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Acantholytic Dyskeratosis

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Amos Buchner – One of the best experts on this subject based on the ideXlab platform.

  • warty dyskeratoma focal Acantholytic Dyskeratosis an update on a rare oral lesion
    Journal of Oral Pathology & Medicine, 2012
    Co-Authors: Irit Allon, Amos Buchner

    Abstract:

    J Oral Pathol Med (2012) 41: 261–267

    Background:  Warty dyskeratoma (WD) is an uncommon lesion of the skin that is considered to be associated with the pilosebaceous apparatus. Histologically similar lesions have been described in the oral region mainly by case reports and under the terms ‘WD’ or ‘focal Acantholytic Dyskeratosis (FAD)’. Owing to the paucity of reports, many aspects of the oral lesions remain unclear. The purpose of this study is to report a new case in an extremely rare location, the buccal mucosa, and to present a comprehensive updated review and analysis of the literature.

    Methods:  We reviewed all cases of oral lesions that were diagnosed as WD and FAD and analyzed them according to their clinical and pathologic features.

    Results:  The search yielded only 41 cases. The lesions usually appeared as asymptomatic, solitary, white nodules, papules, or patches on bone-bound mucosa. They occasionally had a rough surface and depressed center. The lesions were most common in the fifth to seventh decades. Use of tobacco appeared to be the most prevalent predisposing factor. The histopathological differential diagnosis of the lesion included Acantholytic squamous cell carcinoma, keratoacanthoma, and Darier’s disease.

    Conclusion:  Warty dyskeratoma/FAD are uncommon oral lesions which are not encountered in the daily practice of oral pathologists. The absence of an association of oral lesions with the pilosebaceous apparatus suggests that they are probably distinctly different from cutaneous ones. As such, we suggest the histologic term isolated FAD for oral lesions, rather than WD.

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  • Warty dyskeratoma/focal Acantholytic Dyskeratosis–an update on a rare oral lesion.
    Journal of Oral Pathology & Medicine, 2011
    Co-Authors: Irit Allon, Amos Buchner

    Abstract:

    J Oral Pathol Med (2012) 41: 261–267

    Background:  Warty dyskeratoma (WD) is an uncommon lesion of the skin that is considered to be associated with the pilosebaceous apparatus. Histologically similar lesions have been described in the oral region mainly by case reports and under the terms ‘WD’ or ‘focal Acantholytic Dyskeratosis (FAD)’. Owing to the paucity of reports, many aspects of the oral lesions remain unclear. The purpose of this study is to report a new case in an extremely rare location, the buccal mucosa, and to present a comprehensive updated review and analysis of the literature.

    Methods:  We reviewed all cases of oral lesions that were diagnosed as WD and FAD and analyzed them according to their clinical and pathologic features.

    Results:  The search yielded only 41 cases. The lesions usually appeared as asymptomatic, solitary, white nodules, papules, or patches on bone-bound mucosa. They occasionally had a rough surface and depressed center. The lesions were most common in the fifth to seventh decades. Use of tobacco appeared to be the most prevalent predisposing factor. The histopathological differential diagnosis of the lesion included Acantholytic squamous cell carcinoma, keratoacanthoma, and Darier’s disease.

    Conclusion:  Warty dyskeratoma/FAD are uncommon oral lesions which are not encountered in the daily practice of oral pathologists. The absence of an association of oral lesions with the pilosebaceous apparatus suggests that they are probably distinctly different from cutaneous ones. As such, we suggest the histologic term isolated FAD for oral lesions, rather than WD.

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Sanz A Trelles – One of the best experts on this subject based on the ideXlab platform.

  • pityriasis rubra pilaris with focal Acantholytic Dyskeratosis during treatment with imiquimod 5 cream
    Actas Dermo-Sifiliográficas, 2010
    Co-Authors: Elisabeth Gomezmoyano, A Crespoerchiga, Vera A Casano, Sanz A Trelles

    Abstract:

    Un varon de 56 anos se encontraba en la segunda semana de tratamiento con imiquimod crema 5% por un carcinoma basocelular superficial localizado en la espalda cuando desarrollo un cuadro pseudogripal acompanado de una erupcion eritematodescamativa que se inicio en la cabeza y se extendio rapidamente con progresion craneocaudal. A la exploracion se objetivaba una eritrodermia con pequenos islotes de piel sana y un incipiente engrosamiento anaranjado en las palmas y las plantas. En la cara se apreciaba un eritema anaranjado junto a un leve ectropion. En el torax se observaban pequenas papulas queratosicas foliculares (fig. 1). Las mucosas estaban respetadas. Se tomaron 2 biopsias cutaneas, una del abdomen y otra de una papula queratosica del torax, y ambas mostraron hallazgos identicos. Se apreciaba una paraqueratosis alternante junto a areas de disqueratosis focal con acantolisis, discreta espongiosis y un infiltrado linfocitario en la dermis superficial en banda (fig. 2). Los resultados analiticos fueron normales y la serologia para HIV resulto negativa. El tratamiento con imiquimod fue suspendido y se inicio acitretino a dosis de 35mg/d con completa resolucion de las lesiones tras 2 meses de tratamiento. El paciente rechazo estudio alergologico para descartar un posible papel del imiquimod en el desarrollo del

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Irit Allon – One of the best experts on this subject based on the ideXlab platform.

  • warty dyskeratoma focal Acantholytic Dyskeratosis an update on a rare oral lesion
    Journal of Oral Pathology & Medicine, 2012
    Co-Authors: Irit Allon, Amos Buchner

    Abstract:

    J Oral Pathol Med (2012) 41: 261–267

    Background:  Warty dyskeratoma (WD) is an uncommon lesion of the skin that is considered to be associated with the pilosebaceous apparatus. Histologically similar lesions have been described in the oral region mainly by case reports and under the terms ‘WD’ or ‘focal Acantholytic Dyskeratosis (FAD)’. Owing to the paucity of reports, many aspects of the oral lesions remain unclear. The purpose of this study is to report a new case in an extremely rare location, the buccal mucosa, and to present a comprehensive updated review and analysis of the literature.

    Methods:  We reviewed all cases of oral lesions that were diagnosed as WD and FAD and analyzed them according to their clinical and pathologic features.

    Results:  The search yielded only 41 cases. The lesions usually appeared as asymptomatic, solitary, white nodules, papules, or patches on bone-bound mucosa. They occasionally had a rough surface and depressed center. The lesions were most common in the fifth to seventh decades. Use of tobacco appeared to be the most prevalent predisposing factor. The histopathological differential diagnosis of the lesion included Acantholytic squamous cell carcinoma, keratoacanthoma, and Darier’s disease.

    Conclusion:  Warty dyskeratoma/FAD are uncommon oral lesions which are not encountered in the daily practice of oral pathologists. The absence of an association of oral lesions with the pilosebaceous apparatus suggests that they are probably distinctly different from cutaneous ones. As such, we suggest the histologic term isolated FAD for oral lesions, rather than WD.

    Free Register to Access Article

  • Warty dyskeratoma/focal Acantholytic Dyskeratosis–an update on a rare oral lesion.
    Journal of Oral Pathology & Medicine, 2011
    Co-Authors: Irit Allon, Amos Buchner

    Abstract:

    J Oral Pathol Med (2012) 41: 261–267

    Background:  Warty dyskeratoma (WD) is an uncommon lesion of the skin that is considered to be associated with the pilosebaceous apparatus. Histologically similar lesions have been described in the oral region mainly by case reports and under the terms ‘WD’ or ‘focal Acantholytic Dyskeratosis (FAD)’. Owing to the paucity of reports, many aspects of the oral lesions remain unclear. The purpose of this study is to report a new case in an extremely rare location, the buccal mucosa, and to present a comprehensive updated review and analysis of the literature.

    Methods:  We reviewed all cases of oral lesions that were diagnosed as WD and FAD and analyzed them according to their clinical and pathologic features.

    Results:  The search yielded only 41 cases. The lesions usually appeared as asymptomatic, solitary, white nodules, papules, or patches on bone-bound mucosa. They occasionally had a rough surface and depressed center. The lesions were most common in the fifth to seventh decades. Use of tobacco appeared to be the most prevalent predisposing factor. The histopathological differential diagnosis of the lesion included Acantholytic squamous cell carcinoma, keratoacanthoma, and Darier’s disease.

    Conclusion:  Warty dyskeratoma/FAD are uncommon oral lesions which are not encountered in the daily practice of oral pathologists. The absence of an association of oral lesions with the pilosebaceous apparatus suggests that they are probably distinctly different from cutaneous ones. As such, we suggest the histologic term isolated FAD for oral lesions, rather than WD.

    Free Register to Access Article