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Didier Raoult - One of the best experts on this subject based on the ideXlab platform.

A Morand - One of the best experts on this subject based on the ideXlab platform.

Issei Seyama - One of the best experts on this subject based on the ideXlab platform.

  • effect of Urine ph changed by dietary intervention on uric acid clearance mechanism of ph dependent excretion of urinary uric acid
    Nutrition Journal, 2012
    Co-Authors: Aya Kanbara, Yoshisuke Miura, Hideyuki Hyogo, Kazuaki Chayama, Issei Seyama

    Background The finding reported in a previous paper - alkalization of Urine facilitates uric acid excretion - is contradictory to what one might expect to occur: because food materials for the alkalization of Urine contain fewer pUrine bodies than those for acidification, less uric acid in alkaline Urine should have been excreted than in acid Urine. To make clear what component of uric acid excretion mechanisms is responsible for this unexpected finding, we simultaneously collected data for the concentration of both creatinine and uric acid in serum as well as in Urine, in order to calculate both uric acid and creatinine clearances.

  • Urine alkalization facilitates uric acid excretion
    Nutrition Journal, 2010
    Co-Authors: Aya Kanbara, Masayuki Hakoda, Issei Seyama

    Background: Increase in the incidence of hyperuricemia associated with gout as well as hypertension, renal diseases and cardiovascular diseases has been a public health concern. We examined the possibility of facilitated excretion of uric acid by change in Urine pH by managing food materials. Methods: Within the framework of the Japanese government’s health promotion program, we made recipes which consist of protein-rich and less vegetable-fruit food materials for H + -load (acid diet) and others composed of less protein but vegetable-fruit rich food materials (alkali diet). Healthy female students were enrolled in this consecutive 5-day study for each test. From whole-day collected Urine, total volume, pH, organic acid, creatinine, uric acid and all cations (Na + ,K + ,Ca 2+ ,Mg 2+ ,NH4 + ) and anions (Cl - ,SO4 2- ,PO4 - ) necessary for the estimation of acidbase balance were measured. Results: Urine pH reached a steady state 3 days after switching from ordinary daily diets to specified regimens. The amount of acid generated ([SO4 2- ] +organic acid-gut alkai) were linearly related with those of the excretion of acid (titratable acidity+ [NH4 + ] - [HCO3 - ]), indicating that H + in Urine is generated by the metabolic degradation of food materials. Uric acid and excreted Urine pH retained a linear relationship, where uric acid excretion increased from 302 mg/day at pH 5.9 to 413 mg/day at pH 6.5, despite the fact that the alkali diet contained a smaller pUrine load than the acid diet. Conclusion: We conclude that alkalization of Urine by eating nutritionally well-designed food is effective for removing uric acid from the body.

Matthew D. Collins - One of the best experts on this subject based on the ideXlab platform.

  • Aerococcus urinaehominis sp. nov., isolated from human Urine.
    International Journal of Systematic and Evolutionary Microbiology, 2001
    Co-Authors: Paul A. Lawson, Enevold Falsen, Maria Ohlén, Matthew D. Collins

    Phenotypic and phylogenetic studies were performed on an unknown Gram-positive catalase-negative coccus isolated from human Urine. Comparative 16S rRNA gene sequencing demonstrated that the organism represents a new subline within the genus Aerococcus. The unknown bacterium was readily distinguished from the three currently recognized Aerococcus species, Aerococcus christensenii, Aerococcus urinae and Aerococcus viridans, by biochemical tests and electrophoretic analysis of whole-cell proteins. Based on phylogenetic and phenotypic evidence, it is proposed that the unknown bacterium from Urine be classified as Aerococcus urinaehominis sp. nov. The type strain of Aerococcus urinaehominis is CCUG 42038bT (= CIP 106675T).

Murray K. Clayton - One of the best experts on this subject based on the ideXlab platform.

  • Effect of replacing alfalfa silage with high moisture corn on ruminal protein synthesis estimated from excretion of total pUrine derivatives.
    Journal of Dairy Science, 1999
    Co-Authors: Rilene Ferreira Diniz Valadares, S. C. Valadares Filho, Glen A. Broderick, Murray K. Clayton

    Abstract Twenty-four multiparous dairy cows (eight with ruminal cannulae) were blocked by days in milk and assigned to six balanced 4 x 4 Latin squares with 21-d periods. The four diets, formulated from alfalfa silage plus a concentrate mix based on ground high moisture ear corn, contained (dry matter basis): 1) 20% concentrate, 80% alfalfa silage (24% nonfiber carbohydrate; NFC), 2) 35% concentrate, 65% alfalfa silage (30% NFC), 3) 50% concentrate, 50% alfalfa silage (37% NFC), or 4) 65% concentrate, 35% alfalfa silage (43% NFC). Soybean meal and urea were added to make diets isonitrogenous with equal nonprotein nitrogen (NPN) (43% of total N). Total Urine was collected with indwelling Folley catheters for 24h during each period. There was no effect of diet on urinary creatinine excretion (average 29 mg/kg of BW/d). There were quadratic effects of diet on total urinary ecretion of allantoin, uric acid, and pUrine derivatives (allantoin plus uric acid), and on ruminal synthesis of microbial N estimated from pUrine derivatives; maxima occurred at about 35% dietary NFC. Urinary excretion also was estimated with spot Urine samples from creatinine concentration and the mean daily creatinine excretion. Daily excretion of allantoin, uric acid, and pUrine derivatives estimated from spot Urine sampling followed the same pattern as that observed with total collection; differences between measured and estimated Urine volume were significant only for 35% dietary concentrate. Spot Urine sampling appeared to yield satisfactory estimates of pUrine derivative excretion. Maximal urea N excretion was estimated to occur at about 31% dietary NFC. Milk allantoin secretion increased linearly with concentrate and accounted for 4 to 6% of the total pUrine derivative excretion. Microbial yield was maximal at 35% dietary NFC, suggesting that this was the optimal level for utilization of dietary NPN from alfalfa silage and other sources.

  • Excretion of pUrine derivatives by Holstein cows abomasally infused with incremental amounts of pUrines
    Journal of Dairy Science, 1997
    Co-Authors: David B. Vagnoni, Glen A. Broderick, Murray K. Clayton, R.d. Hatfield

    Five multiparous, ruminally cannulated Holstein cows (two lactating and three dry) weighing ( X ± SD) 667 ± 35 kg were used to study the effect of abomasal pUrine infusion on the excretion of pUrine derivatives. Cows were fed corn silage four times daily at 90% of ad libitum intake ( X = 9.16 kg of dry matter/d). PUrines were infused into the abomasum as brewer’s yeast suspensions in five incremental amounts ( 0 to 380 mmol/d) during five experimental periods according to a 5 × 5 Latin square design. Periods were 7 d; pUrine infusions were conducted during the last 4 d, and Urine was collected during the last 3 d of each period. Ruminal pUrine outflow in all cows was measured during an experimental period immediately preceding and immediately following the five infusion periods and in each cow during the 0-mmol/d infusion period of the experiment. The relationship between total (milk plus Urine) daily excretion of pUrine derivatives (allantoin plus uric acid) and total (abomasal infusion plus ruminal outflow) daily pUrine flow was quantified by linear regression analysis and was described by the relationship: Y = 0.856X + 103 (r 2 = 0.93). The slope (0.856) indicated that 86% of pUrines that reached the omasum were excreted as pUrine derivatives. In the two lactating cows, urinary pUrine derivatives accounted for 98.4% of the total pUrine derivatives that were excreted. Ruminal flow of microbial CP can be estimated from the CP:pUrine ratio of ruminal microorganisms and the excretion of pUrine derivatives.