The Experts below are selected from a list of 6 Experts worldwide ranked by ideXlab platform
Toshihiko Toida - One of the best experts on this subject based on the ideXlab platform.
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inverse correlation between stroke and urinary 3 hydroxypropyl mercapturic acid an Acrolein glutathione metabolite
Clinica Chimica Acta, 2012Co-Authors: Madoka Yoshida, Takahiro Mikami, Kyohei Higashi, Ryotaro Saiki, Mutsumi Mizoi, Kazumasa Fukuda, Takao Nakamura, Itsuko Ishii, Kazuhiro Nishimura, Toshihiko ToidaAbstract:Abstract Background We found previously that increases in plasma levels of protein-conjugated Acrolein and polyamine oxidases, enzymes that produce Acrolein, are good biomarkers for stroke. The aim of this study was to test whether 3-hydroxypropyl mercapturic acid (3-HPMA), an Acrolein-glutathione metabolite, was increased in the urine of stroke patients. Methods The level of 3-HPMA in urine was measured by liquid chromatography with tandem mass spectrometry (LC-MS/MS). Stroke (78 subjects) was divided into 52 cerebral infarction (CI) and 26 cerebral hemorrhage (CH) on the basis of clinical information including brain imaging. Results A major Acrolein Derivative in urine is 3-HPMA. Being different from the results of PC-Acro in plasma, 3-HPMA in urine decreased following stroke. The median value of μmol 3-HPMA/g creatinine (Cre) for 90 control subjects was 2.83, while that for 78 stroke patients was 1.56. The degree of the decrease in 3-HPMA was similar in both CI and CH patients. Furthermore, the median value of μmol 3-HPMA/g Cre in 56 patients with lesions ≥ 1 cm in diameter (1.39) was significantly lower than that in 20 patients with lesion Conclusion Inverse correlation between stroke and urinary 3-HPMA was observed. The results suggest that stroke is aggravated when nervous system tissues have a reduced level of glutathione.
Madoka Yoshida - One of the best experts on this subject based on the ideXlab platform.
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inverse correlation between stroke and urinary 3 hydroxypropyl mercapturic acid an Acrolein glutathione metabolite
Clinica Chimica Acta, 2012Co-Authors: Madoka Yoshida, Takahiro Mikami, Kyohei Higashi, Ryotaro Saiki, Mutsumi Mizoi, Kazumasa Fukuda, Takao Nakamura, Itsuko Ishii, Kazuhiro Nishimura, Toshihiko ToidaAbstract:Abstract Background We found previously that increases in plasma levels of protein-conjugated Acrolein and polyamine oxidases, enzymes that produce Acrolein, are good biomarkers for stroke. The aim of this study was to test whether 3-hydroxypropyl mercapturic acid (3-HPMA), an Acrolein-glutathione metabolite, was increased in the urine of stroke patients. Methods The level of 3-HPMA in urine was measured by liquid chromatography with tandem mass spectrometry (LC-MS/MS). Stroke (78 subjects) was divided into 52 cerebral infarction (CI) and 26 cerebral hemorrhage (CH) on the basis of clinical information including brain imaging. Results A major Acrolein Derivative in urine is 3-HPMA. Being different from the results of PC-Acro in plasma, 3-HPMA in urine decreased following stroke. The median value of μmol 3-HPMA/g creatinine (Cre) for 90 control subjects was 2.83, while that for 78 stroke patients was 1.56. The degree of the decrease in 3-HPMA was similar in both CI and CH patients. Furthermore, the median value of μmol 3-HPMA/g Cre in 56 patients with lesions ≥ 1 cm in diameter (1.39) was significantly lower than that in 20 patients with lesion Conclusion Inverse correlation between stroke and urinary 3-HPMA was observed. The results suggest that stroke is aggravated when nervous system tissues have a reduced level of glutathione.
Takahiro Mikami - One of the best experts on this subject based on the ideXlab platform.
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inverse correlation between stroke and urinary 3 hydroxypropyl mercapturic acid an Acrolein glutathione metabolite
Clinica Chimica Acta, 2012Co-Authors: Madoka Yoshida, Takahiro Mikami, Kyohei Higashi, Ryotaro Saiki, Mutsumi Mizoi, Kazumasa Fukuda, Takao Nakamura, Itsuko Ishii, Kazuhiro Nishimura, Toshihiko ToidaAbstract:Abstract Background We found previously that increases in plasma levels of protein-conjugated Acrolein and polyamine oxidases, enzymes that produce Acrolein, are good biomarkers for stroke. The aim of this study was to test whether 3-hydroxypropyl mercapturic acid (3-HPMA), an Acrolein-glutathione metabolite, was increased in the urine of stroke patients. Methods The level of 3-HPMA in urine was measured by liquid chromatography with tandem mass spectrometry (LC-MS/MS). Stroke (78 subjects) was divided into 52 cerebral infarction (CI) and 26 cerebral hemorrhage (CH) on the basis of clinical information including brain imaging. Results A major Acrolein Derivative in urine is 3-HPMA. Being different from the results of PC-Acro in plasma, 3-HPMA in urine decreased following stroke. The median value of μmol 3-HPMA/g creatinine (Cre) for 90 control subjects was 2.83, while that for 78 stroke patients was 1.56. The degree of the decrease in 3-HPMA was similar in both CI and CH patients. Furthermore, the median value of μmol 3-HPMA/g Cre in 56 patients with lesions ≥ 1 cm in diameter (1.39) was significantly lower than that in 20 patients with lesion Conclusion Inverse correlation between stroke and urinary 3-HPMA was observed. The results suggest that stroke is aggravated when nervous system tissues have a reduced level of glutathione.
Kyohei Higashi - One of the best experts on this subject based on the ideXlab platform.
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inverse correlation between stroke and urinary 3 hydroxypropyl mercapturic acid an Acrolein glutathione metabolite
Clinica Chimica Acta, 2012Co-Authors: Madoka Yoshida, Takahiro Mikami, Kyohei Higashi, Ryotaro Saiki, Mutsumi Mizoi, Kazumasa Fukuda, Takao Nakamura, Itsuko Ishii, Kazuhiro Nishimura, Toshihiko ToidaAbstract:Abstract Background We found previously that increases in plasma levels of protein-conjugated Acrolein and polyamine oxidases, enzymes that produce Acrolein, are good biomarkers for stroke. The aim of this study was to test whether 3-hydroxypropyl mercapturic acid (3-HPMA), an Acrolein-glutathione metabolite, was increased in the urine of stroke patients. Methods The level of 3-HPMA in urine was measured by liquid chromatography with tandem mass spectrometry (LC-MS/MS). Stroke (78 subjects) was divided into 52 cerebral infarction (CI) and 26 cerebral hemorrhage (CH) on the basis of clinical information including brain imaging. Results A major Acrolein Derivative in urine is 3-HPMA. Being different from the results of PC-Acro in plasma, 3-HPMA in urine decreased following stroke. The median value of μmol 3-HPMA/g creatinine (Cre) for 90 control subjects was 2.83, while that for 78 stroke patients was 1.56. The degree of the decrease in 3-HPMA was similar in both CI and CH patients. Furthermore, the median value of μmol 3-HPMA/g Cre in 56 patients with lesions ≥ 1 cm in diameter (1.39) was significantly lower than that in 20 patients with lesion Conclusion Inverse correlation between stroke and urinary 3-HPMA was observed. The results suggest that stroke is aggravated when nervous system tissues have a reduced level of glutathione.
Ryotaro Saiki - One of the best experts on this subject based on the ideXlab platform.
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inverse correlation between stroke and urinary 3 hydroxypropyl mercapturic acid an Acrolein glutathione metabolite
Clinica Chimica Acta, 2012Co-Authors: Madoka Yoshida, Takahiro Mikami, Kyohei Higashi, Ryotaro Saiki, Mutsumi Mizoi, Kazumasa Fukuda, Takao Nakamura, Itsuko Ishii, Kazuhiro Nishimura, Toshihiko ToidaAbstract:Abstract Background We found previously that increases in plasma levels of protein-conjugated Acrolein and polyamine oxidases, enzymes that produce Acrolein, are good biomarkers for stroke. The aim of this study was to test whether 3-hydroxypropyl mercapturic acid (3-HPMA), an Acrolein-glutathione metabolite, was increased in the urine of stroke patients. Methods The level of 3-HPMA in urine was measured by liquid chromatography with tandem mass spectrometry (LC-MS/MS). Stroke (78 subjects) was divided into 52 cerebral infarction (CI) and 26 cerebral hemorrhage (CH) on the basis of clinical information including brain imaging. Results A major Acrolein Derivative in urine is 3-HPMA. Being different from the results of PC-Acro in plasma, 3-HPMA in urine decreased following stroke. The median value of μmol 3-HPMA/g creatinine (Cre) for 90 control subjects was 2.83, while that for 78 stroke patients was 1.56. The degree of the decrease in 3-HPMA was similar in both CI and CH patients. Furthermore, the median value of μmol 3-HPMA/g Cre in 56 patients with lesions ≥ 1 cm in diameter (1.39) was significantly lower than that in 20 patients with lesion Conclusion Inverse correlation between stroke and urinary 3-HPMA was observed. The results suggest that stroke is aggravated when nervous system tissues have a reduced level of glutathione.
