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Jorge H Mestman - One of the best experts on this subject based on the ideXlab platform.
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hyperandrogenism due to a testosterone secreting sertoli leydig cell tumor associated with a dehydroepiandrosterone sulfate secreting Adrenal Adenoma in a postmenopausal woman case presentation and review of literature
Endocrine Practice, 2009Co-Authors: Jorge D Herrera, Jaime A Davidson, Jorge H MestmanAbstract:OBJECTIVE: To report a case of hyperandrogenism attributable to the presence of an Adrenal Adenoma secreting dehydroepiandrosterone sulfate (DHEA-S) and an ovarian Sertoli-Leydig cell tumor secreting testosterone in a postmenopausal woman. METHODS: The laboratory, radiologic, and pathologic findings in our case are described. In addition, the pertinent literature is reviewed. RESULTS: A 56-year-old woman presented with a history of gradual increase in facial and body hair, scalp hair loss, male pattern baldness, and deepening of her voice, beginning a few years after spontaneous menopause at age 49 years. She had hypertension, obesity, and type 2 diabetes mellitus. Laboratory tests showed elevated levels of total testosterone (348 ng/dL) and DHEA-S (2,058 microg/dL), and a left Adrenal tumor (3 by 4 cm) was detected on abdominal computed tomographic scan. Laparoscopic left Adrenalectomy was performed, and the pathologic diagnosis was Adrenal Adenoma. The DHEA-S returned to normal levels, but the serum testosterone concentration remained elevated. Transvaginal ultrasonography disclosed an ovarian tumor. Bilateral oophorectomy was performed, and an ovarian Sertoli-Leydig cell tumor was diagnosed. The hormonal and clinical picture normalized after this surgical intervention. CONCLUSION: After extensive review of the literature, we believe that this is the first reported case of a coincidental DHEA-S-secreting Adrenal Adenoma and a testosterone- secreting ovarian Leydig cell tumor causing signs of virilization.
Jorge D Herrera - One of the best experts on this subject based on the ideXlab platform.
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hyperandrogenism due to a testosterone secreting sertoli leydig cell tumor associated with a dehydroepiandrosterone sulfate secreting Adrenal Adenoma in a postmenopausal woman case presentation and review of literature
Endocrine Practice, 2009Co-Authors: Jorge D Herrera, Jaime A Davidson, Jorge H MestmanAbstract:OBJECTIVE: To report a case of hyperandrogenism attributable to the presence of an Adrenal Adenoma secreting dehydroepiandrosterone sulfate (DHEA-S) and an ovarian Sertoli-Leydig cell tumor secreting testosterone in a postmenopausal woman. METHODS: The laboratory, radiologic, and pathologic findings in our case are described. In addition, the pertinent literature is reviewed. RESULTS: A 56-year-old woman presented with a history of gradual increase in facial and body hair, scalp hair loss, male pattern baldness, and deepening of her voice, beginning a few years after spontaneous menopause at age 49 years. She had hypertension, obesity, and type 2 diabetes mellitus. Laboratory tests showed elevated levels of total testosterone (348 ng/dL) and DHEA-S (2,058 microg/dL), and a left Adrenal tumor (3 by 4 cm) was detected on abdominal computed tomographic scan. Laparoscopic left Adrenalectomy was performed, and the pathologic diagnosis was Adrenal Adenoma. The DHEA-S returned to normal levels, but the serum testosterone concentration remained elevated. Transvaginal ultrasonography disclosed an ovarian tumor. Bilateral oophorectomy was performed, and an ovarian Sertoli-Leydig cell tumor was diagnosed. The hormonal and clinical picture normalized after this surgical intervention. CONCLUSION: After extensive review of the literature, we believe that this is the first reported case of a coincidental DHEA-S-secreting Adrenal Adenoma and a testosterone- secreting ovarian Leydig cell tumor causing signs of virilization.
Adrian Marinovich - One of the best experts on this subject based on the ideXlab platform.
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renal Adrenal fusion instance of an Adrenal Adenoma mimicking a solid renal mass at ct case report
Radiology, 2009Co-Authors: Soham Mahadevia, Alla M Rozenblit, David Milikow, Adrian MarinovichAbstract:The authors report an unusual case of unilateral renal-Adrenal fusion with a concurrent Adrenal Adenoma. At computed tomography, this abnormality appeared as a solid enhancing lesion in the upper pole of the kidney, mimicking a renal mass. The ambiguous characteristics of this lesion at cross-sectional imaging, along with alternative diagnostic possibilities, are discussed. © RSNA, 2009
Gudmundur Johannsson - One of the best experts on this subject based on the ideXlab platform.
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long term cognitive impairments and attentional deficits in patients with cushing s disease and cortisol producing Adrenal Adenoma in remission
The Journal of Clinical Endocrinology and Metabolism, 2012Co-Authors: Oskar Ragnarsson, Peter Berglund, Derek N Eder, Gudmundur JohannssonAbstract:Context: Cognitive function is impaired in patients with active Cushing's syndrome (CS). Objective: The aim was to study cognitive function in patients with CS in long-term remission. Design: We conducted a cross-sectional, case-controlled, single center study. Patients: Fifty-five patients previously treated for Cushing's disease (n = 43) and cortisol-producing Adrenal Adenoma (n = 12) and 55 controls matched for age, gender, and educational level participated in the study. Methods: Working memory, attention, information-processing speed, verbal fluency, and reading speed were studied using standardized neuropsychological testing and alerting, orienting, and executive control using the Attentional Network Test. Fatigue impact scale and the comprehensive psychopathological rating scale were used to evaluate fatigue and affective disorder. Results: Median (interquartile range) duration of remission was 13 (5–19) yr and the mean ± sd age at follow-up was 54 ± 14 yr. Compared to controls, patients had a high...
Vinay Tomar - One of the best experts on this subject based on the ideXlab platform.
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Pure androgen secreting Adrenal Adenoma: a case report and review of literature
Clinical Nephrology and Urology Science, 2015Co-Authors: Goto Gangkak, Suresh Yadav, Shashi Verma, Neeraj Agarwal, Sher Singh Yadav, Vinay TomarAbstract:Pure androgen secreting Adrenal Adenoma is exceptionally rare. Till now only around 20 cases of exclusively androgen secreting Adrenal Adenomas have been reported in English literature. These tumours may present with virilisation, hirsutism, menstrual abnormalities and even infertility. Various hormonal characteristic including rare presentation of responsiveness to gonadotrophins have been reported. We present here our rare case of virilising purely androgen secreting Adrenal Adenoma in a 32 year old female and review of literature.