxyphenyl)-piperazin-1-yl]ethoxy}-1,3-dihydro-2 H -benzimidazole-2-thione (27) has a maximal number of attractive interactions. A satisfactory correlation between docking of the compounds into the D 2 receptor and competition binding results was observed.

Yuqi Feng - One of the best experts on this subject based on the ideXlab platform.

  • nickel oxide nanoparticle deposited silica composite solid phase extraction for benzimidazole residue analysis in milk and eggs by liquid chromatography mass spectrometry
    Journal of Agricultural and Food Chemistry, 2016
    Co-Authors: Qiongwei Yu, Haibo He, Qian Lu, Yuqi Feng
    Abstract:

    A novel nickel oxide nanoparticle-deposited silica (SiO2@NiO) composite was prepared via liquid-phase deposition (LPD) and then employed as a solid-phase extraction (SPE) sorbent. When the SPE was coupled with liquid chromatography–electrospray ionization mass spectrometry (LC–ESI/MS) analysis, an analytical platform for the sensitive determination of benzimidazole residues in egg and milk was established. The limits of detection of nine benzimidazoles were in the range of 0.8–2.2 ng/mL in milk and 0.3–2.1 ng/g in eggs, respectively, which was 5–10 times superior to the methods with other adsorbents for SPE. The recoveries of nine benzimidazoles spiked in milk and egg ranged from 70.8 to 118.7%, with relative standard deviations (RSDs) being less than 18.9%. This work presented the excellent extraction performance of NiO on benzimidazoles for the first time, and the applicability of the LPD technique used as sorbents for trace analysis in complex matrices was also demonstrated.

  • determination of benzimidazole residues in edible animal food by polymer monolith microextraction combined with liquid chromatography mass spectrometry
    Journal of Agricultural and Food Chemistry, 2010
    Co-Authors: Jianxing Wang, Yuqi Feng
    Abstract:

    A sensitive method has been developed for the simultaneous determination of 10 benzimidazole residues and some of their metabolites in egg, milk, chicken, and pork. This method is based on the combination of polymer monolith microextraction (PMME) technique with liquid chromatography and electrospray ionization mass spectrometry (LC-ESI/MS). The extraction was performed with a poly(methacrylic acid-co-ethylene glycol dimethacrylate) (MAA-co-EGDMA) monolithic capillary column. Under the optimized extraction conditions, good extraction efficiencies for the targets were obtained with no matrix interference in the subsequent detection. The LODs (S/N = 3) for 10 benzimidazoles were found to be 0.56−2.76 ng g−1 in egg, 0.50−1.41 ng mL−1 in milk, 0.09−0.28 ng g−1 in chicken, and 0.08−0.15 ng g−1 in pork. The recoveries in egg, milk, chicken, and pork matrices ranged from 75.2 to 116.8% spiked at different levels with analytes, with RSDs of <13.7%. The method was later successfully applied for the determination o...

Ray J Butcher - One of the best experts on this subject based on the ideXlab platform.

  • synthesis and structure of the mercury chloride complex of 2 2 2 bromo 5 tert butyl 1 3 phenyl ene bis 1 methyl 1h benzimidazole
    Acta Crystallographica Section E: Crystallographic Communications, 2017
    Co-Authors: Varsha Rani, Harkesh B Singh, Ray J Butcher
    Abstract:

    In the title mercury complex, catena-poly[[di­chlorido­mercury(II)]-μ-2,2′-(2-bromo-5-tert-butyl-1,3-phenyl­ene)bis­(1-methyl-1H-Benzimidazole)-κ2N3:N3′], [HgCl2(C26H25BrN4)]n, the HgII atom is coordinated by two Cl atoms and by two N atoms from two 2,2′-(2-bromo-5-tert-butyl-1,3-phenyl­ene)bis­(1-methyl-1H-Benzimidazole) ligands. The metal cation adopts a distorted tetrahedral coordination geometry with with bond angles around mercury of 100.59 (15)° [N—Hg—N] and 126.35 (7)° [Cl—Hg—Cl]. This arrangement gives rise to a zigzag helical 1-D polymer propagating along the b-axis direction.

  • Synthesis and structure of the mercury chloride complex of 2,2′-(2-bromo-5-tert-butyl-1,3-phenylene)bis(1-methyl-1H-Benzimidazole)
    International Union of Crystallography, 2017
    Co-Authors: Varsha Rani, Harkesh B Singh, Ray J Butcher
    Abstract:

    In the title mercury complex, catena-poly[[dichloridomercury(II)]-μ-2,2′-(2-bromo-5-tert-butyl-1,3-phenylene)bis(1-methyl-1H-Benzimidazole)-κ2N3:N3′], [HgCl2(C26H25BrN4)]n, the HgII atom is coordinated by two Cl atoms and by two N atoms from two 2,2′-(2-bromo-5-tert-butyl-1,3-phenylene)bis(1-methyl-1H-Benzimidazole) ligands. The metal cation adopts a distorted tetrahedral coordination geometry with with bond angles around mercury of 100.59 (15)° [N—Hg—N] and 126.35 (7)° [Cl—Hg—Cl]. This arrangement gives rise to a zigzag helical 1-D polymer propagating along the b-axis direction

Vladimir Sukalovic - One of the best experts on this subject based on the ideXlab platform.

  • synthesis dopamine d2 receptor binding studies and docking analysis of 5 3 4 arylpiperazin 1 yl propyl 1h benzimidazole 5 2 4 arylpiperazin 1 yl ethoxy 1h benzimidazole and their analogs
    European Journal of Medicinal Chemistry, 2005
    Co-Authors: Vladimir Sukalovic, Deana Andric, Goran Roglic, Sladjana Kosticrajacic, Andre Schrattenholz, Vukic Soskic
    Abstract:

    Abstract 5-[3-(4-Arylpiperazin-1-yl)propyl]-1 H -benzimidazoles and 5-[2-(4-arylpiperazin-1-yl)ethoxy]-1 H -benzimidazoles were synthesized and their affinity for the D 1 , D 2 and 5-HT 1A receptors examined. They expressed a rather high affinity for the D 2 dopamine receptor. The main features of ligand–D 2 receptor interactions revealed by docking analyses were: salt bridge between piperazine ring protonated N 1 and Asp 86, hydrogen bonds of ligand bezimidazole part with Ser 141, Ser 122 and His 189, edge-to-face interactions of arylpiperazine aromatic ring with Phe 178, Tyr 216 and Trp 182 and hydrogen bond between ethereal oxygen in ethylenoxy ligands and hydrogen of Phe 185 or Trp 115. The most active 5-{2-[4-(2-methoxyphenyl)-piperazin-1-yl]ethoxy}-1,3-dihydro-2 H -benzimidazole-2-thione (27) has a maximal number of attractive interactions. A satisfactory correlation between docking of the compounds into the D 2 receptor and competition binding results was observed.

Varsha Rani - One of the best experts on this subject based on the ideXlab platform.

  • synthesis and structure of the mercury chloride complex of 2 2 2 bromo 5 tert butyl 1 3 phenyl ene bis 1 methyl 1h benzimidazole
    Acta Crystallographica Section E: Crystallographic Communications, 2017
    Co-Authors: Varsha Rani, Harkesh B Singh, Ray J Butcher
    Abstract:

    In the title mercury complex, catena-poly[[di­chlorido­mercury(II)]-μ-2,2′-(2-bromo-5-tert-butyl-1,3-phenyl­ene)bis­(1-methyl-1H-Benzimidazole)-κ2N3:N3′], [HgCl2(C26H25BrN4)]n, the HgII atom is coordinated by two Cl atoms and by two N atoms from two 2,2′-(2-bromo-5-tert-butyl-1,3-phenyl­ene)bis­(1-methyl-1H-Benzimidazole) ligands. The metal cation adopts a distorted tetrahedral coordination geometry with with bond angles around mercury of 100.59 (15)° [N—Hg—N] and 126.35 (7)° [Cl—Hg—Cl]. This arrangement gives rise to a zigzag helical 1-D polymer propagating along the b-axis direction.

  • Synthesis and structure of the mercury chloride complex of 2,2′-(2-bromo-5-tert-butyl-1,3-phenylene)bis(1-methyl-1H-Benzimidazole)
    International Union of Crystallography, 2017
    Co-Authors: Varsha Rani, Harkesh B Singh, Ray J Butcher
    Abstract:

    In the title mercury complex, catena-poly[[dichloridomercury(II)]-μ-2,2′-(2-bromo-5-tert-butyl-1,3-phenylene)bis(1-methyl-1H-Benzimidazole)-κ2N3:N3′], [HgCl2(C26H25BrN4)]n, the HgII atom is coordinated by two Cl atoms and by two N atoms from two 2,2′-(2-bromo-5-tert-butyl-1,3-phenylene)bis(1-methyl-1H-Benzimidazole) ligands. The metal cation adopts a distorted tetrahedral coordination geometry with with bond angles around mercury of 100.59 (15)° [N—Hg—N] and 126.35 (7)° [Cl—Hg—Cl]. This arrangement gives rise to a zigzag helical 1-D polymer propagating along the b-axis direction

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