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Abdominopelvic Cavity

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Hai Jeon Yoon – One of the best experts on this subject based on the ideXlab platform.

Sang Eun Kim – One of the best experts on this subject based on the ideXlab platform.

Pietro Santulli – One of the best experts on this subject based on the ideXlab platform.

  • ORIGINAL ARTICLE Gynaecology Profibrotic interleukin-33 is correlated with uterine leiomyoma tumour burden
    , 2016
    Co-Authors: Pietro Santulli, Bruno Borghese, Anne-elodie Millischer, Marc Even, Rine Chouzenoux, Dominique De Ziegler, Charles Chapron
    Abstract:

    study question: Are interleukin-33 (IL-33) serum levels higher in women with uterine leiomyoma compared with controls without leiomyoma? summaryanswer: Serum IL-33 is elevated inwomenwith uterine leiomyoma and correlatedwith features of uterine leiomyoma tumour burden, namely fibroid number, size and weight. what is known already: Uterine leiomyomas are the most common benign tumours in premenopausal women associated with major tissue fibrosis. IL-33 is a cytokine involved in fibrotic disorders. The potential role of IL-33 in leiomyoma has not been reported before. studydesign, size, duration: This is a prospective laboratory study conducted in a tertiary-careuniversity hospital between January 2005 and December 2010.We investigated non-pregnant, 42-year-old patients (n 151) during surgery for a benign gynaecological condition. participants/materials, setting, methods: After complete surgical exploration of the Abdominopelvic Cavity, 59 women with histologically proved uterine leiomyoma and 92 leiomyoma-free control womenwere enrolled.Womenwith endometriosis or past history of ovarianmalignancy and borderline tumourswere not included. The control group includedwomenwith benign ovarian cysts, paratubal cysts o

  • Role of the protein kinase BRAF in the pathogenesis of endometriosis.
    Expert opinion on therapeutic targets, 2016
    Co-Authors: Pietro Santulli, Charles Chapron, Louis Marcellin, Sandrine Chouzenoux, Veronique Boulard, Pierre-alexandre Just, Carole Nicco, Christiane Chéreau, Claudia Tosti, Frédéric Batteux
    Abstract:

    ABSTRACTObjective: Mitogen-activated protein kinases (MAPKs) are involved in the proliferation and survival of endometriotic lesions. Vemurafenib (PLX4032) is a novel protein kinase inhibitor that targets BRAF, a member of the MAPK pathway. The present study tested the in vitro and in vivo effects of PLX4032 on endometriotic cells.Research design and methods: We conducted a laboratory study in a tertiary-care university hospital from January 2013 to September 2013. We enrolled a cohort of 40 patients: 20 with histologically proven endometriosis and 20 unaffected women. A thorough surgical examination of the Abdominopelvic Cavity was performed on all of the study participants. Ex vivo stromal and epithelial cells were extracted from endometrial and endometriotic biopsies from both sets of patients. Proliferation, apoptosis, pERK/ERK ratio, cell cycle regulation (Cyclin D1 and CDK4) and inflammation (PTGS2) were explored with and without PLX4032 treatment. Human endometriotic lesions were implanted into 40 …

  • Increased serum oxidative stress markers in women with uterine leiomyoma.
    Public Library of Science (PLoS), 1
    Co-Authors: Pietro Santulli, Bruno Borghese, Herve Lemaréchal, Mahaut Leconte, Anne-elodie Millischer, Frédéric Batteux, Charles Chapron, Didier Borderie
    Abstract:

    BACKGROUND: Uterine leiomyomas (fibroids) are the most common gynaecological benign tumors in premenopausal women. Evidences support the role of oxidative stress in the development of uterine leiomyoma. We have analysed oxidative stress markers (thiols, advanced oxidized protein products (AOPP), protein carbonyls and nitrates/nitrites) in preoperative sera from women with histologically proven uterine leiomyoma. METHODOLOGY/PRINCIPAL FINDINGS: We conducted a laboratory study in a tertiary-care university hospital. Fifty-nine women with histologically proven uterine leiomyoma and ninety-two leiomyoma-free control women have been enrolled in this study. Complete surgical exploration of the Abdominopelvic Cavity was performed in each patient. Preoperative serum samples were obtained from all study participants to assay serum thiols, AOPP, protein carbonyls and nitrates/nitrites. Concentrations of serum protein carbonyl groups and AOPP were higher in leiomyoma patients than in the control group (p=0.005 and p

Charles Chapron – One of the best experts on this subject based on the ideXlab platform.

  • ORIGINAL ARTICLE Gynaecology Profibrotic interleukin-33 is correlated with uterine leiomyoma tumour burden
    , 2016
    Co-Authors: Pietro Santulli, Bruno Borghese, Anne-elodie Millischer, Marc Even, Rine Chouzenoux, Dominique De Ziegler, Charles Chapron
    Abstract:

    study question: Are interleukin-33 (IL-33) serum levels higher in women with uterine leiomyoma compared with controls without leiomyoma? summaryanswer: Serum IL-33 is elevated inwomenwith uterine leiomyoma and correlatedwith features of uterine leiomyoma tumour burden, namely fibroid number, size and weight. what is known already: Uterine leiomyomas are the most common benign tumours in premenopausal women associated with major tissue fibrosis. IL-33 is a cytokine involved in fibrotic disorders. The potential role of IL-33 in leiomyoma has not been reported before. studydesign, size, duration: This is a prospective laboratory study conducted in a tertiary-careuniversity hospital between January 2005 and December 2010.We investigated non-pregnant, 42-year-old patients (n 151) during surgery for a benign gynaecological condition. participants/materials, setting, methods: After complete surgical exploration of the Abdominopelvic Cavity, 59 women with histologically proved uterine leiomyoma and 92 leiomyoma-free control womenwere enrolled.Womenwith endometriosis or past history of ovarianmalignancy and borderline tumourswere not included. The control group includedwomenwith benign ovarian cysts, paratubal cysts o

  • Role of the protein kinase BRAF in the pathogenesis of endometriosis.
    Expert opinion on therapeutic targets, 2016
    Co-Authors: Pietro Santulli, Charles Chapron, Louis Marcellin, Sandrine Chouzenoux, Veronique Boulard, Pierre-alexandre Just, Carole Nicco, Christiane Chéreau, Claudia Tosti, Frédéric Batteux
    Abstract:

    ABSTRACTObjective: Mitogen-activated protein kinases (MAPKs) are involved in the proliferation and survival of endometriotic lesions. Vemurafenib (PLX4032) is a novel protein kinase inhibitor that targets BRAF, a member of the MAPK pathway. The present study tested the in vitro and in vivo effects of PLX4032 on endometriotic cells.Research design and methods: We conducted a laboratory study in a tertiary-care university hospital from January 2013 to September 2013. We enrolled a cohort of 40 patients: 20 with histologically proven endometriosis and 20 unaffected women. A thorough surgical examination of the Abdominopelvic Cavity was performed on all of the study participants. Ex vivo stromal and epithelial cells were extracted from endometrial and endometriotic biopsies from both sets of patients. Proliferation, apoptosis, pERK/ERK ratio, cell cycle regulation (Cyclin D1 and CDK4) and inflammation (PTGS2) were explored with and without PLX4032 treatment. Human endometriotic lesions were implanted into 40 …

  • Increased serum oxidative stress markers in women with uterine leiomyoma.
    Public Library of Science (PLoS), 1
    Co-Authors: Pietro Santulli, Bruno Borghese, Herve Lemaréchal, Mahaut Leconte, Anne-elodie Millischer, Frédéric Batteux, Charles Chapron, Didier Borderie
    Abstract:

    BACKGROUND: Uterine leiomyomas (fibroids) are the most common gynaecological benign tumors in premenopausal women. Evidences support the role of oxidative stress in the development of uterine leiomyoma. We have analysed oxidative stress markers (thiols, advanced oxidized protein products (AOPP), protein carbonyls and nitrates/nitrites) in preoperative sera from women with histologically proven uterine leiomyoma. METHODOLOGY/PRINCIPAL FINDINGS: We conducted a laboratory study in a tertiary-care university hospital. Fifty-nine women with histologically proven uterine leiomyoma and ninety-two leiomyoma-free control women have been enrolled in this study. Complete surgical exploration of the Abdominopelvic Cavity was performed in each patient. Preoperative serum samples were obtained from all study participants to assay serum thiols, AOPP, protein carbonyls and nitrates/nitrites. Concentrations of serum protein carbonyl groups and AOPP were higher in leiomyoma patients than in the control group (p=0.005 and p

Frédéric Batteux – One of the best experts on this subject based on the ideXlab platform.

  • Role of the protein kinase BRAF in the pathogenesis of endometriosis.
    Expert opinion on therapeutic targets, 2016
    Co-Authors: Pietro Santulli, Charles Chapron, Louis Marcellin, Sandrine Chouzenoux, Veronique Boulard, Pierre-alexandre Just, Carole Nicco, Christiane Chéreau, Claudia Tosti, Frédéric Batteux
    Abstract:

    ABSTRACTObjective: Mitogen-activated protein kinases (MAPKs) are involved in the proliferation and survival of endometriotic lesions. Vemurafenib (PLX4032) is a novel protein kinase inhibitor that targets BRAF, a member of the MAPK pathway. The present study tested the in vitro and in vivo effects of PLX4032 on endometriotic cells.Research design and methods: We conducted a laboratory study in a tertiary-care university hospital from January 2013 to September 2013. We enrolled a cohort of 40 patients: 20 with histologically proven endometriosis and 20 unaffected women. A thorough surgical examination of the Abdominopelvic Cavity was performed on all of the study participants. Ex vivo stromal and epithelial cells were extracted from endometrial and endometriotic biopsies from both sets of patients. Proliferation, apoptosis, pERK/ERK ratio, cell cycle regulation (Cyclin D1 and CDK4) and inflammation (PTGS2) were explored with and without PLX4032 treatment. Human endometriotic lesions were implanted into 40 …

  • Increased serum oxidative stress markers in women with uterine leiomyoma.
    Public Library of Science (PLoS), 1
    Co-Authors: Pietro Santulli, Bruno Borghese, Herve Lemaréchal, Mahaut Leconte, Anne-elodie Millischer, Frédéric Batteux, Charles Chapron, Didier Borderie
    Abstract:

    BACKGROUND: Uterine leiomyomas (fibroids) are the most common gynaecological benign tumors in premenopausal women. Evidences support the role of oxidative stress in the development of uterine leiomyoma. We have analysed oxidative stress markers (thiols, advanced oxidized protein products (AOPP), protein carbonyls and nitrates/nitrites) in preoperative sera from women with histologically proven uterine leiomyoma. METHODOLOGY/PRINCIPAL FINDINGS: We conducted a laboratory study in a tertiary-care university hospital. Fifty-nine women with histologically proven uterine leiomyoma and ninety-two leiomyoma-free control women have been enrolled in this study. Complete surgical exploration of the Abdominopelvic Cavity was performed in each patient. Preoperative serum samples were obtained from all study participants to assay serum thiols, AOPP, protein carbonyls and nitrates/nitrites. Concentrations of serum protein carbonyl groups and AOPP were higher in leiomyoma patients than in the control group (p=0.005 and p