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6 Hydroxymelatonin

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Russel J. Reiter – One of the best experts on this subject based on the ideXlab platform.

  • N-Acetylserotonin and 6Hydroxymelatonin against Oxidative Stress: Implications for the Overall Protection Exerted by Melatonin.
    The journal of physical chemistry. B, 2015
    Co-Authors: Ruslan Álvarez-diduk, Annia Galano, Dun Xian Tan, Russel J. Reiter
    Abstract:

    The protection exerted by N-acetylserotonin (NAS) and 6Hydroxymelatonin (6OHM) against oxidative stress was investigated using the density functional theory. It was found that these compounds are better peroxyl radical scavengers than melatonin itself, Trolox, caffeine, or genistein both in lipid and aqueous solutions. The related kinetic data is provided for the first time. The solvent polarity influences not only the absolute reactivity of NAS and 6OHM toward peroxyl radicals, but also their relative scavenging activity. In addition, they both fully inhibit the oxidative effects of copper-ascorbate mixtures, and •OH production via the Haber–Weiss reaction, albeit the effects on the later are only partial. On the basis of comparisons with other melatonin-related compounds, it is proposed that the role of NAS and 6OHM on the overall protection exerted by melatonin against oxidative stress is mainly related to their free radical scavenging activities. Moreover, they increase such protection. The role of t…

  • N-Acetylserotonin and 6Hydroxymelatonin against Oxidative Stress: Implications for the Overall Protection Exerted by Melatonin B
    The Journal of Physical Chemistry, 2015
    Co-Authors: Ruslan Álvarez-diduk, Annia Galano, Dun Xian Tan, Russel J. Reiter
    Abstract:

    The protection exerted by N-acetylserotonin (NAS) and 6Hydroxymelatonin (6OHM) against oxidative stress was investigated using the density functional theory. It was found that these compounds are better peroxyl radical scavengers than melatonin itself, Trolox, caffeine, or genistein both in lipid and aqueous solutions. The related kinetic data is provided for the first time. The solvent polarity influences not only the absolute reactivity of NAS and 6OHM toward peroxyl radicals, but also their relative scavenging activity. In addition, they both fully inhibit the oxidative effects of copper-ascorbate mixtures, and •OH production via the Haber–Weiss reaction, albeit the effects on the later are only partial. On the basis of comparisons with other melatonin-related compounds, it is proposed that the role of NAS and 6OHM on the overall protection exerted by melatonin against oxidative stress is mainly related to their free radical scavenging activities. Moreover, they increase such protection. The role of the phenol moiety on such activity is demonstrated.

  • Characterization of the protective effects of melatonin and related indoles against α‐naphthylisothiocyanate‐induced liver injury in rats
    Journal of cellular biochemistry, 2001
    Co-Authors: Juan R. Calvo, Russel J. Reiter, Dun Xian Tan, J. J. Garca, Genaro G. Ortiz, Malgorzata Karbownik
    Abstract:

    The protective effect of melatonin, 6Hydroxymelatonin and N-acetylserotonin against α-naphthylisothiocyanate (ANIT)-induced liver injury was investigated and compared in rats injected once with the hepatotoxicant (75 mg/kg body weight). In rats injected with ANIT alone, liver injury with cholestasis developed within 24 h, as indicated by both serum levels of alanine aminotransferase (SGPT) and aspartic acid aminotransferase (SGOT) activities and serum total bilirubin concentration. The administration of melatonin or 6Hydroxymelatonin (10 mg/kg body weight) to ANIT-injected rats reduced significantly the serum levels of both SGPT and SGOT and the serum total bilirubin concentration. For all hepatic biochemical markers, melatonin was more effective that 6Hydroxymelatonin. By comparison, the administration of N-acetylserotonin (10 mg/kg body weight) to ANIT-injected rats did not reduce the serum levels of either hepatic enzymes or the serum total bilirubin concentration. In ANIT-injected rats, hepatic lipid peroxidation (LPO) was significantly higher than in control animals and this increase was significantly reduced by either melatonin, 6Hydroxymelatonin or N-acetylserotonin. Furthermore, ANIT treatment caused a significant reduction in liver microsomal membrane fluidity and this reduction was completely reversed by the three indoles. The liver from ANIT-injected rats showed several histopathological alterations; above all there was an acute infiltration of polymorphonuclear neutrophils and an increase in the number of apparent apoptotic hepatocytes. The concurrent administration of melatonin reduced the severity of all morphological alterations, specially the neutrophil infiltration and the number of presumed apoptotic cells. On the contrary, the administration of 6Hydroxymelatonin or N-acetylserotonin did not provide any protective effect in terms of the histopathological alterations. These results indicate that melatonin protects against ANIT-induced liver injury with cholestasis in rats, and suggests that this protective effect is likely due to its antioxidant properties and above all to its capacity to inhibit liver neutrophil infiltration, a critical factor in the pathogenesis of ANIT-induced liver injury. 6Hydroxymelatonin, although able to provide partial protection against the ANIT-induced hepatic injury, probably through its antioxidant properties by mechanisms that are unclear, was unable to reduce neutrophil infiltration. Finally, N-acetylserotonin in the experimental conditions of this study, only exhibited some antioxidant protection but had no protective effect against ANIT-induced hepatic damage. J. Cell. Biochem. 80:461–470, 2001. © 2001 Wiley-Liss, Inc.

Thomas Remer – One of the best experts on this subject based on the ideXlab platform.

  • Excretion of 6Hydroxymelatonin Sulfate (6-OHMS) in Siblings during Childhood and Adolescence
    Neuroendocrinology, 2003
    Co-Authors: Barbara Griefahn, Peter Bröde, Thomas Remer, Meinolf Blaszkewicz
    Abstract:

    The analysis was performed to support the assumption that in inter-individual variations melatonin production is determined genetically. Sixty-six siblings from 31 families (27 girls, 39 boys, 3–18 ye

  • Melatonin production during childhood and adolescence: a longitudinal study on the excretion of urinary 6Hydroxymelatonin sulfate.
    Journal of pineal research, 2002
    Co-Authors: Barbara Griefahn, Peter Bröde, Meinolf Blaszkewicz, Thomas Remer
    Abstract:

    Cross-sectional data on urinary 6Hydroxymelatonin sulfate (6-OHMS) excretion in children suggest a constant melatonin secretion during growth. The present longitudinal study concerned, accordingly, the intra-individual stability of melatonin production during childhood and adolescence. Urine samples collected during a longitudinal investigation of healthy white children and adolescents were analyzed. Forty-six boys and 38 girls were chosen for the present study. They had passed 3-15 annual examinations between their 3rd and 18th yr of age. Each examination included the collection of urine over 24 hr. The daily urinary output of 6-OHMS of the overall 621 samples was quantified by enzyme-linked immunosorbent assay. The analyses clearly revealed for the first time that, despite huge inter-individual differences, melatonin production remains constant in one and the same individual during childhood and adolescence. Additionally, neither a significant sex difference was observed nor was the 6-OHMS output affected by season. The dramatic decrease of plasma melatonin levels as described in the literature is mainly related to an increase in body size rather than to decreasing pineal secretion.

  • Long-term stability of 6Hydroxymelatonin sulfate in 24-h urine samples stored at −20°C
    Endocrine, 2001
    Co-Authors: Barbara Griefahn, Thomas Remer, Meinolf Blaszkewicz, Peter Bröde
    Abstract:

    The purpose of the present feasibility study was to determine whether the concentration of 6Hydroxymelatonin sulfate (6-OHMS) remains stable in urine samples stored over at least 15 yr. To test this, 117 twenty-four-hour urine samples were analyzed, which were obtained from healthy children ages 8 to 9 yr within the periods of 1985–1987, 1991–1993, and 1997–1999. 6-OHMS concentrations were determined by enzyme-linked immunosorbent assay. The statistical analyses clearly indicate that the concentration of 6-OHMS remains stable for at least 15 yr if the urine is stored at −20°C.

Barbara Griefahn – One of the best experts on this subject based on the ideXlab platform.

  • Excretion of 6Hydroxymelatonin Sulfate (6-OHMS) in Siblings during Childhood and Adolescence
    Neuroendocrinology, 2003
    Co-Authors: Barbara Griefahn, Peter Bröde, Thomas Remer, Meinolf Blaszkewicz
    Abstract:

    The analysis was performed to support the assumption that in inter-individual variations melatonin production is determined genetically. Sixty-six siblings from 31 families (27 girls, 39 boys, 3–18 ye

  • Melatonin production during childhood and adolescence: a longitudinal study on the excretion of urinary 6Hydroxymelatonin sulfate.
    Journal of pineal research, 2002
    Co-Authors: Barbara Griefahn, Peter Bröde, Meinolf Blaszkewicz, Thomas Remer
    Abstract:

    Cross-sectional data on urinary 6Hydroxymelatonin sulfate (6-OHMS) excretion in children suggest a constant melatonin secretion during growth. The present longitudinal study concerned, accordingly, the intra-individual stability of melatonin production during childhood and adolescence. Urine samples collected during a longitudinal investigation of healthy white children and adolescents were analyzed. Forty-six boys and 38 girls were chosen for the present study. They had passed 3-15 annual examinations between their 3rd and 18th yr of age. Each examination included the collection of urine over 24 hr. The daily urinary output of 6-OHMS of the overall 621 samples was quantified by enzyme-linked immunosorbent assay. The analyses clearly revealed for the first time that, despite huge inter-individual differences, melatonin production remains constant in one and the same individual during childhood and adolescence. Additionally, neither a significant sex difference was observed nor was the 6-OHMS output affected by season. The dramatic decrease of plasma melatonin levels as described in the literature is mainly related to an increase in body size rather than to decreasing pineal secretion.

  • Long-term stability of 6Hydroxymelatonin sulfate in 24-h urine samples stored at −20°C
    Endocrine, 2001
    Co-Authors: Barbara Griefahn, Thomas Remer, Meinolf Blaszkewicz, Peter Bröde
    Abstract:

    The purpose of the present feasibility study was to determine whether the concentration of 6Hydroxymelatonin sulfate (6-OHMS) remains stable in urine samples stored over at least 15 yr. To test this, 117 twenty-four-hour urine samples were analyzed, which were obtained from healthy children ages 8 to 9 yr within the periods of 1985–1987, 1991–1993, and 1997–1999. 6-OHMS concentrations were determined by enzyme-linked immunosorbent assay. The statistical analyses clearly indicate that the concentration of 6-OHMS remains stable for at least 15 yr if the urine is stored at −20°C.