The Experts below are selected from a list of 72 Experts worldwide ranked by ideXlab platform
Tom L Broderick - One of the best experts on this subject based on the ideXlab platform.
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beneficial effects of resveratrol and exercise training on cardiac and aortic function and structure in the 3XTg Mouse model of alzheimer s disease
Drug Design Development and Therapy, 2019Co-Authors: Mitra Esfandiarei, Brikena Hoxha, Nicholas A Talley, Miranda Anderson, Mustafa F Alkhouli, Michaela Squire, Delrae M Eckman, Jeganathan Ramesh Babu, Gary D Lopaschuk, Tom L BroderickAbstract:Background: Studies have indicated an association between Alzheimer's disease (AD) and increased risk of developing cardiovascular complications. Lifestyle modifiable factors, such as exercise and diet, are known to prevent cardio-cerebral disease. Recent studies demonstrate that hearts from early onset triple-transgenic AD mice exhibit pathologies, but it is not clear whether cardiovascular function is altered in this model. Methods: In this study, we measured in vivo cardiovascular function in 7-month-old male 3XTg mice and age-matched wild-type (WT) mice using high-frequency high-resolution ultrasound imaging. Results: Our findings indicated that aortic root measurements and interventricular septal dimensions were similar in 3XTg and wild-type mice. Systolic function, expressed as ejection fraction and fractional shortening, were decreased in 3XTg mice. Late (A) ventricular filling velocities, the early/atrial (E/A) ratio, and mitral valve deceleration time, all indices of diastolic function, were increased in 3XTg mice compared to WT mice. Treadmill exercise training and resveratrol supplementation in the diet for 5 months improved ejection fraction, fractional shortening, and restored diastolic deceleration times. Pulse wave velocity was ~33% higher in 3XTg, and accompanied by a significant increase in elastin fiber fragmentation within the aortic wall, which was associated with decrease in elastin content and fiber length. Aortic wall and adventitia thickness were increased in 3XTg mice compared to the WT group. Exercise training and resveratrol supplementation, or both, improved overall aortic morphology with no change in pulse wave velocity. Conclusion: Taken together, the results indicate that the aberrations in cardiac function and aortic elastin morphology observed in the 3XTg Mouse model of AD can be prevented with exercise training and treatment with resveratrol. The benefits of regular exercise training and resveratrol supplementation of heart and aortic structure in the 3XTg Mouse support the value of healthy lifestyle factors on cardiovascular health.
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exercise and resveratrol increase fracture resistance in the 3XTg ad Mouse model of alzheimer s disease
BMC Complementary and Alternative Medicine, 2019Co-Authors: Mustafa F Alkhouli, Miranda Anderson, Michaela Squire, Jeganathan Ramesh Babu, Tom L Broderick, Jun Hung, Monica Castro, Layla Alnakkash, Jeffrey H PlochockiAbstract:Alzheimer’s disease (AD) and osteoporosis are progressive diseases that affect the elderly population. Both conditions are associated with fracture risk that is greater than twice that of the healthy population. Resveratrol and exercise are two treatments that have been linked with attenuation of age-related diseases, including the risk of bone fractures. In this study, we test the hypothesis that these treatments improve fracture resistance in a Mouse model representative of the AD condition. Three-month-old male 3XTg-AD mice were treated for 4 months with resveratrol or exercise or both combined, and compared with wild type mice. Exercise training was performed on a treadmill at 15 m/min for 45 min/day, 5 days/week. Resveratrol was given at 4 g/kg diet in the form of pellets. Three-point bending, cross-sectional geometric, and fluorescence analyses were conducted on tibias and compared by treatment group. Tibias of 3XTg mice exhibited signs of diminished bone quality and fracture under less force than age-matched wild type mice (P < 0.05). Treatment with both resveratrol and exercise improved indicators of fracture resistance and bone quality in AD mice to levels comparable to that of wild type mice (P < 0.05). The 3XTg Mouse model of AD is at elevated risk for limb bone fracture compared to wild type controls. Treatment with resveratrol, exercise, or both in combination improves fracture resistance and cross-sectional geometric indicators of bone strength.
Kerry M Obanion - One of the best experts on this subject based on the ideXlab platform.
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space radiation does not alter amyloid or tau pathology in the 3XTg Mouse model of alzheimer s disease
Life sciences in space research, 2020Co-Authors: Laura Owlett, Dawling A Dionisiosantos, John A Olschowka, Elizabeth Belcher, Jacqueline P Williams, Kerry M ObanionAbstract:Abstract Space radiation is comprised of highly charged ions (HZE particles) and protons that are able to pass through matter and cause radiation-induced injury, including neuronal damage and degeneration, glial activation, and oxidative stress. Previous work demonstrated a worsening of Alzheimer's disease pathology in the APP/PS1 transgenic Mouse model, however effects of space radiation on tau pathology have not been studied. To determine whether tau pathology is altered by HZE particle or proton irradiation, we exposed 3XTg mice, which acquire both amyloid plaque and tau pathology with age, to iron, silicon, or solar particle event (SPE) irradiation at 9 months of age and evaluated behavior and brain pathology at 16 months of age. We found no differences in performance in fear conditioning and novel object recognition tasks between groups of mice exposed to sham, iron (10 and 100 cGy), silicon (10 and 100 cGy), or solar particle event radiation (200 cGy), though female mice had higher freezing responses than males. 200 cGy SPE irradiated female mice had fewer plaques than sham-irradiated females but had no differences in tau pathology. Overall, females had worse amyloid and tau pathology at 16 months of age and demonstrated a reduced neuroinflammatory gene expression response to radiation. These findings uncover differences between Mouse models following radiation injury and corroborate prior reports of sex differences within the 3XTg Mouse model.
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evaluating the effect of interleukin 4 in the 3XTg Mouse model of alzheimer s disease
Frontiers in Neuroscience, 2020Co-Authors: Dawling A Dionisiosantos, Adib Behrouzi, John A Olschowka, Kerry M ObanionAbstract:Chronic neuroinflammation has long been hypothesized to be involved in Alzheimer's Disease (AD) progression. Previous research suggests that both anti-inflammatory and inflammatory microglia ameliorate amyloid pathology, but the latter worsen tau pathology. In this study, we sought to determine whether induction of arginase-1 positive microglia with the anti-inflammatory cytokine IL-4 modulates pathology in the 3XTg Mouse model of AD. Our findings indicate that a single intracranial IL-4 injection positively modulated performance of 3XTg AD mice in a Novel Object Recognition task, and locally increased the levels of arginase-1 positive myeloid cells when assessed one-week post injection. Furthermore, immunohistochemical analysis revealed decreased tau phosphorylation in IL-4 injected animals; however, we were not able to detect significant changes in tau phosphorylation utilizing Western blot. Lastly, IL-4 injection did not appear to cause significant changes in amyloid β load. In conclusion, acute intracranial IL-4 led to some positive benefits in the 3XTg Mouse model of AD. Although more work remains, these results support therapeutic strategies aimed at modifying microglial activation states in neurodegenerative diseases.
Mustafa F Alkhouli - One of the best experts on this subject based on the ideXlab platform.
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beneficial effects of resveratrol and exercise training on cardiac and aortic function and structure in the 3XTg Mouse model of alzheimer s disease
Drug Design Development and Therapy, 2019Co-Authors: Mitra Esfandiarei, Brikena Hoxha, Nicholas A Talley, Miranda Anderson, Mustafa F Alkhouli, Michaela Squire, Delrae M Eckman, Jeganathan Ramesh Babu, Gary D Lopaschuk, Tom L BroderickAbstract:Background: Studies have indicated an association between Alzheimer's disease (AD) and increased risk of developing cardiovascular complications. Lifestyle modifiable factors, such as exercise and diet, are known to prevent cardio-cerebral disease. Recent studies demonstrate that hearts from early onset triple-transgenic AD mice exhibit pathologies, but it is not clear whether cardiovascular function is altered in this model. Methods: In this study, we measured in vivo cardiovascular function in 7-month-old male 3XTg mice and age-matched wild-type (WT) mice using high-frequency high-resolution ultrasound imaging. Results: Our findings indicated that aortic root measurements and interventricular septal dimensions were similar in 3XTg and wild-type mice. Systolic function, expressed as ejection fraction and fractional shortening, were decreased in 3XTg mice. Late (A) ventricular filling velocities, the early/atrial (E/A) ratio, and mitral valve deceleration time, all indices of diastolic function, were increased in 3XTg mice compared to WT mice. Treadmill exercise training and resveratrol supplementation in the diet for 5 months improved ejection fraction, fractional shortening, and restored diastolic deceleration times. Pulse wave velocity was ~33% higher in 3XTg, and accompanied by a significant increase in elastin fiber fragmentation within the aortic wall, which was associated with decrease in elastin content and fiber length. Aortic wall and adventitia thickness were increased in 3XTg mice compared to the WT group. Exercise training and resveratrol supplementation, or both, improved overall aortic morphology with no change in pulse wave velocity. Conclusion: Taken together, the results indicate that the aberrations in cardiac function and aortic elastin morphology observed in the 3XTg Mouse model of AD can be prevented with exercise training and treatment with resveratrol. The benefits of regular exercise training and resveratrol supplementation of heart and aortic structure in the 3XTg Mouse support the value of healthy lifestyle factors on cardiovascular health.
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exercise and resveratrol increase fracture resistance in the 3XTg ad Mouse model of alzheimer s disease
BMC Complementary and Alternative Medicine, 2019Co-Authors: Mustafa F Alkhouli, Miranda Anderson, Michaela Squire, Jeganathan Ramesh Babu, Tom L Broderick, Jun Hung, Monica Castro, Layla Alnakkash, Jeffrey H PlochockiAbstract:Alzheimer’s disease (AD) and osteoporosis are progressive diseases that affect the elderly population. Both conditions are associated with fracture risk that is greater than twice that of the healthy population. Resveratrol and exercise are two treatments that have been linked with attenuation of age-related diseases, including the risk of bone fractures. In this study, we test the hypothesis that these treatments improve fracture resistance in a Mouse model representative of the AD condition. Three-month-old male 3XTg-AD mice were treated for 4 months with resveratrol or exercise or both combined, and compared with wild type mice. Exercise training was performed on a treadmill at 15 m/min for 45 min/day, 5 days/week. Resveratrol was given at 4 g/kg diet in the form of pellets. Three-point bending, cross-sectional geometric, and fluorescence analyses were conducted on tibias and compared by treatment group. Tibias of 3XTg mice exhibited signs of diminished bone quality and fracture under less force than age-matched wild type mice (P < 0.05). Treatment with both resveratrol and exercise improved indicators of fracture resistance and bone quality in AD mice to levels comparable to that of wild type mice (P < 0.05). The 3XTg Mouse model of AD is at elevated risk for limb bone fracture compared to wild type controls. Treatment with resveratrol, exercise, or both in combination improves fracture resistance and cross-sectional geometric indicators of bone strength.
Jeganathan Ramesh Babu - One of the best experts on this subject based on the ideXlab platform.
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beneficial effects of resveratrol and exercise training on cardiac and aortic function and structure in the 3XTg Mouse model of alzheimer s disease
Drug Design Development and Therapy, 2019Co-Authors: Mitra Esfandiarei, Brikena Hoxha, Nicholas A Talley, Miranda Anderson, Mustafa F Alkhouli, Michaela Squire, Delrae M Eckman, Jeganathan Ramesh Babu, Gary D Lopaschuk, Tom L BroderickAbstract:Background: Studies have indicated an association between Alzheimer's disease (AD) and increased risk of developing cardiovascular complications. Lifestyle modifiable factors, such as exercise and diet, are known to prevent cardio-cerebral disease. Recent studies demonstrate that hearts from early onset triple-transgenic AD mice exhibit pathologies, but it is not clear whether cardiovascular function is altered in this model. Methods: In this study, we measured in vivo cardiovascular function in 7-month-old male 3XTg mice and age-matched wild-type (WT) mice using high-frequency high-resolution ultrasound imaging. Results: Our findings indicated that aortic root measurements and interventricular septal dimensions were similar in 3XTg and wild-type mice. Systolic function, expressed as ejection fraction and fractional shortening, were decreased in 3XTg mice. Late (A) ventricular filling velocities, the early/atrial (E/A) ratio, and mitral valve deceleration time, all indices of diastolic function, were increased in 3XTg mice compared to WT mice. Treadmill exercise training and resveratrol supplementation in the diet for 5 months improved ejection fraction, fractional shortening, and restored diastolic deceleration times. Pulse wave velocity was ~33% higher in 3XTg, and accompanied by a significant increase in elastin fiber fragmentation within the aortic wall, which was associated with decrease in elastin content and fiber length. Aortic wall and adventitia thickness were increased in 3XTg mice compared to the WT group. Exercise training and resveratrol supplementation, or both, improved overall aortic morphology with no change in pulse wave velocity. Conclusion: Taken together, the results indicate that the aberrations in cardiac function and aortic elastin morphology observed in the 3XTg Mouse model of AD can be prevented with exercise training and treatment with resveratrol. The benefits of regular exercise training and resveratrol supplementation of heart and aortic structure in the 3XTg Mouse support the value of healthy lifestyle factors on cardiovascular health.
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exercise and resveratrol increase fracture resistance in the 3XTg ad Mouse model of alzheimer s disease
BMC Complementary and Alternative Medicine, 2019Co-Authors: Mustafa F Alkhouli, Miranda Anderson, Michaela Squire, Jeganathan Ramesh Babu, Tom L Broderick, Jun Hung, Monica Castro, Layla Alnakkash, Jeffrey H PlochockiAbstract:Alzheimer’s disease (AD) and osteoporosis are progressive diseases that affect the elderly population. Both conditions are associated with fracture risk that is greater than twice that of the healthy population. Resveratrol and exercise are two treatments that have been linked with attenuation of age-related diseases, including the risk of bone fractures. In this study, we test the hypothesis that these treatments improve fracture resistance in a Mouse model representative of the AD condition. Three-month-old male 3XTg-AD mice were treated for 4 months with resveratrol or exercise or both combined, and compared with wild type mice. Exercise training was performed on a treadmill at 15 m/min for 45 min/day, 5 days/week. Resveratrol was given at 4 g/kg diet in the form of pellets. Three-point bending, cross-sectional geometric, and fluorescence analyses were conducted on tibias and compared by treatment group. Tibias of 3XTg mice exhibited signs of diminished bone quality and fracture under less force than age-matched wild type mice (P < 0.05). Treatment with both resveratrol and exercise improved indicators of fracture resistance and bone quality in AD mice to levels comparable to that of wild type mice (P < 0.05). The 3XTg Mouse model of AD is at elevated risk for limb bone fracture compared to wild type controls. Treatment with resveratrol, exercise, or both in combination improves fracture resistance and cross-sectional geometric indicators of bone strength.
Michaela Squire - One of the best experts on this subject based on the ideXlab platform.
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beneficial effects of resveratrol and exercise training on cardiac and aortic function and structure in the 3XTg Mouse model of alzheimer s disease
Drug Design Development and Therapy, 2019Co-Authors: Mitra Esfandiarei, Brikena Hoxha, Nicholas A Talley, Miranda Anderson, Mustafa F Alkhouli, Michaela Squire, Delrae M Eckman, Jeganathan Ramesh Babu, Gary D Lopaschuk, Tom L BroderickAbstract:Background: Studies have indicated an association between Alzheimer's disease (AD) and increased risk of developing cardiovascular complications. Lifestyle modifiable factors, such as exercise and diet, are known to prevent cardio-cerebral disease. Recent studies demonstrate that hearts from early onset triple-transgenic AD mice exhibit pathologies, but it is not clear whether cardiovascular function is altered in this model. Methods: In this study, we measured in vivo cardiovascular function in 7-month-old male 3XTg mice and age-matched wild-type (WT) mice using high-frequency high-resolution ultrasound imaging. Results: Our findings indicated that aortic root measurements and interventricular septal dimensions were similar in 3XTg and wild-type mice. Systolic function, expressed as ejection fraction and fractional shortening, were decreased in 3XTg mice. Late (A) ventricular filling velocities, the early/atrial (E/A) ratio, and mitral valve deceleration time, all indices of diastolic function, were increased in 3XTg mice compared to WT mice. Treadmill exercise training and resveratrol supplementation in the diet for 5 months improved ejection fraction, fractional shortening, and restored diastolic deceleration times. Pulse wave velocity was ~33% higher in 3XTg, and accompanied by a significant increase in elastin fiber fragmentation within the aortic wall, which was associated with decrease in elastin content and fiber length. Aortic wall and adventitia thickness were increased in 3XTg mice compared to the WT group. Exercise training and resveratrol supplementation, or both, improved overall aortic morphology with no change in pulse wave velocity. Conclusion: Taken together, the results indicate that the aberrations in cardiac function and aortic elastin morphology observed in the 3XTg Mouse model of AD can be prevented with exercise training and treatment with resveratrol. The benefits of regular exercise training and resveratrol supplementation of heart and aortic structure in the 3XTg Mouse support the value of healthy lifestyle factors on cardiovascular health.
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exercise and resveratrol increase fracture resistance in the 3XTg ad Mouse model of alzheimer s disease
BMC Complementary and Alternative Medicine, 2019Co-Authors: Mustafa F Alkhouli, Miranda Anderson, Michaela Squire, Jeganathan Ramesh Babu, Tom L Broderick, Jun Hung, Monica Castro, Layla Alnakkash, Jeffrey H PlochockiAbstract:Alzheimer’s disease (AD) and osteoporosis are progressive diseases that affect the elderly population. Both conditions are associated with fracture risk that is greater than twice that of the healthy population. Resveratrol and exercise are two treatments that have been linked with attenuation of age-related diseases, including the risk of bone fractures. In this study, we test the hypothesis that these treatments improve fracture resistance in a Mouse model representative of the AD condition. Three-month-old male 3XTg-AD mice were treated for 4 months with resveratrol or exercise or both combined, and compared with wild type mice. Exercise training was performed on a treadmill at 15 m/min for 45 min/day, 5 days/week. Resveratrol was given at 4 g/kg diet in the form of pellets. Three-point bending, cross-sectional geometric, and fluorescence analyses were conducted on tibias and compared by treatment group. Tibias of 3XTg mice exhibited signs of diminished bone quality and fracture under less force than age-matched wild type mice (P < 0.05). Treatment with both resveratrol and exercise improved indicators of fracture resistance and bone quality in AD mice to levels comparable to that of wild type mice (P < 0.05). The 3XTg Mouse model of AD is at elevated risk for limb bone fracture compared to wild type controls. Treatment with resveratrol, exercise, or both in combination improves fracture resistance and cross-sectional geometric indicators of bone strength.
