Acupuncture Analgesia

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Bao-cheng Lin - One of the best experts on this subject based on the ideXlab platform.

  • Effect of arginine vasopressin on Acupuncture Analgesia in the rat.
    Peptides, 2008
    Co-Authors: Jun Yang, Yu Yang, Wen-yan Liu, Cheng-hai Wang, Wang, Bao-cheng Lin
    Abstract:

    Arginine vasopressin (AVP) has been proven to be involved in the process of pain regulation. This communication was designed to investigate the effect of AVP on Acupuncture Analgesia in the rat model. The results showed that intraventricular injection (icv) of AVP could enhance Acupuncture Analgesia in a dose-dependent manner, whereas icv of anti-AVP serum decreased Acupuncture Analgesia. However, neither intrathecal (ith) nor intravenous injection (iv) of AVP or anti-AVP serum could influence Acupuncture Analgesia. Electrical Acupuncture of “Zusanli” points (St. 36) decreased AVP concentration in the hypothalamic paraventricular nucleus (PVN), and increased AVP concentration in the hypothalamic supraoptic nucleus (SON), periaqueductial gray (PAG), caudate nucleus (CdN) and raphe magnus nucleus (RMN), but did not change AVP concentration in the pituitary, spinal cord and plasma. The effect of AVP on Acupuncture Analgesia was partly reversed by pretreatment with naloxone, an opiate receptor antagonist. These data suggested that AVP in the brain played a role in the process of Acupuncture Analgesia in combination with the endogenous opiate peptide system.

  • Effect of oxytocin on Acupuncture Analgesia in the rat.
    Neuropeptides, 2007
    Co-Authors: Jun Yang, Yu Yang, Jian-min Chen, Wen-yan Liu, Cheng-hai Wang, Bao-cheng Lin
    Abstract:

    Oxytocin has been demonstrated to be involved in pain modulation. Acupuncture Analgesia is a very useful clinical tool for pain relief, which has over 2500-year history in China. The present study investigated the role of oxytocin in Acupuncture Analgesia in the rat through oxytocin administration and measurement. Central administration of oxytocin (intraventricular injection or intrathecal injection) enhanced Acupuncture Analgesia, while central administration of anti-oxytocin serum weakened Acupuncture Analgesia in a dose-dependent manner. However, intravenous injection of oxytocin or anti-oxytocin serum did not influence Acupuncture Analgesia. Electrical Acupuncture of "Zusanli" (St. 36) reduced oxytocin concentration in the hypothalamic supraoptic nucleus, and elevated oxytocin concentration in the hypothalamic suprachiasmatic nucleus, hypothalamic ventromedial nucleus, thalamic ventral nucleus, periaqueductal gray, raphe magnus nucleus, caudate nucleus, thoracic spinal cord and lumbar spinal cord, but did not alter oxytocin concentration in the hypothalamic paraventricular nucleus, anterior pituitary, posterior pituitary and plasma. The data suggested that oxytocin in central nervous system rather than in peripheral organs is involved in Acupuncture Analgesia.

  • Through central arginine vasopressin, not oxytocin and endogenous opiate peptides, glutamate sodium induces hypothalamic paraventricular nucleus enhancing Acupuncture Analgesia in the rat.
    Neuroscience research, 2005
    Co-Authors: Jun Yang, Wen-yan Liu, Cao-you Song, Bao-cheng Lin
    Abstract:

    Abstract Our previous study proved that the hypothalamic paraventricular nucleus (PVH) plays an important role in Acupuncture Analgesia. The neuropeptides involving in the PVH regulation of Acupuncture Analgesia was investigated in the rat. The changes of pain threshold, which was induced by electrical Acupuncture of “Zusanli” points (St. 36), were measured as Acupuncture Analgesia. Microinjection of l -glutamate sodium into the PVH, which only excites the PVH neurons, could dose-dependently enhance the Acupuncture Analgesia, but microinjection of l -glutamate sodium into the area nearby the PVH did not alter Acupuncture Analgesia. Removing pituitary did not influence this effect of l -glutamate sodium. Microinjection of l -glutamate sodium into the PVH only increased the arginine vasopressin (AVP), not oxytocin (OXT), leucine enkephaline (L-Ek), β-endorphine (β-Ep) and dynorphinA 1–13 (DynA 1–13 ) concentrations in the PVH perfuse liquid using radioimmunoassay. Intraventricular injection of anti-arginine vasopressin serum (AAVPS) could completely reverse the effect of microinjection of l -glutamate sodium into the PVH enhancing Acupuncture Analgesia. Intraventricular injection of naloxone, one opiate peptide antagonist, partly attenuated this effect of l -glutamate sodium, and intraventricular of anti-oxytocin serum (AOXTS) did not change this effect of l -glutamate sodium. The results suggested that l -glutamate sodium induces the PVH enhancing Acupuncture Analgesia only through AVP, not OXT and endogenous opiate peptides in central nervous system.

  • Hypothalamic paraventricular nucleus plays a role in Acupuncture Analgesia through the central nervous system in the rat.
    Acupuncture & electro-therapeutics research, 1992
    Co-Authors: Jun Yang, Bao-cheng Lin
    Abstract:

    This work investigates the effect of hypothalamic paraventricular nucleus (PVN) on Acupuncture Analgesia in the rat. Electrical stimulation of PVN or injection of L-glutamate sodium into PVN could enhance the analgesic effect induced by Acupuncture Zusanli (St. 36) while the electrical cauterization of PVN is decreased; Removal of the pituitary could not influence the effect of enhancing Acupuncture Analgesia induced by the injection of L-glutamate sodium into PVN. These results suggest that PVN might play an important role in Acupuncture Analgesia through central nervous system.

Jun Yang - One of the best experts on this subject based on the ideXlab platform.

  • Effect of arginine vasopressin on Acupuncture Analgesia in the rat.
    Peptides, 2008
    Co-Authors: Jun Yang, Yu Yang, Wen-yan Liu, Cheng-hai Wang, Wang, Bao-cheng Lin
    Abstract:

    Arginine vasopressin (AVP) has been proven to be involved in the process of pain regulation. This communication was designed to investigate the effect of AVP on Acupuncture Analgesia in the rat model. The results showed that intraventricular injection (icv) of AVP could enhance Acupuncture Analgesia in a dose-dependent manner, whereas icv of anti-AVP serum decreased Acupuncture Analgesia. However, neither intrathecal (ith) nor intravenous injection (iv) of AVP or anti-AVP serum could influence Acupuncture Analgesia. Electrical Acupuncture of “Zusanli” points (St. 36) decreased AVP concentration in the hypothalamic paraventricular nucleus (PVN), and increased AVP concentration in the hypothalamic supraoptic nucleus (SON), periaqueductial gray (PAG), caudate nucleus (CdN) and raphe magnus nucleus (RMN), but did not change AVP concentration in the pituitary, spinal cord and plasma. The effect of AVP on Acupuncture Analgesia was partly reversed by pretreatment with naloxone, an opiate receptor antagonist. These data suggested that AVP in the brain played a role in the process of Acupuncture Analgesia in combination with the endogenous opiate peptide system.

  • Effect of hypothalamic supraoptic nucleus on Acupuncture Analgesia in the rat.
    Brain research bulletin, 2007
    Co-Authors: Jun Yang, Yu Yang, Jian-min Chen, Wen-yan Liu, Bao-chen Lin
    Abstract:

    Hypothalamic supraoptic nucleus (SON) has been demonstrated to involve in pain modulation. Acupuncture Analgesia is a very useful clinical skill for pain relief, which has over 2500-year history in China. The present study investigated the effect of SON on Acupuncture Analgesia in the rat. Electrical stimulation of the SON or microinjection of a small dose L-glutamate sodium into the SON enhanced Acupuncture Analgesia in a dose-dependent manner, while cauterization of the SON weakened Acupuncture Analgesia. Pituitary removal did not influence the effect of L-glutamate sodium that enhanced Acupuncture Analgesia in the SON. The data suggested that the neurons and not the nerve fibers in the SON played an important role in Acupuncture Analgesia, which effect might be through the central nervous system rather than the hypothalamo-neurohypophyseal system.

  • Effect of oxytocin on Acupuncture Analgesia in the rat.
    Neuropeptides, 2007
    Co-Authors: Jun Yang, Yu Yang, Jian-min Chen, Wen-yan Liu, Cheng-hai Wang, Bao-cheng Lin
    Abstract:

    Oxytocin has been demonstrated to be involved in pain modulation. Acupuncture Analgesia is a very useful clinical tool for pain relief, which has over 2500-year history in China. The present study investigated the role of oxytocin in Acupuncture Analgesia in the rat through oxytocin administration and measurement. Central administration of oxytocin (intraventricular injection or intrathecal injection) enhanced Acupuncture Analgesia, while central administration of anti-oxytocin serum weakened Acupuncture Analgesia in a dose-dependent manner. However, intravenous injection of oxytocin or anti-oxytocin serum did not influence Acupuncture Analgesia. Electrical Acupuncture of "Zusanli" (St. 36) reduced oxytocin concentration in the hypothalamic supraoptic nucleus, and elevated oxytocin concentration in the hypothalamic suprachiasmatic nucleus, hypothalamic ventromedial nucleus, thalamic ventral nucleus, periaqueductal gray, raphe magnus nucleus, caudate nucleus, thoracic spinal cord and lumbar spinal cord, but did not alter oxytocin concentration in the hypothalamic paraventricular nucleus, anterior pituitary, posterior pituitary and plasma. The data suggested that oxytocin in central nervous system rather than in peripheral organs is involved in Acupuncture Analgesia.

  • Through central arginine vasopressin, not oxytocin and endogenous opiate peptides, glutamate sodium induces hypothalamic paraventricular nucleus enhancing Acupuncture Analgesia in the rat.
    Neuroscience research, 2005
    Co-Authors: Jun Yang, Wen-yan Liu, Cao-you Song, Bao-cheng Lin
    Abstract:

    Abstract Our previous study proved that the hypothalamic paraventricular nucleus (PVH) plays an important role in Acupuncture Analgesia. The neuropeptides involving in the PVH regulation of Acupuncture Analgesia was investigated in the rat. The changes of pain threshold, which was induced by electrical Acupuncture of “Zusanli” points (St. 36), were measured as Acupuncture Analgesia. Microinjection of l -glutamate sodium into the PVH, which only excites the PVH neurons, could dose-dependently enhance the Acupuncture Analgesia, but microinjection of l -glutamate sodium into the area nearby the PVH did not alter Acupuncture Analgesia. Removing pituitary did not influence this effect of l -glutamate sodium. Microinjection of l -glutamate sodium into the PVH only increased the arginine vasopressin (AVP), not oxytocin (OXT), leucine enkephaline (L-Ek), β-endorphine (β-Ep) and dynorphinA 1–13 (DynA 1–13 ) concentrations in the PVH perfuse liquid using radioimmunoassay. Intraventricular injection of anti-arginine vasopressin serum (AAVPS) could completely reverse the effect of microinjection of l -glutamate sodium into the PVH enhancing Acupuncture Analgesia. Intraventricular injection of naloxone, one opiate peptide antagonist, partly attenuated this effect of l -glutamate sodium, and intraventricular of anti-oxytocin serum (AOXTS) did not change this effect of l -glutamate sodium. The results suggested that l -glutamate sodium induces the PVH enhancing Acupuncture Analgesia only through AVP, not OXT and endogenous opiate peptides in central nervous system.

  • Hypothalamic paraventricular nucleus plays a role in Acupuncture Analgesia through the central nervous system in the rat.
    Acupuncture & electro-therapeutics research, 1992
    Co-Authors: Jun Yang, Bao-cheng Lin
    Abstract:

    This work investigates the effect of hypothalamic paraventricular nucleus (PVN) on Acupuncture Analgesia in the rat. Electrical stimulation of PVN or injection of L-glutamate sodium into PVN could enhance the analgesic effect induced by Acupuncture Zusanli (St. 36) while the electrical cauterization of PVN is decreased; Removal of the pituitary could not influence the effect of enhancing Acupuncture Analgesia induced by the injection of L-glutamate sodium into PVN. These results suggest that PVN might play an important role in Acupuncture Analgesia through central nervous system.

Wen-yan Liu - One of the best experts on this subject based on the ideXlab platform.

  • Effect of arginine vasopressin on Acupuncture Analgesia in the rat.
    Peptides, 2008
    Co-Authors: Jun Yang, Yu Yang, Wen-yan Liu, Cheng-hai Wang, Wang, Bao-cheng Lin
    Abstract:

    Arginine vasopressin (AVP) has been proven to be involved in the process of pain regulation. This communication was designed to investigate the effect of AVP on Acupuncture Analgesia in the rat model. The results showed that intraventricular injection (icv) of AVP could enhance Acupuncture Analgesia in a dose-dependent manner, whereas icv of anti-AVP serum decreased Acupuncture Analgesia. However, neither intrathecal (ith) nor intravenous injection (iv) of AVP or anti-AVP serum could influence Acupuncture Analgesia. Electrical Acupuncture of “Zusanli” points (St. 36) decreased AVP concentration in the hypothalamic paraventricular nucleus (PVN), and increased AVP concentration in the hypothalamic supraoptic nucleus (SON), periaqueductial gray (PAG), caudate nucleus (CdN) and raphe magnus nucleus (RMN), but did not change AVP concentration in the pituitary, spinal cord and plasma. The effect of AVP on Acupuncture Analgesia was partly reversed by pretreatment with naloxone, an opiate receptor antagonist. These data suggested that AVP in the brain played a role in the process of Acupuncture Analgesia in combination with the endogenous opiate peptide system.

  • Effect of hypothalamic supraoptic nucleus on Acupuncture Analgesia in the rat.
    Brain research bulletin, 2007
    Co-Authors: Jun Yang, Yu Yang, Jian-min Chen, Wen-yan Liu, Bao-chen Lin
    Abstract:

    Hypothalamic supraoptic nucleus (SON) has been demonstrated to involve in pain modulation. Acupuncture Analgesia is a very useful clinical skill for pain relief, which has over 2500-year history in China. The present study investigated the effect of SON on Acupuncture Analgesia in the rat. Electrical stimulation of the SON or microinjection of a small dose L-glutamate sodium into the SON enhanced Acupuncture Analgesia in a dose-dependent manner, while cauterization of the SON weakened Acupuncture Analgesia. Pituitary removal did not influence the effect of L-glutamate sodium that enhanced Acupuncture Analgesia in the SON. The data suggested that the neurons and not the nerve fibers in the SON played an important role in Acupuncture Analgesia, which effect might be through the central nervous system rather than the hypothalamo-neurohypophyseal system.

  • Effect of oxytocin on Acupuncture Analgesia in the rat.
    Neuropeptides, 2007
    Co-Authors: Jun Yang, Yu Yang, Jian-min Chen, Wen-yan Liu, Cheng-hai Wang, Bao-cheng Lin
    Abstract:

    Oxytocin has been demonstrated to be involved in pain modulation. Acupuncture Analgesia is a very useful clinical tool for pain relief, which has over 2500-year history in China. The present study investigated the role of oxytocin in Acupuncture Analgesia in the rat through oxytocin administration and measurement. Central administration of oxytocin (intraventricular injection or intrathecal injection) enhanced Acupuncture Analgesia, while central administration of anti-oxytocin serum weakened Acupuncture Analgesia in a dose-dependent manner. However, intravenous injection of oxytocin or anti-oxytocin serum did not influence Acupuncture Analgesia. Electrical Acupuncture of "Zusanli" (St. 36) reduced oxytocin concentration in the hypothalamic supraoptic nucleus, and elevated oxytocin concentration in the hypothalamic suprachiasmatic nucleus, hypothalamic ventromedial nucleus, thalamic ventral nucleus, periaqueductal gray, raphe magnus nucleus, caudate nucleus, thoracic spinal cord and lumbar spinal cord, but did not alter oxytocin concentration in the hypothalamic paraventricular nucleus, anterior pituitary, posterior pituitary and plasma. The data suggested that oxytocin in central nervous system rather than in peripheral organs is involved in Acupuncture Analgesia.

  • Through central arginine vasopressin, not oxytocin and endogenous opiate peptides, glutamate sodium induces hypothalamic paraventricular nucleus enhancing Acupuncture Analgesia in the rat.
    Neuroscience research, 2005
    Co-Authors: Jun Yang, Wen-yan Liu, Cao-you Song, Bao-cheng Lin
    Abstract:

    Abstract Our previous study proved that the hypothalamic paraventricular nucleus (PVH) plays an important role in Acupuncture Analgesia. The neuropeptides involving in the PVH regulation of Acupuncture Analgesia was investigated in the rat. The changes of pain threshold, which was induced by electrical Acupuncture of “Zusanli” points (St. 36), were measured as Acupuncture Analgesia. Microinjection of l -glutamate sodium into the PVH, which only excites the PVH neurons, could dose-dependently enhance the Acupuncture Analgesia, but microinjection of l -glutamate sodium into the area nearby the PVH did not alter Acupuncture Analgesia. Removing pituitary did not influence this effect of l -glutamate sodium. Microinjection of l -glutamate sodium into the PVH only increased the arginine vasopressin (AVP), not oxytocin (OXT), leucine enkephaline (L-Ek), β-endorphine (β-Ep) and dynorphinA 1–13 (DynA 1–13 ) concentrations in the PVH perfuse liquid using radioimmunoassay. Intraventricular injection of anti-arginine vasopressin serum (AAVPS) could completely reverse the effect of microinjection of l -glutamate sodium into the PVH enhancing Acupuncture Analgesia. Intraventricular injection of naloxone, one opiate peptide antagonist, partly attenuated this effect of l -glutamate sodium, and intraventricular of anti-oxytocin serum (AOXTS) did not change this effect of l -glutamate sodium. The results suggested that l -glutamate sodium induces the PVH enhancing Acupuncture Analgesia only through AVP, not OXT and endogenous opiate peptides in central nervous system.

Yu Yang - One of the best experts on this subject based on the ideXlab platform.

  • Effect of arginine vasopressin on Acupuncture Analgesia in the rat.
    Peptides, 2008
    Co-Authors: Jun Yang, Yu Yang, Wen-yan Liu, Cheng-hai Wang, Wang, Bao-cheng Lin
    Abstract:

    Arginine vasopressin (AVP) has been proven to be involved in the process of pain regulation. This communication was designed to investigate the effect of AVP on Acupuncture Analgesia in the rat model. The results showed that intraventricular injection (icv) of AVP could enhance Acupuncture Analgesia in a dose-dependent manner, whereas icv of anti-AVP serum decreased Acupuncture Analgesia. However, neither intrathecal (ith) nor intravenous injection (iv) of AVP or anti-AVP serum could influence Acupuncture Analgesia. Electrical Acupuncture of “Zusanli” points (St. 36) decreased AVP concentration in the hypothalamic paraventricular nucleus (PVN), and increased AVP concentration in the hypothalamic supraoptic nucleus (SON), periaqueductial gray (PAG), caudate nucleus (CdN) and raphe magnus nucleus (RMN), but did not change AVP concentration in the pituitary, spinal cord and plasma. The effect of AVP on Acupuncture Analgesia was partly reversed by pretreatment with naloxone, an opiate receptor antagonist. These data suggested that AVP in the brain played a role in the process of Acupuncture Analgesia in combination with the endogenous opiate peptide system.

  • Effect of hypothalamic supraoptic nucleus on Acupuncture Analgesia in the rat.
    Brain research bulletin, 2007
    Co-Authors: Jun Yang, Yu Yang, Jian-min Chen, Wen-yan Liu, Bao-chen Lin
    Abstract:

    Hypothalamic supraoptic nucleus (SON) has been demonstrated to involve in pain modulation. Acupuncture Analgesia is a very useful clinical skill for pain relief, which has over 2500-year history in China. The present study investigated the effect of SON on Acupuncture Analgesia in the rat. Electrical stimulation of the SON or microinjection of a small dose L-glutamate sodium into the SON enhanced Acupuncture Analgesia in a dose-dependent manner, while cauterization of the SON weakened Acupuncture Analgesia. Pituitary removal did not influence the effect of L-glutamate sodium that enhanced Acupuncture Analgesia in the SON. The data suggested that the neurons and not the nerve fibers in the SON played an important role in Acupuncture Analgesia, which effect might be through the central nervous system rather than the hypothalamo-neurohypophyseal system.

  • Effect of oxytocin on Acupuncture Analgesia in the rat.
    Neuropeptides, 2007
    Co-Authors: Jun Yang, Yu Yang, Jian-min Chen, Wen-yan Liu, Cheng-hai Wang, Bao-cheng Lin
    Abstract:

    Oxytocin has been demonstrated to be involved in pain modulation. Acupuncture Analgesia is a very useful clinical tool for pain relief, which has over 2500-year history in China. The present study investigated the role of oxytocin in Acupuncture Analgesia in the rat through oxytocin administration and measurement. Central administration of oxytocin (intraventricular injection or intrathecal injection) enhanced Acupuncture Analgesia, while central administration of anti-oxytocin serum weakened Acupuncture Analgesia in a dose-dependent manner. However, intravenous injection of oxytocin or anti-oxytocin serum did not influence Acupuncture Analgesia. Electrical Acupuncture of "Zusanli" (St. 36) reduced oxytocin concentration in the hypothalamic supraoptic nucleus, and elevated oxytocin concentration in the hypothalamic suprachiasmatic nucleus, hypothalamic ventromedial nucleus, thalamic ventral nucleus, periaqueductal gray, raphe magnus nucleus, caudate nucleus, thoracic spinal cord and lumbar spinal cord, but did not alter oxytocin concentration in the hypothalamic paraventricular nucleus, anterior pituitary, posterior pituitary and plasma. The data suggested that oxytocin in central nervous system rather than in peripheral organs is involved in Acupuncture Analgesia.

Lene Vase - One of the best experts on this subject based on the ideXlab platform.

  • specifying the nonspecific components of Acupuncture Analgesia
    Enzyme and Microbial Technology, 2014
    Co-Authors: Lene Vase, Sara Baram, Nobuari Takakura, Hiroyoshi Yajima, Miho Takayama, Ted J. Kaptchuk, Søren Schou, Troels S. Jensen, Robert Zachariae
    Abstract:

    It is well known that Acupuncture has pain-relieving effects, but the contribution of specific and especially nonspecific factors to Acupuncture Analgesia is less clear. One hundred one patients who developed pain of P3 on a visual analog scale (VAS, 0 to 10) after third molar surgery were randomized to receive active Acupuncture, placebo Acupuncture, or no treatment for 30 min with Acupuncture needles with potential for double-blinding. Patients' perception of the treatment (active or placebo) and expected pain levels (VAS) were assessed before and halfway through the treatment. Looking at actual treatment allocation, there was no specific effect of active Acupuncture (P = .240), but there was a large and significant nonspecific effect of placebo Acupuncture (P

  • Specifying the nonspecific components of Acupuncture Analgesia.
    Pain, 2013
    Co-Authors: Lene Vase, Sara Baram, Nobuari Takakura, Hiroyoshi Yajima, Miho Takayama, Ted J. Kaptchuk, Søren Schou, Troels S. Jensen, Robert Zachariae, Peter Svensson
    Abstract:

    It is well known that Acupuncture has pain-relieving effects, but the contribution of specific and especially nonspecific factors to Acupuncture Analgesia is less clear. One hundred one patients who developed pain of P3 on a visual analog scale (VAS, 0 to 10) after third molar surgery were randomized to receive active Acupuncture, placebo Acupuncture, or no treatment for 30 min with Acupuncture needles with potential for double-blinding. Patients’ perception of the treatment (active or placebo) and expected pain levels (VAS) were assessed before and halfway through the treatment. Looking at actual treatment allocation, there was no specific effect of active Acupuncture (P = .240), but there was a large and significant nonspecific effect of placebo Acupuncture (P < .001), which increased over time. Interestingly, however, looking at perceived treatment allocation, there was a significant effect of Acupuncture (P < .001), indicating that patients who believed they received active Acupuncture had significantly lower pain levels than those who believed they received placebo Acupuncture. Expected pain levels accounted for significant and progressively larger amounts of the variance in pain ratings after both active and placebo Acupuncture (up to 69.8%). This is the first study to show that under optimized blinding conditions, nonspecific factors such as patients’ perception of and expectations toward treatment are central to the efficacy of Acupuncture Analgesia and that these factors may contribute to self-reinforcing effects in Acupuncture treatment. To obtain an effect of Acupuncture in clinical practice, it may therefore be important to incorporate and optimize these factors.