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Urszula Domanska - One of the best experts on this subject based on the ideXlab platform.
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solubility of ionic liquids in water and octan 1 ol and octan 1 ol water or 2 phenylethanol water partition coefficients
The Journal of Chemical Thermodynamics, 2012Co-Authors: Urszula Domanska, Marek Krolikowski, Aneta Pobudkowska, Patrycja BochenskaAbstract:Abstract The solubility of 1-ethyl-3-methylimidazolium tris(pentafluoroethyl)trifluorophosphate, [EMIM][FAP] and 1-hexyl-3-methylpyridinium triflate, [HM 3 Py][CF 3 SO 3 ] in octan-1-ol, water, and 2-Phenylethanol have been determined at ambient pressure. A dynamic method was used over a broad range of mole fractions and temperatures from 270 K to 360 K. The immiscibility in the liquid phase with an upper critical solution temperature (UCST) was observed in ([EMIM][FAP] + octan-1-ol, or water). The complete miscibility in the liquid phase was observed for the binary system ([EMIM][FAP] + 2-Phenylethanol). The simple liquidus curves with complete miscibility in the liquid phase were observed for the binary systems ([HM 3 Py][CF 3 SO 3 ] + 1-octanol, or 2-Phenylethanol) and with miscibility gap in water. The octan-1-ol/water, K ow and 2-Phenylethanol/water, K Phw partition coefficients in ternary liquid-liquid phase equilibrium were determined for the systems {[EMIM][FAP], or [HM 3 Py][CF 3 SO 3 ], or N -octylisoquinolinium bis{(trifluoromethyl)sulfonyl}imide, [OiQuin][NTf 2 ] (1) + octan-1-ol (2) + water (3)} at temperature T = 298.15 K.
Aneta Pobudkowska - One of the best experts on this subject based on the ideXlab platform.
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solubility of ionic liquids in water and octan 1 ol and octan 1 ol water or 2 phenylethanol water partition coefficients
The Journal of Chemical Thermodynamics, 2012Co-Authors: Urszula Domanska, Marek Krolikowski, Aneta Pobudkowska, Patrycja BochenskaAbstract:Abstract The solubility of 1-ethyl-3-methylimidazolium tris(pentafluoroethyl)trifluorophosphate, [EMIM][FAP] and 1-hexyl-3-methylpyridinium triflate, [HM 3 Py][CF 3 SO 3 ] in octan-1-ol, water, and 2-Phenylethanol have been determined at ambient pressure. A dynamic method was used over a broad range of mole fractions and temperatures from 270 K to 360 K. The immiscibility in the liquid phase with an upper critical solution temperature (UCST) was observed in ([EMIM][FAP] + octan-1-ol, or water). The complete miscibility in the liquid phase was observed for the binary system ([EMIM][FAP] + 2-Phenylethanol). The simple liquidus curves with complete miscibility in the liquid phase were observed for the binary systems ([HM 3 Py][CF 3 SO 3 ] + 1-octanol, or 2-Phenylethanol) and with miscibility gap in water. The octan-1-ol/water, K ow and 2-Phenylethanol/water, K Phw partition coefficients in ternary liquid-liquid phase equilibrium were determined for the systems {[EMIM][FAP], or [HM 3 Py][CF 3 SO 3 ], or N -octylisoquinolinium bis{(trifluoromethyl)sulfonyl}imide, [OiQuin][NTf 2 ] (1) + octan-1-ol (2) + water (3)} at temperature T = 298.15 K.
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Solubility of ionic liquids in water and octan-1-ol and octan-1-ol/water, or 2-Phenylethanol/water partition coefficients
The Journal of Chemical Thermodynamics, 2012Co-Authors: Urszula Domańska, Marek Krolikowski, Aneta Pobudkowska, Patrycja BocheńskaAbstract:Abstract The solubility of 1-ethyl-3-methylimidazolium tris(pentafluoroethyl)trifluorophosphate, [EMIM][FAP] and 1-hexyl-3-methylpyridinium triflate, [HM 3 Py][CF 3 SO 3 ] in octan-1-ol, water, and 2-Phenylethanol have been determined at ambient pressure. A dynamic method was used over a broad range of mole fractions and temperatures from 270 K to 360 K. The immiscibility in the liquid phase with an upper critical solution temperature (UCST) was observed in ([EMIM][FAP] + octan-1-ol, or water). The complete miscibility in the liquid phase was observed for the binary system ([EMIM][FAP] + 2-Phenylethanol). The simple liquidus curves with complete miscibility in the liquid phase were observed for the binary systems ([HM 3 Py][CF 3 SO 3 ] + 1-octanol, or 2-Phenylethanol) and with miscibility gap in water. The octan-1-ol/water, K ow and 2-Phenylethanol/water, K Phw partition coefficients in ternary liquid-liquid phase equilibrium were determined for the systems {[EMIM][FAP], or [HM 3 Py][CF 3 SO 3 ], or N -octylisoquinolinium bis{(trifluoromethyl)sulfonyl}imide, [OiQuin][NTf 2 ] (1) + octan-1-ol (2) + water (3)} at temperature T = 298.15 K.
Patrycja Bochenska - One of the best experts on this subject based on the ideXlab platform.
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solubility of ionic liquids in water and octan 1 ol and octan 1 ol water or 2 phenylethanol water partition coefficients
The Journal of Chemical Thermodynamics, 2012Co-Authors: Urszula Domanska, Marek Krolikowski, Aneta Pobudkowska, Patrycja BochenskaAbstract:Abstract The solubility of 1-ethyl-3-methylimidazolium tris(pentafluoroethyl)trifluorophosphate, [EMIM][FAP] and 1-hexyl-3-methylpyridinium triflate, [HM 3 Py][CF 3 SO 3 ] in octan-1-ol, water, and 2-Phenylethanol have been determined at ambient pressure. A dynamic method was used over a broad range of mole fractions and temperatures from 270 K to 360 K. The immiscibility in the liquid phase with an upper critical solution temperature (UCST) was observed in ([EMIM][FAP] + octan-1-ol, or water). The complete miscibility in the liquid phase was observed for the binary system ([EMIM][FAP] + 2-Phenylethanol). The simple liquidus curves with complete miscibility in the liquid phase were observed for the binary systems ([HM 3 Py][CF 3 SO 3 ] + 1-octanol, or 2-Phenylethanol) and with miscibility gap in water. The octan-1-ol/water, K ow and 2-Phenylethanol/water, K Phw partition coefficients in ternary liquid-liquid phase equilibrium were determined for the systems {[EMIM][FAP], or [HM 3 Py][CF 3 SO 3 ], or N -octylisoquinolinium bis{(trifluoromethyl)sulfonyl}imide, [OiQuin][NTf 2 ] (1) + octan-1-ol (2) + water (3)} at temperature T = 298.15 K.
Jozef Markoš - One of the best experts on this subject based on the ideXlab platform.
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Modeling of 2-Phenylethanol adsorption onto polymeric resin from aqueous solution: Intraparticle diffusion evaluation and dynamic fixed bed adsorption
Chemical Engineering Research & Design, 2019Co-Authors: Ivan Červeňanský, Mário Mihaľ, Jozef MarkošAbstract:Abstract Adsorption of 2-Phenylethanol from an aqueous solution onto hyper-crossed-linked adsorption resin Macronet MN270 was investigated in a fixed bed column. Adsorption equilibrium was obtained in batch experiments and the results were fitted with the Langmuir isotherm model. A batch adsorption experiment was performed to determine the intraparticle diffusion mechanism. It was found that pore volume diffusion cannot solely govern the intraparticle mass transfer. According to the results of the batch experiment, surface diffusion plays an important role in the adsorption of 2-Phenylethanol. Diffusion coefficients obtained in the batch experiment were further verified by comparison of the experimental data with the results of the mathematical model of fixed bed adsorption which was able to predict experimental breakthrough curves obtained under various conditions. A better description of the experimental data was obtained using the mathematical model which considered pore volume diffusion together with surface diffusion. The varying parameters in the measurements of breakthrough curves were: particle diameter, column diameter, volumetric flow rate and the inlet column concentration. Fixed bed adsorption experiments showed that smaller particles together with lower volumetric flow rate produce sharper breakthrough curves. The effect of external mass transfer and axial dispersion was not very significant. Lastly, fixed bed desorption of 2-Phenylethanol with water was tested and was shown to be ineffective. Therefore, different solvents for 2-Phenylethanol desorption were recommended.
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Design of hybrid systems with in-situ product removal from fermentation broth: Case study for 2-Phenylethanol production
Chemical Engineering and Processing, 2018Co-Authors: Peter Vargai, Mário Mihaľ, Ivan Červeňanský, Jozef MarkošAbstract:Abstract Many natural compounds used as flavours and aromas, such as 2-Phenylethanol, can be produced both synthetically and biotechnologically. Large amounts of cheap product can be synthesised, however, a substance to be used in food and pharmaceutical industry or perfumery has to be produced from natural precursors. Biotechnologically, this can be accomplished in a classic batch process - by transforming L-phenylalanine into 2-Phenylethanol using Saccharomyces cerevisiae as a production strain followed by the product separation. The major downside of the configuration is the inhibition effect of the product on the production strain – concentration of 2-Phenylethanol above 4 g L−1 is fatal for the yeasts. One way of solving the problem is to combine the fermentation and separation processes and continuously remove the product from the bioreactor during fermentation. This process configuration is called hybrid system. In this work, two batch configurations and three hybrid systems are presented and compared considering overall production rate, cost of operation units, raw materials and energy consumption. It has been shown that hybrid systems in which microfiltration is not present during in-situ product removal perform better than traditional batch systems or hybrid system with microfiltration.
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Design of Biotechnological Production of 2-Phenylethanol
Computer Aided Chemical Engineering, 2018Co-Authors: Peter Vargai, Mário Mihaľ, Ivan Červeňanský, Jozef MarkošAbstract:Abstract Biocatalytic production of many natural compounds is usually connected with strong inhibition effect of the product; therefore, an innovative process, where reaction and separation steps are integrated into one operational unit, has been developed. There are no general rules for optimal hybrid system design and final decision is made after the economic analysis of different production alternatives (Krishna, 2002). In this paper, the comparison of different process configurations for biotechnological production of 2-Phenylethanol from L-phenylalanine by yeasts Saccharomyces cerevisiae with strong inhibitory effect on the production strain is presented. Classical fed-batch fermentation and two different hybrid systems were simulated using appropriate mathematical models and compared considering: overall production rate of target product, performance cost of proposed technology, investment cost, energy consumption, waste production. It has been shown that the hybrid system with in-situ product removal using an immersed extractive hollow fibre membrane module with continuous regeneration of organic solvent provides better results in 2-Phenylethanol production compared to traditional batch technology.
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Intensive 2-Phenylethanol production in a hybrid system combined of a stirred tank reactor and an immersed extraction membrane module
Chemical Papers, 2014Co-Authors: Mário Mihaľ, Ramiro F. Goncalves, Jozef MarkošAbstract:Bioconversion of l-phenylalanine to 2-Phenylethanol using Saccharomyces cerevisiae is connected with the growth of biomass strongly limited by product inhibition. Therefore, fermentation can proceed only at low conversions of l-phenylalanine with very low yield of the desired product, which allows reaching the maximum concentration of 2-Phenylethanol, 4 g L−1, in an ordinary batch, fed-batch, or chemostat bioreactor. To minimize capital and operating costs in the bioproduction of chemical specialties where the product inhibits the bioreaction, using a hybrid system based on the application of membrane extraction integrated in the bioreactor to remove the product is a suitable solution. Integration can be done by an external module for membrane extraction or, as a more efficient solution, by an extraction membrane module immersed directly in the bioreactor. Such a hybrid system can be used to remove 2-Phenylethanol from the fermentation media and thus to overcome the product inhibition of the biotransformation process. In this paper, a hybrid system consisting of a stirred tank bioreactor (3.5 L) and an immersed extraction hollow fiber membrane module was studied. In the proposed system, the kinetics of 2-Phenylethanol extraction from a water solution with and without biomass in the bioreactor to alkanes at different operational conditions was measured. Extraction kinetics was compared with the predictions obtained by a mathematical model. In the hybrid system, two extractive biotransformation experiments were performed and compared with that without product removal. Experimental data were also mathematically predicted with good accuracy between the simulation and the experiment.
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Airlift reactor — membrane extraction hybrid system for aroma production
Chemical Papers, 2013Co-Authors: Mário Mihaľ, Sean Peter Gavin, Jozef MarkošAbstract:In recent times, environmental production methods and organic products are increasingly sought after in food, perfume, and cosmetic industries, where the products are consumed or come into direct contact with humans. One such additive is 2-Phenylethanol, an alcoholic aromatic rose like smell compound, mainly used as a flavor and aroma. 2-Phenylethanol can be produced by bioconversion from l -phenylalanine using Saccharomyces cerevisiae . This type of biotransformation is strongly limited by product inhibition which allows reaching the maximum concentration of 2-Phenylethanol, 4 g L^−1, in an ordinary batch, fed-batch, or chemostat bioreactor. The main aim of the presented work was to study the possible yield increase of 2-Phenylethanol in a hybrid system consisting of membrane extraction performed by a hollow fiber membrane module immersed in the downcomer of an airlift reactor. Such hybrid system can be used to remove 2-Phenylethanol from the fermentation medium and thus to overcome the product inhibition of biotransformation. In this paper, the influence of biomass on membrane extraction of 2-Phenylethanol from aqueous solution in an airlift reactor to alkanes at different operational conditions was studied. The measured extraction kinetics was compared with the predictions obtained by a mathematical model. Hydrodynamics of the hybrid system was also studied.
Christoph Spondlin - One of the best experts on this subject based on the ideXlab platform.
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efficient preparation of r and s 2 amino 1 phenylethanol
Organic Process Research & Development, 1997Co-Authors: Christoph SpondlinAbstract:The preparation of optically pure 2-amino-1-phenylethanol was investigated using three methods. The opening of styrene oxide with ammonia, the reduction of mandelamide, and the resolution of (±)-2-amino-1-phenylethanol were compared from a process R&D viewpoint. The resolution using di-O-p-toluoyltartaric acid was found to be the method of choice and was optimised to yield 62% of optically pure substance.
