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Leal, Miriam Oliveira - One of the best experts on this subject based on the ideXlab platform.

  • Descrição da doença oncológica em Arctocephalus pusillus pusillus- estudo realizado num parque zoológico
    2016
    Co-Authors: Leal, Miriam Oliveira
    Abstract:

    A casuística da doença oncológica relatada em pinípedes, tem sido crescente nos últimos anos. No entanto, o desenvolvimento desta área continua com bastantes lacunas devido à inexistência de estudos comparativos que estabeleçam padrões de incidência, prevalência e patofisiologia em animais provenientes de ambiente selvagem e sob cuidados humanos. Com a presente dissertação procurámos identificar a doença oncológica em Arctocephalus pusillus pusillus, descrevendo-a, e identificando diferentes tipos de neoplasias nestes animais. A amostragem inicial deste estudo foi constituída por 10 animais (4 fêmeas e 6 machos), sendo diagnosticados 4 casos oncológicos, com recurso a procedimentos de necrópsia e técnicas complementares de diagnóstico, como a histopatologia, testes imunohistoquímicos e estudos bacteriológicos. As neoplasias identificadas durante o processo de investigação foram: o melanoma maligno, o carcinoma mamário, o Adenoma da tiroide, o Adenoma do córtex Adrenal, o sarcoma anaplásico, o carcinoma de células escamosas da nasofarínge e o condroma da costela. Este estudo permitiu-nos ainda identificar neoplasias que não estavam reportadas em Arctocephalus pusillus pusillus e na família Otariidae, representando um impulso para a investigação da presente doença em leões marinhos.The number of reported cancer in pinnipeds has been increasing in recent years, however, knowledge in this area still presents many gaps due to the lack of comparative studies to establish patterns of incidence, prevalence and pathophysiology in wild animals and animals under human care. In this thesis we proposed to identify oncological disease in Arctocephalus pusillus pusillus (under human care), describ it, and identify different types of tumors in these animals. The initial sample for this study consisted of 10 animals (4 females/6 males), 4 of which diagnosed with oncological disease, having undergone necropsy and complementary diagnostic techniques procedures such as histopathology, immunohistochemistry tests and bacteriological studies. During the research process the following neoplasias were identified: malignant melanoma, mammarian carcinoma, thyroid Adenoma, Adrenal Cortex Adenoma, anaplatic sarcoma, nasopharyngeal squamous cell carcinoma and rib chondroma. In this study we were able to identify oncological process that had not yet been reported in the Arctocephalus pusillus pusillus species or in the Otariidae family, which represents a boost for the investigation of this disease in sea lions.Orientação : Pedro Faísca ; co-orientação : Carla Flanaga

J C Desportes - One of the best experts on this subject based on the ideXlab platform.

X U Peiyuan - One of the best experts on this subject based on the ideXlab platform.

  • expression and its significance of pomc gene in cortical tissue around functioning Adrenal Cortex Adenoma
    Chinese journal of experimental surgery, 2005
    Co-Authors: X U Peiyuan
    Abstract:

    Objective To detect the expression of pro-opiomelanocortin (POMC) gene coding ACTH seguence in cortical tissue around functional Adrenal Cortex Adenoma.Methods The expression of ACTH in Adenoma and paraAdenoma tissue in 35 cases of Adenoma producing cortisol,31 cases of Adenoma producing aldosterone was detected.By using RT-PCR,POMC gene coding ACTH was determined semi-quantitively in all samples,and its DNA sequence was analyzed.Results The rate of ACTH expression in Adenoma producing cortisol and cortical tissue around it,in Adenoma producing aldosterone and cortical tissue around it was 91.4% and 17.1%, 90.3% and 16.1% respectively,with the difference between them being significant ( P 0.05). The expression of POMC gene coding ACTH mRNA in Adenoma producing cortisol and cortical tissue around it,in Adenoma producing aldosterone and cortical tissue around it,was 1.02± 0.10 and 0.76± 0.03, 0.83± 0.06 and 0.35± 0.01 respectively,with the difference between them being significant ( P 0.05), and its sequence was the same as in Genebank.Conclusion Overproduction of ACTH in the intraAdrenal especially paraAdenoma tissue maybe play important roles in the development of Adrenal Cortex Adenoma.

C Ribot - One of the best experts on this subject based on the ideXlab platform.

Yoshimitsu Fukushima - One of the best experts on this subject based on the ideXlab platform.

  • Cancer Genetics Report Novel 14 Base-Pair Deletion of the MEN1 Gene in a Patient with Recurrent Primary Hyperparathyroidism
    2006
    Co-Authors: Miyuki Katai, Akihiro Sakurai, Shinya Uchino, Kesami Minemura, Kiyoshi Hashizume, Yoshimitsu Fukushima
    Abstract:

    MEN1 is the causative gene for multiple endocrine neoplasia type 1 (MEN1), a hereditary syn-drome characterized by hyperplastic and neoplastic disorder of endocrine organs such as para-thyroid, anterior pituitary and gastroenteropancreatic endocrine tissues. More than 300 germline mutations have already been reported in patients with MEN1. We here report a novel deletional mutation identified inaJapanesewomanwithapparently sporadic recurrenthyperparathyroidism. Genetic testing revealed a heterozygous deletion involving 14 bp in exon 6 (starting at amino acid codon 293) ofMEN1, which results in early termination of the protein. This deletionalmutation has not previously been described elsewhere. Key words: multiple endocrine neoplasia type 1 – mutation – parathyroid hyperplasia CASE REPORT AND GENETIC ANALYSIS Multiple endocrine neoplasia type 1 (MEN1) is a hereditary disease characterized by hyperplastic and neoplastic disorder of endocrine organs such as parathyroid, anterior pituitary and gastroenteropancreatic endocrine tissues. Less frequent mani-festations include Adrenal Cortex Adenoma, foregut carcinoi