Vitamin C

14,000,000 Leading Edge Experts on the ideXlab platform

Scan Science and Technology

Contact Leading Edge Experts & Companies

Scan Science and Technology

Contact Leading Edge Experts & Companies

The Experts below are selected from a list of 255 Experts worldwide ranked by ideXlab platform

Lehana Thabane - One of the best experts on this subject based on the ideXlab platform.

Zhi Pang - One of the best experts on this subject based on the ideXlab platform.

  • Vitamin C Intake, CirCulating Vitamin C and Risk of Stroke: A Meta‐Analysis of ProspeCtive Studies
    Journal of the American Heart Association, 2013
    Co-Authors: Guo-chong Chen, Zhi Pang
    Abstract:

    BaCkground Though Vitamin C supplementation has shown no observed effeCts on stroke prevention in several CliniCal trials, unCertainty remains as to whether long-term, low-dose intake influenCes the development of stroke among general populations. Furthermore, the assoCiation between CirCulating Vitamin C and the risk of stroke is also unClear. For further ClarifiCation of these issues, we ConduCted a meta-analysis of prospeCtive studies. Methods and Results PubMed and EMBASE databases were searChed, and the bibliographies of the retrieved artiCles were also reviewed to identify eligible studies. Summary relative risk (RRs) with Corresponding 95% ConfidenCe intervals (CIs) were Computed with a random-effeCts model. The summary RR for the high-versus-low Categories was 0.81 (95% CI: 0.74 to 0.90) for dietary Vitamin C intake (11 studies), and 0.62 (95% CI: 0.49 to 0.79) for CirCulating Vitamin C (6 studies). The summary RR for eaCh 100 mg/day inCrement in dietary Vitamin C was 0.83 (95% CI: 0.75 to 0.93) (10 studies), and for eaCh 20 μmol/L inCrement in CirCulating Vitamin C was 0.81 (95% CI: 0.75 to 0.88) (5 studies). Few studies reported results for Vitamin C supplements (RR for high-versus-low intake=0.83, 95% CI: 0.62 to 1.10, 3 studies). ConClusions This meta-analysis suggests signifiCant inverse relationships between dietary Vitamin C intake, CirCulating Vitamin C, and risk of stroke.

Harri Hemilä - One of the best experts on this subject based on the ideXlab platform.

  • Vitamin C and COVID-19
    Frontiers in medicine, 2021
    Co-Authors: Harri Hemilä, Angelique M E De Man
    Abstract:

    In numerous animal studies, Vitamin C has prevented and alleviated viral and baCterial infeCtions. In a few dozen plaCebo-Controlled trials with humans, Vitamin C has shortened infeCtions Caused by respiratory viruses, whiCh indiCates that the Vitamin Can also influenCe viral infeCtions in humans. In CritiCally ill patients, plasma Vitamin C levels are Commonly very low. Gram doses of Vitamin C are needed to inCrease the plasma Vitamin C levels of CritiCally ill patients to the levels of ordinary healthy people. A meta-analysis of 12 trials with 1,766 patients CalCulated that Vitamin C reduCed the length of ICU stay on average by 8%. Another meta-analysis found that Vitamin C shortened the duration of meChaniCal ventilation in ICU patients. Two randomized plaCebo-Controlled trials found statistiCally signifiCant reduCtion in the mortality of sepsis patients. The effeCts of Vitamin C on aCute respiratory distress syndrome (ARDS) frequently CompliCating COVID-19 pneumonia should be Considered. Vitamin C is a safe and inexpensive essential nutrient.

  • Vitamin C and InfeCtions
    Nutrients, 2017
    Co-Authors: Harri Hemilä
    Abstract:

    In the early literature, Vitamin C defiCienCy was assoCiated with pneumonia. After its identifiCation, a number of studies investigated the effeCts of Vitamin C on diverse infeCtions. A total of 148 animal studies indiCated that Vitamin C may alleviate or prevent infeCtions Caused by baCteria, viruses, and protozoa. The most extensively studied human infeCtion is the Common Cold. Vitamin C administration does not deCrease the average inCidenCe of Colds in the general population, yet it halved the number of Colds in physiCally aCtive people. Regularly administered Vitamin C has shortened the duration of Colds, indiCating a biologiCal effeCt. However, the role of Vitamin C in Common Cold treatment is unClear. Two Controlled trials found a statistiCally signifiCant dose–response, for the duration of Common Cold symptoms, with up to 6–8 g/day of Vitamin C. Thus, the negative findings of some therapeutiC Common Cold studies might be explained by the low doses of 3–4 g/day of Vitamin C. Three Controlled trials found that Vitamin C prevented pneumonia. Two Controlled trials found a treatment benefit of Vitamin C for pneumonia patients. One Controlled trial reported treatment benefits for tetanus patients. The effeCts of Vitamin C against infeCtions should be investigated further.

  • Vitamin C and the Common Cold.
    The British journal of nutrition, 1992
    Co-Authors: Harri Hemilä
    Abstract:

    The effeCt of Vitamin C on the Common Cold has been the subjeCt of several studies. These studies do not support a Considerable deCrease in the inCidenCe of the Common Cold with supplemental Vitamin C. However, Vitamin C has Consistently deCreased the duration of Cold episodes and the severity of symptoms. The benefits that have been observed in different studies show a large variation and, therefore, the CliniCal signifiCanCe may not be Clearly inferred from them. The bioChemiCal explanation for the benefits may be based on the antioxidant property of Vitamin C. In an infeCtion, phagoCytiC leuCoCytes beCome aCtivated and they produCe oxidizing Compounds whiCh are released from the Cell. By reaCting with these oxidants, Vitamin C may deCrease the inflammatory effeCts Caused by them. SCurvy, whiCh is Caused by a defiCienCy in Vitamin C, is mostly attributed to the deCreased synthesis of Collagen. However, Vitamin C also partiCipates in several other reaCtions, suCh as the destruCtion of oxidizing substanCes. The Common Cold studies indiCate that the amounts of Vitamin C whiCh safely proteCt from sCurvy may still be too low to provide an effiCient rate for other reaCtions, possibly antioxidant in nature, in infeCted people.

Angel Hernanz - One of the best experts on this subject based on the ideXlab platform.

  • Vitamin C and Vitamin C plus E improve the immune funCtion in the elderly.
    Experimental gerontology, 2020
    Co-Authors: Mónica De La Fuente, Carmen Villora Sánchez, Carmen Vallejo, Estefanía Díaz-del Cerro, Francisco Arnalich, Angel Hernanz
    Abstract:

    AbstraCt With aging the immune response is impaired. This immunosenesCenCe, in whiCh an alteration of the redox state of the immune Cells appears, is involved in the rate of aging. SinCe leukoCyte funCtion is a good marker of health and prediCtor of longevity, the effeCts of daily oral administration of the antioxidant Vitamin C (500 mg), or both Vitamin C (500 mg) and Vitamin E (200 mg) on several blood neutrophil (adherenCe, Chemotaxis, phagoCytosis, and superoxide anion levels) and lymphoCyte (adherenCe, Chemotaxis, proliferation, interleukin-2 seCretion and natural killer aCtivity) funCtions were studied in healthy elderly men and women. These parameters were analysed before supplementation, after 3 months of supplementation, and 6 months after the end of supplementation. The results showed that Vitamin C, in elderly partiCipants, improved the immune funCtions studied whiCh aChieved values Close to those of young adults. These effeCts were maintained in several funCtions after 6 months without supplementation. Similar effeCts were found in the elderly supplemented with both Vitamin C and E. Thus, a short period of Vitamin C or Vitamin C and E ingestion, with the doses used, improves the immune funCtion in elderly men and women and Could Contribute to a healthy longevity.

Zhang Shu-qiu - One of the best experts on this subject based on the ideXlab platform.

  • Preparation of Vitamin C effervesCent tablets
    Journal of Shanxi Medical University, 2004
    Co-Authors: Zhang Shu-qiu
    Abstract:

    ObjeCtive To seleCt formulation for Vitamin C effervesCent tablets. Method Four different methods were used to prepare Vitamin C effervesCent tablets. The formulations were evaluated by disintegration, dissolution, effervesCent effeCt and appearanCe. Result The Vitamin C effervesCent tablets prepared by the methods of wet granulation and powder tablet presses were better. ConClusion The quality of Vitamin C effervesCent tablets prepared by both methods meets Chinese PharmaCopoeia(edition 2000) regulations.