4-Nitroquinoline 1-Oxide

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Qingyi Wei - One of the best experts on this subject based on the ideXlab platform.

Siddavaram Nagini - One of the best experts on this subject based on the ideXlab platform.

  • Prevention of 4-Nitroquinoline 1-Oxide-induced rat tongue carcinogenesis by garlic.
    Fitoterapia, 2001
    Co-Authors: Seetharaman Balasenthil, C. R. Ramachandran, Siddavaram Nagini
    Abstract:

    The present study was undertaken to examine the inhibitory effect of garlic (Allium sativum) on 4-Nitroquinoline 1-Oxide (4NQO)-induced tongue carcinogenesis in male rats, both in the initiation and post-initiation phases. Lipid peroxidation, reduced glutathione (GSH), glutathione peroxidase (GPx), and glutathione S-transferase (GST) were used to monitor the chemopreventive potential of garlic. Biochemical estimations were carried out on tumour and normal tongue tissues. Diminished lipid peroxidation in the tumour tissue was accompanied by a significant increase in the levels of GSH, GPx and GST. Administration of garlic (250 mg/kg, p.o., three times a week) effectively suppressed 4NQO-induced tongue carcinogenesis as revealed by the absence of carcinomas in the initiation phase and their reduced incidence in the post-initiation phase. The results of the present study suggest that garlic may exert its chemopreventive effects by modulating lipid peroxidation and enhancing the levels of GSH, GPx and GST.

  • Garlic exerts hepatoprotective effects during 4-Nitroquinoline 1-Oxide-induced oral carcinogenesis in rats.
    Asia Pacific journal of clinical nutrition, 2000
    Co-Authors: Seetharaman Balasenthil, Siddavaram Nagini
    Abstract:

    The modifying effects of garlic (Allium sativum Linn.) on hepatic lipid peroxidation and antioxidant status during 4-Nitroquinoline 1-Oxide (4NQO)-induced oral carcinogenesis were investigated in male Wistar rats. Enhanced lipid peroxidation in the liver of tumour-bearing animals was accompanied by significant decreases in the activities of glutathione peroxidase (GPx), glutathione S-transferase (GST) and reduced glutathione (GSH) levels. Administration of aqueous garlic extract significantly lowered lipid peroxidation and enhanced the levels of hepatic antioxidants and detoxifying enzymes. The results of the present study suggest that garlic exerts its hepatoprotective effects by influencing hepatic biotransformation enzymes and antioxidants.

  • Biomonitoring the Chemopreventive Potential of the Plant Products Neem and Turmeric in 4-Nitroquinoline 1-Oxide-Induced Oral Carcinogenesis
    Journal of Clinical Biochemistry and Nutrition, 1997
    Co-Authors: Siddavaram Nagini, Shanmugham Manoharan
    Abstract:

    The modifying effects of the plant products neem and turmeric during the pre-initiation and post-initiation phases of oral carcinogenesis induced by 4-Nitroquinoline 1-Oxide were investigated in male Wistar rats. The chemopreventive potential of these plant products was biomonitored by measurement of lipid peroxidation and antioxidant status in the host liver and circulation of tumor-bearing animals. Both neem and turmeric significantly decreased the formation of lipid peroxides and enhanced the levels of enzymic and non-enzymic antioxidants in the pre-initiation as well as post-initiation phases. We speculate that the anticarcinogenic effect of these plant products is partly related to their antioxidant functions.

  • Inhibition of 4-Nitroquinoline-1-Oxide-induced oral carcinogenesis by plant products
    Journal of Clinical Biochemistry and Nutrition, 1996
    Co-Authors: Shanmugam Manoharan, C. Rajamani Ramachandran, Vemban Ramachandran, Siddavaram Nagini
    Abstract:

    The modifying effects of naturally occurring plant products such as neem leaf and turmeric extracts on 4-Nitroquinoline-1-Oxide (4NQO)-induced oral carcinoma were investigated in male Wistar strain rats. All the animals painted with 4NQO on their cheek mucosa for 20 weeks developed oral neoplasms identified histologically as squamous cell carcinoma. The oral tumor tissue showed a decrease in lipid peroxidation with concomitant changes in antioxidant activity. In groups of animals painted with 4NQO and simultaneous oral administration of neem leaf and turmeric extract, respectively, no tumors were observed; and the lipid peroxidation and antioxidant levels showed a pattern similar to that of untreated controls. Thus, the anticarcinogenic effect of neem leaf and turmeric extract appears to be related to their antioxidant function. We envisage that measurement of lipid peroxidation and antioxidant status with histological changes could be used to biomonitor tumor progression and evaluate the therapeutic response.

Li E Wang - One of the best experts on this subject based on the ideXlab platform.

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Related terms

  • oxide induced oral squamous
  • oxide induced oral carcinogenesis
  • oxide induced mutagen sensitivity
  • nitroquinoline 1 oxide induced
  • nitroquinoline 1 oxide 4
  • 1 oxide induced tongue
  • 1 oxide induced oral
  • 1 oxide induced mutagen
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