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5-Methyltetrahydrofolate

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Nicolle Breusing – One of the best experts on this subject based on the ideXlab platform.

  • 5-Methyltetrahydrofolate and thiamine diphosphate in cord-blood erythrocytes of preterm versus term newborns
    European Journal of Clinical Nutrition, 2013
    Co-Authors: Daniela Weber, Wolfgang Stuetz, Wolfgang Bernhard, M Raith, Tilman Grune, A Franz, Nicolle Breusing

    Abstract:

    Background/objectives: A low folate or low thiamine status may be associated with the risk of preterm delivery, small for gestational age (SGA) offspring and adverse pregnancy outcomes. Subjects/methods: 5-Methyltetrahydrofolate (5MTHF) and thiamine diphosphate (TDP) were measured directly in cord-blood erythrocytes (CBEs) of early preterm ( n =26;

  • 5-Methyltetrahydrofolate and thiamine diphosphate in cord-blood erythrocytes of preterm versus term newborns.
    European Journal of Clinical Nutrition, 2013
    Co-Authors: Daniela Weber, Wolfgang Stuetz, Wolfgang Bernhard, Axel R. Franz, M Raith, Tilman Grune, Nicolle Breusing

    Abstract:

    5-Methyltetrahydrofolate and thiamine diphosphate in cord-blood erythrocytes of preterm versus term newborns

Michael Rychlik – One of the best experts on this subject based on the ideXlab platform.

  • Stability of 5-Methyltetrahydrofolate in fortified apple and carrot purées
    LWT, 2019
    Co-Authors: Anna-lena Herbig, Nicolas Delchier, Lisa Striegel, Michael Rychlik, Catherine M.g.c. Renard

    Abstract:

    Abstract 5-Methyltetrahydrofolate, the naturally abundant folate vitamer, has been proposed as an alternative to folic acid for fortification. However, it is less stable than folic acid. In a formate buffer (pH 3.5), folic acid was entirely preserved after heating the solution for 3 h at 80 °C. In contrast, 5-Methyltetrahydrofolate was completely degraded in less than 15 min. As in the buffer, 5-Methyltetrahydrofolate in apple or carrot purees degraded rapidly without the addition of ascorbic acid. By adding ascorbic acid, the stability could be increased, but the chosen amount was crucial. An excess of vitamin C compared to 5-Methyltetrahydrofolate was not always sufficient for the complete protection of 5-Methyltetrahydrofolate during 3 h at 80 °C. Only by adding 2840 μmol/kg of ascorbic acid (equivalent to 500 mg/kg), 5-Methyltetrahydrofolate seemed to remain stable. Degradation started after approximately 60 min when 570 μmol/kg of ascorbic acid (equivalent to 100 mg/kg) were added; after 120 min with 1420 μmol/kg (equivalent to 250 mg/kg). In addition, a temperature decrease to 70 °C or 60 °C did not increase the stability of 5-Methyltetrahydrofolate.

  • Stability of 5-Methyltetrahydrofolate in fortified apple and carrot purées
    LWT – Food Science and Technology, 2019
    Co-Authors: Anna-lena Herbig, Nicolas Delchier, Lisa Striegel, Michael Rychlik, Catherine Renard

    Abstract:

    5-Methyltetrahydrofolate, the naturally abundant folate vitamer, has been proposed as an alternative to folic acid for fortification. However, it is less stable than folic acid. In a formate buffer (pH 3.5), folic acid was entirely preserved after heating the solution for 3 h at 80 °C. In contrast, 5-Methyltetrahydrofolate was completely degraded in less than 15 min. As in the buffer, 5-Methyltetrahydrofolate in apple or carrot purées degraded rapidly without the addition of ascorbic acid. By adding ascorbic acid, the stability could be increased, but the chosen amount was crucial. An excess of vitamin C compared to 5-Methyltetrahydrofolate was not always sufficient for the complete protection of 5-Methyltetrahydrofolate during 3 h at 80 °C. Only by adding 2840 μmol/kg of ascorbic acid (equivalent to 500 mg/kg), 5-Methyltetrahydrofolate seemed to remain stable. Degradation started after approximately 60 min when 570 μmol/kg of ascorbic acid (equivalent to 100 mg/kg) were added; after 120 min with 1420 μmol/kg (equivalent to 250 mg/kg). In addition, a temperature decrease to 70 °C or 60 °C did not increase the stability of 5-Methyltetrahydrofolate.

  • Study design.
    , 2019
    Co-Authors: Lisa Striegel, Beate Brandl, Markus Kopp, Lukas Sam, Thomas Skurk, Michael Rychlik

    Abstract:

    Overview of the timeline and the different blood sampling time points for one of the three interventions. Details are described in the text. 5-CH3-H4folate, 5-Methyltetrahydrofolate; STD, standardized.

Daniela Weber – One of the best experts on this subject based on the ideXlab platform.

  • 5-Methyltetrahydrofolate and thiamine diphosphate in cord-blood erythrocytes of preterm versus term newborns
    European Journal of Clinical Nutrition, 2013
    Co-Authors: Daniela Weber, Wolfgang Stuetz, Wolfgang Bernhard, M Raith, Tilman Grune, A Franz, Nicolle Breusing

    Abstract:

    Background/objectives: A low folate or low thiamine status may be associated with the risk of preterm delivery, small for gestational age (SGA) offspring and adverse pregnancy outcomes. Subjects/methods: 5-Methyltetrahydrofolate (5MTHF) and thiamine diphosphate (TDP) were measured directly in cord-blood erythrocytes (CBEs) of early preterm ( n =26;

  • 5-Methyltetrahydrofolate and thiamine diphosphate in cord-blood erythrocytes of preterm versus term newborns.
    European Journal of Clinical Nutrition, 2013
    Co-Authors: Daniela Weber, Wolfgang Stuetz, Wolfgang Bernhard, Axel R. Franz, M Raith, Tilman Grune, Nicolle Breusing

    Abstract:

    5-Methyltetrahydrofolate and thiamine diphosphate in cord-blood erythrocytes of preterm versus term newborns