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Charlotte A Peterson - One of the best experts on this subject based on the ideXlab platform.

  • fibre type specific satellite cell response to Aerobic Training in sedentary adults
    The Journal of Physiology, 2014
    Co-Authors: Brian Noehren, Jyothi Mula, Margo F. Ubele, Philip M. Westgate, Philip A. Kern, Charlotte A Peterson
    Abstract:

    Key points Satellite cell activation and fusion accompany resistance exercise Training. Aerobic exercise Training is capable of inducing subtle muscle fibre hypertrophy; however, the role of satellite cell activation during Aerobic exercise-induced muscle adaptation is unknown. Twelve weeks of Aerobic Training in sedentary subjects yielded an increase in myosin heavy chain type I and type II muscle fibre cross-sectional area. Satellite cell activation and myonuclear addition occurred only in myosin heavy chain type I fibres, with no change in myosin heavy chain type II fibres. These results help us better understand the role of satellite cells in muscle fibre adaptation to Aerobic exercise, and suggest differential fibre type regulation of the myonuclear domain. Abstract In the present study, we sought to determine the effect of a traditional, 12 week Aerobic Training protocol on skeletal muscle fibre type distribution and satellite cell content in sedentary subjects. Muscle biopsies were obtained from the vastus lateralis [n = 23 subjects (six male and 17 female); body mass index 30.7 ± 1.2 kg m−2] before and after 12 weeks of Aerobic Training performed on a cycle ergometer. Immunohistochemical analyses were used to quantify myosin heavy chain (MyHC) isoform expression, cross-sectional area and satellite cell and myonuclear content. Following Training, a decrease in MyHC hybrid type IIa/IIx fibre frequency occurred, with a concomitant increase in pure MyHC type IIa fibres. PreTraining fibre type correlated with body mass index, and the change in fibre type following Training was associated with improvements in maximal oxygen consumption. Twelve weeks of Aerobic Training also induced increases in mean cross-sectional area in both MyHC type I and type IIa fibres. Satellite cell content was also increased following Training, specifically in MyHC type I fibres, with no change in the number of satellite cells associated with MyHC type II fibres. With the increased satellite cell content following Training, an increase in myonuclear number per fibre also occurred in MyHC type I fibres. Hypertrophy of MyHC type II fibres occurred without detectable myonuclear addition, suggesting that the mechanisms underlying growth in fast and slow fibres differ. These data provide intriguing evidence for a fibre type-specific role of satellite cells in muscle adaptation following Aerobic Training.

  • Fibre type-specific satellite cell response to Aerobic Training in sedentary adults
    Journal of Physiology, 2014
    Co-Authors: Christophe S Fry, Jyothi Mula, Margo F. Ubele, Brian Noehren, Philip M. Westgate, Philip A. Kern, Charlotte A Peterson
    Abstract:

    In the present study, we sought to determine the effect of a traditional, 12 week Aerobic Training protocol on skeletal muscle fibre type distribution and satellite cell content in sedentary subjects. Muscle biopsies were obtained from the vastus lateralis [n = 23 subjects (six male and 17 female); body mass index 30.7 ± 1.2 kg m(-2)] before and after 12 weeks of Aerobic Training performed on a cycle ergometer. Immunohistochemical analyses were used to quantify myosin heavy chain (MyHC) isoform expression, cross-sectional area and satellite cell and myonuclear content. Following Training, a decrease in MyHC hybrid type IIa/IIx fibre frequency occurred, with a concomitant increase in pure MyHC type IIa fibres. PreTraining fibre type correlated with body mass index, and the change in fibre type following Training was associated with improvements in maximal oxygen consumption. Twelve weeks of Aerobic Training also induced increases in mean cross-sectional area in both MyHC type I and type IIa fibres. Satellite cell content was also increased following Training, specifically in MyHC type I fibres, with no change in the number of satellite cells associated with MyHC type II fibres. With the increased satellite cell content following Training, an increase in myonuclear number per fibre also occurred in MyHC type I fibres. Hypertrophy of MyHC type II fibres occurred without detectable myonuclear addition, suggesting that the mechanisms underlying growth in fast and slow fibres differ. These data provide intriguing evidence for a fibre type-specific role of satellite cells in muscle adaptation following Aerobic Training.

Brian Noehren - One of the best experts on this subject based on the ideXlab platform.

  • fibre type specific satellite cell response to Aerobic Training in sedentary adults
    The Journal of Physiology, 2014
    Co-Authors: Brian Noehren, Jyothi Mula, Margo F. Ubele, Philip M. Westgate, Philip A. Kern, Charlotte A Peterson
    Abstract:

    Key points Satellite cell activation and fusion accompany resistance exercise Training. Aerobic exercise Training is capable of inducing subtle muscle fibre hypertrophy; however, the role of satellite cell activation during Aerobic exercise-induced muscle adaptation is unknown. Twelve weeks of Aerobic Training in sedentary subjects yielded an increase in myosin heavy chain type I and type II muscle fibre cross-sectional area. Satellite cell activation and myonuclear addition occurred only in myosin heavy chain type I fibres, with no change in myosin heavy chain type II fibres. These results help us better understand the role of satellite cells in muscle fibre adaptation to Aerobic exercise, and suggest differential fibre type regulation of the myonuclear domain. Abstract In the present study, we sought to determine the effect of a traditional, 12 week Aerobic Training protocol on skeletal muscle fibre type distribution and satellite cell content in sedentary subjects. Muscle biopsies were obtained from the vastus lateralis [n = 23 subjects (six male and 17 female); body mass index 30.7 ± 1.2 kg m−2] before and after 12 weeks of Aerobic Training performed on a cycle ergometer. Immunohistochemical analyses were used to quantify myosin heavy chain (MyHC) isoform expression, cross-sectional area and satellite cell and myonuclear content. Following Training, a decrease in MyHC hybrid type IIa/IIx fibre frequency occurred, with a concomitant increase in pure MyHC type IIa fibres. PreTraining fibre type correlated with body mass index, and the change in fibre type following Training was associated with improvements in maximal oxygen consumption. Twelve weeks of Aerobic Training also induced increases in mean cross-sectional area in both MyHC type I and type IIa fibres. Satellite cell content was also increased following Training, specifically in MyHC type I fibres, with no change in the number of satellite cells associated with MyHC type II fibres. With the increased satellite cell content following Training, an increase in myonuclear number per fibre also occurred in MyHC type I fibres. Hypertrophy of MyHC type II fibres occurred without detectable myonuclear addition, suggesting that the mechanisms underlying growth in fast and slow fibres differ. These data provide intriguing evidence for a fibre type-specific role of satellite cells in muscle adaptation following Aerobic Training.

  • Fibre type-specific satellite cell response to Aerobic Training in sedentary adults
    Journal of Physiology, 2014
    Co-Authors: Christophe S Fry, Jyothi Mula, Margo F. Ubele, Brian Noehren, Philip M. Westgate, Philip A. Kern, Charlotte A Peterson
    Abstract:

    In the present study, we sought to determine the effect of a traditional, 12 week Aerobic Training protocol on skeletal muscle fibre type distribution and satellite cell content in sedentary subjects. Muscle biopsies were obtained from the vastus lateralis [n = 23 subjects (six male and 17 female); body mass index 30.7 ± 1.2 kg m(-2)] before and after 12 weeks of Aerobic Training performed on a cycle ergometer. Immunohistochemical analyses were used to quantify myosin heavy chain (MyHC) isoform expression, cross-sectional area and satellite cell and myonuclear content. Following Training, a decrease in MyHC hybrid type IIa/IIx fibre frequency occurred, with a concomitant increase in pure MyHC type IIa fibres. PreTraining fibre type correlated with body mass index, and the change in fibre type following Training was associated with improvements in maximal oxygen consumption. Twelve weeks of Aerobic Training also induced increases in mean cross-sectional area in both MyHC type I and type IIa fibres. Satellite cell content was also increased following Training, specifically in MyHC type I fibres, with no change in the number of satellite cells associated with MyHC type II fibres. With the increased satellite cell content following Training, an increase in myonuclear number per fibre also occurred in MyHC type I fibres. Hypertrophy of MyHC type II fibres occurred without detectable myonuclear addition, suggesting that the mechanisms underlying growth in fast and slow fibres differ. These data provide intriguing evidence for a fibre type-specific role of satellite cells in muscle adaptation following Aerobic Training.

Pamela S Douglas - One of the best experts on this subject based on the ideXlab platform.

  • safety and efficacy of Aerobic Training in operable breast cancer patients receiving neoadjuvant chemotherapy a phase ii randomized trial
    Acta Oncologica, 2014
    Co-Authors: Whitney E Hornsby, James E Herndon, Pamela S Douglas, Miranda J West, Aarti A Kenjale, Amy R Lane, Emily Schwitzer, Kaitlin A Ray, April Coan, Antonio Gutierrez
    Abstract:

    AbstractBackground. To evaluate the safety and efficacy of moderate-to-high intensity Aerobic Training in breast cancer patients receiving neoadjuvant chemotherapy. Methods. Twenty patients with stage IIB–IIIC operable breast cancer were randomly assigned to receive doxorubicin plus cyclophosphamide (AC) or AC in combination with Aerobic Training (AC + AET) (n = 10/group) for 12 weeks. The AC+ AET group performed three supervised Aerobic cycle ergometry sessions per week at 60%–100% of exercise capacity (VO2peak). Safety outcomes included exercise testing as well as treatment- and exercise Training-related adverse events (AEs), whereas efficacy outcomes included cardiopulmonary function and patient-reported outcomes (PROs) as measured by a cardiopulmonary exercise test (CPET) and Functional Assessment of Cancer Therapy-Breast (FACT-B) scale. Results. Twelve non-significant ECG abnormalities and three non-life threatening events occurred during CPET procedures. One AE was reported during Aerobic Training. ...

  • rationale and design of the exercise intensity trial excite a randomized trial comparing the effects of moderate versus moderate to high intensity Aerobic Training in women with operable breast cancer
    BMC Cancer, 2010
    Co-Authors: Lee W Jones, James E Herndon, Pamela S Douglas, Neil D Eves, Kelly P Marcom, William E Kraus, Brant A Inman, Jason D Allen, Jeffrey Peppercorn
    Abstract:

    The Exercise Intensity Trial (EXcITe) is a randomized trial to compare the efficacy of supervised moderate-intensity Aerobic Training to moderate to high-intensity Aerobic Training, relative to attention control, on Aerobic capacity, physiologic mechanisms, patient-reported outcomes, and biomarkers in women with operable breast cancer following the completion of definitive adjuvant therapy. Using a single-center, randomized design, 174 postmenopausal women (58 patients/study arm) with histologically confirmed, operable breast cancer presenting to Duke University Medical Center (DUMC) will be enrolled in this trial following completion of primary therapy (including surgery, radiation therapy, and chemotherapy). After baseline assessments, eligible participants will be randomized to one of two supervised Aerobic Training interventions (moderate-intensity or moderate/high-intensity Aerobic Training) or an attention-control group (progressive stretching). The Aerobic Training interventions will include 150 mins.wk-1 of supervised treadmill walking per week at an intensity of 60%-70% (moderate-intensity) or 60% to 100% (moderate to high-intensity) of the individually determined peak oxygen consumption (VO2peak) between 20-45 minutes/session for 16 weeks. The progressive stretching program will be consistent with the exercise interventions in terms of program length (16 weeks), social interaction (participants will receive one-on-one instruction), and duration (20-45 mins/session). The primary study endpoint is VO2peak, as measured by an incremental cardiopulmonary exercise test. Secondary endpoints include physiologic determinants that govern VO2peak, patient-reported outcomes, and biomarkers associated with breast cancer recurrence/mortality. All endpoints will be assessed at baseline and after the intervention (16 weeks). EXCITE is designed to investigate the intensity of Aerobic Training required to induce optimal improvements in VO2peak and other pertinent outcomes in women who have completed definitive adjuvant therapy for operable breast cancer. Overall, this trial will inform and refine exercise guidelines to optimize recovery in breast and other cancer survivors following the completion of primary cytotoxic therapy. NCT01186367

  • the lung cancer exercise Training study a randomized trial of Aerobic Training resistance Training or both in postsurgical lung cancer patients rationale and design
    BMC Cancer, 2010
    Co-Authors: Lee W Jones, Neil D Eves, William E Kraus, Anil Potti, Jeffrey Crawford, James A Blumenthal, Bercedis L Peterson, Pamela S Douglas
    Abstract:

    The Lung Cancer Exercise Training Study (LUNGEVITY) is a randomized trial to investigate the efficacy of different types of exercise Training on cardiorespiratory fitness (VO2peak), patient-reported outcomes, and the organ components that govern VO2peak in post-operative non-small cell lung cancer (NSCLC) patients. Using a single-center, randomized design, 160 subjects (40 patients/study arm) with histologically confirmed stage I-IIIA NSCLC following curative-intent complete surgical resection at Duke University Medical Center (DUMC) will be potentially eligible for this trial. Following baseline assessments, eligible participants will be randomly assigned to one of four conditions: (1) Aerobic Training alone, (2) resistance Training alone, (3) the combination of Aerobic and resistance Training, or (4) attention-control (progressive stretching). The ultimate goal for all exercise Training groups will be 3 supervised exercise sessions per week an intensity above 70% of the individually determined VO2peak for Aerobic Training and an intensity between 60 and 80% of one-repetition maximum for resistance Training, for 30-45 minutes/session. Progressive stretching will be matched to the exercise groups in terms of program length (i.e., 16 weeks), social interaction (participants will receive one-on-one instruction), and duration (30-45 mins/session). The primary study endpoint is VO2peak. Secondary endpoints include: patient-reported outcomes (PROs) (e.g., quality of life, fatigue, depression, etc.) and organ components of the oxygen cascade (i.e., pulmonary function, cardiac function, skeletal muscle function). All endpoints will be assessed at baseline and postintervention (16 weeks). Substudies will include genetic studies regarding individual responses to an exercise stimulus, theoretical determinants of exercise adherence, examination of the psychological mediators of the exercise - PRO relationship, and exercise-induced changes in gene expression. VO2peak is becoming increasingly recognized as an outcome of major importance in NSCLC. LUNGEVITY will identify the optimal form of exercise Training for NSCLC survivors as well as provide insight into the physiological mechanisms underlying this effect. Overall, this study will contribute to the establishment of clinical exercise therapy rehabilitation guidelines for patients across the entire NSCLC continuum. NCT00018255

  • safety and feasibility of Aerobic Training on cardiopulmonary function and quality of life in postsurgical nonsmall cell lung cancer patients a pilot study
    Cancer, 2008
    Co-Authors: Lee W Jones, Miranda J West, Neil D Eves, William E Kraus, Jeffrey Crawford, Bercedis L Peterson, Jennifer Garst, Stephanie Mabe, David H Harpole, Pamela S Douglas
    Abstract:

    BACKGROUND. A feasibility study examining the effects of supervised Aerobic exercise Training on cardiopulmonary and quality of life (QOL) endpoints among postsurgical nonsmall cell lung cancer (NSCLC) patients was conducted. METHODS. Using a single-group design, 20 patients with stage I-IIIB NSCLC performed 3 Aerobic cycle ergometry sessions per week at 60% to 100% of peak workload for 14 weeks. Peak oxygen consumption (VO2peak) was assessed using an incremental exercise test. QOL and fatigue were assessed using the Functional Assessment of Cancer Therapy–Lung (FACT-L) scale. RESULTS. Nineteen patients completed the study. Intention-to-treat analysis indicated that VO2peak increased 1.1 mL/kg 21 /min 21 (95% confidence interval [CI], 20.3-2.5; P 5 .109) and peak workload increased 9 W (95% CI, 3-14; P 5 .003), whereas FACT-L increased 10 points (95% CI, 21-22; P 5 .071) and fatigue decreased 7 points (95% CI; 2 1t o217; P 5 .029) from baseline to postintervention. Per protocol analyses indicated greater improvements in cardiopulmonary and QOL endpoints among patients not receiving adjuvant chemotherapy. CONCLUSIONS. This pilot study provided proof of principle that supervised Aerobic Training is safe and feasible for postsurgical NSCLC patients. Aerobic exercise Training is also associated with significant improvements in QOL and select cardiopulmonary endpoints, particularly among patients not receiving chemotherapy. Larger randomized trials are warranted. Cancer 2008;113:3430–9. � 2008 American Cancer Society.

Lee W Jones - One of the best experts on this subject based on the ideXlab platform.

  • effects of nonlinear Aerobic Training on erectile dysfunction and cardiovascular function following radical prostatectomy for clinically localized prostate cancer
    European Urology, 2014
    Co-Authors: Lee W Jones, Whitney E Hornsby, Miranda J West, Aarti A Kenjale, Amy R Lane, Jason D Allen, Stephen J Freedland, Judd W Moul, Michael N Ferrandino, Samantha M Thomas
    Abstract:

    Erectile dysfunction (ED) is a major adverse effect of radical prostatectomy (RP). We conducted a randomized controlled trial to examine the efficacy of Aerobic Training (AT) compared with usual care (UC) on ED prevalence in 50 men (n = 25 per group) after RP. AT consisted of five walking sessions per week at 55–100% of peak oxygen uptake (VO2peak) for 30–60 min per session following a nonlinear prescription. The primary outcome was change in the prevalence of ED, as measured by the International Index of Erectile Function (IIEF), from baseline to 6 mo. Secondary outcomes were brachial artery flow–mediated dilation (FMD), VO2peak, cardiovascular (CV) risk profile (eg, lipid profile, body composition), and patient-reported outcomes (PROs). The prevalence of ED (IIEF score ≤21) decreased by 20% in the AT group and by 24% in the UC group (difference: p = 0.406). There were no significant between-group differences in any erectile function subscale (p > 0.05). Significant between-group differences were observed for changes in FMD and VO2peak, favoring AT. There were no group differences in other markers of CV risk profile or PROs. In summary, nonlinear AT does not improve ED in men with localized prostate cancer in the acute period following RP.

  • rationale and design of the exercise intensity trial excite a randomized trial comparing the effects of moderate versus moderate to high intensity Aerobic Training in women with operable breast cancer
    BMC Cancer, 2010
    Co-Authors: Lee W Jones, James E Herndon, Pamela S Douglas, Neil D Eves, Kelly P Marcom, William E Kraus, Brant A Inman, Jason D Allen, Jeffrey Peppercorn
    Abstract:

    The Exercise Intensity Trial (EXcITe) is a randomized trial to compare the efficacy of supervised moderate-intensity Aerobic Training to moderate to high-intensity Aerobic Training, relative to attention control, on Aerobic capacity, physiologic mechanisms, patient-reported outcomes, and biomarkers in women with operable breast cancer following the completion of definitive adjuvant therapy. Using a single-center, randomized design, 174 postmenopausal women (58 patients/study arm) with histologically confirmed, operable breast cancer presenting to Duke University Medical Center (DUMC) will be enrolled in this trial following completion of primary therapy (including surgery, radiation therapy, and chemotherapy). After baseline assessments, eligible participants will be randomized to one of two supervised Aerobic Training interventions (moderate-intensity or moderate/high-intensity Aerobic Training) or an attention-control group (progressive stretching). The Aerobic Training interventions will include 150 mins.wk-1 of supervised treadmill walking per week at an intensity of 60%-70% (moderate-intensity) or 60% to 100% (moderate to high-intensity) of the individually determined peak oxygen consumption (VO2peak) between 20-45 minutes/session for 16 weeks. The progressive stretching program will be consistent with the exercise interventions in terms of program length (16 weeks), social interaction (participants will receive one-on-one instruction), and duration (20-45 mins/session). The primary study endpoint is VO2peak, as measured by an incremental cardiopulmonary exercise test. Secondary endpoints include physiologic determinants that govern VO2peak, patient-reported outcomes, and biomarkers associated with breast cancer recurrence/mortality. All endpoints will be assessed at baseline and after the intervention (16 weeks). EXCITE is designed to investigate the intensity of Aerobic Training required to induce optimal improvements in VO2peak and other pertinent outcomes in women who have completed definitive adjuvant therapy for operable breast cancer. Overall, this trial will inform and refine exercise guidelines to optimize recovery in breast and other cancer survivors following the completion of primary cytotoxic therapy. NCT01186367

  • the lung cancer exercise Training study a randomized trial of Aerobic Training resistance Training or both in postsurgical lung cancer patients rationale and design
    BMC Cancer, 2010
    Co-Authors: Lee W Jones, Neil D Eves, William E Kraus, Anil Potti, Jeffrey Crawford, James A Blumenthal, Bercedis L Peterson, Pamela S Douglas
    Abstract:

    The Lung Cancer Exercise Training Study (LUNGEVITY) is a randomized trial to investigate the efficacy of different types of exercise Training on cardiorespiratory fitness (VO2peak), patient-reported outcomes, and the organ components that govern VO2peak in post-operative non-small cell lung cancer (NSCLC) patients. Using a single-center, randomized design, 160 subjects (40 patients/study arm) with histologically confirmed stage I-IIIA NSCLC following curative-intent complete surgical resection at Duke University Medical Center (DUMC) will be potentially eligible for this trial. Following baseline assessments, eligible participants will be randomly assigned to one of four conditions: (1) Aerobic Training alone, (2) resistance Training alone, (3) the combination of Aerobic and resistance Training, or (4) attention-control (progressive stretching). The ultimate goal for all exercise Training groups will be 3 supervised exercise sessions per week an intensity above 70% of the individually determined VO2peak for Aerobic Training and an intensity between 60 and 80% of one-repetition maximum for resistance Training, for 30-45 minutes/session. Progressive stretching will be matched to the exercise groups in terms of program length (i.e., 16 weeks), social interaction (participants will receive one-on-one instruction), and duration (30-45 mins/session). The primary study endpoint is VO2peak. Secondary endpoints include: patient-reported outcomes (PROs) (e.g., quality of life, fatigue, depression, etc.) and organ components of the oxygen cascade (i.e., pulmonary function, cardiac function, skeletal muscle function). All endpoints will be assessed at baseline and postintervention (16 weeks). Substudies will include genetic studies regarding individual responses to an exercise stimulus, theoretical determinants of exercise adherence, examination of the psychological mediators of the exercise - PRO relationship, and exercise-induced changes in gene expression. VO2peak is becoming increasingly recognized as an outcome of major importance in NSCLC. LUNGEVITY will identify the optimal form of exercise Training for NSCLC survivors as well as provide insight into the physiological mechanisms underlying this effect. Overall, this study will contribute to the establishment of clinical exercise therapy rehabilitation guidelines for patients across the entire NSCLC continuum. NCT00018255

  • safety and feasibility of Aerobic Training on cardiopulmonary function and quality of life in postsurgical nonsmall cell lung cancer patients a pilot study
    Cancer, 2008
    Co-Authors: Lee W Jones, Miranda J West, Neil D Eves, William E Kraus, Jeffrey Crawford, Bercedis L Peterson, Jennifer Garst, Stephanie Mabe, David H Harpole, Pamela S Douglas
    Abstract:

    BACKGROUND. A feasibility study examining the effects of supervised Aerobic exercise Training on cardiopulmonary and quality of life (QOL) endpoints among postsurgical nonsmall cell lung cancer (NSCLC) patients was conducted. METHODS. Using a single-group design, 20 patients with stage I-IIIB NSCLC performed 3 Aerobic cycle ergometry sessions per week at 60% to 100% of peak workload for 14 weeks. Peak oxygen consumption (VO2peak) was assessed using an incremental exercise test. QOL and fatigue were assessed using the Functional Assessment of Cancer Therapy–Lung (FACT-L) scale. RESULTS. Nineteen patients completed the study. Intention-to-treat analysis indicated that VO2peak increased 1.1 mL/kg 21 /min 21 (95% confidence interval [CI], 20.3-2.5; P 5 .109) and peak workload increased 9 W (95% CI, 3-14; P 5 .003), whereas FACT-L increased 10 points (95% CI, 21-22; P 5 .071) and fatigue decreased 7 points (95% CI; 2 1t o217; P 5 .029) from baseline to postintervention. Per protocol analyses indicated greater improvements in cardiopulmonary and QOL endpoints among patients not receiving adjuvant chemotherapy. CONCLUSIONS. This pilot study provided proof of principle that supervised Aerobic Training is safe and feasible for postsurgical NSCLC patients. Aerobic exercise Training is also associated with significant improvements in QOL and select cardiopulmonary endpoints, particularly among patients not receiving chemotherapy. Larger randomized trials are warranted. Cancer 2008;113:3430–9. � 2008 American Cancer Society.

John Vissing - One of the best experts on this subject based on the ideXlab platform.

  • Aerobic Training in myotonia congenita effect on myotonia and fitness
    Muscle & Nerve, 2017
    Co-Authors: Grete Andersen, Nicoline Lokken, John Vissing
    Abstract:

    Introduction Exercise has not been investigated in myotonia congenita (MC). We investigated whether regular Aerobic Training can reduce myotonia and improve fitness. Methods Untrained patients with MC (age: 24–62 years; n = 6) completed 28 ± 3 sessions of 30-minute cycle ergometer Training at 75% of maximal capacity for 11 ± 1 weeks. Fitness was evaluated by maximal oxygen uptake. The level of myotonia was assessed by the Myotonia Behavior Scale, 14 step stair test, timed up and go test, and hand and eye closure-open tests. Results Training increased fitness by 9% (95% confidence interval [CI], 1–17%; P = 0.02) and maximal workload by 10% (95% CI, 3–18%; P = 0.03). None of the myotonia tests changed in a clinically meaningful way. Conclusions Regular endurance Training improves fitness and maximal workload performance in patients with MC. The lack of creatine kinase elevations indicates that muscle damage did not occur. Improved fitness, however, did not change myotonic symptoms in this small cohort. Muscle Nerve 56: 696–699, 2017

  • Aerobic Training and postexercise protein in facioscapulohumeral muscular dystrophy rct study
    Neurology, 2015
    Co-Authors: Grete Andersen, Kira Philipsen Prahm, Julia R Dahlqvist, Gulsenay Citirak, John Vissing
    Abstract:

    Objective: To investigate the effect of regular Aerobic Training and postexercise protein-carbohydrate supplementation in patients with facioscapulohumeral muscular dystrophy (FSHD). Methods: In this randomized, double-blind, placebo-controlled parallel study, we randomized untrained men (n = 21) and women (n = 20) with FSHD (age 19–65 years) to 2 Training groups—Training with protein supplement (n = 18) and Training with placebo supplement (n = 13)—and a nonintervention control group (n = 10). We assessed fitness, walking speed, muscle strength, questionnaires, and daily activity levels before and after 12 weeks of interventions. Training involved 36 sessions of 30-minute cycle-ergometer Training. After each session, patients drank either a protein-carbohydrate or placebo beverage. Results: In the trained participants, fitness, workload, and walking speed improved (10% [confidence interval (CI) 4%–15%], 18% [CI 10%–26%], 7% [CI 4%–11%], respectively, p Conclusions: This randomized, controlled study showed that regular endurance Training improves fitness, walking speed, and self-assessed health in patients with FSHD without causing muscle damage. Postexercise protein-carbohydrate supplementation does not add any further improvement to Training effects alone. Classification of evidence: This study provides Class II evidence that regular Aerobic Training with or without postexercise protein-carbohydrate supplementation improves fitness and workload in patients with FSHD.

  • Aerobic Training is safe and improves exercise capacity in patients with mitochondrial myopathy
    Brain, 2006
    Co-Authors: Tina D Jeppesen, David B Olsen, Marianne Schwartz, Flemming Wibrand, Thomas O Krag, Morten Duno, Simon Hauerslev, John Vissing
    Abstract:

    Exercise intolerance is a prominent symptom in patients with mitochondrial myopathy (MM), but it is still unsettled whether exercise Training is safe and beneficial for patients with MM. To address this, we studied the effect of 12 weeks cycle Training on exercise capacity, quality of life and underlying molecular and cellular events in five patients with single large-scale deletions, one with a microdeletion and 14 with point mutations of mitochondrial DNA (mtDNA), and 13 healthy subjects. Each Training session lasted 30 min, and was performed at an intensity of 70% of VO2max (maximal oxygen uptake). Each subject performed 50 Training sessions in 12 weeks. All subjects were evaluated before and after Training, and 13 MM patients were studied after 8 weeks of deconditioning. Evaluation included VO2max and mutation load and mtDNA quantity, mitochondrial enzymatic activity, and number of centrally nucleated, apoptotic, ragged red and cytochrome oxidase (COX)-negative fibres in muscle biopsies from the quadriceps muscle. After 12 weeks of Training, VO2max and muscle citrate synthase increased in MM (26 and 67%) and healthy (17 and 65%) subjects, while mtDNA quantity in muscle only increased in the MM patients (81%). In the MM patients, Training did not change mtDNA mutation load in muscle, mitochondrial enzyme complex activities, muscle morphology and plasma creatine kinase. After deconditioning, VO2max and citrate synthase activity returned to values before Training, while muscle mtDNA mutation load decreased. These findings show that Aerobic Training efficiently improves oxidative capacity in MM patients. Based on unchanged levels of mutant load in muscle, morphological findings on muscle biopsy and plasma creatine kinase levels during Training, the treatment appears to be safe. Regular, supervised Aerobic exercise is therefore recommended in MM patients with the studied mutations.

  • Aerobic Training improves exercise performance in facioscapulohumeral muscular dystrophy
    Neurology, 2005
    Co-Authors: David B Olsen, Mette Cathrine Orngreen, John Vissing
    Abstract:

    Exercise programs have been shown to increase strength and endurance in patients with myopathic disorders. The authors investigated the effect of Aerobic Training in patients with facioscapulohumeral dystrophy (FSHD). Twelve weeks of low-intense Aerobic exercise improved maximal oxygen uptake and workload with no signs of muscle damage. The authors conclude that Aerobic Training is a safe method to increase exercise performance in patients with FSHD.