The Experts below are selected from a list of 13926 Experts worldwide ranked by ideXlab platform
J H Nam - One of the best experts on this subject based on the ideXlab platform.
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outcomes after radical hysterectomy in patients with early stage adenocarcinoma of Uterine Cervix
British Journal of Cancer, 2010Co-Authors: Jeongyeol Park, D Y Kim, J H Kim, Y M Kim, Y T Kim, J H NamAbstract:To determine the prognostic factors and treatment outcomes of patients with early-stage adenocarcinoma (AdCa) of Uterine Cervix who underwent radical hysterectomy (RH). Patients with early-stage squamous cell carcinoma (SCCa) of the Uterine Cervix who underwent RH were compared with patients with AdCa by multivariate analysis. A total of 1218 patients were eligible, of which 996 (81.8%) had SCCa and 222 (18.2%) had AdCa. In multivariate analysis, parametrial involvement and lymph node metastasis were significant factors for both recurrence-free survival(RFS) and overall survival (OS) of patients with AdCa, whereas age, tumour size, parametrial involvement and lymph node metastasis were significant factors for both RFS and OS of patients with SCCa. After adjusting for significant prognostic factors, patients with AdCa had significantly poorer RFS (odds ratio (OR)=2.07, 95% confidence interval (CI)=1.37–3.12, P=0.001) and OS (OR=2.56, 95% CI=1.65–3.96, P<0.001) than patients with SCCa. Recurrence outside the pelvis was more frequent in AdCa than in those with SCCa (75 vs 57.8%, P=0.084). Although RH is still acceptable for treatment of patients with AdCa, a more effective systemic adjuvant therapy is required.
Athanasios Gouliamos - One of the best experts on this subject based on the ideXlab platform.
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embryonal rhabdomyosarcoma of the Uterine Cervix
Clinical & Translational Oncology, 2009Co-Authors: Georgios V Koukourakis, Vassilios Kouloulias, Georgios Zacharias, Georgios Maravelis, Christos Papadimitriou, Kaliopi Platoni, Athanasios GouliamosAbstract:Introduction Embryonal rhabdomyosarcoma (RMS) of the Uterine Cervix is a rare and extremely malignant entity. Generally, embryonal RMS originating in the Uterine Cervix is usually diagnosed in adolescence. Before the introduction of effective adjuvant chemotherapy, the prognosis of these lesions was poor. We have treated a young woman suffering from this disease using a combination of surgery, chemotherapy and radiation therapy (RT) with excellent results. The medical community should keep in mind that embryonal RMS of the Uterine Cervix, despite its malignancy and rarity, can be cured if adequate treatment is given.
Hisashi Narahara - One of the best experts on this subject based on the ideXlab platform.
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small cell carcinoma of the Uterine Cervix discovered with quadriplegia caused by cervical spine metastasis
Clinical medicine insights. Case reports, 2020Co-Authors: Tomoko Oishi, Masakazu Nishida, Kanetoshi Takebayashi, Kaei Nasu, Hisashi NaraharaAbstract:Small-cell carcinoma of the Uterine Cervix is a rare and aggressive tumor, and the prognosis is poor compared with those of squamous cell carcinoma and adenocarcinoma of the Uterine Cervix, even wh...
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A case of lymphoepithelioma-like carcinoma in the Uterine Cervix
SAGE Publishing, 2015Co-Authors: Kanetoshi Takebayashi, Masakazu Nishida, Kaei Nasu, Harunobu Matsumoto, Hisashi NaraharaAbstract:Lymphoepithelioma-like carcinoma occurring in the reproductive organs is a rare variant of squamous cell carcinoma, and this tumor of the Uterine Cervix accounts for 0.7% of all primary cervical Uterine neoplasms. Associations with Epstein-Barr virus (EBV) and human papilloma virus (HPV) have been demonstrated in some studies. Some investigators suggested that EBV has an important role in the initiation of lymphoepithelioma-like carcinoma in Asian women. Here we report the case of a 45-year-old Japanese woman, gravida 2 and parity 2. She was admitted due to severe atypical genital bleeding caused by Uterine cervical cancer. A >60-mm tumor was detected at the Uterine Cervix, and no distal metastasis or swallowing of lymph nodes was revealed by magnetic resonance imaging and a computed tomography scan. The cervical cancer stage FIGO Ib2 was diagnosed, and a radical hysterectomy was performed for this malignant tumor. The in situ hybridization for EBV was negative. HVP infection was strongly suspected because the squamous cell carcinoma was observed macroscopically in the Uterine Cervix. The prognosis of Uterine lymphoepithelioma-like carcinoma is thought to be better than those of other cervical cancer types, but careful follow-up at fixed intervals is recommended. The patient has been followed up for 4 months since her surgery, and no evidence of recurrence has been detected
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clear cell adenocarcinoma in the Uterine Cervix associated with malformation of the uterus
Journal of Obstetrics and Gynaecology, 2013Co-Authors: Yukie Kawano, Masakazu Nishida, Kaei Nasu, Tomoko Hirakawa, Kentaro Kai, Hisashi NaraharaAbstract:Clear cell adenocarcinomas of the Uterine Cervix are identified by cytological, histological and structural findings in the female genital tract, such as the vagina, endometrium and ovary. Clear ce...
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advanced small cell carcinoma of the Uterine Cervix treated by neoadjuvant chemotherapy with irinotecan and cisplatin followed by radical surgery
Rare Tumors, 2011Co-Authors: Kaei Nasu, Masakazu Nishida, Harunobu Matsumoto, Tomoko Hirakawa, Mamiko Okamoto, Chihiro Kiyoshima, Noriyuki Takai, Hisashi NaraharaAbstract:Small cell carcinoma of the Uterine Cervix is a rare form of cervical cancer characterized by extreme aggressiveness and poor prognosis because of its rapid growth, frequent distant metastases, and resistance to conventional treatment modalities. We report here a case of advanced-stage small cell carcinoma of the Uterine Cervix treated by neoadjuvant chemotherapy, followed by radical surgery, resulting in locoregional disease control. A 39-year-old Japanese woman was diagnosed as having stage IIIb small cell carcinoma of the Uterine Cervix. She was treated by neoadjuvant chemotherapy with irinotecan/cisplatin, followed by extended radical hysterectomy with pelvic and paraaortic lymphadenectomy. The patient was further treated by adjuvant chemotherapy with irinotecan/cisplatin. Intrapelvic recurrence has not been detected throughout the postoperative course. However, the patient died with distant metastases of the disease, 27 months following the initial treatment. It has been suggested that neoadjuvant chemotherapy therapy followed by radical surgery is a treatment option for advanced-stage small cell carcinoma of the Uterine Cervix for the locoregional disease control. Further studies are necessary to obtain information regarding multimodal treatment including sequence, duration, frequency, and type of effective chemotherapy agents to be used in the treatment of small cell carcinoma of the Uterine Cervix.
Sandra Hermana - One of the best experts on this subject based on the ideXlab platform.
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arteriovenous malformation of the Uterine Cervix
Pathology Research and Practice, 2016Co-Authors: J F Valbernal, Sandra HermanaAbstract:A Uterine arteriovenous malformation (AVM) is an uncommon cause of Uterine bleeding. Location of this lesion in the Uterine Cervix is exceptional. We report a case of a 34-year-old woman who presented with chronic menorrhagias and hypochromic anemia. A sonographic study revealed a 10-cm, fundal, intramural, Uterine well-circumscribed mass that distorted the endometrial cavity. The patient underwent hysterectomy for a large Uterine leiomyoma. The pathological study revealed an incidental AVM of the posterior half of the Cervix measuring 5.5 cm in major diameter. We suggest that in our case cervical AVM might have occurred due to a large corporal leiomyoma distorting the Uterine circulation. Differential diagnosis includes capillary hemangioma, venous malformation, or arteriovenous fistula.
Akihiko Wakatsuki - One of the best experts on this subject based on the ideXlab platform.
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clear cell adenocarcinoma of the Uterine Cervix in a 17 year old adolescent
International Journal of Clinical Oncology, 2008Co-Authors: Hiromitsu Yabushita, Kouhei Kanyama, Rinko Sekiya, Mari Noguchi, Akihiko WakatsukiAbstract:This report describes the case of the youngest Japanese person to be diagnosed with endocervical clearcell adenocarcinoma. In September 2005, a 17-year-old female adolescent visited a physician because of vaginal bleeding. A cervical tumor was discovered, and the patient was referred to our outpatient department. Vaginal examination showed a bleeding tumor approximately 1.5 cm in size protruding from the cervical os. The cytological finding of the Uterine Cervix was positive for malignancy, and the histological diagnosis by punch biopsy was clear-cell adenocarcinoma of the Uterine Cervix. A radical abdominal hysterectomy and pelvic lymphadenectomy were performed on October 30. Macroscopic findings showed a tumor, 1.5 cm in diameter, growing from the right side of the Uterine Cervix. The pathological diagnosis was clear-cell adenocarcinoma of the Cervix (PT1b1NR0M0). The patient was discharged from our hospital without any adjuvant therapy. No signs of recurrence have been detected in the 2-year follow up.
