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Michael G Aman - One of the best experts on this subject based on the ideXlab platform.
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Factor Structure of the Aberrant Behavior Checklist in Individuals with Fragile X Syndrome: Clarifications and Future Guidance
Journal of child and adolescent psychopharmacology, 2020Co-Authors: Michael G Aman, Anne C. Wheeler, Carla M. Bann, Aaron J Kaat, Megan Norris, Howard Andrews, Tse Hwei Choo, Chen Chen, Craig A. EricksonAbstract:Objective: The Aberrant Behavior Checklist (ABC) is a standardized rating scale used for assessing problematic Behavior of individuals with developmental disabilities. It has five subscales: Irritability, Social Withdrawal, Stereotypic Behavior, Hyperactivity, and Inappropriate Speech. A previous study in individuals with fragile X syndrome (FXS) reported six factors, with the Social Withdrawal factor bifurcating into Socially Unresponsive and Social Avoidance factors, suggesting a different factor structure in people with FXS. Methods: We assessed the ABC's factor structure (with both exploratory and confirmatory analyses) in 797 people with FXS and we compared these findings with exploratory factors derived from an independent sample of 357 individuals with FXS. In an ancillary analysis, we compared the overlap of the traditional ABC's Social Withdrawal scores with the Social Avoidance scores from the FXS-derived newer scale to determine whether overlap between these was very high and essentially redundant. Finally, we computed norms using both the traditional and the FXS-specific algorithms. Results: In confirmatory factor analyses, the FXS-specific algorithm produced the most consistent factor structure for the sample of 797 participants, but model fit was only marginally better than that derived by the original ABC scoring algorithm. Comparisons of factor structures from separate exploratory analyses revealed no consistent advantage of the FXS algorithm over the traditional algorithm. While a Social Avoidance subscale did emerge in some analyses, in other analyses, this was accompanied by loss of coherence on other domains of interest, such as the Socially Unresponsive/Social Withdrawal subscale. Conclusion: We question whether the newer FXS scoring algorithm contributes data that are consistently helpful in evaluating Behavior of people with FXS. In general, we recommend continued use of the original ABC algorithm for scoring Behavior of clients with FXS. However, we acknowledge that there may be circumscribed times when the new algorithm may be appropriate for scoring, namely when anxiety and/or social avoidance constructs are the central and unequivocal domains of interest.
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Psychometric Properties of the Norwegian Aberrant Behavior Checklist and Diagnostic Relationships in a Neuro-pediatric Sample
Journal of Mental Health Research in Intellectual Disabilities, 2019Co-Authors: Marianne Halvorsen, Michael G Aman, Børge Mathiassen, Per Håkan Brøndbo, Oddmar Ole Steinsvik, Monica MartinussenAbstract:Introduction: Although the Aberrant Behavior Checklist (ABC) is one of the most widely used Behavioral rating scales among people with developmental disabilities, very few studies have examined the...
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Psychometric characteristics of the Aberrant Behavior Checklist in a well-defined sample of youth with autism Spectrum disorder
Research in Autism Spectrum Disorders, 2019Co-Authors: Megan Norris, Michael G Aman, Micah O. Mazurek, Jessica F. Scherr, Eric ButterAbstract:Abstract Background Behavior and emotional difficulties often occur in children and adolescents with Autism Spectrum Disorder (ASD), yet there are few instruments available to assess such problems in this population. The Aberrant Behavior Checklist (ABC), one option for this, is widely used and has substantial psychometric support. Despite this, only two studies to date have examined its structural validity in samples of individuals diagnosed exclusively with Autism Spectrum Disorder (ASD). This study sought to further examine the ABC’s validity for use with children and adolescents with ASD. Method Data from 470 individuals aged 2–14 years were submitted to confirmatory factor analysis (CFA). Correlations with other measures were examined. MANOVA was conducted to examine effects of subject characteristics on subscale scores of the ABC and assist in developing norms. Results Results supported the original factor structure of the ABC. Convergent and divergent validity analyses indicated correspondence with analogous measures and lack of relationship for dissimilar constructs. Results of normative analyses were very comparable to the only previously published norms for youth with ASD. Conclusions Overall, results provide further psychometric support for use of the ABC in individuals with ASD and better understanding the ABC’s clinical usefulness, particularly given the similarity between current and previous normative data. In a broader context, these results lend further support to the ABC as an instrument with wide applications.
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validity of the Aberrant Behavior Checklist in children with autism spectrum disorder
Journal of Autism and Developmental Disorders, 2014Co-Authors: Aaron J Kaat, Luc Lecavalier, Michael G AmanAbstract:The Aberrant Behavior Checklist (ABC) is a widely used measure in autism spectrum disorder (ASD) treatment studies. We conducted confirmatory and exploratory factor analyses of the ABC in 1,893 children evaluated as part of the Autism Treatment Network. The root mean square error of approximation was .086 for the standard item assignment, and in exploratory factor analysis, the large majority of items continued to load on the originally assigned factors. Correlations between the ABC subscales and multiple external variables including the Child Behavior Checklist and demographic variables supported the convergent and divergent validity of the ABC as a measure of Behavior problems in ASD. Finally, we examined the impact of participant characteristics on subscale scores and present normative data.
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brief report social disability in autism spectrum disorder results from research units on pediatric psychopharmacology rupp autism network trials
Journal of Autism and Developmental Disorders, 2013Co-Authors: Lawrence Scahill, Victoria Hallett, Michael G Aman, Christopher J Mcdougle, Eugene L Arnold, James T Mccracken, Elaine TierneyAbstract:There is growing interest in measuring social disability as a core element of autism spectrum disorders in medication trials. We conducted a secondary analysis on the Aberrant Behavior Checklist Social Withdrawal subscale using data from two federally-funded, multi-site, randomized trials with risperidone. Study 1 included 52 subjects assigned to placebo and 49 subjects to risperidone under double-blind conditions. Study 2 included 49 subjects assigned to risperidone only and 75 subjects assigned to risperidone plus parent training. After 8 weeks of treatment, all active treatments were superior to placebo (effect sizes ranging from 0.42 to 0.65). The findings suggest that the Social Withdrawal subscale may be a useful measure of social disability in acute treatment trials.
Craig A. Erickson - One of the best experts on this subject based on the ideXlab platform.
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Factor Structure of the Aberrant Behavior Checklist in Individuals with Fragile X Syndrome: Clarifications and Future Guidance
Journal of child and adolescent psychopharmacology, 2020Co-Authors: Michael G Aman, Anne C. Wheeler, Carla M. Bann, Aaron J Kaat, Megan Norris, Howard Andrews, Tse Hwei Choo, Chen Chen, Craig A. EricksonAbstract:Objective: The Aberrant Behavior Checklist (ABC) is a standardized rating scale used for assessing problematic Behavior of individuals with developmental disabilities. It has five subscales: Irritability, Social Withdrawal, Stereotypic Behavior, Hyperactivity, and Inappropriate Speech. A previous study in individuals with fragile X syndrome (FXS) reported six factors, with the Social Withdrawal factor bifurcating into Socially Unresponsive and Social Avoidance factors, suggesting a different factor structure in people with FXS. Methods: We assessed the ABC's factor structure (with both exploratory and confirmatory analyses) in 797 people with FXS and we compared these findings with exploratory factors derived from an independent sample of 357 individuals with FXS. In an ancillary analysis, we compared the overlap of the traditional ABC's Social Withdrawal scores with the Social Avoidance scores from the FXS-derived newer scale to determine whether overlap between these was very high and essentially redundant. Finally, we computed norms using both the traditional and the FXS-specific algorithms. Results: In confirmatory factor analyses, the FXS-specific algorithm produced the most consistent factor structure for the sample of 797 participants, but model fit was only marginally better than that derived by the original ABC scoring algorithm. Comparisons of factor structures from separate exploratory analyses revealed no consistent advantage of the FXS algorithm over the traditional algorithm. While a Social Avoidance subscale did emerge in some analyses, in other analyses, this was accompanied by loss of coherence on other domains of interest, such as the Socially Unresponsive/Social Withdrawal subscale. Conclusion: We question whether the newer FXS scoring algorithm contributes data that are consistently helpful in evaluating Behavior of people with FXS. In general, we recommend continued use of the original ABC algorithm for scoring Behavior of clients with FXS. However, we acknowledge that there may be circumscribed times when the new algorithm may be appropriate for scoring, namely when anxiety and/or social avoidance constructs are the central and unequivocal domains of interest.
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Brief Report: Intranasal Ketamine in Adolescents and Young Adults with Autism Spectrum Disorder—Initial Results of a Randomized, Controlled, Crossover, Pilot Study
Journal of Autism and Developmental Disorders, 2020Co-Authors: Logan K. Wink, Debra L. Reisinger, Paul Horn, Rebecca C. Shaffer, Kaela O’brien, Lauren Schmitt, Kelli R. Dominick, Ernest V. Pedapati, Craig A. EricksonAbstract:Dysregulation of glutamate neurotransmission plays a critical role in autism spectrum disorder (ASD) pathophysiology and is a primary target for core deficit research treatment trials. The mechanism of action of ketamine has striking overlap with the theory of ASD as a disorder of synaptic communication and neuronal networks. This two-dose, double-blind, placebo controlled, cross-over pilot trial of intranasal (IN) ketamine targeting core social impairment included individuals with ASD ( N = 21) between 14 and 29 years. Participants were randomized to received two doses of IN ketamine (30 and 50 mg) and two doses of matching placebo. No significant impact was noted on the Aberrant Behavior Checklist Social Withdraw subscale. The IN ketamine was well tolerated, with only transient mild adverse effects.
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Brief Report: Intranasal Ketamine in Adolescents and Young Adults with Autism Spectrum Disorder-Initial Results of a Randomized, Controlled, Crossover, Pilot Study.
Journal of autism and developmental disorders, 2020Co-Authors: Logan K. Wink, Debra L. Reisinger, Rebecca C. Shaffer, Kaela O’brien, Kelli R. Dominick, Ernest V. Pedapati, Paul S. Horn, Lauren M. Schmitt, Craig A. EricksonAbstract:Dysregulation of glutamate neurotransmission plays a critical role in autism spectrum disorder (ASD) pathophysiology and is a primary target for core deficit research treatment trials. The mechanism of action of ketamine has striking overlap with the theory of ASD as a disorder of synaptic communication and neuronal networks. This two-dose, double-blind, placebo controlled, cross-over pilot trial of intranasal (IN) ketamine targeting core social impairment included individuals with ASD (N = 21) between 14 and 29 years. Participants were randomized to received two doses of IN ketamine (30 and 50 mg) and two doses of matching placebo. No significant impact was noted on the Aberrant Behavior Checklist Social Withdraw subscale. The IN ketamine was well tolerated, with only transient mild adverse effects.
Lawrence Scahill - One of the best experts on this subject based on the ideXlab platform.
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A Feasibility Randomized Clinical Trial of a Structured Function-Based Intervention for Elopement in Children with Autism Spectrum Disorder
Journal of Autism and Developmental Disorders, 2020Co-Authors: Mindy Scheithauer, Nathan A. Call, Joanna Lomas Mevers, Courtney E. Mccracken, Lawrence ScahillAbstract:Elopement is a common and dangerous concern in autism spectrum disorder (ASD). There is evidence that Behavior analytic treatments can successfully treat elopement, but the research is limited due to small samples and treatment components varying across studies. The current study evaluated the feasibility of studying a manualized intervention for elopement, based on strategies from single-subject research, in a randomized clinical trial with 24 individuals with ASD. Results demonstrated that recruitment was feasible; the manual was acceptable to parents; and therapists followed the manual with high-integrity. Initial efficacy results measured by the Aberrant Behavior Checklist, Clinical Global Impression Scale, and a Home Elopement Safety Checklist suggested improvement in the treatment group that should be studied in future research.
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a pilot study of parent training in young children with autism spectrum disorders and disruptive Behavior
Journal of Autism and Developmental Disorders, 2013Co-Authors: Karen Bearss, Cynthia R. Johnson, Benjamin L Handen, Tristram Smith, Lawrence ScahillAbstract:Guidance on effective interventions for disruptive Behavior in young children with autism spectrum disorders (ASDs) is limited. We present feasibility and initial efficacy data on a structured parent training program for 16 children (ages 3–6) with ASD and disruptive Behavior. The 6-month intervention included 11 Core and up to 2 Optional sessions. The program was acceptable to parents as evidenced by an attendance rate of 84 % for Core sessions. Fourteen of 16 families completed the treatment. An independent clinician rated 14 of 16 subjects as much improved or very much improved at Week 24. Using last observation carried forward, the parent-rated Aberrant Behavior Checklist-Irritability subscale decreased 54 % from 16.00 (SD = 9.21) to 7.38 (SD = 6.15).
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brief report social disability in autism spectrum disorder results from research units on pediatric psychopharmacology rupp autism network trials
Journal of Autism and Developmental Disorders, 2013Co-Authors: Lawrence Scahill, Victoria Hallett, Michael G Aman, Christopher J Mcdougle, Eugene L Arnold, James T Mccracken, Elaine TierneyAbstract:There is growing interest in measuring social disability as a core element of autism spectrum disorders in medication trials. We conducted a secondary analysis on the Aberrant Behavior Checklist Social Withdrawal subscale using data from two federally-funded, multi-site, randomized trials with risperidone. Study 1 included 52 subjects assigned to placebo and 49 subjects to risperidone under double-blind conditions. Study 2 included 49 subjects assigned to risperidone only and 75 subjects assigned to risperidone plus parent training. After 8 weeks of treatment, all active treatments were superior to placebo (effect sizes ranging from 0.42 to 0.65). The findings suggest that the Social Withdrawal subscale may be a useful measure of social disability in acute treatment trials.
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Predictors and Moderators of Parent Training Efficacy in a Sample of Children with Autism Spectrum Disorders and Serious Behavioral Problems
Journal of autism and developmental disorders, 2011Co-Authors: Cristan Farmer, Lawrence Scahill, Christopher J Mcdougle, Luc Lecavalier, L. Eugene Arnold, Kimberly A. Stigler, Cynthia R. Johnson, Benjamin L Handen, Karen BearssAbstract:The Research Units on Pediatric Psychopharmacology—Autism Network reported additional benefit when adding parent training (PT) to antipsychotic medication in children with autism spectrum disorders and serious Behavior problems. The intent-to-treat analyses were rerun with putative predictors and moderators. The Home Situations Questionnaire (HSQ) and the Hyperactivity/Noncompliance subscale of the Aberrant Behavior Checklist were used as outcome measures. Candidate predictors and moderators included 21 demographics and baseline measures of Behavior. Higher baseline HSQ scores predicted greater improvement on the HSQ regardless of treatment assignment, but no other predictors of outcome were observed. None of the variables measured in this study moderated response to PT. Antipsychotic medication plus PT appears to be equally effective for children with a wide range of demographic and Behavioral characteristics.
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Developmental disabilities modification of the Children's Global Assessment Scale.
Biological psychiatry, 2007Co-Authors: Ann Wagner, Lawrence Scahill, Michael G Aman, Christopher J Mcdougle, Luc Lecavalier, L. Eugene Arnold, Kimberly A. Stigler, Cynthia R. Johnson, Benedetto VitielloAbstract:Background Interventions for pervasive developmental disorders (PDD) aim to alleviate symptoms and improve functioning. To measure global functioning in treatment studies, the Children’s Global Assessment Scale was modified and psychometric properties of the revised version (DD-CGAS) were assessed in children with PDD. Methods Developmental disabilities–relevant descriptors were developed for the DD-CGAS, and administration procedures were established to enhance rater consistency. Ratings of clinical case vignettes were used to assess inter-rater reliability and temporal stability. Validity was assessed by correlating the DD-CGAS with measures of functioning and symptoms in 83 youngsters with PDD. Sensitivity to change was assessed by comparing change from baseline to post-treatment with change on the Aberrant Behavior Checklist–Irritability and Clinical Global Impressions–Improvement subscale scores in a subset of 14 children. Results Inter-rater reliability (intraclass correlation coefficient [ICC] = .79) and temporal stability (average ICC = .86) were excellent. The DD-CGAS scores correlated with measures of functioning and symptoms with moderate to large effect sizes. Changes on the DD-CGAS correlated with changes on the Aberrant Behavior Checklist–I (r = −.71) and Global Impressions Scale–I (r = −.52). The pre-post DD-CGAS change had an effect size of .72. Conclusions The DD-CGAS is a reliable instrument with apparent convergent validity for measuring global functioning of children with PDD in treatment studies.
Jing Liu - One of the best experts on this subject based on the ideXlab platform.
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Reliability and Validity of the Simplified Chinese Version of the Aberrant Behavior Checklist in Chinese Autism Population.
Frontiers in psychiatry, 2020Co-Authors: Siuching Kat, Yanqing Guo, Xinzhou Tang, Yulu Yang, Hui Wang, Jing LiuAbstract:Background: The Aberrant Behavior Checklist is a widely used scale in autism clinical intervention research for the assessment of core symptoms and comorbid emotional and Behavioral problems among people with autism. The aim of this study was to examine the psychometric properties of the Simplified Chinese version of Aberrant Behavior Checklist (SC-ABC) using a sample of people with autism in Chinese population. Methods: In total, we enrolled 799 patients aged 1.5-33 years old. We collected data using the SC-ABC (n=799), Autism Behavior Checklist (n=743), Attention Deficit Hyperactivity Disorder Rating Scale-IV (n=433) and Achenbach Child Behavior Checklist (n=319). Eighty-four patients were separately assessed with the SC-ABC by two caregivers simultaneously. Forty-four patients were assessed with the SC-ABC again by same caregiver two weeks after the first assessment. SC-ABC data from the whole sample were used for confirmatory factor analysis. We evaluated criterion validity using Spearman’s correlation coefficient between scores of the SC-ABC and scores of the Autism Behavior Checklist, Attention Deficit Hyperactivity Disorder Rating Scale-IV and Achenbach Child Behavior Checklist separately in the whole sample and different age groups. We calculated the intragroup correlation coefficients and Spearman’s correlation coefficient for interrater reliability in 84 samples and test-retest reliability in 44 samples. We conducted Cronbach’s α for internal consistency. Results: For the SC-ABC, the intragroup correlation coefficients of five subscales and the total score in interrater and test-retest reliability ranged from 0.87 to 0.92 and from 0.93 to 0.97 (all P＜0.01). The Spearman’s correlation coefficient of five subscales and the total score in interrater and test-retest reliability ranged from 0.78 to 0.85 and 0.86 to 0.94, respectively (all P＜0.01). Cronbach’s α of five subscales and the total score ranged from 0.75 to 0.96 (all P＜0.01). The Spearman’s correlation coefficient for criterion validity for the whole sample and different age groups ranged from 0.39 to 0.76 (all P＜0.01). The model fit for the original five factor model was acceptable, with fit indices of SMR=0.062 and RMSEA=0.052. Conclusions: The SC-ABC has satisfactory psychometric properties and can be used in the assessment of core symptoms and comorbid emotional and Behavioral problems in patients with autism.
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reliability and validity of the simplified chinese version of the Aberrant Behavior Checklist in chinese autism population
Frontiers in Psychiatry, 2020Co-Authors: Siuching Kat, Yanqing Guo, Xinzhou Tang, Yulu Yang, Hui Wang, Jing LiuAbstract:Background: The Aberrant Behavior Checklist (ABC) is a widely used scale in autism clinical intervention research for the assessment of core symptoms and comorbid emotional and Behavioral problems among people with autism. The aim of this study was to examine the psychometric properties of the Simplified Chinese version of the Aberrant Behavior Checklist (SC-ABC) using a sample of people with autism in a Chinese population. Methods: In total, we enrolled 799 patients aged 1.5-33 years old. We collected data using the SC-ABC (n = 799), Autism Behavior Checklist (n = 743), Attention Deficit Hyperactivity Disorder Rating Scale-IV (ADHD-RS-IV) (n = 433) and Achenbach Child Behavior Checklist (CBCL) (n = 319). Eighty-four patients were separately assessed with the SC-ABC by two caregivers simultaneously. Forty-four patients were assessed with the SC-ABC again by same caregiver 2 weeks after the first assessment. SC-ABC data from the whole sample were used for confirmatory factor analysis. We evaluated criterion validity using Spearman's correlation coefficient between scores of the SC-ABC and scores of the Autism Behavior Checklist, ADHD-RS-IV and CBCL separately in the whole sample and different age groups. We calculated the intragroup correlation coefficients and Spearman's correlation coefficient for interrater reliability in 84 samples and test-retest reliability in 44 samples. We conducted Cronbach's α for internal consistency. Results: For the SC-ABC, the intragroup correlation coefficients of five subscales and the total score in interrater and test-retest reliability ranged from 0.87 to 0.92 and from 0.93 to 0.97 (all P < 0.01). The Spearman's correlation coefficient of five subscales and the total score in interrater and test-retest reliability ranged from 0.78 to 0.85 and 0.86 to 0.94, respectively (all P < 0.01). Cronbach's α of five subscales and the total score ranged from 0.75 to 0.96 (all P < 0.01). The Spearman's correlation coefficient for criterion validity for the whole sample and different age groups ranged from 0.39 to 0.76 (all P < 0.01). The model fit for the original five factor model was acceptable, with fit indices of SMR = 0.062 and RMSEA = 0.052. Conclusions: The SC-ABC has satisfactory psychometric properties and can be used in the assessment of core symptoms and comorbid emotional and Behavioral problems in patients with autism.
Logan K. Wink - One of the best experts on this subject based on the ideXlab platform.
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Brief Report: Intranasal Ketamine in Adolescents and Young Adults with Autism Spectrum Disorder—Initial Results of a Randomized, Controlled, Crossover, Pilot Study
Journal of Autism and Developmental Disorders, 2020Co-Authors: Logan K. Wink, Debra L. Reisinger, Paul Horn, Rebecca C. Shaffer, Kaela O’brien, Lauren Schmitt, Kelli R. Dominick, Ernest V. Pedapati, Craig A. EricksonAbstract:Dysregulation of glutamate neurotransmission plays a critical role in autism spectrum disorder (ASD) pathophysiology and is a primary target for core deficit research treatment trials. The mechanism of action of ketamine has striking overlap with the theory of ASD as a disorder of synaptic communication and neuronal networks. This two-dose, double-blind, placebo controlled, cross-over pilot trial of intranasal (IN) ketamine targeting core social impairment included individuals with ASD ( N = 21) between 14 and 29 years. Participants were randomized to received two doses of IN ketamine (30 and 50 mg) and two doses of matching placebo. No significant impact was noted on the Aberrant Behavior Checklist Social Withdraw subscale. The IN ketamine was well tolerated, with only transient mild adverse effects.
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Brief Report: Intranasal Ketamine in Adolescents and Young Adults with Autism Spectrum Disorder-Initial Results of a Randomized, Controlled, Crossover, Pilot Study.
Journal of autism and developmental disorders, 2020Co-Authors: Logan K. Wink, Debra L. Reisinger, Rebecca C. Shaffer, Kaela O’brien, Kelli R. Dominick, Ernest V. Pedapati, Paul S. Horn, Lauren M. Schmitt, Craig A. EricksonAbstract:Dysregulation of glutamate neurotransmission plays a critical role in autism spectrum disorder (ASD) pathophysiology and is a primary target for core deficit research treatment trials. The mechanism of action of ketamine has striking overlap with the theory of ASD as a disorder of synaptic communication and neuronal networks. This two-dose, double-blind, placebo controlled, cross-over pilot trial of intranasal (IN) ketamine targeting core social impairment included individuals with ASD (N = 21) between 14 and 29 years. Participants were randomized to received two doses of IN ketamine (30 and 50 mg) and two doses of matching placebo. No significant impact was noted on the Aberrant Behavior Checklist Social Withdraw subscale. The IN ketamine was well tolerated, with only transient mild adverse effects.
