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Adenoid Cystic Carcinoma

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J. Dempster – One of the best experts on this subject based on the ideXlab platform.

  • Adenoid Cystic Carcinoma of the nasal septum.
    Rhinology, 2003
    Co-Authors: N. Sivaji, S. Basavaraj, William Stewart, J. Dempster
    Abstract:

    Adenoid Cystic Carcinoma is a malignant tumour frequently described arising from seromucinous salivary tissue in the major and minor salivary glands. Within the nasal cavity, it is uncommon and usually involves the lateral wall. A rare case of Adenoid Cystic Carcinoma of the nasal septseptum is presented along with a review of the literature. The presentation and management of this uncommon condition is discussed.

Santiago Madero-garcía – One of the best experts on this subject based on the ideXlab platform.

  • Primary cutaneous Adenoid Cystic Carcinoma of the eyelid
    American journal of ophthalmology, 2001
    Co-Authors: Enrique Mencía-gutiérrez, Esperanza Gutiérrez-díaz, J. R. Ricoy, Santiago Madero-garcía
    Abstract:

    Abstract PURPOSE: To report a case of primary cutaneous Adenoid Cystic Carcinoma involving the eyelid. METHODS: We examined a 70-year-old woman with an 18-month history of a gradually enlarging, blue-colored mass in the medial third of the right upper eyeleyelid. Excisional biopsy and additional resection of the medially infiltrated margin resulted in tumor-free edges. Superior cervical and orbital evaluations were performed. RESULTS: Histopathologic evaluation revealed a primary cutaneous Adenoid Cystic Carcinoma. No gland pathology was documented. No tumor recurrence has been noted. CONCLUSION: Primary cutaneous Adenoid Cystic Carcinoma, an uncommon tumor of the skin, should be added to the differential diagnosis of eyelid tumors.

Kenji Kashima – One of the best experts on this subject based on the ideXlab platform.

  • Adenoid Cystic Carcinoma of the uterine cervix.
    International journal of clinical oncology, 2005
    Co-Authors: Masakazu Nishida, Kaei Nasu, Noriyuki Takai, Isao Miyakawa, Kenji Kashima
    Abstract:

    Adenoid Cystic Carcinoma of the uterine cervix is a rare and peculiar variant of adenoCarcinoma. This tumor represents 3% of all primary cervical adenoCarcinomas, and it is locally aggressive and capable of metastasis to other organs even in its early stage. We report a case of Adenoid Cystic Carcinoma stage IIIb that was successfully treated with radiotherapy. The patient shows no evidence of recurrent tumor at 5 years after radiotherapy. Generally, radiotherapy and chemotherapy are chosen as the first treatment, because this cancer is seen most commonly in the elderly.

  • Mutations in components of the Wnt signaling pathway in Adenoid Cystic Carcinoma
    Modern Pathology, 2004
    Co-Authors: Kenji Kashima, Naomi Kaku, Masashi Suzuki, Shigeo Yokoyama
    Abstract:

    The Wnt signaling pathway is essential for normal development and organogenesis. However, inappropriate activation of Wnt signaling, which results in the nuclear translocation of β –catenin, is associated with the development of various types of neoplasm. In this study, we investigated possible mutations in the genes for components of this pathway, namely, CTNNB1 (the gene for β –catenin), AXIN1 , and APC , in Adenoid Cystic Carcinoma, by PCR, analysis of single-strand conformational polymorphism, and sequencing. Among a total of 20 cases of Adenoid Cystic Carcinoma, seven cases (35%) were associated with mutations in one or more of these three components. A mutation in CTNNB1 was detected in one case. Five cases, including the case with a mutation in CTNNB1 , were associated with missense mutations in AXIN1 . An aberration in the mutation cluster region of APC was detected in two cases. Mutations trended to be detected more frequently in Adenoid Cystic Carcinoma with solid growth pattern than that with tubular and cribriform growth pattern. In the cases in which we detected mutations, it is possible that the presence of the abnormal products of the mutated genes resulted in the inappropriate activation of the Wnt signaling pathway to tumorigenesis and the growth of Adenoid Cystic Carcinoma.

Sasmita Behuria – One of the best experts on this subject based on the ideXlab platform.

  • Adenoid Cystic Carcinoma in the uterine cervix: a case report
    Acta Cytologica, 2010
    Co-Authors: Dilleswari Pradhan, Kaumudee Pattnaik, Jagannath Pahi, Pranati Mohanty, Surama Satpathy, Sasmita Behuria
    Abstract:

    Background Adenoid Cystic Carcinoma, a variant of adenoCarcinoma of the uterine cervix, is an extremely rare neoplasm. This report describes a case of primary Adenoid Cystic Carcinoma of the uterine cervix and includes the cytopathologic and histopathologic findings. Case A 55-year-old woman presented with postmenopausal bleeding for 2 months. Speculum examination showed a firm mass in the uterine cervix. A Pap smeasmear was obtained, which showed small epithelial cells with hyperchromatic nuclei and coarse chromatin dispersed and adhered around hyaline stromal globular material, along with a few atypical squamous cells. The diagnosis of Adenoid Cystic Carcinoma was confirmed by the histopathologic examination of the biopsy specimen as well as the excised specimen, which characteristically revealed the presence of a cribriform pattern of the tumor cells. Conclusion We reported a case of a rare and unusual variant of adenoCarcinoma of the uterine cervix by considering the characteristic cytologic features of the globules of pale, translucent material surrounded by halos of cells in cribriform Adenoid Cystic Carcinoma.

N. Sivaji – One of the best experts on this subject based on the ideXlab platform.

  • Adenoid Cystic Carcinoma of the nasal septum.
    Rhinology, 2003
    Co-Authors: N. Sivaji, S. Basavaraj, William Stewart, J. Dempster
    Abstract:

    Adenoid Cystic Carcinoma is a malignant tumour frequently described arising from seromucinous salivary tissue in the major and minor salivary glands. Within the nasal cavity, it is uncommon and usually involves the lateral wall. A rare case of Adenoid Cystic Carcinoma of the nasal septum is presented along with a review of the literature. The presentation and management of this uncommon condition is discussed.