Acne

14,000,000 Leading Edge Experts on the ideXlab platform

Scan Science and Technology

Contact Leading Edge Experts & Companies

Scan Science and Technology

Contact Leading Edge Experts & Companies

The Experts below are selected from a list of 24972 Experts worldwide ranked by ideXlab platform

Tadashi Tezuka - One of the best experts on this subject based on the ideXlab platform.

  • Acne phototherapy with a high intensity enhanced narrow band blue light source an open study and in vitro investigation
    Journal of Dermatological Science, 2002
    Co-Authors: Akira Kawada, Hiroko Kameyama, Yoshiko Sangen, Yoshinori Aragane, Tadashi Tezuka
    Abstract:

    The purpose of this study was to investigate the efficacy of phototherapy with a newly-developed high-intensity, enhanced, narrow-band, blue light source in patients with mild to moderate Acne. An open study was performed in Acne patients who were treated twice a week up to 5 weeks. Acne lesions were reduced by 64%. Two patients experienced dryness. No patient discontinued treatment due to adverse effects. In vitro investigation revealed that irradiation from this light source reduced the number of Propionibacterium Acnes (P. Acnes) , but not Staphylococcus epidermidis that were isolated from the Acne patients. Phototherapy using this blue light source was effective and well tolerated in Acne patients and had an ability to decrease numbers of P. Acnes in vitro, suggesting that this phototherapy may be a new modality for the treatment of Acne. # 2002 Elsevier Science Ireland Ltd. All rights reserved.

  • Acne phototherapy with a high intensity enhanced narrow band blue light source an open study and in vitro investigation
    Journal of Dermatological Science, 2002
    Co-Authors: Akira Kawada, Hiroko Kameyama, Yoshiko Sangen, Yoshinori Aragane, Tadashi Tezuka
    Abstract:

    The purpose of this study was to investigate the efficacy of phototherapy with a newly-developed high-intensity, enhanced, narrow-band, blue light source in patients with mild to moderate Acne. An open study was performed in Acne patients who were treated twice a week up to 5 weeks. Acne lesions were reduced by 64%. Two patients experienced dryness. No patient discontinued treatment due to adverse effects. In vitro investigation revealed that irradiation from this light source reduced the number of Propionibacterium Acnes (P. Acnes), but not Staphylococcus epidermidis that were isolated from the Acne patients. Phototherapy using this blue light source was effective and well tolerated in Acne patients and had an ability to decrease numbers of P. Acnes in vitro, suggesting that this phototherapy may be a new modality for the treatment of Acne.

Chunming Huang - One of the best experts on this subject based on the ideXlab platform.

  • a microtube array membrane mtam encapsulated live fermenting staphylococcus epidermidis as a skin probiotic patch against cutibacterium Acnes
    International Journal of Molecular Sciences, 2018
    Co-Authors: Albertjackson Yang, Chunming Huang, Shinta Marito, Johnjackson Yang, Sunita Keshari, Cheeho Chew, Chienchung Chen
    Abstract:

    Antibiotics without selectivity for Acne treatment may destroy the beneficial microbes in the human microbiome that helps to fight Cutibacterium Acnes (C. Acnes), a bacterium associated with inflammatory Acne vulgaris. Probiotic treatment by direct application of live Staphylococcus epidermidis (S. epidermidis) onto the open Acne lesions may run the risk of bloodstream infections. Here, we fabricated the polysulfone microtube array membranes (PSF MTAM) to encapsulate probiotic S. epidermidis. We demonstrate that the application of the encapsulation of S. epidermidis in PSF MTAM enhanced the glycerol fermentation activities of S. epidermidis. To mimic the granulomatous type of Acne inflammatory Acne vulgaris, the ears of mice were injected intradermally with C. Acnes to induce the secretion of macrophage inflammatory protein-2 (MIP-2), a murine counterpart of human interleukin (IL)-8. The C. Acnes-injected mouse ears were covered with a PST MTAM encapsulated with or without S. epidermidis in the presence of glycerol. The application of S. epidermidis-encapsulated PST MTAM plus glycerol onto the C. Acnes-injected mouse ears considerably reduced the growth of C. Acnes and the production of MIP-2. Furthermore, no S. epidermidis leaked from PSF MTAM into mouse skin. The S. epidermidis-encapsulated PST MTAM functions as a probiotic Acne patch.

  • the anti inflammatory activities of propionibacterium Acnes camp factor targeted Acne vaccines
    Journal of Investigative Dermatology, 2018
    Co-Authors: Yanhan Wang, Christos C Zouboulis, Richard L Gallo, Chunming Huang, Tissa Hata, Yun Larry Tong, Mingshan Kao
    Abstract:

    Inflammatory Acne vulgaris afflicts hundreds of millions of people globally. Propionibacterium Acnes, an opportunistic skin bacterium, has been linked to the pathogenesis of Acne vulgaris. Our results show that a secretory Christie-Atkins-Munch-Petersen (CAMP) factor of P. Acnes is up-regulated in anaerobic cultures. Mutation of CAMP factor significantly diminishes P. Acnes colonization and inflammation in mice, demonstrating the essential role of CAMP factor in the cytotoxicity of P. Acnes. Vaccination of mice with CAMP factor considerably reduced the growth of P. Acnes and production of MIP-2, a murine counterpart of human IL-8. Acne lesions were collected from patients to establish an ex vivo Acne model for validation of the efficacy of CAMP factor antibodies in the neutralization of the Acne inflammatory response. The P. Acnes CAMP factor and two proinflammatory cytokines (IL-8 and IL-1β) were expressed at higher levels in Acne lesions than those in nonlesional skin. Incubation of ex vivo Acne explants with monoclonal antibodies to CAMP factor markedly attenuated the amounts of IL-8 and IL-1β. Our work using an ex vivo Acne model shows that P. Acnes CAMP factor is an essential source of inflammation in Acne vulgaris.

  • antimicrobial property of lauric acid against propionibacterium Acnes its therapeutic potential for inflammatory Acne vulgaris
    Journal of Investigative Dermatology, 2009
    Co-Authors: Teruaki Nakatsuji, Mandy C Kao, Jiayou Fang, Christos C Zouboulis, Liangfang Zhang, Richard L Gallo, Chunming Huang
    Abstract:

    The strong bactericidal properties of lauric acid (C12:0), a middle chain-free fatty acid commonly found in natural products, have been shown in a number of studies. However, it has not been demonstrated whether lauric acid can be used for Acne treatment as a natural antibiotic against Propionibacterium Acnes (P. Acnes), which promotes follicular inflammation (inflammatory Acne). This study evaluated the antimicrobial property of lauric acid against P. Acnes both in vitro and in vivo. Incubation of the skin bacteria P. Acnes, Staphylococcus aureus (S. aureus), and Staphylococcus epidermidis (S. epidermidis) with lauric acid yielded minimal inhibitory concentration (MIC) values against the bacterial growth over 15 times lower than those of benzoyl peroxide (BPO). The lower MIC values of lauric acid indicate stronger antimicrobial properties than that of BPO. The detected values of half maximal effective concentration (EC50) of lauric acid on P. Acnes, S. aureus, and S. epidermidis growth indicate that P. Acnes is the most sensitive to lauric acid among these bacteria. In addition, lauric acid did not induce cytotoxicity to human sebocytes. Notably, both intradermal injection and epicutaneous application of lauric acid effectively decreased the number of P. Acnes colonized with mouse ears, thereby relieving P. Acnes-induced ear swelling and granulomatous inflammation. The obtained data highlight the potential of using lauric acid as an alternative treatment for antibiotic therapy of Acne vulgaris.

  • the antimicrobial activity of liposomal lauric acids against propionibacterium Acnes
    Biomaterials, 2009
    Co-Authors: Darren Yang, Teruaki Nakatsuji, Chunming Huang, Dissaya Pornpattananangkul, Michael Chan, Dennis A Carson, Liangfang Zhang
    Abstract:

    This study evaluated the antimicrobial activity of lauric acid (LA) and its liposomal derivatives against Propionibacterium Acnes (P. Acnes), the bacterium that promotes inflammatory Acne. First, the antimicrobial study of three free fatty acids (lauric acid, palmitic acid and oleic acid) demonstrated that LA gives the strongest bactericidal activity against P. Acnes. However, a setback of using LA as a potential treatment for inflammatory Acne is its poor water solubility. Then the LA was incorporated into a liposome formulation to aid its delivery to P. Acnes. It was demonstrated that the antimicrobial activity of LA was not only well maintained in its liposomal derivatives but also enhanced at low LA concentration. In addition, the antimicrobial activity of LA-loaded liposomes (LipoLA) mainly depended on the LA loading concentration per single liposomes. Further study found that the LipoLA could fuse with the membranes of P. Acnes and release the carried LA directly into the bacterial membranes, thereby killing the bacteria effectively. Since LA is a natural compound that is the main acid in coconut oil and also resides in human breast milk and liposomes have been successfully and widely applied as a drug delivery vehicle in the clinic, the LipoLA developed in this work holds great potential of becoming an innate, safe and effective therapeutic medication for Acne vulgaris and other P. Acnes associated diseases.

  • antibodies elicited by inactivated propionibacterium Acnes based vaccines exert protective immunity and attenuate the il 8 production in human sebocytes relevance to therapy for Acne vulgaris
    Journal of Investigative Dermatology, 2008
    Co-Authors: Teruaki Nakatsuji, Richard L Gallo, Yutsueng Liu, Chengpo Huang, Chunming Huang
    Abstract:

    Propionibacterium Acnes is a key pathogen involved in the progression of inflammation in Acne vulgaris. We examined whether vaccination against P. Acnes suppressed P. Acnes-induced skin inflammation. Inactivation of P. Acnes with heat was employed to create a P. Acnes-based vaccine. Intranasal immunization in mice with this inactivated vaccine provoked specific antibodies against P. Acnes. Most notably, immunization with inactivated vaccines generated in vivo protective immunity against P. Acnes challenge and facilitated the resolution of ear inflammation in mice. In addition, antibodies elicited by inactivated vaccines effectively neutralized the cytotoxicity of P. Acnes and attenuated the production of proinflammatory cytokine IL-8 in human sebocyte SZ95 cells. Intranasal immunization using heat-inactivated P. Acnes-based vaccines provided a simple modality to develop Acne vaccines. These observations highlight the concept that development of vaccines targeting microbial products may represent an alternative strategy to conventional antibiotic therapy.

Akira Kawada - One of the best experts on this subject based on the ideXlab platform.

  • Acne phototherapy with a high intensity enhanced narrow band blue light source an open study and in vitro investigation
    Journal of Dermatological Science, 2002
    Co-Authors: Akira Kawada, Hiroko Kameyama, Yoshiko Sangen, Yoshinori Aragane, Tadashi Tezuka
    Abstract:

    The purpose of this study was to investigate the efficacy of phototherapy with a newly-developed high-intensity, enhanced, narrow-band, blue light source in patients with mild to moderate Acne. An open study was performed in Acne patients who were treated twice a week up to 5 weeks. Acne lesions were reduced by 64%. Two patients experienced dryness. No patient discontinued treatment due to adverse effects. In vitro investigation revealed that irradiation from this light source reduced the number of Propionibacterium Acnes (P. Acnes) , but not Staphylococcus epidermidis that were isolated from the Acne patients. Phototherapy using this blue light source was effective and well tolerated in Acne patients and had an ability to decrease numbers of P. Acnes in vitro, suggesting that this phototherapy may be a new modality for the treatment of Acne. # 2002 Elsevier Science Ireland Ltd. All rights reserved.

  • Acne phototherapy with a high intensity enhanced narrow band blue light source an open study and in vitro investigation
    Journal of Dermatological Science, 2002
    Co-Authors: Akira Kawada, Hiroko Kameyama, Yoshiko Sangen, Yoshinori Aragane, Tadashi Tezuka
    Abstract:

    The purpose of this study was to investigate the efficacy of phototherapy with a newly-developed high-intensity, enhanced, narrow-band, blue light source in patients with mild to moderate Acne. An open study was performed in Acne patients who were treated twice a week up to 5 weeks. Acne lesions were reduced by 64%. Two patients experienced dryness. No patient discontinued treatment due to adverse effects. In vitro investigation revealed that irradiation from this light source reduced the number of Propionibacterium Acnes (P. Acnes), but not Staphylococcus epidermidis that were isolated from the Acne patients. Phototherapy using this blue light source was effective and well tolerated in Acne patients and had an ability to decrease numbers of P. Acnes in vitro, suggesting that this phototherapy may be a new modality for the treatment of Acne.

Hiroko Kameyama - One of the best experts on this subject based on the ideXlab platform.

  • Acne phototherapy with a high intensity enhanced narrow band blue light source an open study and in vitro investigation
    Journal of Dermatological Science, 2002
    Co-Authors: Akira Kawada, Hiroko Kameyama, Yoshiko Sangen, Yoshinori Aragane, Tadashi Tezuka
    Abstract:

    The purpose of this study was to investigate the efficacy of phototherapy with a newly-developed high-intensity, enhanced, narrow-band, blue light source in patients with mild to moderate Acne. An open study was performed in Acne patients who were treated twice a week up to 5 weeks. Acne lesions were reduced by 64%. Two patients experienced dryness. No patient discontinued treatment due to adverse effects. In vitro investigation revealed that irradiation from this light source reduced the number of Propionibacterium Acnes (P. Acnes) , but not Staphylococcus epidermidis that were isolated from the Acne patients. Phototherapy using this blue light source was effective and well tolerated in Acne patients and had an ability to decrease numbers of P. Acnes in vitro, suggesting that this phototherapy may be a new modality for the treatment of Acne. # 2002 Elsevier Science Ireland Ltd. All rights reserved.

  • Acne phototherapy with a high intensity enhanced narrow band blue light source an open study and in vitro investigation
    Journal of Dermatological Science, 2002
    Co-Authors: Akira Kawada, Hiroko Kameyama, Yoshiko Sangen, Yoshinori Aragane, Tadashi Tezuka
    Abstract:

    The purpose of this study was to investigate the efficacy of phototherapy with a newly-developed high-intensity, enhanced, narrow-band, blue light source in patients with mild to moderate Acne. An open study was performed in Acne patients who were treated twice a week up to 5 weeks. Acne lesions were reduced by 64%. Two patients experienced dryness. No patient discontinued treatment due to adverse effects. In vitro investigation revealed that irradiation from this light source reduced the number of Propionibacterium Acnes (P. Acnes), but not Staphylococcus epidermidis that were isolated from the Acne patients. Phototherapy using this blue light source was effective and well tolerated in Acne patients and had an ability to decrease numbers of P. Acnes in vitro, suggesting that this phototherapy may be a new modality for the treatment of Acne.

Yoshinori Aragane - One of the best experts on this subject based on the ideXlab platform.

  • Acne phototherapy with a high intensity enhanced narrow band blue light source an open study and in vitro investigation
    Journal of Dermatological Science, 2002
    Co-Authors: Akira Kawada, Hiroko Kameyama, Yoshiko Sangen, Yoshinori Aragane, Tadashi Tezuka
    Abstract:

    The purpose of this study was to investigate the efficacy of phototherapy with a newly-developed high-intensity, enhanced, narrow-band, blue light source in patients with mild to moderate Acne. An open study was performed in Acne patients who were treated twice a week up to 5 weeks. Acne lesions were reduced by 64%. Two patients experienced dryness. No patient discontinued treatment due to adverse effects. In vitro investigation revealed that irradiation from this light source reduced the number of Propionibacterium Acnes (P. Acnes) , but not Staphylococcus epidermidis that were isolated from the Acne patients. Phototherapy using this blue light source was effective and well tolerated in Acne patients and had an ability to decrease numbers of P. Acnes in vitro, suggesting that this phototherapy may be a new modality for the treatment of Acne. # 2002 Elsevier Science Ireland Ltd. All rights reserved.

  • Acne phototherapy with a high intensity enhanced narrow band blue light source an open study and in vitro investigation
    Journal of Dermatological Science, 2002
    Co-Authors: Akira Kawada, Hiroko Kameyama, Yoshiko Sangen, Yoshinori Aragane, Tadashi Tezuka
    Abstract:

    The purpose of this study was to investigate the efficacy of phototherapy with a newly-developed high-intensity, enhanced, narrow-band, blue light source in patients with mild to moderate Acne. An open study was performed in Acne patients who were treated twice a week up to 5 weeks. Acne lesions were reduced by 64%. Two patients experienced dryness. No patient discontinued treatment due to adverse effects. In vitro investigation revealed that irradiation from this light source reduced the number of Propionibacterium Acnes (P. Acnes), but not Staphylococcus epidermidis that were isolated from the Acne patients. Phototherapy using this blue light source was effective and well tolerated in Acne patients and had an ability to decrease numbers of P. Acnes in vitro, suggesting that this phototherapy may be a new modality for the treatment of Acne.

Related terms

Acne - 15 days free trial to Access Experts & Abstracts