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Acinic Cell Carcinoma

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Iran Seif – 1st expert on this subject based on the ideXlab platform

  • Papillary Cystic Acinic Cell Carcinoma with Many Psammoma Bodies, So-Called Psammoma Body–Rich Papillary Cystic Acinic Cell Carcinoma
    Acta Cytologica, 2009
    Co-Authors: Shahrzad Negahban, Yahya Daneshbod, Bijan Khademi, Iran Seif

    Abstract:

    Background Psammoma bodies are infrequent in salivary gland aspirates. We present a case of papillary cystic Acinic Cell Carcinoma with many psammoma bodies and discuss the diagnostic pitfalls with other salivary gland tumors. Case A 24-year-old woman presented with a 5-month history of a gradually enlarging, painless lump in the left side of the face. Physical examination demonstrated a 2 x 2-cm, nontender, rubbery mass inferior to the auricle in the left parotid area. Sonography showed a 2-cm, cystic mass in the left parotid. Fine needle aspiration was performed and showed mainly papillary clusters and isolated Cells with vacuolated cytoplasm and a round nucleus with an inconspicuous nucleolus resembling foamy histiocytes and many psammoma bodies, some of which were surrounded by Cells resembling cannonballs. A preliminary diagnosis of papillary cystic salivary gland neoplasm was made and superficial parotidectomy performed. A diagnosis ofpapillary cystic Acinic Cell Carcinoma with many psammoma bodies was made. Conclusion Aspiration cytology of papillary cystic Acinic Cell Carcinoma with many psammoma bodies can be confused with more common tumors, such as cystic mixed tumor and adenoid cystic Carcinoma with cannonballs, low grade mucoepidermoid Carcinoma or cystic papillary Carcinoma of the thyroid.

  • papillary cystic Acinic Cell Carcinoma with many psammoma bodies so called psammoma body rich papillary cystic Acinic Cell Carcinoma report of a case with fine needle aspiration findings
    Acta Cytologica, 2009
    Co-Authors: Shahrzad Negahban, Yahya Daneshbod, Bijan Khademi, Iran Seif

    Abstract:

    Background Psammoma bodies are infrequent in salivary gland aspirates. We present a case of papillary cystic Acinic Cell Carcinoma with many psammoma bodies and discuss the diagnostic pitfalls with other salivary gland tumors. Case A 24-year-old woman presented with a 5-month history of a gradually enlarging, painless lump in the left side of the face. Physical examination demonstrated a 2 x 2-cm, nontender, rubbery mass inferior to the auricle in the left parotid area. Sonography showed a 2-cm, cystic mass in the left parotid. Fine needle aspiration was performed and showed mainly papillary clusters and isolated Cells with vacuolated cytoplasm and a round nucleus with an inconspicuous nucleolus resembling foamy histiocytes and many psammoma bodies, some of which were surrounded by Cells resembling cannonballs. A preliminary diagnosis of papillary cystic salivary gland neoplasm was made and superficial parotidectomy performed. A diagnosis ofpapillary cystic Acinic Cell Carcinoma with many psammoma bodies was made. Conclusion Aspiration cytology of papillary cystic Acinic Cell Carcinoma with many psammoma bodies can be confused with more common tumors, such as cystic mixed tumor and adenoid cystic Carcinoma with cannonballs, low grade mucoepidermoid Carcinoma or cystic papillary Carcinoma of the thyroid.

Shahrzad Negahban – 2nd expert on this subject based on the ideXlab platform

  • Papillary Cystic Acinic Cell Carcinoma with Many Psammoma Bodies, So-Called Psammoma Body–Rich Papillary Cystic Acinic Cell Carcinoma
    Acta Cytologica, 2009
    Co-Authors: Shahrzad Negahban, Yahya Daneshbod, Bijan Khademi, Iran Seif

    Abstract:

    Background Psammoma bodies are infrequent in salivary gland aspirates. We present a case of papillary cystic Acinic Cell Carcinoma with many psammoma bodies and discuss the diagnostic pitfalls with other salivary gland tumors. Case A 24-year-old woman presented with a 5-month history of a gradually enlarging, painless lump in the left side of the face. Physical examination demonstrated a 2 x 2-cm, nontender, rubbery mass inferior to the auricle in the left parotid area. Sonography showed a 2-cm, cystic mass in the left parotid. Fine needle aspiration was performed and showed mainly papillary clusters and isolated Cells with vacuolated cytoplasm and a round nucleus with an inconspicuous nucleolus resembling foamy histiocytes and many psammoma bodies, some of which were surrounded by Cells resembling cannonballs. A preliminary diagnosis of papillary cystic salivary gland neoplasm was made and superficial parotidectomy performed. A diagnosis ofpapillary cystic Acinic Cell Carcinoma with many psammoma bodies was made. Conclusion Aspiration cytology of papillary cystic Acinic Cell Carcinoma with many psammoma bodies can be confused with more common tumors, such as cystic mixed tumor and adenoid cystic Carcinoma with cannonballs, low grade mucoepidermoid Carcinoma or cystic papillary Carcinoma of the thyroid.

  • papillary cystic Acinic Cell Carcinoma with many psammoma bodies so called psammoma body rich papillary cystic Acinic Cell Carcinoma report of a case with fine needle aspiration findings
    Acta Cytologica, 2009
    Co-Authors: Shahrzad Negahban, Yahya Daneshbod, Bijan Khademi, Iran Seif

    Abstract:

    Background Psammoma bodies are infrequent in salivary gland aspirates. We present a case of papillary cystic Acinic Cell Carcinoma with many psammoma bodies and discuss the diagnostic pitfalls with other salivary gland tumors. Case A 24-year-old woman presented with a 5-month history of a gradually enlarging, painless lump in the left side of the face. Physical examination demonstrated a 2 x 2-cm, nontender, rubbery mass inferior to the auricle in the left parotid area. Sonography showed a 2-cm, cystic mass in the left parotid. Fine needle aspiration was performed and showed mainly papillary clusters and isolated Cells with vacuolated cytoplasm and a round nucleus with an inconspicuous nucleolus resembling foamy histiocytes and many psammoma bodies, some of which were surrounded by Cells resembling cannonballs. A preliminary diagnosis of papillary cystic salivary gland neoplasm was made and superficial parotidectomy performed. A diagnosis ofpapillary cystic Acinic Cell Carcinoma with many psammoma bodies was made. Conclusion Aspiration cytology of papillary cystic Acinic Cell Carcinoma with many psammoma bodies can be confused with more common tumors, such as cystic mixed tumor and adenoid cystic Carcinoma with cannonballs, low grade mucoepidermoid Carcinoma or cystic papillary Carcinoma of the thyroid.

Roshni Chinoy – 3rd expert on this subject based on the ideXlab platform

  • cytomorphologic patterns in papillary cystic variant of Acinic Cell Carcinoma of the salivary gland
    Acta Cytologica, 2006
    Co-Authors: Tanuja Shet, Ratnaprabha Ghodke, Shubda Kane, Roshni Chinoy

    Abstract:

    OBJECTIVE: To study the cytomorphologic profile of the papillary and cystic variant of Acinic Cell Carcinoma (ACC-PCV) of the salivary glands. STUDY DESIGN: We studied 6 aspirates from 5 cases of ACC-PCV. RESULTS: All the cases had varied cytomorphologic features depending upon the degree of vacuolation of Cells. However, common to all was a papillary pattern and a cystic fluid background with or without mucin blobs; that led to misdiagnosing the tumor as mucoepidermoid Carcinoma on 2 occasions. The smears showed papillary fragments, sheets or clusters of vacuolated/histiocyte like Cells and granular Cells. The histiocytelike Cells resembled macrophages, with finely vacuolated cytoplasm and an eccentrically placed nucleus with frequent binucleation. Vascular cores were seen in a few aspirates. The granular Cells were similar to those seen in the usual Acinic Cell Carcinoma but were smaller. The tumor did not show any acinar pattern and lacked naked nuclei in the background. In 4 aspirates finely distributed, brown hemosiderin pigment was detected in the vacuolated Cells. CONCLUSION: ACC-PCV is papillary and cystic and hence is often not recognized as Acinic Cell Carcinoma. However, papillary fragments of vacuolated Cells or histiocytelike Cells and granular Cells are clues to the diagnosis.