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Harold E Carlson - One of the best experts on this subject based on the ideXlab platform.

  • human Adrenal Cortex Hyperfunction due to lh hcg
    Molecular and Cellular Endocrinology, 2007
    Co-Authors: Harold E Carlson
    Abstract:

    Adrenal Cortex Hyperfunction may occasionally be due to stimulation of steroid hormone production by LH/hCG. The recent demonstration of the LH/hCG receptor in a variety of normal and abnormal human Adrenal tissues has provided a novel explanation for these clinical observations and offers the possibility of spontaneous remission (as in pregnancy-related Hyperfunction) or effective treatment with GnRH-agonists (to down-regulate LH secretion in menopausal patients). Involvement of Adrenal LH/hCG receptors should be considered in pregnant or post-menopausal patients with ACTH-independent Cushing's syndrome or androgen excess. Additional investigations are needed to better define the role of the LH/hCG receptor in the normal adult and fetal human Adrenal and to understand how this system is excessively activated in rare cases of human disease.