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Marc N Potenza – One of the best experts on this subject based on the ideXlab platform.

  • clarifying terminologies in research on gaming Disorder and other Addictive behaviors distinctions between core symptoms and underlying psychological processes
    Current opinion in psychology, 2020
    Co-Authors: Marc N Potenza, Matthias Brand, Hansjurgen Rumpf, Daniel L King, Elisa Wegmann

    Abstract:

    There exists ongoing debate regarding the clinical validity of single symptoms of and diagnostic criteria for gaming Disorder. In particular, the potential symptom of gaming Disorder that addresses coping with and escaping from negative feelings has received much attention and remains a focus of intensive discussion. We argue that it is important to consider differences or distinguish between, on the one hand, symptoms of and criteria for a Disorder due to Addictive behaviors, such as gaming Disorder, versus, on the other hand, motivations, mechanisms, and psychological processes that may be involved in promoting Addictive behaviors and that may explain symptom severity and course of the Addictive Disorder including potential treatment responses.

  • Clinical neuropsychiatric considerations regarding nonsubstance or behavioral addictions.
    , 2017
    Co-Authors: Marc N Potenza

    Abstract:

    Over the past several decades, non-substance-use behaviors like gambling, gaming, and sex have received greater consideration as possible foci of addictions. In this article, I will review the recent history and current status of non-substance or behavioral addictions. A main focus will involve gambling and gambling Disorder, given that the latter is currently the sole non-substance Addictive Disorder described in the main text of the current (fifth) edition of the . Internet gaming Disorder, currently in the section addressing conditions that may need additional research, will also be considered, as will the concept of Internet addiction. Compulsive sexual behaviors (including problematic pornography use) will be considered, particularly with respect to how behavioral addictions may be considered in the forthcoming 11th edition of the International Classification of Diseases (ICD-11).

  • pathological gambling a review of the neurobiological evidence relevant for its classification as an Addictive Disorder
    Addiction Biology, 2017
    Co-Authors: Mira Fauthbuhler, Karl Mann, Marc N Potenza

    Abstract:

    In light of the upcoming eleventh edition of the International Classification of Diseases (ICD-11), the question arises as to the most appropriate classification of ‘Pathological Gambling’ (‘PG’). Some academic opinion favors leaving PG in the ‘Impulse Control Disorder‘ (‘ICD’) category, as in ICD-10, whereas others argue that new data especially from the neurobiological area favor allocating it to the category of ‘Substance-related and Addictive Disorders’ (‘SADs’), following the decision in the fifth revision of the Diagnostic and Statistical Manual of Mental Disorders. The current review examines important findings in relation to PG, with the aim of enabling a well-informed decision to be made with respect to the classification of PG as a SAD or ICD in ICD-11. Particular attention is given to cognitive deficits and underlying neurobiological mechanisms that play a role in SADs and ICDs. These processes are impulsivity, compulsivity, reward/punishment processing and decision-making. In summary, the strongest arguments for subsuming PG under a larger SAD category relate to the existence of similar diagnostic characteristics; the high co-morbidity rates between the Disorders; their common core features including reward-related aspects (positive reinforcement: behaviors are pleasurable at the beginning which is not the case for ICDs); the findings that the same brain structures are involved in PG and SADs, including the ventral striatum. Research on compulsivity suggests a relationship with PG and SAD, particularly in later stages of the Disorders. Although research is limited for ICDs, current data do not support continuing to classify PG as an ICD.

Florence Thibaut – One of the best experts on this subject based on the ideXlab platform.

  • Pharmacotherapy of Sexual Addiction
    Current Psychiatry Reports, 2020
    Co-Authors: Leo Malandain, Florian Ferreri, Jean-victor Blanc, Florence Thibaut

    Abstract:

    Purpose of Review We reviewed recent data on sexual addiction and its treatment. We examined the different definitions of this Disorder, related to the pathophysiological mechanisms. We addressed the pharmacological treatment of sexual addiction. Recent Findings Hypersexual behavior can be considered an Addictive Disorder. Sexual addiction is accompanied by significant psychiatric and Addictive comorbidities and is responsible for life impairment. A comprehensive and efficient treatment must be proposed. Summary Selective serotonin reuptake inhibitors seem the first-line pharmacological treatment for sexual addiction. Naltrexone could be another therapeutic option. Psychotherapy and preferentially cognitive-behavioral therapy should be used in association with pharmacotherapy and treatments of comorbidities.

  • Pharmacotherapy of Sexual Addiction
    Current Psychiatry Reports, 2020
    Co-Authors: Leo Malandain, Florian Ferreri, Jean-victor Blanc, Florence Thibaut

    Abstract:

    Purpose of review: We reviewed recent data on sexual addiction and its treatment. We examined the different definitions of this Disorder, related to the pathophysiological mechanisms. We addressed the pharmacological treatment of sexual addiction. Recent findings: Hypersexual behavior can be considered an Addictive Disorder. Sexual addiction is accompanied by significant psychiatric and Addictive comorbidities and is responsible for life impairment. A comprehensive and efficient treatment must be proposed. Selective serotonin reuptake inhibitors seem the first-line pharmacological treatment for sexual addiction. Naltrexone could be another therapeutic option. Summary: Psychotherapy and preferentially cognitive-behavioral therapy should be used in association with pharmacotherapy and treatments of comorbidities. Selective serotonin reuptake inhibitors seem the first-line pharmacological treatment for sexual addiction. Naltrexone could be another therapeutic option. Psychotherapy and preferentially cognitive-behavioral therapy should be used in association with pharmacotherapy and treatments of comorbidities.

Jon E. Grant – One of the best experts on this subject based on the ideXlab platform.

  • Efficacy of Pharmacological Interventions in Targeting Decision-Making Impairments across Substance and Behavioral Addictions.
    Neuropsychology Review, 2019
    Co-Authors: Samuel R. Chamberlain, Jon E. Grant

    Abstract:

    Decision-making impairments reflect tendencies towards risky or unwise choices as manifested by presence of psychiatric symptoms or cognitive impairment (e.g. representation of value, inhibitory control-response selection, learning). Such impairments are suggested by the hallmark symptoms of substance and behavioral addictions, which include escalation over time (of substance intake or a given behavior), lack of control, neglect of other domains of life, and cognitive distortions (such as ‘chasing losses’ in gambling Disorder). Amongst the putative behavioral addictions, most epidemiological data exist for gambling Disorder, which is now included in DSM-5 as a substance-related and Addictive Disorder. However, other Disorders share parallels and may also constitute behavioral addictions, such as compulsive stealing (kleptomania), compulsive shopping, and compulsive sexual behavior. The current paper presents a narrative review of evidence for cognitive decision-making impairments in addictions, as well as pharmacological treatments of these Disorders that may have relevance for improving decision-making. We find that objective decision-making deficits have been widely reported in patients with substance use Disorders and gambling Disorder, compared to controls. Decision-making in the other behavioral addictions is under-studied. Evidence-based pharmacological treatments for some of these Addictive Disorders, for example, opioid antagonists and glutamatergic agents, modulate neural systems playing key roles in decision-making. But clinical trials have seldom examined effects of such treatments on objective decision-making measures. Future research directions are discussed, including the need to include standardized outcome measures of decision-making (tasks and imaging) alongside traditional clinical measures, to better understand and enhance underlying treatment mechanisms.