7?-Hydroxycholesterol

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Wen Guo Jiang - One of the best experts on this subject based on the ideXlab platform.

  • interleukin 7 il 7 and il 7 receptor il 7r signalling complex in human solid tumours
    Histology and Histopathology, 2003
    Co-Authors: M A A Alrawi, R E Mansel, Wen Guo Jiang
    Abstract:

    Interleukin-7 (IL-7) plays an important role in the normal development and maintenance of the human immune system. Its effects are mediated via its receptor, IL-7R. Ligand-receptor engagement results in a cascade of phosphorylation events mediated by various molecules including the Janus kinases (Jak1 and Jak3), PI3-kinase, Stats (signal transducers and activators of transcription) and other molecules. The activation of IL- 7 signalling pathway results in survival, proliferation, differentiation and maturation of haematopoietic cells including B and T lymphocytes. Although the relationship of IL-7 with the development and differentiation of some haematological cancers like leukaemias and lymphomas is well recognised, little is known about it involvement with solid tumours. There are several studies that have revealed IL-7/IL-7R expression in epithelial systems and some human solid epithelial tumours. Furthermore, IL-7 can be produced by some human tumour cells and involved in tumour development and progression. In this review article we have summarised the main biological activities of IL-7 and its downstream signalling complex in relation to some human solid malignancies.

Frank Seela - One of the best experts on this subject based on the ideXlab platform.

M J Maeurer - One of the best experts on this subject based on the ideXlab platform.

  • Interleukin-7 (IL-7) and IL-7 splice variants affect differentiation of human neural progenitor cells
    Genes & Immunity, 2010
    Co-Authors: M Moors, N K Vudattu, J Abel, U Krämer, L Rane, N Ulfig, S Ceccatelli, V Seyfert-margolies, E Fritsche, M J Maeurer
    Abstract:

    Alternative splicing of pre-mRNA increases proteomic diversity, a crucial mechanism in defining tissue identity. We demonstrate differentially spliced interleukin (IL)-7 in distinct anatomic areas in the adult, in developing human brains and in normal human neuronal progenitor (NHNP) cells. IL-7c (c, the canonical form spanning all six exons) or its variants IL-7δ5, δ4 or δ4/5 were cloned and expressed as recombinant proteins. IL-7 and splice variants were able to shift the differentiation of NHNP cells as compared with the diluent control ( P δ4/5>IL-7δ5); IL-7δ4 exhibited a significantly weaker potency. Differentiation was confirmed by transcriptome analysis of IL-7c-stimulated neural NHNP cells, resulting in 58 differentially expressed genes; some of these are involved in neural differentiation, for example, the developmentally regulated transcription factor krüppel-like factor 12, musashi 2, a translational regulator of cell fate or the sonic hedgehog receptor patch 1. This suggests that IL-7 influences neural development at a molecular level by participating in human brain architecture through glia cell formation: a paradigm that alternative splicing in cytokines, for example, for IL-7, has a physiological role in human organ development and progenitor cell differentiation.

Tai-c. Chiang - One of the best experts on this subject based on the ideXlab platform.

  • C60 encapsulation of the Si(111)‐(7×7) surface
    Applied Physics Letters, 1992
    Co-Authors: Hawoong Hong, W. E. Mcmahon, Paul Zschack, Deng-sung Lin, R. D. Aburano, Haydn Chen, Tai-c. Chiang
    Abstract:

    The structure of a Si(111)‐(7×7) surface capped by a 200 A film of C60 was studied by grazing‐incidence x‐ray diffraction. The Si(111)‐(7×7) reconstruction prepared in vacuum, including the loosely bonded ‘‘adatoms’’ on the surface, is preserved under the C60 overlayer. This result illustrates that C60 can be used as an inert cap for surfaces and suggests potentially interesting applications in surface science research and electronic device engineering.

Xiaohua Peng - One of the best experts on this subject based on the ideXlab platform.