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Adrenal Adenoma

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Jorge H Mestman – 1st expert on this subject based on the ideXlab platform

  • hyperandrogenism due to a testosterone secreting sertoli leydig cell tumor associated with a dehydroepiandrosterone sulfate secreting Adrenal Adenoma in a postmenopausal woman case presentation and review of literature
    Endocrine Practice, 2009
    Co-Authors: Jorge D Herrera, Jaime A Davidson, Jorge H Mestman

    Abstract:

    OBJECTIVE: To report a case of hyperandrogenism attributable to the presence of an Adrenal Adenoma secreting dehydroepiandrosterone sulfate (DHEA-S) and an ovarian Sertoli-Leydig cell tumor secreting testosterone in a postmenopausal woman. METHODS: The laboratory, radiologic, and pathologic findings in our case are described. In addition, the pertinent literature is reviewed. RESULTS: A 56-year-old woman presented with a history of gradual increase in facial and body hair, scalp hair loss, male pattern baldness, and deepening of her voice, beginning a few years after spontaneous menopause at age 49 years. She had hypertension, obesity, and type 2 diabetes mellitus. Laboratory tests showed elevated levels of total testosterone (348 ng/dL) and DHEA-S (2,058 microg/dL), and a left Adrenal tumor (3 by 4 cm) was detected on abdominal computed tomographic scan. Laparoscopic left Adrenalectomy was performed, and the pathologic diagnosis was Adrenal Adenoma. The DHEA-S returned to normal levels, but the serum testosterone concentration remained elevated. Transvaginal ultrasonography disclosed an ovarian tumor. Bilateral oophorectomy was performed, and an ovarian Sertoli-Leydig cell tumor was diagnosed. The hormonal and clinical picture normalized after this surgical intervention. CONCLUSION: After extensive review of the literature, we believe that this is the first reported case of a coincidental DHEA-S-secreting Adrenal Adenoma and a testosterone- secreting ovarian Leydig cell tumor causing signs of virilization.

Jorge D Herrera – 2nd expert on this subject based on the ideXlab platform

  • hyperandrogenism due to a testosterone secreting sertoli leydig cell tumor associated with a dehydroepiandrosterone sulfate secreting Adrenal Adenoma in a postmenopausal woman case presentation and review of literature
    Endocrine Practice, 2009
    Co-Authors: Jorge D Herrera, Jaime A Davidson, Jorge H Mestman

    Abstract:

    OBJECTIVE: To report a case of hyperandrogenism attributable to the presence of an Adrenal Adenoma secreting dehydroepiandrosterone sulfate (DHEA-S) and an ovarian Sertoli-Leydig cell tumor secreting testosterone in a postmenopausal woman. METHODS: The laboratory, radiologic, and pathologic findings in our case are described. In addition, the pertinent literature is reviewed. RESULTS: A 56-year-old woman presented with a history of gradual increase in facial and body hair, scalp hair loss, male pattern baldness, and deepening of her voice, beginning a few years after spontaneous menopause at age 49 years. She had hypertension, obesity, and type 2 diabetes mellitus. Laboratory tests showed elevated levels of total testosterone (348 ng/dL) and DHEA-S (2,058 microg/dL), and a left Adrenal tumor (3 by 4 cm) was detected on abdominal computed tomographic scan. Laparoscopic left Adrenalectomy was performed, and the pathologic diagnosis was Adrenal Adenoma. The DHEA-S returned to normal levels, but the serum testosterone concentration remained elevated. Transvaginal ultrasonography disclosed an ovarian tumor. Bilateral oophorectomy was performed, and an ovarian Sertoli-Leydig cell tumor was diagnosed. The hormonal and clinical picture normalized after this surgical intervention. CONCLUSION: After extensive review of the literature, we believe that this is the first reported case of a coincidental DHEA-S-secreting Adrenal Adenoma and a testosterone- secreting ovarian Leydig cell tumor causing signs of virilization.

Adrian Marinovich – 3rd expert on this subject based on the ideXlab platform

  • renal Adrenal fusion instance of an Adrenal Adenoma mimicking a solid renal mass at ct case report
    Radiology, 2009
    Co-Authors: Soham Mahadevia, Alla M Rozenblit, David Milikow, Adrian Marinovich

    Abstract:

    The authors report an unusual case of unilateral renal-Adrenal fusion with a concurrent Adrenal Adenoma. At computed tomography, this abnormality appeared as a solid enhancing lesion in the upper pole of the kidney, mimicking a renal mass. The ambiguous characteristics of this lesion at cross-sectional imaging, along with alternative diagnostic possibilities, are discussed. © RSNA, 2009