The Experts below are selected from a list of 9 Experts worldwide ranked by ideXlab platform
Alexander G. Pletnev - One of the best experts on this subject based on the ideXlab platform.
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WNV-labeled neurons in the subcortical structures, midbrain, pons, and medulla oblongata.
2016Co-Authors: Olga A. Maximova, John G. Bernbaum, Alexander G. PletnevAbstract:(A) Neurons in the motor thalamus display intense WNV-labeling in the neuronal perikarya and dendritic/axonal profiles (7 dpi). (B) WNV-labeled neuron in the basal ganglia. Note its close vicinity to a perivascular inflammatory infiltrate (7 dpi). (C) WNV-labeled neurons in the substantia nigra pars compacta (9 dpi). (D) Red Nucleus magnocellular part (9 dpi). Perikarya of large neurons display granular WNV-labeling. Also note WNV-labeled neuritic profile emanating from the infected neuron in the lower-left corner of the field. Representative images of WNV-labeled neurons in the brainstem are shown in E (pontine nuclei; 7 dpi), F (vestibular nuclei; 9 dpi), G (medullary reticular formation; 7 dpi), H (inferior olivary nuclei; 7 dpi), and I (Accessory Cuneate Nucleus; 9 dpi). Scale bars: 100 μm.
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Proposed directionality of WNV spread based on the neuroanatomical connectivity and time of immunohistochemical virus detection.
2016Co-Authors: Olga A. Maximova, John G. Bernbaum, Alexander G. PletnevAbstract:The connectograms illustrate most probable routes and directionality of WNV spread within the CNS in our NHP model of neuroinfection at 7 dpi (A) and 9/10 dpi (B). Construction and elements of the connectogram are described in Materials and Methods and text. Each arrow has the same color as the structure in the ring from which it originates. The circled numbers 1 to 4 represent most probable “order” of infected neurons within the corresponding anatomical structures. Solid arrows indicate most probable routes of anterograde spread; dashed arrows indicate most probable routes of retrograde spread. White lines indicate the possibility of both, anterograde and retrograde virus spread, due to existence of reciprocal connections between the same orders of neurons. Abbreviations: Mthal, motor thalamus; BG, basal ganglia; CSMN, corticospinal motor neurons; SNC, substantia nigra pars compacta; RnM, red Nucleus magnocellular; SMN, spinal motor neurons (C—cervical; T—thoracic; L—lumbar); CC, Clarke’s column; DCN, deep cerebellar nuclei; ACu, Accessory Cuneate Nucleus; IO, inferior olivary nuclear complex; MeRF, Medullary reticular formation; Ve, vestibular nuclei; PN, pontine nuclei.
Olga A. Maximova - One of the best experts on this subject based on the ideXlab platform.
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WNV-labeled neurons in the subcortical structures, midbrain, pons, and medulla oblongata.
2016Co-Authors: Olga A. Maximova, John G. Bernbaum, Alexander G. PletnevAbstract:(A) Neurons in the motor thalamus display intense WNV-labeling in the neuronal perikarya and dendritic/axonal profiles (7 dpi). (B) WNV-labeled neuron in the basal ganglia. Note its close vicinity to a perivascular inflammatory infiltrate (7 dpi). (C) WNV-labeled neurons in the substantia nigra pars compacta (9 dpi). (D) Red Nucleus magnocellular part (9 dpi). Perikarya of large neurons display granular WNV-labeling. Also note WNV-labeled neuritic profile emanating from the infected neuron in the lower-left corner of the field. Representative images of WNV-labeled neurons in the brainstem are shown in E (pontine nuclei; 7 dpi), F (vestibular nuclei; 9 dpi), G (medullary reticular formation; 7 dpi), H (inferior olivary nuclei; 7 dpi), and I (Accessory Cuneate Nucleus; 9 dpi). Scale bars: 100 μm.
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Proposed directionality of WNV spread based on the neuroanatomical connectivity and time of immunohistochemical virus detection.
2016Co-Authors: Olga A. Maximova, John G. Bernbaum, Alexander G. PletnevAbstract:The connectograms illustrate most probable routes and directionality of WNV spread within the CNS in our NHP model of neuroinfection at 7 dpi (A) and 9/10 dpi (B). Construction and elements of the connectogram are described in Materials and Methods and text. Each arrow has the same color as the structure in the ring from which it originates. The circled numbers 1 to 4 represent most probable “order” of infected neurons within the corresponding anatomical structures. Solid arrows indicate most probable routes of anterograde spread; dashed arrows indicate most probable routes of retrograde spread. White lines indicate the possibility of both, anterograde and retrograde virus spread, due to existence of reciprocal connections between the same orders of neurons. Abbreviations: Mthal, motor thalamus; BG, basal ganglia; CSMN, corticospinal motor neurons; SNC, substantia nigra pars compacta; RnM, red Nucleus magnocellular; SMN, spinal motor neurons (C—cervical; T—thoracic; L—lumbar); CC, Clarke’s column; DCN, deep cerebellar nuclei; ACu, Accessory Cuneate Nucleus; IO, inferior olivary nuclear complex; MeRF, Medullary reticular formation; Ve, vestibular nuclei; PN, pontine nuclei.
John G. Bernbaum - One of the best experts on this subject based on the ideXlab platform.
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WNV-labeled neurons in the subcortical structures, midbrain, pons, and medulla oblongata.
2016Co-Authors: Olga A. Maximova, John G. Bernbaum, Alexander G. PletnevAbstract:(A) Neurons in the motor thalamus display intense WNV-labeling in the neuronal perikarya and dendritic/axonal profiles (7 dpi). (B) WNV-labeled neuron in the basal ganglia. Note its close vicinity to a perivascular inflammatory infiltrate (7 dpi). (C) WNV-labeled neurons in the substantia nigra pars compacta (9 dpi). (D) Red Nucleus magnocellular part (9 dpi). Perikarya of large neurons display granular WNV-labeling. Also note WNV-labeled neuritic profile emanating from the infected neuron in the lower-left corner of the field. Representative images of WNV-labeled neurons in the brainstem are shown in E (pontine nuclei; 7 dpi), F (vestibular nuclei; 9 dpi), G (medullary reticular formation; 7 dpi), H (inferior olivary nuclei; 7 dpi), and I (Accessory Cuneate Nucleus; 9 dpi). Scale bars: 100 μm.
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Proposed directionality of WNV spread based on the neuroanatomical connectivity and time of immunohistochemical virus detection.
2016Co-Authors: Olga A. Maximova, John G. Bernbaum, Alexander G. PletnevAbstract:The connectograms illustrate most probable routes and directionality of WNV spread within the CNS in our NHP model of neuroinfection at 7 dpi (A) and 9/10 dpi (B). Construction and elements of the connectogram are described in Materials and Methods and text. Each arrow has the same color as the structure in the ring from which it originates. The circled numbers 1 to 4 represent most probable “order” of infected neurons within the corresponding anatomical structures. Solid arrows indicate most probable routes of anterograde spread; dashed arrows indicate most probable routes of retrograde spread. White lines indicate the possibility of both, anterograde and retrograde virus spread, due to existence of reciprocal connections between the same orders of neurons. Abbreviations: Mthal, motor thalamus; BG, basal ganglia; CSMN, corticospinal motor neurons; SNC, substantia nigra pars compacta; RnM, red Nucleus magnocellular; SMN, spinal motor neurons (C—cervical; T—thoracic; L—lumbar); CC, Clarke’s column; DCN, deep cerebellar nuclei; ACu, Accessory Cuneate Nucleus; IO, inferior olivary nuclear complex; MeRF, Medullary reticular formation; Ve, vestibular nuclei; PN, pontine nuclei.
Elena Berrone - One of the best experts on this subject based on the ideXlab platform.
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Mean values of vacuolar lesion profiles.
2018Co-Authors: Elena Vallino Costassa, Antonio D’angelo, Maria Mazza, Daniela Meloni, Elisa Baioni, Cristiana Maurella, Silvia Colussi, Nicola Martinelli, Monica Lo Faro, Elena BerroneAbstract:Square = BSE i.c. goats; rhombus = L-BSE i.c. goats (Brain areas, Medulla (at obex): 1 Dorsal Nucleus of the vagus nerve, 2 Nucleus of the hypoglossal nerve, 3 Reticular formation, 4 Midline Raphe, 5 Accessory Cuneate Nucleus, 6 Olivary nuclei; Rostral medulla: 7 Vestibular nuclear complex, 8 Cochlear Nucleus, 9 Nucleus of the spinal tract of the trigeminal nerve, 10 Midline raphe; Cerebellar vermis: 11 Nodulus±granular layer, 12 Nodulus±molecular layer; Midbrain: 13 Central grey matter, 14 Red Nucleus, 15 Substantia nigra, 16 Lateral geniculate Nucleus; Thalamus: 17 Dorsomedial thalamic Nucleus, 18 Ventral thalamic nuclei, 19 Area hypothalamica; Frontal: 20 Caudate Nucleus, 21 Nucleus accumbens, 22 Frontal cortex).X-axis: brain areas; Y-axis: mean vacuolation score with error bars (standard deviation).
Elena Vallino Costassa - One of the best experts on this subject based on the ideXlab platform.
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Mean values of vacuolar lesion profiles.
2018Co-Authors: Elena Vallino Costassa, Antonio D’angelo, Maria Mazza, Daniela Meloni, Elisa Baioni, Cristiana Maurella, Silvia Colussi, Nicola Martinelli, Monica Lo Faro, Elena BerroneAbstract:Square = BSE i.c. goats; rhombus = L-BSE i.c. goats (Brain areas, Medulla (at obex): 1 Dorsal Nucleus of the vagus nerve, 2 Nucleus of the hypoglossal nerve, 3 Reticular formation, 4 Midline Raphe, 5 Accessory Cuneate Nucleus, 6 Olivary nuclei; Rostral medulla: 7 Vestibular nuclear complex, 8 Cochlear Nucleus, 9 Nucleus of the spinal tract of the trigeminal nerve, 10 Midline raphe; Cerebellar vermis: 11 Nodulus±granular layer, 12 Nodulus±molecular layer; Midbrain: 13 Central grey matter, 14 Red Nucleus, 15 Substantia nigra, 16 Lateral geniculate Nucleus; Thalamus: 17 Dorsomedial thalamic Nucleus, 18 Ventral thalamic nuclei, 19 Area hypothalamica; Frontal: 20 Caudate Nucleus, 21 Nucleus accumbens, 22 Frontal cortex).X-axis: brain areas; Y-axis: mean vacuolation score with error bars (standard deviation).
