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Pavol Kovac - One of the best experts on this subject based on the ideXlab platform.

  • synthesis of a conjugation ready phosphorylated tetrasaccharide fragment of the o ps of vibrio cholerae o139
    Journal of Organic Chemistry, 2015
    Co-Authors: Sameh E Soliman, Pavol Kovac
    Abstract:

    A new pathway to the tetrasaccharide α-Colp-(1→2)-4,6-P-β-d-Galp-(1→3)-[α-Colp-(1→4)]-β-d-GlcpNAc-1-(OCH2CH2)3NH2 has been developed. Glycosylation of 8-azido-3,6-dioxaoctyl 4,6-O-benzylidene-2-deoxy-2-trichloroacetamido-β-d-glucopyranoside with 3,4,6-tri-O-acetyl-2-O-bromoacetyl-α-d-galactopyranosyl bromide afforded the β-linked disaccharide. Debromoacetylation followed by reductive opening of the benzylidene acetal afforded the disaccharide diol acceptor. Halide-assisted glycosylation with 2,4-di-O-benzyl-α-colitosyl bromide gave the 1,2-cis-coupling product. Deacetylation followed by regioselective phosphorylation gave isomeric (R,S)-(P)-4(II),6(II)-cyclic phosphates, which were globally deprotected by one-step catalytic (Pd/C) hydrogenation/hydrogenolysis. The target tetrasaccharide, obtained in high overall yield, is amenable for conjugation to proteins.

  • stereoselective syntheses of the conjugation ready downstream disaccharide and phosphorylated upstream branched trisaccharide fragments of the o ps of vibrio cholerae o139
    Journal of Organic Chemistry, 2015
    Co-Authors: Sameh E Solima, Pavol Kovac
    Abstract:

    N-Bromosuccinimide-mediated 4,6-O-benzylidene ring opening in 8-azido-3,6-dioxaoctyl 4,6-O-benzylidene-2-deoxy-2-trichloroacetamido-β-d-glucopyranoside afforded the corresponding 4-O-benzoyl-6-bromo-6-deoxy analogue, which was coupled with 3,4,6-tri-O-acetyl-2-O-benzyl-α-d-galactopyranosyl chloride to give the 1,2-cis α-linked disaccharide as the major product. Conventional hydroxyl group manipulation in the latter and products of further conversions gave the desired, functionalized disaccharide α-d-GalpA-(1→3)-β-d-QuipNAc. The rare, foregoing sequence forms the downstream end in the O-specific polysaccharide of both Vibrio cholerae O22 and O139. Halide-assisted glycosylation at 4I-OH in 8-azido-3,6-dioxaoctyl 6-O-benzyl-2-deoxy-3-O-(2,3,4,6-tetra-O-acetyl-β-d-galactopyranosyl)-2-trichloroacetamido-β-d-glucopyranoside, obtained by regioselective reductive opening of the acetal ring in the parent 4I,6I-O-benzylidene derivative, with 2,4-di-O-benzyl-α-colitosyl bromide, gave exclusively the α-linked trisacc...

Stefan Oscarson - One of the best experts on this subject based on the ideXlab platform.

  • synthesis of benzyl protected β d glca 1 2 α d man thioglycoside building blocks for construction of cryptococcus neoformans capsular polysaccharide structures
    Carbohydrate Research, 2014
    Co-Authors: Lorenzo Guazzelli, Rebecca Ulc, Stefan Oscarson
    Abstract:

    In a project targeting the synthesis of large oligosaccharide structures corresponding to the Cryptococcus neoformans GXM capsular polysaccharide, an easy access to thiodisaccharide building blocks comprising a β-linked glucuronic acid moiety and a 6-O-acetyl group was required. Several pathways to such building blocks have been investigated, addressing the problem of constructing a β-linked glucuronic acid residue protected with groups that are orthogonal to a primary acetyl group. Two efficient routes have been developed, one using benzoylated glucosyl donors to form the β-linkage followed by a change of protecting groups to benzyls and subsequent introduction of the carboxyl function and the acetyl group. The second route explored the possibility to achieve β-selectivity using glucuronyl donors without acyl protecting groups. BF3-etherate promoted glycosylations with benzyl (2,3,4-tri-O-benzyl-α-D-glucupyranosyl)uronate trichloroacetimidate in the presence of nitrile solvents and at low temperatures reproducibly gave good yields of disaccharides with high β-selectivity. Furthermore, the use of recently reported glucuronyl thioglycoside donors protected with a cyclic 2,4-silylene acetal was found to represent another efficient and completely β-selective way to desired disaccharide building blocks.

Senra, João Felipe De Brites - One of the best experts on this subject based on the ideXlab platform.

  • Mapeamento e validação de QTLs para isoflavonas em linhagens endogâmicas recombinantes de soja
    Universidade Federal do Espírito Santo, 2013
    Co-Authors: Senra, João Felipe De Brites
    Abstract:

    O Brasil é um dos grandes produtores mundiais de soja, sendo o seu cultivo bem distribuído no território nacional. A cultura caracteriza-se pelo potencial para produção de isoflavonas, fitoestrógenos de ocorrência natural nas plantas e com estrutura química comparável a do estradiol. As principais isoflavonas são as agliconas (genisteína, daidzeína e gliciteína) e as β-glicosídeo (genistina, daidzina e glicitina, 6 "-O-acetil genistina, 6"-O-acetil daidzina e 6 "-O-acetil glicitina, 6 "-O-malonil genistina, 6"-O-malonil daidzina, 6 "-O-malonil glicitina) Existem relatos sobre a influência benéfica destes sobre a saúde humana, quanto a redução de doenças coronarianas, retardam a manifestação de arteriosclerose, possuem efeitos benéficos na hipercolesterolemia, protegem contra diversos tipos de câncer e melhoria da atividade hormonal. Nas plantas as isoflavonas estimulam o microrganismo Bradirizobium do solo, a formação de nódulos nas raízes para fixação e atividade contra fungos fitopatogênicos e aumenta a resistência ao ataque de pulgões. Mediante os benefícios das isoflavonas na alimentação, sua influência na fisiologia da planta e a complexidade de sua extração e quantificação, torna-se necessário avaliar e estudar o controle genético desta característica, estimando os marcadores moleculares ligados aos QTLs que as controlam. O objetivo deste trabalho foi mapear e validar QTLs para isoflavonas utilizando linhagens endogâmicas recombinantes RIL (Recombinant Imbred Lines) e comparar os resultados obtidos pelo mapeamento por intervalo simples (IM Simple Interval Mapping) e mapeamento por intervalo composto (CIM Composite Interval Mapping). A população é constituída por linhagens endogâmicas recombinantes RIL (Recombinant Imbred Lines) pertencentes ao programa de melhoramento de soja da Universidade Federal de Viçosa, oriundas do cruzamento entre a cultivar Hartwig e a linhagem Y-23, contrastantes para o teor de daidzina, glicitina, genistina, malonil daidzina, malonil glicitina, acetil daidzina, daidzeína, acetil genistina, genisteína, daidzeína total, genisteína total, gliciteína total, e isoflavonas totais. O processo de extração foi realizado por cromatografia líquida de alta eficiência (HPLC high performance liquid chromatography), e a quantificação por padronização externa, sendo os resultados obtidos em μg.g-1. Foram utilizados 133 marcadores polimórficos, com os quais foi obtido um mapa de ligação com 24 grupos de ligação, frequência máxima de recombinação de 25 cM e LOD mínimo de 3,0. Foi realizado o mapeamento por marca simples MAS (single-marker locus analysis) por análise de variância e regressão, pelo método do intervalo simples (IM, simple interval mapping), pelo método da regressão e da máxima verossimilhança, e o mapeamento pelo intervalo composto (CIM, composite interval mapping). A determinação da posição do QTL foi realizada pelo teste de permutação, com 10000 permutas, possibilitando estabelecer níveis de significância de 5 e 1%. Nas características malonil daidzina e acetil genistina não ocorreram linhagens transgressivas. O genótipo 2.27 apresentou as maiores concentrações em oito isoflavonas e o 4.75 as menores em 12. Existem altas correlações entre as isoflavonas do grupo DAC com genistina, genisteína e genisteína total e baixa entre glicitina com DAC e genistina, genisteína e genisteína total. Foram validados QTLs nos GLs A2, D2, E, H, K, M e N para DAC, em C2, D2, K e M para GEC, em A2, C2, D1a, D2, H, K, M e N para GLC e para isoflavonas totais no GLs G, H e O. No GL G foram encontrados QTLs de grande efeito para DAC, e um grande número de QTLs para GEC, apesar de não serem citados QTLs neste GL para estas isoflavonas. Existem indícios de relação entre controle genético da resistência ao nematoide do cisto e isoflavonas nesta população, devido à proximidade dos QTLs que controlam estas características. O método mais eficiente de mapeamento foi o CIM, em virtude da seleção de cofatores que permitiu eliminar os QTL fantasmas, o que não foi possível pelo IM pelo método da regressão e máxima verossimilhança. O mapeamento pelo CIM detectou 44, 40, 29 e 10 QTLs para DAC, GEC, GLC e isoflavonas totais respectivamente. O IM por regressão posicionou nove, cinco, quatro e dois QTL para DAC, GEC, GLC e isoflavonas totais respectivamente. O IM pela abordagem da máxima verossimilhança posicionou seis QTLs para DAC e 12 para GEC respectivamenteBrazil is a major world producer of soybeans, its cultivation being well distributed throughout the country. The culture is characterized by the potential for production of isoflavones, phytoestrogens naturally occurring in plants and chemical structure comparable to that of estradiol. The principal isoflavone aglycones are (genistein, daidzein and glycitein) and β-glucoside (genistin, daidzin and glycitin, 6 "-O-acetyl genistin, 6"-O-acetyl daidzin and 6 "-O-acetyl glycitin, 6 "-O-malonyl genistein, 6"-O-malonyl daidzein, 6 "-O-malonyl glycitin). There are reports on the beneficial effects of these on human health, and the reduction of coronary heart disease, delay the manifestation of atherosclerosis, have beneficial effects on hypercholesterolemia, protects against various types of cancer and improving hormonal activity. In plants isoflavones stimulate soil microorganism Bradirizobium, the formation of nodules on the roots and for fixing activity against pathogenic fungi and increases resistance to attack by aphids. Through the benefits of isoflavones in the feed, their influence on plant physiology and complexity of their extraction and quantification, it is necessary to evaluate and study the genetic control of this characteristic estimating the molecular markers linked to the QTL that control them. The objective of this work was to map and validate QTLs for isoflavone using recombinant inbred lines RIL (Recombinant Imbred Lines) and compare the results obtained by simple interval mapping (IM Simple Interval Mapping) and composite interval mapping (CIM Composite Interval Mapping). The population consists of recombinant inbred lines RIL (Recombinant Imbred Lines) belonging to soybean breeding program at the Federal University of Viçosa, from the cross between the cultivar Hartwig and lineage Y-23, contrasting the content of daidzin, glycitin, genistin , malonyl daidzin, malonyl glycitin, acetyl daidzin, daidzein, acetyl genistin, genistein, daidzein, total genistein total glycitein total, and total isoflavones. The extraction process was performed by high performance liquid chromatography (HPLC), and quantified by external standard, and the results obtained in μg.g-1. Markers were used 133 polymorphic, which was obtained with a linkage map with 24 linkage groups, recombination frequency of 25 cM and a minimum LOD of 3.0. Mapping was carried out by simple brand MAS (single-marker locus analysis) by analysis of variance and regression, by the method of simple interval (IM, simple interval mapping), by the method of regression and maximum likelihood, and the composite interval mapping (CIM composite interval mapping). The positioning of QTL was performed by permutation test with 10,000 permutations, allowing establish significance levels of 5 and 1%. In the characteristics malonyl daidzin and acetyl genistin were not transgressive lines. The genotype 2.27 presented the highest levels in eight isoflavones and 4.75 in the lower 12. There are high correlations between the group DAC with isoflavones genistin, genistein and genistein total and low glycitin between DAC and genistin, genistein and genistein total. QTLs were validated in GLs A2, D2, E, H, K, M and N for CAD, C2, D2, K and M for GEC in A2, C2, D1a, D2, H, K, M and N for GLC and total isoflavone in GLs G, H and O. In GL G were found QTLs of large effect for DAC, and a large number of QTLs for GEC, although not mentioned in this GL QTLs for these isoflavones. There is evidence of a relationship between genetic control of resistance to the cyst nematode and isoflavones in this population due to the proximity of the QTL controlling these traits. The most efficient method of mapping the CIM was due to the selection of cofactors that allowed QTL eliminate ghosting, which was not possible for the IM method and maximum likelihood regression. The mapping CIM detected by 44, 40, 29 and 10 QTLs for CHD, GEC, GLC and total isoflavones respectively. The IM regression positioned nine, five, four and two QTL for CAD, GEC, GLC and total isoflavones respectively. The IM approach by maximum likelihood for DAC positioned six QTLs for GEC and 12 respectivel

  • Mapeamento e validação de QTLs para isoflavonas em linhagens endogâmicas recombinantes de soja
    UFES, 2013
    Co-Authors: Senra, João Felipe De Brites
    Abstract:

    Brazil is a major world producer of soybeans, its cultivation being well distributed throughout the country. The culture is characterized by the potential for production of isoflavones, phytoestrogens naturally occurring in plants and chemical structure comparable to that of estradiol. The principal isoflavone aglycones are (genistein, daidzein and glycitein) and β-glucoside (genistin, daidzin and glycitin, 6 "-O-acetyl genistin, 6"-O-acetyl daidzin and 6 "-O-acetyl glycitin, 6 "-O-malonyl genistein, 6"-O-malonyl daidzein, 6 "-O-malonyl glycitin). There are reports on the beneficial effects of these on human health, and the reduction of coronary heart disease, delay the manifestation of atherosclerosis, have beneficial effects on hypercholesterolemia, protects against various types of cancer and improving hormonal activity. In plants isoflavones stimulate soil microorganism Bradirizobium, the formation of nodules on the roots and for fixing activity against pathogenic fungi and increases resistance to attack by aphids. Through the benefits of isoflavones in the feed, their influence on plant physiology and complexity of their extraction and quantification, it is necessary to evaluate and study the genetic control of this characteristic estimating the molecular markers linked to the QTL that control them. The objective of this work was to map and validate QTLs for isoflavone using recombinant inbred lines RIL (Recombinant Imbred Lines) and compare the results obtained by simple interval mapping (IM Simple Interval Mapping) and composite interval mapping (CIM Composite Interval Mapping). The population consists of recombinant inbred lines RIL (Recombinant Imbred Lines) belonging to soybean breeding program at the Federal University of Viçosa, from the cross between the cultivar Hartwig and lineage Y-23, contrasting the content of daidzin, glycitin, genistin , malonyl daidzin, malonyl glycitin, acetyl daidzin, daidzein, acetyl genistin, genistein, daidzein, total genistein total glycitein total, and total isoflavones. The extraction process was performed by high performance liquid chromatography (HPLC), and quantified by external standard, and the results obtained in μg.g-1. Markers were used 133 polymorphic, which was obtained with a linkage map with 24 linkage groups, recombination frequency of 25 cM and a minimum LOD of 3.0. Mapping was carried out by simple brand MAS (single-marker locus analysis) by analysis of variance and regression, by the method of simple interval (IM, simple interval mapping), by the method of regression and maximum likelihood, and the composite interval mapping (CIM composite interval mapping). The positioning of QTL was performed by permutation test with 10,000 permutations, allowing establish significance levels of 5 and 1%. In the characteristics malonyl daidzin and acetyl genistin were not transgressive lines. The genotype 2.27 presented the highest levels in eight isoflavones and 4.75 in the lower 12. There are high correlations between the group DAC with isoflavones genistin, genistein and genistein total and low glycitin between DAC and genistin, genistein and genistein total. QTLs were validated in GLs A2, D2, E, H, K, M and N for CAD, C2, D2, K and M for GEC in A2, C2, D1a, D2, H, K, M and N for GLC and total isoflavone in GLs G, H and O. In GL G were found QTLs of large effect for DAC, and a large number of QTLs for GEC, although not mentioned in this GL QTLs for these isoflavones. There is evidence of a relationship between genetic control of resistance to the cyst nematode and isoflavones in this population due to the proximity of the QTL controlling these traits. The most efficient method of mapping the CIM was due to the selection of cofactors that allowed QTL eliminate ghosting, which was not possible for the IM method and maximum likelihood regression. The mapping CIM detected by 44, 40, 29 and 10 QTLs for CHD, GEC, GLC and total isoflavones respectively. The IM regression positioned nine, five, four and two QTL for CAD, GEC, GLC and total isoflavones respectively. The IM approach by maximum likelihood for DAC positioned six QTLs for GEC and 12 respectivelyO Brasil é um dos grandes produtores mundiais de soja, sendo o seu cultivo bem distribuído no território nacional. A cultura caracteriza-se pelo potencial para produção de isoflavonas, fitoestrógenos de ocorrência natural nas plantas e com estrutura química comparável a do estradiol. As principais isoflavonas são as agliconas (genisteína, daidzeína e gliciteína) e as β-glicosídeo (genistina, daidzina e glicitina, 6 "-O-acetil genistina, 6"-O-acetil daidzina e 6 "-O-acetil glicitina, 6 "-O-malonil genistina, 6"-O-malonil daidzina, 6 "-O-malonil glicitina) Existem relatos sobre a influência benéfica destes sobre a saúde humana, quanto a redução de doenças coronarianas, retardam a manifestação de arteriosclerose, possuem efeitos benéficos na hipercolesterolemia, protegem contra diversos tipos de câncer e melhoria da atividade hormonal. Nas plantas as isoflavonas estimulam o microrganismo Bradirizobium do solo, a formação de nódulos nas raízes para fixação e atividade contra fungos fitopatogênicos e aumenta a resistência ao ataque de pulgões. Mediante os benefícios das isoflavonas na alimentação, sua influência na fisiologia da planta e a complexidade de sua extração e quantificação, torna-se necessário avaliar e estudar o controle genético desta característica, estimando os marcadores moleculares ligados aos QTLs que as controlam. O objetivo deste trabalho foi mapear e validar QTLs para isoflavonas utilizando linhagens endogâmicas recombinantes RIL (Recombinant Imbred Lines) e comparar os resultados obtidos pelo mapeamento por intervalo simples (IM Simple Interval Mapping) e mapeamento por intervalo composto (CIM Composite Interval Mapping). A população é constituída por linhagens endogâmicas recombinantes RIL (Recombinant Imbred Lines) pertencentes ao programa de melhoramento de soja da Universidade Federal de Viçosa, oriundas do cruzamento entre a cultivar Hartwig e a linhagem Y-23, contrastantes para o teor de daidzina, glicitina, genistina, malonil daidzina, malonil glicitina, acetil daidzina, daidzeína, acetil genistina, genisteína, daidzeína total, genisteína total, gliciteína total, e isoflavonas totais. O processo de extração foi realizado por cromatografia líquida de alta eficiência (HPLC high performance liquid chromatography), e a quantificação por padronização externa, sendo os resultados obtidos em μg.g-1. Foram utilizados 133 marcadores polimórficos, com os quais foi obtido um mapa de ligação com 24 grupos de ligação, frequência máxima de recombinação de 25 cM e LOD mínimo de 3,0. Foi realizado o mapeamento por marca simples MAS (single-marker locus analysis) por análise de variância e regressão, pelo método do intervalo simples (IM, simple interval mapping), pelo método da regressão e da máxima verossimilhança, e o mapeamento pelo intervalo composto (CIM, composite interval mapping). A determinação da posição do QTL foi realizada pelo teste de permutação, com 10000 permutas, possibilitando estabelecer níveis de significância de 5 e 1%. Nas características malonil daidzina e acetil genistina não ocorreram linhagens transgressivas. O genótipo 2.27 apresentou as maiores concentrações em oito isoflavonas e o 4.75 as menores em 12. Existem altas correlações entre as isoflavonas do grupo DAC com genistina, genisteína e genisteína total e baixa entre glicitina com DAC e genistina, genisteína e genisteína total. Foram validados QTLs nos GLs A2, D2, E, H, K, M e N para DAC, em C2, D2, K e M para GEC, em A2, C2, D1a, D2, H, K, M e N para GLC e para isoflavonas totais no GLs G, H e O. No GL G foram encontrados QTLs de grande efeito para DAC, e um grande número de QTLs para GEC, apesar de não serem citados QTLs neste GL para estas isoflavonas. Existem indícios de relação entre controle genético da resistência ao nematoide do cisto e isoflavonas nesta população, devido à proximidade dos QTLs que controlam estas características. O método mais eficiente de mapeamento foi o CIM, em virtude da seleção de cofatores que permitiu eliminar os QTL fantasmas, o que não foi possível pelo IM pelo método da regressão e máxima verossimilhança. O mapeamento pelo CIM detectou 44, 40, 29 e 10 QTLs para DAC, GEC, GLC e isoflavonas totais respectivamente. O IM por regressão posicionou nove, cinco, quatro e dois QTL para DAC, GEC, GLC e isoflavonas totais respectivamente. O IM pela abordagem da máxima verossimilhança posicionou seis QTLs para DAC e 12 para GEC respectivament

Sameh E Soliman - One of the best experts on this subject based on the ideXlab platform.

  • synthesis of a conjugation ready phosphorylated tetrasaccharide fragment of the o ps of vibrio cholerae o139
    Journal of Organic Chemistry, 2015
    Co-Authors: Sameh E Soliman, Pavol Kovac
    Abstract:

    A new pathway to the tetrasaccharide α-Colp-(1→2)-4,6-P-β-d-Galp-(1→3)-[α-Colp-(1→4)]-β-d-GlcpNAc-1-(OCH2CH2)3NH2 has been developed. Glycosylation of 8-azido-3,6-dioxaoctyl 4,6-O-benzylidene-2-deoxy-2-trichloroacetamido-β-d-glucopyranoside with 3,4,6-tri-O-acetyl-2-O-bromoacetyl-α-d-galactopyranosyl bromide afforded the β-linked disaccharide. Debromoacetylation followed by reductive opening of the benzylidene acetal afforded the disaccharide diol acceptor. Halide-assisted glycosylation with 2,4-di-O-benzyl-α-colitosyl bromide gave the 1,2-cis-coupling product. Deacetylation followed by regioselective phosphorylation gave isomeric (R,S)-(P)-4(II),6(II)-cyclic phosphates, which were globally deprotected by one-step catalytic (Pd/C) hydrogenation/hydrogenolysis. The target tetrasaccharide, obtained in high overall yield, is amenable for conjugation to proteins.

Xiaohao Liu - One of the best experts on this subject based on the ideXlab platform.

  • a mechanism study on the efficient conversion of cellulose to Acetol over sn co catalysts with low sn content
    Green Chemistry, 2020
    Co-Authors: Xiaohao Liu, Xiaodong Liu, Haiyong Wang, Tianci Xiao, Ying Zhang
    Abstract:

    Efficient conversion of renewable cellulose to high value-added C3 chemicals is a great challenge in the field of biomass valorization. In this work, we found that the combination of Co and Sn could significantly improve the efficiency of cellulose conversion to Acetol. 54.4% yield of Acetol and 66.6% total yield of C3 products were obtained when using 2%Sn–10%Co/SiO2 (2 wt% Sn content) as a catalyst. However, using the same Sn content of 2%Sn–10%Ni/SiO2, no Acetol and only 7.1% yield of C3 products were produced. By studying the effects of different Sn and Co concentrations on cellulose conversion, it was found that the Sn species play an important role in catalyzing glucose conversion to C3 intermediates, while Co mainly played a role in hydrogenation, the same as Ni. The study demonstrated that Sn–Co/SiO2 with low Sn content can convert glucose to C3 intermediates more efficiently than the Sn–Ni/SiO2 catalyst. Moreover, Sn–Co/SiO2 could effectively convert C3 intermediates to Acetol at a high temperature which is essential for Acetol production from cellulose; but under the same conditions, the Sn–Ni/SiO2 catalyst tended to catalyze the polymerization of C3 intermediates. A series of characterization methods including AAS, TEM, HRTEM, EDS, XRD, ex situ XPS, in situ XPS, and CO2-TPD found that the combination of Sn and Co could significantly increase the noninteger valent SnOx species in the catalyst. These species increased the basicity of the catalyst and were beneficial in catalyzing the isomerization of glucose and the retro-aldol condensation of fructose.

  • highly efficient catalytic conversion of cellulose into Acetol over ni sn supported on nanosilica and the mechanism study
    Green Chemistry, 2019
    Co-Authors: Xiaohao Liu, Xiaodong Liu, Ying Zhang, Chenguang Wang
    Abstract:

    Selective conversion of cellulose into high value-added C3 chemicals is a great challenge in biorefinery due to the complicated reaction process. In this work, 61.6% yield of Acetol was obtained by one pot conversion of cellulose using Ni–Sn/SiO2 catalysts. A series of characterization methods including TEM, STEM-HAADF, EDS, AAS, XRD, XPS, H2-TPR, Py-FTIR, and CO2-TPD were carried out to explore the structure–activity relationship. The strong basicity of the catalysts was a key factor affecting the production of Acetol. In addition, catalysts with the hydrothermally stable L-acid sites and no B-acid sites inhibited side reactions and ensured efficient conversion of cellulose into small molecules. Further studies showed that the formation of the Ni3Sn4 alloy significantly promoted the Acetol production, and its weak hydrogenation activity inhibited further conversion of Acetol. Noninteger valence tin species (Snδ+ and SnOx) were formed both in Ni3Sn4 and Sn/SiO2. These Sn species were the source of basic sites and the active sites for catalyzing cellulose to Acetol. Under the synergistic catalysis of Sn/SiO2 and the Ni3Sn4 alloy, cellulose was efficiently converted into Acetol. This work provides guidance for the selective conversion of cellulose into C3 products.