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Absence of Complications

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Sarvesh R. Saroj – One of the best experts on this subject based on the ideXlab platform.

  • The role of enzymes of the glyoxalase system in relation to Complications in type II diabetes mellitus
    International Journal of Research in Medical Sciences, 2015
    Co-Authors: Vinay Govind Patke, Sarvesh R. Saroj
    Abstract:

    Background: Metabolism of methylglyoxal by the glyoxalase system may be linked to the development of diabetic Complications. It was considered worthwhile to find out whether changes observed in the levels of glyoxalase I, glyoxalase II, aldose reductase & D-lactate are prognostic indicators for the development of Complications of diabetes or merely reflect the result of changes associated with Complications. Methods: The glyoxalase system was characterized in erythrocytes of blood samples from patients with type II diabetes mellitus (n=177), and normal healthy control subjects (n=40). Diabetics were divided into 3 main groups based on presence or Absence of Complications. Results: The concentrations of RBC glyoxalase I, glyoxalase II, aldose reductase, and D-lactate were significantly increased in all groups of diabetic patients, (P

  • Research Article The role of enzymes of the glyoxalase system in relation to Complications in type II diabetes mellitus
    , 2015
    Co-Authors: Vinay Govind Patke, Sarvesh R. Saroj
    Abstract:

    Background: Metabolism of methylglyoxal by the glyoxalase system may be linked to the development of diabetic Complications. It was considered worthwhile to find out whether changes observed in the levels of glyoxalase I, glyoxalase II, aldose reductase & D-lactate are prognostic indicators for the development of Complications of diabetes or merely reflect the result of changes associated with Complications. Methods: The glyoxalase system was characterized in erythrocytes of blood samples from patients with type II diabetes mellitus (n=177), and normal healthy control subjects (n=40). Diabetics were divided into 3 main groups based on presence or Absence of Complications. Results: The concentrations of RBC glyoxalase I, glyoxalase II, aldose reductase, and D-lactate were significantly increased in all groups of diabetic patients, (P

  • Research Article Erythrocyte enzymes of Glyoxalase system as indicators of beneficial effects of antihyperglycemic agents in Type 2 Diabetes
    , 2015
    Co-Authors: Vinay Govind Patke, Sarvesh R. Saroj
    Abstract:

    Background: Methylglyoxal (MG), a product of sustained hyperglycemia, is a reactive carbonyl toxin responsible for development of Complications in diabetes. Glyoxalase system detoxify MG to prevent Complications. Some antihyperglycemic agents, may inhibit deleterious effects of MG by independent mechanisms. It was considered worthwhile to identify such agents and to find out whether changes observed in the erythrocyte levels of Glyoxalase I, Glyoxalase II, Aldose Reductase & D-Lactate are indicators of the beneficial effects through their direct action on MG, or merely a result of good glycemic control in response to treatment. Methods: The glyoxalase system was characterized in erythrocytes of blood samples from patients with Type 2 Diabetes (n = 147), and normal healthy control subjects (n = 40). Diabetics were divided into groups based on presence or Absence of Complications; & further divided into subgroups based on medication with sulphonylurea, metformin, insulin and combination therapy. Results: Erythrocyte Glyoxalase I, Glyoxalase II, Aldose Reductase, and D-Lactate levels significantly increased in all diabetics, (p

Shirley F. Jones – One of the best experts on this subject based on the ideXlab platform.

  • Resolution of subcutaneous emphysema with placement of subcutaneous fenestrated angiocatheter
    Respiratory Medicine Extra, 2007
    Co-Authors: Linda A. Perkins, Shirley F. Jones
    Abstract:

    Summary Subcutaneous emphysema can occur idiopathically or as a consequence of invasive procedures. While it normally does not lead to any significant medical problems, it can add to patient discomfort. Other described techniques to treat subcutaneous emphysema have been ineffective or associated with Complications. Successful utilization of a fenestrated subcutaneous angiocatheter for treatment of severe subcutaneous emphysema has been described in the literature. This case report serves as a literature review, as well as additional evidence to the efficacy of its use in the Absence of Complications.

M. E. Safar – One of the best experts on this subject based on the ideXlab platform.

  • Arteriosclerosis obliterans of the lower limbs as a model of peripheral vascular disease with hypertension.
    Journal of Cardiovascular Pharmacology, 1991
    Co-Authors: M. E. Safar
    Abstract:

    In patients with arteriosclerosis obliterans of the lower limbs, hypertension is often characterized by a disproportionate increase in systolic pressure whereas diastolic blood pressure remains normal or even low. This hemodynamic pattern is associated with a reduction in systemic and forearm arterial compliance, whereas cardiac output and peripheral vascular resistance remains within the normal range in the Absence of Complications

  • Arteriosclerosis obliterans of the lower limbs as a model of peripheral vascular disease with hypertension.
    Journal of cardiovascular pharmacology, 1991
    Co-Authors: M. E. Safar
    Abstract:

    In patients with arteriosclerosis obliterans of the lower limbs, hypertension is often characterized by a disproportionate increase in systolic pressure whereas diastolic blood pressure remains normal or even low. This hemodynamic pattern is associated with a reduction in systemic and forearm arterial compliance, whereas cardiac output and peripheral vascular resistance remains within the normal range in the Absence of Complications. The reduced arterial compliance is influenced not only by structural modifications of the arterial wall but also by changes in vasomotor tone. Whereas increased sodium intake and beta-blockade by propranolol reduce arterial compliance, nitrate derivatives increase arterial compliance with a resulting selective decrease in systolic pressure.