The Experts below are selected from a list of 156561 Experts worldwide ranked by ideXlab platform
Melissa Hensley - One of the best experts on this subject based on the ideXlab platform.
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post high school service use among young adults with an autism Spectrum Disorder
JAMA Pediatrics, 2011Co-Authors: Paul T Shattuck, Mary Wagner, Sarah Carter Narendorf, Paul R Sterzing, Melissa HensleyAbstract:Objectives To produce nationally representative population estimates of rates of service use among young adults with an autism Spectrum Disorder during their first few years after leaving high school and to examine correlates of use. Design Nationally representative telephone survey from April 2007 to February 2008. Setting United States. Participants Parents and guardians of young adults with autism Spectrum Disorders aged 19 to 23 years. Main Exposure Autism Spectrum Disorder. Main Outcome Measures Use of the following services in the prior 2 years or since leaving high school: mental health services, medical evaluation and assessment, speech therapy, and case management. Results Rates of service use ranged from 9.1% for speech therapy to 41.9% for case management; 39.1% of youths with an autism Spectrum Disorder represented by the survey received no services. The adjusted odds of no services were higher among African American participants and those with low incomes. The adjusted odds of case management were lower among youths with high functional skills and those with low incomes. Conclusions Rates of service disengagement are high after exiting high school. Disparities by race and socioeconomic status indicate a need for targeted outreach and services.
Matthew W. State - One of the best experts on this subject based on the ideXlab platform.
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Autism Spectrum Disorder
Nature Reviews Disease Primers, 2020Co-Authors: Catherine Lord, Traolach S. Brugha, Tony Charman, James Cusack, Guillaume Dumas, Thomas Frazier, Emily J. H. Jones, Rebecca M. Jones, Andrew Pickles, Matthew W. StateAbstract:Autism Spectrum Disorder is a construct used to describe individuals with a specific combination of impairments in social communication and repetitive behaviours, highly restricted interests and/or sensory behaviours beginning early in life. The worldwide prevalence of autism is just under 1%, but estimates are higher in high-income countries. Although gross brain pathology is not characteristic of autism, subtle anatomical and functional differences have been observed in post-mortem, neuroimaging and electrophysiological studies. Initially, it was hoped that accurate measurement of behavioural phenotypes would lead to specific genetic subtypes, but genetic findings have mainly applied to heterogeneous groups that are not specific to autism. Psychosocial interventions in children can improve specific behaviours, such as joint attention, language and social engagement, that may affect further development and could reduce symptom severity. However, further research is necessary to identify the long-term needs of people with autism, and treatments and the mechanisms behind them that could result in improved independence and quality of life over time. Families are often the major source of support for people with autism throughout much of life and need to be considered, along with the perspectives of autistic individuals, in both research and practice. Autism Spectrum Disorder — or autism — is a neurodevelopmental Disorder that typically manifests in young children. This Primer by Lord and colleagues reviews the epidemiology, mechanisms, clinical detection and treatment of autism.
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gene hunting in autism Spectrum Disorder on the path to precision medicine
Lancet Neurology, 2015Co-Authors: Daniel H Geschwind, Matthew W. StateAbstract:Summary Autism Spectrum Disorder is typical of the majority of neuropsychiatric syndromes in that it is defined by signs and symptoms, rather than by aetiology. Not surprisingly, the causes of this complex human condition are manifold and include a substantial genetic component. Recent developments in gene-hunting technologies and methods, and the resulting plethora of genetic findings, promise to open new avenues to understanding of disease pathophysiology and to contribute to improved clinical management. Despite remarkable genetic heterogeneity, evidence is emerging for converging pathophysiology in autism Spectrum Disorder, but how this notion of convergent pathways will translate into therapeutics remains to be established. Leveraging genetic findings through advances in model systems and integrative genomic approaches could lead to the development of new classes of therapies and a personalised approach to treatment.
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practice parameter for the assessment and treatment of children and adolescents with autism Spectrum Disorder
Journal of the American Academy of Child and Adolescent Psychiatry, 2014Co-Authors: Fred R Volkmar, Bryan H King, James T. Mccracken, Marc Woodburysmith, Matthew Siegel, Matthew W. StateAbstract:Autism Spectrum Disorder is characterized by patterns of delay and deviance in the development of social, communicative, and cognitive skills that arise in the first years of life. Although frequently associated with intellectual disability, this condition is distinctive in its course, impact, and treatment. Autism Spectrum Disorder has a wide range of syndrome expression and its management presents particular challenges for clinicians. Individuals with an autism Spectrum Disorder can present for clinical care at any point in development. The multiple developmental and behavioral problems associated with this condition necessitate multidisciplinary care, coordination of services, and advocacy for individuals and their families. Early, sustained intervention and the use of multiple treatment modalities are indicated. J. Am. Acad. Child Adolesc. Psychiatry, 2014;53(2):237–257. Key Words: autism, Practice Parameters, guidelines, developmental Disorders, pervasive developmental Disorders
Paul T Shattuck - One of the best experts on this subject based on the ideXlab platform.
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post high school service use among young adults with an autism Spectrum Disorder
JAMA Pediatrics, 2011Co-Authors: Paul T Shattuck, Mary Wagner, Sarah Carter Narendorf, Paul R Sterzing, Melissa HensleyAbstract:Objectives To produce nationally representative population estimates of rates of service use among young adults with an autism Spectrum Disorder during their first few years after leaving high school and to examine correlates of use. Design Nationally representative telephone survey from April 2007 to February 2008. Setting United States. Participants Parents and guardians of young adults with autism Spectrum Disorders aged 19 to 23 years. Main Exposure Autism Spectrum Disorder. Main Outcome Measures Use of the following services in the prior 2 years or since leaving high school: mental health services, medical evaluation and assessment, speech therapy, and case management. Results Rates of service use ranged from 9.1% for speech therapy to 41.9% for case management; 39.1% of youths with an autism Spectrum Disorder represented by the survey received no services. The adjusted odds of no services were higher among African American participants and those with low incomes. The adjusted odds of case management were lower among youths with high functional skills and those with low incomes. Conclusions Rates of service disengagement are high after exiting high school. Disparities by race and socioeconomic status indicate a need for targeted outreach and services.
Natalia Totolyan - One of the best experts on this subject based on the ideXlab platform.
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eculizumab in aquaporin 4 positive neuromyelitis optica Spectrum Disorder
The New England Journal of Medicine, 2019Co-Authors: Sean J Pittock, Achim Berthele, Kazuo Fujihara, Michael J Levy, J Palace, Ichiro Nakashima, Murat Terzi, Natalia TotolyanAbstract:Abstract Background Neuromyelitis optica Spectrum Disorder (NMOSD) is a relapsing, autoimmune, inflammatory Disorder that typically affects the optic nerves and spinal cord. At least two thirds of ...
Amanda Sowden - One of the best experts on this subject based on the ideXlab platform.
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support for adults with autism Spectrum Disorder without intellectual impairment systematic review
Autism, 2018Co-Authors: Theo Lorenc, Mark Rodgers, David Marshall, Hollie Melton, Rebecca Rees, Kath Wright, Amanda SowdenAbstract:Adults with autism Spectrum Disorder without intellectual impairment may benefit from a range of support services. This article presents the results of a systematic review assessing the effectiveness of supportive interventions for adults with autism Spectrum Disorder without intellectual impairment. A total of 32 studies were included; most focused on younger male participants. Although evidence was lacking for most types of intervention, employment programmes and social skills training were found to be effective for more proximal outcomes such as social skills. Evidence that any intervention improves mental health or well-being was very limited. Most interventions focused on mitigating specific deficits, rather than on providing broader support. Further research is needed on the effectiveness of supportive interventions such as advocacy and mentoring.
