The Experts below are selected from a list of 111 Experts worldwide ranked by ideXlab platform
Matthias Tacke - One of the best experts on this subject based on the ideXlab platform.
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diarylmethyl substituted titanocenes promising anti cancer drugs
Polyhedron, 2006Co-Authors: Clara Pampillón, Katja Strohfeldt, Nigel J. Sweeney, Oscar Mendoza, Matthias TackeAbstract:Abstract From the reaction of tert-butyl lithium with p-bromo-N,N-dimethylaniline (1a), p-bromoanisole (1b) or 1-bromo-3,5-dimethoxybenzene (1c), p-N,N-dimethylanilyl lithium (2a), p-anisyl lithium (2b) or (3,5-dimethoxyphenyl) lithium (2c), respectively, were obtained. When reacted with 6-(p-N,N-dimethylanilinyl)fulvene (3a), 6-(p-methoxyphenyl)fulvene (3b) or 3,5-(dimethoxyphenyl)fulvene (3c), the corresponding lithiated intermediates were formed (4a–c). Titanium tetrachloride was added “in situ”, obtaining titanocenes 5a–c, respectively. When these titanocenes were tested against pig kidney carcinoma (LLC-PK) cells, inhibitory concentrations (IC50) of 3.8 × 10−5 M, 4.5 × 10−5 M, and 7.8 × 10−5 M, respectively, were observed. These values represent improved cytotoxicity against LLC-PK, compared to their ansa-analogues.
Clara Pampillón - One of the best experts on this subject based on the ideXlab platform.
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diarylmethyl substituted titanocenes promising anti cancer drugs
Polyhedron, 2006Co-Authors: Clara Pampillón, Katja Strohfeldt, Nigel J. Sweeney, Oscar Mendoza, Matthias TackeAbstract:Abstract From the reaction of tert-butyl lithium with p-bromo-N,N-dimethylaniline (1a), p-bromoanisole (1b) or 1-bromo-3,5-dimethoxybenzene (1c), p-N,N-dimethylanilyl lithium (2a), p-anisyl lithium (2b) or (3,5-dimethoxyphenyl) lithium (2c), respectively, were obtained. When reacted with 6-(p-N,N-dimethylanilinyl)fulvene (3a), 6-(p-methoxyphenyl)fulvene (3b) or 3,5-(dimethoxyphenyl)fulvene (3c), the corresponding lithiated intermediates were formed (4a–c). Titanium tetrachloride was added “in situ”, obtaining titanocenes 5a–c, respectively. When these titanocenes were tested against pig kidney carcinoma (LLC-PK) cells, inhibitory concentrations (IC50) of 3.8 × 10−5 M, 4.5 × 10−5 M, and 7.8 × 10−5 M, respectively, were observed. These values represent improved cytotoxicity against LLC-PK, compared to their ansa-analogues.
Katja Strohfeldt - One of the best experts on this subject based on the ideXlab platform.
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diarylmethyl substituted titanocenes promising anti cancer drugs
Polyhedron, 2006Co-Authors: Clara Pampillón, Katja Strohfeldt, Nigel J. Sweeney, Oscar Mendoza, Matthias TackeAbstract:Abstract From the reaction of tert-butyl lithium with p-bromo-N,N-dimethylaniline (1a), p-bromoanisole (1b) or 1-bromo-3,5-dimethoxybenzene (1c), p-N,N-dimethylanilyl lithium (2a), p-anisyl lithium (2b) or (3,5-dimethoxyphenyl) lithium (2c), respectively, were obtained. When reacted with 6-(p-N,N-dimethylanilinyl)fulvene (3a), 6-(p-methoxyphenyl)fulvene (3b) or 3,5-(dimethoxyphenyl)fulvene (3c), the corresponding lithiated intermediates were formed (4a–c). Titanium tetrachloride was added “in situ”, obtaining titanocenes 5a–c, respectively. When these titanocenes were tested against pig kidney carcinoma (LLC-PK) cells, inhibitory concentrations (IC50) of 3.8 × 10−5 M, 4.5 × 10−5 M, and 7.8 × 10−5 M, respectively, were observed. These values represent improved cytotoxicity against LLC-PK, compared to their ansa-analogues.
Oscar Mendoza - One of the best experts on this subject based on the ideXlab platform.
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diarylmethyl substituted titanocenes promising anti cancer drugs
Polyhedron, 2006Co-Authors: Clara Pampillón, Katja Strohfeldt, Nigel J. Sweeney, Oscar Mendoza, Matthias TackeAbstract:Abstract From the reaction of tert-butyl lithium with p-bromo-N,N-dimethylaniline (1a), p-bromoanisole (1b) or 1-bromo-3,5-dimethoxybenzene (1c), p-N,N-dimethylanilyl lithium (2a), p-anisyl lithium (2b) or (3,5-dimethoxyphenyl) lithium (2c), respectively, were obtained. When reacted with 6-(p-N,N-dimethylanilinyl)fulvene (3a), 6-(p-methoxyphenyl)fulvene (3b) or 3,5-(dimethoxyphenyl)fulvene (3c), the corresponding lithiated intermediates were formed (4a–c). Titanium tetrachloride was added “in situ”, obtaining titanocenes 5a–c, respectively. When these titanocenes were tested against pig kidney carcinoma (LLC-PK) cells, inhibitory concentrations (IC50) of 3.8 × 10−5 M, 4.5 × 10−5 M, and 7.8 × 10−5 M, respectively, were observed. These values represent improved cytotoxicity against LLC-PK, compared to their ansa-analogues.
Nigel J. Sweeney - One of the best experts on this subject based on the ideXlab platform.
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diarylmethyl substituted titanocenes promising anti cancer drugs
Polyhedron, 2006Co-Authors: Clara Pampillón, Katja Strohfeldt, Nigel J. Sweeney, Oscar Mendoza, Matthias TackeAbstract:Abstract From the reaction of tert-butyl lithium with p-bromo-N,N-dimethylaniline (1a), p-bromoanisole (1b) or 1-bromo-3,5-dimethoxybenzene (1c), p-N,N-dimethylanilyl lithium (2a), p-anisyl lithium (2b) or (3,5-dimethoxyphenyl) lithium (2c), respectively, were obtained. When reacted with 6-(p-N,N-dimethylanilinyl)fulvene (3a), 6-(p-methoxyphenyl)fulvene (3b) or 3,5-(dimethoxyphenyl)fulvene (3c), the corresponding lithiated intermediates were formed (4a–c). Titanium tetrachloride was added “in situ”, obtaining titanocenes 5a–c, respectively. When these titanocenes were tested against pig kidney carcinoma (LLC-PK) cells, inhibitory concentrations (IC50) of 3.8 × 10−5 M, 4.5 × 10−5 M, and 7.8 × 10−5 M, respectively, were observed. These values represent improved cytotoxicity against LLC-PK, compared to their ansa-analogues.
