Abdominopelvic Cavity

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Hai Jeon Yoon - One of the best experts on this subject based on the ideXlab platform.

  • FDG-PET/CT Is Superior to Enhanced CT in Detecting Recurrent Subcentimeter Lesions in the Abdominopelvic Cavity in Colorectal Cancer
    Nuclear Medicine and Molecular Imaging, 2011
    Co-Authors: Hai Jeon Yoon
    Abstract:

    Purpose This study aims to compare the performance of contrast-enhanced computed tomography (CeCT) and 18 F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) in detecting small tumor implants and metastatic lymph nodes (LNs) in the Abdominopelvic Cavity in patients with colorectal cancer. Methods We enrolled 16 patients who were clinically suspected of experiencing a recurrence (6 male, 10 female; mean age 61 ± 14 years). All subjects underwent CeCT and PET/CT, and the performance of these methods was compared with regard to detecting recurrences. The final diagnosis of a recurrence was made clinically. Results CeCT identified 38 lesions in 12 patients, all of which were detected by PET/CT. PET/CT found 27 additional lesions in 8 patients, comprising 9 seeding nodules (2 in the right upper quadrant of the abdomen and 7 in the pelvic Cavity) and 18 LNs (2 celiac, 2 paraaortic, 2 hepatic hilar, 11 common iliac, 1 external iliac). Most additional lesions were located in the pelvic Cavity (approximately 78% of seeding nodules and 67% of lymph nodes). The maximum standardized uptake value (SUVmax) of the additional seeding nodules that were detected solely by PET/CT was significantly higher compared with the CeCT- and PET/CT-confirmed nodules (5.5 ± 4.2 vs. 2.9 ± 2.5, p = 0.03). The seeding nodules that were detected only by PET/CT were significantly smaller than the CeCT- and PET/CT-confirmed nodules (long axis: 1.0 ± 0.3 cm vs. 2.0 ± 1.1 cm, p = 0.001; short axis: 0.8 ± 0.3 cm vs. 1.4 ± 0.8 cm, p = 0.004; mean of both axes: 0.9 ± 0.3 cm vs. 1.7 ± 0.9 cm, p = 0.001). Similarly, PET/CT-only-detected LNs were significantly smaller than CeCT- and PET/CT-identified LNs (0.7 ± 0.1 cm vs. 2.3 ± 1.2 cm, p 

  • FDG-PET/CT Is Superior to Enhanced CT in Detecting Recurrent Subcentimeter Lesions in the Abdominopelvic Cavity in Colorectal Cancer.
    Nuclear medicine and molecular imaging, 2011
    Co-Authors: Hai Jeon Yoon, Jong Jin Lee, Yu Kyeong Kim, Sang Eun Kim
    Abstract:

    Purpose This study aims to compare the performance of contrast-enhanced computed tomography (CeCT) and 18 F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) in detecting small tumor implants and metastatic lymph nodes (LNs) in the Abdominopelvic Cavity in patients with colorectal cancer.

  • fdg pet ct is superior to enhanced ct in detecting recurrent subcentimeter lesions in the Abdominopelvic Cavity in colorectal cancer
    Nuclear Medicine and Molecular Imaging, 2011
    Co-Authors: Hai Jeon Yoon, Jong Jin Lee, Yu Kyeong Kim, Sang Eun Kim
    Abstract:

    Purpose This study aims to compare the performance of contrast-enhanced computed tomography (CeCT) and 18 F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) in detecting small tumor implants and metastatic lymph nodes (LNs) in the Abdominopelvic Cavity in patients with colorectal cancer.

Sang Eun Kim - One of the best experts on this subject based on the ideXlab platform.

Pietro Santulli - One of the best experts on this subject based on the ideXlab platform.

  • ORIGINAL ARTICLE Gynaecology Profibrotic interleukin-33 is correlated with uterine leiomyoma tumour burden
    2016
    Co-Authors: Pietro Santulli, Bruno Borghese, Anne-elodie Millischer, Marc Even, Rine Chouzenoux, Dominique De Ziegler, Charles Chapron
    Abstract:

    study question: Are interleukin-33 (IL-33) serum levels higher in women with uterine leiomyoma compared with controls without leiomyoma? summaryanswer: Serum IL-33 is elevated inwomenwith uterine leiomyoma and correlatedwith features of uterine leiomyoma tumour burden, namely fibroid number, size and weight. what is known already: Uterine leiomyomas are the most common benign tumours in premenopausal women associated with major tissue fibrosis. IL-33 is a cytokine involved in fibrotic disorders. The potential role of IL-33 in leiomyoma has not been reported before. studydesign, size, duration: This is a prospective laboratory study conducted in a tertiary-careuniversity hospital between January 2005 and December 2010.We investigated non-pregnant, 42-year-old patients (n 151) during surgery for a benign gynaecological condition. participants/materials, setting, methods: After complete surgical exploration of the Abdominopelvic Cavity, 59 women with histologically proved uterine leiomyoma and 92 leiomyoma-free control womenwere enrolled.Womenwith endometriosis or past history of ovarianmalignancy and borderline tumourswere not included. The control group includedwomenwith benign ovarian cysts, paratubal cysts o

  • Role of the protein kinase BRAF in the pathogenesis of endometriosis.
    Expert opinion on therapeutic targets, 2016
    Co-Authors: Pietro Santulli, Charles Chapron, Louis Marcellin, Sandrine Chouzenoux, Veronique Boulard, Pierre-alexandre Just, Carole Nicco, Christiane Chéreau, Claudia Tosti, Frédéric Batteux
    Abstract:

    ABSTRACTObjective: Mitogen-activated protein kinases (MAPKs) are involved in the proliferation and survival of endometriotic lesions. Vemurafenib (PLX4032) is a novel protein kinase inhibitor that targets BRAF, a member of the MAPK pathway. The present study tested the in vitro and in vivo effects of PLX4032 on endometriotic cells.Research design and methods: We conducted a laboratory study in a tertiary-care university hospital from January 2013 to September 2013. We enrolled a cohort of 40 patients: 20 with histologically proven endometriosis and 20 unaffected women. A thorough surgical examination of the Abdominopelvic Cavity was performed on all of the study participants. Ex vivo stromal and epithelial cells were extracted from endometrial and endometriotic biopsies from both sets of patients. Proliferation, apoptosis, pERK/ERK ratio, cell cycle regulation (Cyclin D1 and CDK4) and inflammation (PTGS2) were explored with and without PLX4032 treatment. Human endometriotic lesions were implanted into 40 ...

  • Increased serum oxidative stress markers in women with uterine leiomyoma.
    Public Library of Science (PLoS), 1
    Co-Authors: Pietro Santulli, Bruno Borghese, Herve Lemaréchal, Mahaut Leconte, Anne-elodie Millischer, Frédéric Batteux, Charles Chapron, Didier Borderie
    Abstract:

    BACKGROUND: Uterine leiomyomas (fibroids) are the most common gynaecological benign tumors in premenopausal women. Evidences support the role of oxidative stress in the development of uterine leiomyoma. We have analysed oxidative stress markers (thiols, advanced oxidized protein products (AOPP), protein carbonyls and nitrates/nitrites) in preoperative sera from women with histologically proven uterine leiomyoma. METHODOLOGY/PRINCIPAL FINDINGS: We conducted a laboratory study in a tertiary-care university hospital. Fifty-nine women with histologically proven uterine leiomyoma and ninety-two leiomyoma-free control women have been enrolled in this study. Complete surgical exploration of the Abdominopelvic Cavity was performed in each patient. Preoperative serum samples were obtained from all study participants to assay serum thiols, AOPP, protein carbonyls and nitrates/nitrites. Concentrations of serum protein carbonyl groups and AOPP were higher in leiomyoma patients than in the control group (p=0.005 and p

Charles Chapron - One of the best experts on this subject based on the ideXlab platform.

  • ORIGINAL ARTICLE Gynaecology Profibrotic interleukin-33 is correlated with uterine leiomyoma tumour burden
    2016
    Co-Authors: Pietro Santulli, Bruno Borghese, Anne-elodie Millischer, Marc Even, Rine Chouzenoux, Dominique De Ziegler, Charles Chapron
    Abstract:

    study question: Are interleukin-33 (IL-33) serum levels higher in women with uterine leiomyoma compared with controls without leiomyoma? summaryanswer: Serum IL-33 is elevated inwomenwith uterine leiomyoma and correlatedwith features of uterine leiomyoma tumour burden, namely fibroid number, size and weight. what is known already: Uterine leiomyomas are the most common benign tumours in premenopausal women associated with major tissue fibrosis. IL-33 is a cytokine involved in fibrotic disorders. The potential role of IL-33 in leiomyoma has not been reported before. studydesign, size, duration: This is a prospective laboratory study conducted in a tertiary-careuniversity hospital between January 2005 and December 2010.We investigated non-pregnant, 42-year-old patients (n 151) during surgery for a benign gynaecological condition. participants/materials, setting, methods: After complete surgical exploration of the Abdominopelvic Cavity, 59 women with histologically proved uterine leiomyoma and 92 leiomyoma-free control womenwere enrolled.Womenwith endometriosis or past history of ovarianmalignancy and borderline tumourswere not included. The control group includedwomenwith benign ovarian cysts, paratubal cysts o

  • Role of the protein kinase BRAF in the pathogenesis of endometriosis.
    Expert opinion on therapeutic targets, 2016
    Co-Authors: Pietro Santulli, Charles Chapron, Louis Marcellin, Sandrine Chouzenoux, Veronique Boulard, Pierre-alexandre Just, Carole Nicco, Christiane Chéreau, Claudia Tosti, Frédéric Batteux
    Abstract:

    ABSTRACTObjective: Mitogen-activated protein kinases (MAPKs) are involved in the proliferation and survival of endometriotic lesions. Vemurafenib (PLX4032) is a novel protein kinase inhibitor that targets BRAF, a member of the MAPK pathway. The present study tested the in vitro and in vivo effects of PLX4032 on endometriotic cells.Research design and methods: We conducted a laboratory study in a tertiary-care university hospital from January 2013 to September 2013. We enrolled a cohort of 40 patients: 20 with histologically proven endometriosis and 20 unaffected women. A thorough surgical examination of the Abdominopelvic Cavity was performed on all of the study participants. Ex vivo stromal and epithelial cells were extracted from endometrial and endometriotic biopsies from both sets of patients. Proliferation, apoptosis, pERK/ERK ratio, cell cycle regulation (Cyclin D1 and CDK4) and inflammation (PTGS2) were explored with and without PLX4032 treatment. Human endometriotic lesions were implanted into 40 ...

  • Increased serum oxidative stress markers in women with uterine leiomyoma.
    Public Library of Science (PLoS), 1
    Co-Authors: Pietro Santulli, Bruno Borghese, Herve Lemaréchal, Mahaut Leconte, Anne-elodie Millischer, Frédéric Batteux, Charles Chapron, Didier Borderie
    Abstract:

    BACKGROUND: Uterine leiomyomas (fibroids) are the most common gynaecological benign tumors in premenopausal women. Evidences support the role of oxidative stress in the development of uterine leiomyoma. We have analysed oxidative stress markers (thiols, advanced oxidized protein products (AOPP), protein carbonyls and nitrates/nitrites) in preoperative sera from women with histologically proven uterine leiomyoma. METHODOLOGY/PRINCIPAL FINDINGS: We conducted a laboratory study in a tertiary-care university hospital. Fifty-nine women with histologically proven uterine leiomyoma and ninety-two leiomyoma-free control women have been enrolled in this study. Complete surgical exploration of the Abdominopelvic Cavity was performed in each patient. Preoperative serum samples were obtained from all study participants to assay serum thiols, AOPP, protein carbonyls and nitrates/nitrites. Concentrations of serum protein carbonyl groups and AOPP were higher in leiomyoma patients than in the control group (p=0.005 and p

Frédéric Batteux - One of the best experts on this subject based on the ideXlab platform.

  • Role of the protein kinase BRAF in the pathogenesis of endometriosis.
    Expert opinion on therapeutic targets, 2016
    Co-Authors: Pietro Santulli, Charles Chapron, Louis Marcellin, Sandrine Chouzenoux, Veronique Boulard, Pierre-alexandre Just, Carole Nicco, Christiane Chéreau, Claudia Tosti, Frédéric Batteux
    Abstract:

    ABSTRACTObjective: Mitogen-activated protein kinases (MAPKs) are involved in the proliferation and survival of endometriotic lesions. Vemurafenib (PLX4032) is a novel protein kinase inhibitor that targets BRAF, a member of the MAPK pathway. The present study tested the in vitro and in vivo effects of PLX4032 on endometriotic cells.Research design and methods: We conducted a laboratory study in a tertiary-care university hospital from January 2013 to September 2013. We enrolled a cohort of 40 patients: 20 with histologically proven endometriosis and 20 unaffected women. A thorough surgical examination of the Abdominopelvic Cavity was performed on all of the study participants. Ex vivo stromal and epithelial cells were extracted from endometrial and endometriotic biopsies from both sets of patients. Proliferation, apoptosis, pERK/ERK ratio, cell cycle regulation (Cyclin D1 and CDK4) and inflammation (PTGS2) were explored with and without PLX4032 treatment. Human endometriotic lesions were implanted into 40 ...

  • Increased serum oxidative stress markers in women with uterine leiomyoma.
    Public Library of Science (PLoS), 1
    Co-Authors: Pietro Santulli, Bruno Borghese, Herve Lemaréchal, Mahaut Leconte, Anne-elodie Millischer, Frédéric Batteux, Charles Chapron, Didier Borderie
    Abstract:

    BACKGROUND: Uterine leiomyomas (fibroids) are the most common gynaecological benign tumors in premenopausal women. Evidences support the role of oxidative stress in the development of uterine leiomyoma. We have analysed oxidative stress markers (thiols, advanced oxidized protein products (AOPP), protein carbonyls and nitrates/nitrites) in preoperative sera from women with histologically proven uterine leiomyoma. METHODOLOGY/PRINCIPAL FINDINGS: We conducted a laboratory study in a tertiary-care university hospital. Fifty-nine women with histologically proven uterine leiomyoma and ninety-two leiomyoma-free control women have been enrolled in this study. Complete surgical exploration of the Abdominopelvic Cavity was performed in each patient. Preoperative serum samples were obtained from all study participants to assay serum thiols, AOPP, protein carbonyls and nitrates/nitrites. Concentrations of serum protein carbonyl groups and AOPP were higher in leiomyoma patients than in the control group (p=0.005 and p

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