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Aberrant Expression

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Naohiko Seki – One of the best experts on this subject based on the ideXlab platform.

  • The functional significance of microRNA-375 in human squamous cell carcinoma: Aberrant Expression and effects on cancer pathways
    Journal of Human Genetics, 2012
    Co-Authors: Takashi Kinoshita, Toyoyuki Hanazawa, Nijiro Nohata, Yoshitaka Okamoto, Naohiko Seki
    Abstract:

    MicroRNAs (miRNAs) are a class of small, non-coding RNA molecules consisting of 19–22 nucleotides that are involved in a variety of biological processes, including development, differentiation, apoptosis and cell proliferation. In cancer research, a growing body of evidence has indicated that miRNAs are Aberrantly expressed in many types of human cancers and can function either as tumor suppressors or oncogenes. Bioinformatic predictions suggest that miRNAs regulate more than 30% of protein-coding genes. Aberrant Expression of miRNAs in cancer cells causes destruction of miRNA-regulated messenger RNA networks. Therefore, the identification of miRNA-regulated cancer pathways is important for understanding the molecular mechanisms of human cancer. Searching for the Aberrant Expression of miRNAs in cancer cells is the first step in the functional analysis of miRNAs in cancer cells. Genome-wide miRNA Expression signatures can rapidly and precisely reveal Aberrant Expression of miRNA in cancers. The miRNA Expression signatures of human cancers have revealed that miR-375 is significantly downregulated in cancer cells. Our recent data on maxillary sinus, hypopharyngeal and esophageal squamous cell carcinomas have suggested that miR-375 is frequently downregulated and functions as a tumor suppressor that targets several oncogenic genes in cancer cells. In this review, we focus on several types of human squamous cell carcinoma and describe the Aberrant Expression of miRNAs and the cancer pathways they regulate in these diseases.

  • The functional significance of microRNA-375 in human squamous cell carcinoma: Aberrant Expression and effects on cancer pathways
    Journal of Human Genetics, 2012
    Co-Authors: Takashi Kinoshita, Toyoyuki Hanazawa, Nijiro Nohata, Yoshitaka Okamoto, Naohiko Seki
    Abstract:

    The functional significance of microRNA-375 in human squamous cell carcinoma: Aberrant Expression and effects on cancer pathways

Nafisa Balasinor – One of the best experts on this subject based on the ideXlab platform.

  • Aberrant Expression of imprinted genes in post-implantation rat embryos.
    Life Sciences, 2011
    Co-Authors: Neelam Kedia-mokashi, Raja C. Mugasimangalam, Mohammed Aiyaz, Srabani Mukherjee, Nafisa Balasinor
    Abstract:

    Abstract Aim Imprinted genes are known regulators of embryo growth. Studies from our laboratory have demonstrated that treatment of adult male rats with tamoxifen increased post-implantation loss at around midgestation. Expression of insulin like growth factor 2 ( Igf2 ), a paternally expressed imprinted gene was down-regulated in the resorbing embryos obtained at embryonic day 13. Hypomethylation of Igf2-H19 imprint control region was observed in the resorbing embryo sires and spermatozoa obtained from tamoxifen-treated rats thereby suggesting that errors in imprint acquisition during spermatogenesis can result in embryo loss. The present study aims at studying the Expression of other imprinted genes, besides Igf2 in the embryos sired by tamoxifen-treated males. Main methods Gene Expression profiles of resorbing versus normal embryos were assessed by microarrays. Real time quantitative RT-PCR for six imprinted genes and four genes involved in cell cycle was done to validate gene Expression data. The affected pathways and functions were identified in the resorbing embryos and effect on cell cycle was confirmed by flow cytometry. Key findings Aberrant Expression of a number of imprinted genes was observed in the resorbing embryos when compared to the normal embryos at embryonic days 11 and 13. Down-regulation of Notch signaling, Wnt signaling and cell cycle pathway was observed in the resorbing embryos. Significance The study suggests that exposure of male germ cells to tamoxifen during adulthood results in Aberrant Expression of imprinted genes and down-regulation of development associated pathways in the F 1 progeny thereby causing embryo loss.

  • Aberrant Expression of imprinted genes in post-implantation rat embryos.
    Life sciences, 2011
    Co-Authors: Neelam Kedia-mokashi, Raja C. Mugasimangalam, Mohammed Aiyaz, Srabani Mukherjee, Nafisa Balasinor
    Abstract:

    Imprinted genes are known regulators of embryo growth. Studies from our laboratory have demonstrated that treatment of adult male rats with tamoxifen increased post-implantation loss at around midgestation. Expression of insulin like growth factor 2 (Igf2), a paternally expressed imprinted gene was down-regulated in the resorbing embryos obtained at embryonic day 13. Hypomethylation of Igf2-H19 imprint control region was observed in the resorbing embryo sires and spermatozoa obtained from tamoxifen-treated rats thereby suggesting that errors in imprint acquisition during spermatogenesis can result in embryo loss. The present study aims at studying the Expression of other imprinted genes, besides Igf2 in the embryos sired by tamoxifen-treated males. Gene Expression profiles of resorbing versus normal embryos were assessed by microarrays. Real time quantitative RT-PCR for six imprinted genes and four genes involved in cell cycle was done to validate gene Expression data. The affected pathways and functions were identified in the resorbing embryos and effect on cell cycle was confirmed by flow cytometry. Aberrant Expression of a number of imprinted genes was observed in the resorbing embryos when compared to the normal embryos at embryonic days 11 and 13. Down-regulation of Notch signaling, Wnt signaling and cell cycle pathway was observed in the resorbing embryos. The study suggests that exposure of male germ cells to tamoxifen during adulthood results in Aberrant Expression of imprinted genes and down-regulation of development associated pathways in the F(1) progeny thereby causing embryo loss. Copyright © 2011 Elsevier Inc. All rights reserved.

Pavel P. Philippov – One of the best experts on this subject based on the ideXlab platform.

Takashi Kinoshita – One of the best experts on this subject based on the ideXlab platform.

  • The functional significance of microRNA-375 in human squamous cell carcinoma: Aberrant Expression and effects on cancer pathways
    Journal of Human Genetics, 2012
    Co-Authors: Takashi Kinoshita, Toyoyuki Hanazawa, Nijiro Nohata, Yoshitaka Okamoto, Naohiko Seki
    Abstract:

    MicroRNAs (miRNAs) are a class of small, non-coding RNA molecules consisting of 19–22 nucleotides that are involved in a variety of biological processes, including development, differentiation, apoptosis and cell proliferation. In cancer research, a growing body of evidence has indicated that miRNAs are Aberrantly expressed in many types of human cancers and can function either as tumor suppressors or oncogenes. Bioinformatic predictions suggest that miRNAs regulate more than 30% of protein-coding genes. Aberrant Expression of miRNAs in cancer cells causes destruction of miRNA-regulated messenger RNA networks. Therefore, the identification of miRNA-regulated cancer pathways is important for understanding the molecular mechanisms of human cancer. Searching for the Aberrant Expression of miRNAs in cancer cells is the first step in the functional analysis of miRNAs in cancer cells. Genome-wide miRNA Expression signatures can rapidly and precisely reveal Aberrant Expression of miRNA in cancers. The miRNA Expression signatures of human cancers have revealed that miR-375 is significantly downregulated in cancer cells. Our recent data on maxillary sinus, hypopharyngeal and esophageal squamous cell carcinomas have suggested that miR-375 is frequently downregulated and functions as a tumor suppressor that targets several oncogenic genes in cancer cells. In this review, we focus on several types of human squamous cell carcinoma and describe the Aberrant Expression of miRNAs and the cancer pathways they regulate in these diseases.

  • The functional significance of microRNA-375 in human squamous cell carcinoma: Aberrant Expression and effects on cancer pathways
    Journal of Human Genetics, 2012
    Co-Authors: Takashi Kinoshita, Toyoyuki Hanazawa, Nijiro Nohata, Yoshitaka Okamoto, Naohiko Seki
    Abstract:

    The functional significance of microRNA-375 in human squamous cell carcinoma: Aberrant Expression and effects on cancer pathways

Ning Zhang – One of the best experts on this subject based on the ideXlab platform.

  • Hypermethylation and Aberrant Expression of secreted fizzled-related protein genes in pancreatic cancer
    World journal of gastroenterology, 2008
    Co-Authors: Cheng-hai Zhao, Ning Zhang, Feng Gao, Shuai Lin, Xian-wei Dai
    Abstract:

    AIM: To determine the methylation status and Aberrant Expression of some secreted frizzled-related protein (SFRP) genes in pancreatic cancer and explore their role in pancreatic carcinogenesis. METHODS: Methylation status and Expression of SFRP genes were detected by methylation-specific PCR (MSPCR) and reverse-transcription PCR (RT-PCR) respectively. RESULTS: The frequencies of methylation for SFRP genes 1, 2, 4, 5 were 70%, 48.3%, 60% and 76.7% in pancreatic cancer samples, and 21.7%, 20%, 10% and 36.7% in matched cancer adjacent normal tissue samples, respectively (χ 2 = 28.23, P < 0.0001 for SFRP gene 1; χ 2 = 10.71, P = 0.001 for SFRP gene 2; χ 2 = 32.97, P < 0.0001 for SFRP gene 4; χ 2 = 19.55, P < 0.0001 for SFRP gene 5). Expression loss of SFRP genes 1, 2, 4 and 5 was found in 65%, 40%, 55% and 71.7% of 60 pancreatic cancer samples, and 25%, 15%, 18.3% and 31.7% of matched cancer adjacent normal tissue samples, respectively (χ 2 = 19.39, P < 0.0001 for SFRP gene 1; χ 2 = 9.40, P = 0.002 for SFRP gene 2; χ 2 = 17.37, P < 0.0001 for SFRP gene 4; χ 2 = 19.22, P < 0.0001 for SFRP gene 5). SFRP gene 1 was methylated but not expressed in PC-3 and PANC-1, SFRP gene 2 was methylated but not expressed in PANC-1 and CFPAC-1, SFRP gene 4 was methylated but not expressed in PC-3, and SFRP gene 5 was methylated but not expressed in CFPAC-1. CONCLUSION: Hypermethylation and Aberrant Expression of SFRP genes are common in pancreatic cancer, which may be involved in pancreatic carcinogenesis.

  • Hypermethylation and Aberrant Expression of Wnt antagonist secreted frizzled-related protein 1 in gastric cancer.
    World journal of gastroenterology, 2007
    Co-Authors: Cheng-hai Zhao, Ning Zhang
    Abstract:

    Hypermethylation and Aberrant Expression of Wnt antagonist secreted frizzled-related protein 1 in gastric cancer