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7?-Hydroxycholesterol

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Wen Guo Jiang – One of the best experts on this subject based on the ideXlab platform.

  • interleukin 7 il 7 and il 7 receptor il 7r signalling complex in human solid tumours
    Histology and Histopathology, 2003
    Co-Authors: M A A Alrawi, R E Mansel, Wen Guo Jiang
    Abstract:

    Interleukin-7 (IL-7) plays an important role in the normal development and maintenance of the human immune system. Its effects are mediated via its receptor, IL-7R. Ligand-receptor engagement results in a cascade of phosphorylation events mediated by various molecules including the Janus kinases (Jak1 and Jak3), PI3-kinase, Stats (signal transducers and activators of transcription) and other molecules. The activation of IL- 7 signalling pathway results in survival, proliferation, differentiation and maturation of haematopoietic cells including B and T lymphocytes. Although the relationship of IL-7 with the development and differentiation of some haematological cancers like leukaemias and lymphomas is well recognised, little is known about it involvement with solid tumours. There are several studies that have revealed IL-7/IL-7R expression in epithelial systems and some human solid epithelial tumours. Furthermore, IL-7 can be produced by some human tumour cells and involved in tumour development and progression. In this review article we have summarised the main biological activities of IL-7 and its downstream signalling complex in relation to some human solid malignancies.

Frank Seela – One of the best experts on this subject based on the ideXlab platform.

  • 7-Halogenated 7-deazapurine 2′- C -methylribonucleosides
    Collection of Czechoslovak Chemical Communications, 2011
    Co-Authors: Frank Seela, Xiaohua Peng, Simone Budow, Henning Eickmeier
    Abstract:

    7-Halogenated 7-deazapurine 2′-C-methylribonucleosides related to adenosine, inosine and guanosine were synthesized employing a “one-pot” glycosylation protocol (Vorbruggen glycosylation). The immunosine 2′-C-methylribonucleoside 4 was prepared by the same glycosylation strategy. By this route, the synthesis of the anti-HCV active compound 7-fluoro-7-deaza-2′-C-methyladenosine (1b) was notably simplified, while other nucleosides were synthesized for the first time. A single-crystal X-ray analysis of 7-fluoro-7-deaza-2′-C-methylinosine (2b) was performed showing that the glycosylic bond adopts an anti orientation (χ = –139.9(2)°), while the sugar moiety has an N conformation (C3′-endo; P = 4.3(1)°, τm = 42.4(1)°).

  • Pyrrolo[2,3- d ]pyrimidine β-L-Nucleosides Containing 7-Deazaadenine, 2-Amino-7-deazaadenine, 7-Deazaguanine, 7-Deazaisoguanine, and 7-Deazaxanthine
    Collection of Czechoslovak Chemical Communications, 2006
    Co-Authors: Frank Seela, Xiaohua Peng
    Abstract:

    The synthesis and properties of 7-deazapurine β-L-nucleosides are described. The stereoselective glycosylation of the anions of 2-amino-6-chloro-7-deazapurines 9a, 9b or 6-chloro-7-deazapurines 13a, 13d with 3,5-di-O-(4-methylbenzoyl)-2-deoxy-α-L-erythro-pentofuranosyl chloride (8) furnished the β-L-2′-deoxyribonucleosides 1-4. The synthesis of β-L-ribonucleosides 5-7 used the Silyl-Hilbert-Johnson reaction (TMSOTf/BSA/MeCN) performed under Vorbruggen conditions for the glycosylation of 7-halogenated 6-chloro-2-pivalamido-7-deazapurines 17b-17d with 1-O-acetyl-2,3,5-tri-O-benzoyl-L-ribofuranose (16). Single-crystal X-ray analyses were performed and CD spectra were measured to assign the configuration. The antiviral activity against selected DNA and RNA viruses is reported.

  • 7-deazapurin-2,6-diamine and 7-deazaguanine: synthesis and property of 7-substituted nucleosides and oligonucleotides.
    Nucleosides nucleotides & nucleic acids, 2005
    Co-Authors: Frank Seela, Xiaohua Peng, Xin Ming
    Abstract:

    The synthesis of 7-substituted 7-deazaguanine and 7-deazaadenine ribonucleosides 1–2, the incorporation of 3a–d into oligonucleotides, and the stability of the corresponding duplexes and base discrimination are described. The pKa values of 3–4 are determined.

M J Maeurer – One of the best experts on this subject based on the ideXlab platform.

  • Interleukin-7 (IL-7) and IL-7 splice variants affect differentiation of human neural progenitor cells
    Genes & Immunity, 2010
    Co-Authors: M Moors, N K Vudattu, J Abel, U Krämer, L Rane, N Ulfig, S Ceccatelli, V Seyfert-margolies, E Fritsche, M J Maeurer
    Abstract:

    Alternative splicing of pre-mRNA increases proteomic diversity, a crucial mechanism in defining tissue identity. We demonstrate differentially spliced interleukin (IL)-7 in distinct anatomic areas in the adult, in developing human brains and in normal human neuronal progenitor (NHNP) cells. IL-7c (c, the canonical form spanning all six exons) or its variants IL-7δ5, δ4 or δ4/5 were cloned and expressed as recombinant proteins. IL-7 and splice variants were able to shift the differentiation of NHNP cells as compared with the diluent control ( P δ4/5>IL-7δ5); IL-7δ4 exhibited a significantly weaker potency. Differentiation was confirmed by transcriptome analysis of IL-7c-stimulated neural NHNP cells, resulting in 58 differentially expressed genes; some of these are involved in neural differentiation, for example, the developmentally regulated transcription factor krüppel-like factor 12, musashi 2, a translational regulator of cell fate or the sonic hedgehog receptor patch 1. This suggests that IL-7 influences neural development at a molecular level by participating in human brain architecture through glia cell formation: a paradigm that alternative splicing in cytokines, for example, for IL-7, has a physiological role in human organ development and progenitor cell differentiation.

Tai-c. Chiang – One of the best experts on this subject based on the ideXlab platform.

  • C60 encapsulation of the Si(111)‐(7×7) surface
    Applied Physics Letters, 1992
    Co-Authors: Hawoong Hong, W. E. Mcmahon, Paul Zschack, Deng-sung Lin, R. D. Aburano, Haydn Chen, Tai-c. Chiang
    Abstract:

    The structure of a Si(111)‐(7×7) surface capped by a 200 A film of C60 was studied by grazing‐incidence x‐ray diffraction. The Si(111)‐(7×7) reconstruction prepared in vacuum, including the loosely bonded ‘‘adatoms’’ on the surface, is preserved under the C60 overlayer. This result illustrates that C60 can be used as an inert cap for surfaces and suggests potentially interesting applications in surface science research and electronic device engineering.

Xiaohua Peng – One of the best experts on this subject based on the ideXlab platform.

  • 7-Halogenated 7-deazapurine 2′- C -methylribonucleosides
    Collection of Czechoslovak Chemical Communications, 2011
    Co-Authors: Frank Seela, Xiaohua Peng, Simone Budow, Henning Eickmeier
    Abstract:

    7-Halogenated 7-deazapurine 2′-C-methylribonucleosides related to adenosine, inosine and guanosine were synthesized employing a “one-pot” glycosylation protocol (Vorbruggen glycosylation). The immunosine 2′-C-methylribonucleoside 4 was prepared by the same glycosylation strategy. By this route, the synthesis of the anti-HCV active compound 7-fluoro-7-deaza-2′-C-methyladenosine (1b) was notably simplified, while other nucleosides were synthesized for the first time. A single-crystal X-ray analysis of 7-fluoro-7-deaza-2′-C-methylinosine (2b) was performed showing that the glycosylic bond adopts an anti orientation (χ = –139.9(2)°), while the sugar moiety has an N conformation (C3′-endo; P = 4.3(1)°, τm = 42.4(1)°).

  • Pyrrolo[2,3- d ]pyrimidine β-L-Nucleosides Containing 7-Deazaadenine, 2-Amino-7-deazaadenine, 7-Deazaguanine, 7-Deazaisoguanine, and 7-Deazaxanthine
    Collection of Czechoslovak Chemical Communications, 2006
    Co-Authors: Frank Seela, Xiaohua Peng
    Abstract:

    The synthesis and properties of 7-deazapurine β-L-nucleosides are described. The stereoselective glycosylation of the anions of 2-amino-6-chloro-7-deazapurines 9a, 9b or 6-chloro-7-deazapurines 13a, 13d with 3,5-di-O-(4-methylbenzoyl)-2-deoxy-α-L-erythro-pentofuranosyl chloride (8) furnished the β-L-2′-deoxyribonucleosides 1-4. The synthesis of β-L-ribonucleosides 5-7 used the Silyl-Hilbert-Johnson reaction (TMSOTf/BSA/MeCN) performed under Vorbruggen conditions for the glycosylation of 7-halogenated 6-chloro-2-pivalamido-7-deazapurines 17b-17d with 1-O-acetyl-2,3,5-tri-O-benzoyl-L-ribofuranose (16). Single-crystal X-ray analyses were performed and CD spectra were measured to assign the configuration. The antiviral activity against selected DNA and RNA viruses is reported.

  • 7-deazapurin-2,6-diamine and 7-deazaguanine: synthesis and property of 7-substituted nucleosides and oligonucleotides.
    Nucleosides nucleotides & nucleic acids, 2005
    Co-Authors: Frank Seela, Xiaohua Peng, Xin Ming
    Abstract:

    The synthesis of 7-substituted 7-deazaguanine and 7-deazaadenine ribonucleosides 1–2, the incorporation of 3a–d into oligonucleotides, and the stability of the corresponding duplexes and base discrimination are described. The pKa values of 3–4 are determined.