The Experts below are selected from a list of 243 Experts worldwide ranked by ideXlab platform
Tatiana Macé - One of the best experts on this subject based on the ideXlab platform.
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Development of a portable reference Aerosol Generator (PRAG) for calibration of particle mass concentration measurements
Particuology, 2018Co-Authors: François Gaie-levrel, Soleiman Bourrous, Tatiana MacéAbstract:The tapered element oscillating microbalance with filter dynamics measurement system (TEOM-FDMS) is an instrument commonly employed by the French air quality monitoring network. This instrument is currently calibrated with calibration weights traceable to SI but having value and mass differences between each of them that are not representative of real atmospheric particle mass measurements. Moreover, these calibration weights do not allow detection of any technical problems associated with either the TEOM-FDMS sampling system upstream of the mass measurement or the intrinsic TEOM-FDMS filtration system. Therefore, a calibration method was developed using a portable reference Aerosol Generator (PRAG) that produces known and stable particle mass concentrations over time. Here, we present the characterization of the PRAG system in terms of a reference range of particle masses between 30 ± 10 and 3456 ± 83 μg at three sampling times. Its coupling with the TEOM-FDMS and a global comparison between the defined reference range of particle masses and the measured masses obtained with each TEOM-FDMS implicated in this study are also presented. © 2017 Chinese Society of Particuology and Institute of Process Engineering, Chinese Academy of Sciences
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Development of a portable reference Aerosol Generator (PRAG) for calibration of particle mass concentration measurements
Particuology, 2017Co-Authors: François Gaie-levrel, Soleiman Bourrous, Tatiana MacéAbstract:Abstract The tapered element oscillating microbalance with filter dynamics measurement system (TEOM-FDMS) is an instrument commonly employed by the French air quality monitoring network. This instrument is currently calibrated with calibration weights traceable to SI but having value and mass differences between each of them that are not representative of real atmospheric particle mass measurements. Moreover, these calibration weights do not allow detection of any technical problems associated with either the TEOM-FDMS sampling system upstream of the mass measurement or the intrinsic TEOM-FDMS filtration system. Therefore, a calibration method was developed using a portable reference Aerosol Generator (PRAG) that produces known and stable particle mass concentrations over time. Here, we present the characterization of the PRAG system in terms of a reference range of particle masses between 30 ± 10 and 3456 ± 83 μg at three sampling times. Its coupling with the TEOM-FDMS and a global comparison between the defined reference range of particle masses and the measured masses obtained with each TEOM-FDMS implicated in this study are also presented.
François Gaie-levrel - One of the best experts on this subject based on the ideXlab platform.
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Development of a portable reference Aerosol Generator (PRAG) for calibration of particle mass concentration measurements
Particuology, 2018Co-Authors: François Gaie-levrel, Soleiman Bourrous, Tatiana MacéAbstract:The tapered element oscillating microbalance with filter dynamics measurement system (TEOM-FDMS) is an instrument commonly employed by the French air quality monitoring network. This instrument is currently calibrated with calibration weights traceable to SI but having value and mass differences between each of them that are not representative of real atmospheric particle mass measurements. Moreover, these calibration weights do not allow detection of any technical problems associated with either the TEOM-FDMS sampling system upstream of the mass measurement or the intrinsic TEOM-FDMS filtration system. Therefore, a calibration method was developed using a portable reference Aerosol Generator (PRAG) that produces known and stable particle mass concentrations over time. Here, we present the characterization of the PRAG system in terms of a reference range of particle masses between 30 ± 10 and 3456 ± 83 μg at three sampling times. Its coupling with the TEOM-FDMS and a global comparison between the defined reference range of particle masses and the measured masses obtained with each TEOM-FDMS implicated in this study are also presented. © 2017 Chinese Society of Particuology and Institute of Process Engineering, Chinese Academy of Sciences
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Development of a portable reference Aerosol Generator (PRAG) for calibration of particle mass concentration measurements
Particuology, 2017Co-Authors: François Gaie-levrel, Soleiman Bourrous, Tatiana MacéAbstract:Abstract The tapered element oscillating microbalance with filter dynamics measurement system (TEOM-FDMS) is an instrument commonly employed by the French air quality monitoring network. This instrument is currently calibrated with calibration weights traceable to SI but having value and mass differences between each of them that are not representative of real atmospheric particle mass measurements. Moreover, these calibration weights do not allow detection of any technical problems associated with either the TEOM-FDMS sampling system upstream of the mass measurement or the intrinsic TEOM-FDMS filtration system. Therefore, a calibration method was developed using a portable reference Aerosol Generator (PRAG) that produces known and stable particle mass concentrations over time. Here, we present the characterization of the PRAG system in terms of a reference range of particle masses between 30 ± 10 and 3456 ± 83 μg at three sampling times. Its coupling with the TEOM-FDMS and a global comparison between the defined reference range of particle masses and the measured masses obtained with each TEOM-FDMS implicated in this study are also presented.
S.m. Wall - One of the best experts on this subject based on the ideXlab platform.
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A monodisperse sulfuric acid Aerosol Generator
Atmospheric Environment, 2003Co-Authors: S.m. WallAbstract:Abstract A simple sulfuric acid Aerosol Generator which provides a reproducible Aerosol of narrow size distribution has been developed. The method is based on the injection of heated SO3 vapor in N2 into a stream of humidified air. Particle diameter is adjustable from approximately 0.3 to 1.5μm with a relative standard deviation of between 0.12 and 0.20. The Generator is also capable of producing particles of 1.5 μm under special conditions. The sulfuric acid Aerosol size distribution was obtained from optical particle counter data and verified using electron microscopy. The sulfuric acid concentration range of the Generator is 0.3–3 mg m−3 depending upon the particle size produced.
Soleiman Bourrous - One of the best experts on this subject based on the ideXlab platform.
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Development of a portable reference Aerosol Generator (PRAG) for calibration of particle mass concentration measurements
Particuology, 2018Co-Authors: François Gaie-levrel, Soleiman Bourrous, Tatiana MacéAbstract:The tapered element oscillating microbalance with filter dynamics measurement system (TEOM-FDMS) is an instrument commonly employed by the French air quality monitoring network. This instrument is currently calibrated with calibration weights traceable to SI but having value and mass differences between each of them that are not representative of real atmospheric particle mass measurements. Moreover, these calibration weights do not allow detection of any technical problems associated with either the TEOM-FDMS sampling system upstream of the mass measurement or the intrinsic TEOM-FDMS filtration system. Therefore, a calibration method was developed using a portable reference Aerosol Generator (PRAG) that produces known and stable particle mass concentrations over time. Here, we present the characterization of the PRAG system in terms of a reference range of particle masses between 30 ± 10 and 3456 ± 83 μg at three sampling times. Its coupling with the TEOM-FDMS and a global comparison between the defined reference range of particle masses and the measured masses obtained with each TEOM-FDMS implicated in this study are also presented. © 2017 Chinese Society of Particuology and Institute of Process Engineering, Chinese Academy of Sciences
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Development of a portable reference Aerosol Generator (PRAG) for calibration of particle mass concentration measurements
Particuology, 2017Co-Authors: François Gaie-levrel, Soleiman Bourrous, Tatiana MacéAbstract:Abstract The tapered element oscillating microbalance with filter dynamics measurement system (TEOM-FDMS) is an instrument commonly employed by the French air quality monitoring network. This instrument is currently calibrated with calibration weights traceable to SI but having value and mass differences between each of them that are not representative of real atmospheric particle mass measurements. Moreover, these calibration weights do not allow detection of any technical problems associated with either the TEOM-FDMS sampling system upstream of the mass measurement or the intrinsic TEOM-FDMS filtration system. Therefore, a calibration method was developed using a portable reference Aerosol Generator (PRAG) that produces known and stable particle mass concentrations over time. Here, we present the characterization of the PRAG system in terms of a reference range of particle masses between 30 ± 10 and 3456 ± 83 μg at three sampling times. Its coupling with the TEOM-FDMS and a global comparison between the defined reference range of particle masses and the measured masses obtained with each TEOM-FDMS implicated in this study are also presented.
Omar S. Usmani - One of the best experts on this subject based on the ideXlab platform.
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Generating monodisperse pharmacological Aerosols using the spinning-top Aerosol Generator.
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung, 2006Co-Authors: Martyn F. Biddiscombe, Peter J. Barnes, Omar S. UsmaniAbstract:Pharmacological Aerosols of precisely controlled particle size and narrow dispersity can be generated using the spinning-top Aerosol Generator (STAG). The ability of the STAG to generate monodisperse Aerosols from solutions of raw drug compounds makes it a valuable research instrument. In this paper, the versatility of this instrument has been further demonstrated by Aerosolizing a range of commercially available nebulized pulmonary therapy preparations. Nebules of Flixotide® (fluticasone propionate), Pulmicort® (budesonide), Combivent ® (salbutamol sulphate and ipratropium bromide), Bricanyl® (terbutaline sulphate), Atrovent® (ipratropium bromide), and Salamol® (salbutamol sulphate) were each mixed with ethanol and delivered to the STAG. Monodisperse drug Aerosol distributions were generated with MMADs of 0.95-6.7 µm. To achieve larger particle sizes from the nebulizer drug suspensions, the STAG formed compound particle agglomerates derived from the smaller insoluble drug particles. These compound agglom...
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Characterization of the generation of radiolabeled monodisperse albuterol particles using the spinning-top Aerosol Generator.
The Journal of Nuclear Medicine, 2004Co-Authors: Omar S. Usmani, Martyn F. Biddiscombe, S. Richard Underwood, Peter J. BarnesAbstract:UNLABELLED: Inhaled radiolabeled Aerosols provide invaluable information about in vivo drug deposition. Here, we report our methodology for radiolabeling and imaging monodisperse pharmacologic Aerosols in order to study basic Aerosol science concepts of drug delivery within the human airways. METHODS: We used a spinning-top Aerosol Generator to produce (99m)Tc-labeled monodisperse albuterol sulfate Aerosols of 1.5-, 3-, and 6- micro m mass median aerodynamic diameter. RESULTS: In vitro Andersen cascade validation data showed that technetium and albuterol were coassociated on each impactor stage for all 3 Aerosols, and the radiolabeling process itself did not affect their particle size distributions. Good-quality gamma-camera scintigraphic images of lung and extrathoracic deposition were obtained within an asthmatic patient. CONCLUSION: We have successfully radiolabeled and imaged monodisperse albuterol Aerosols within the human lungs. This novel technique provides an important tool to relate fundamental concepts of Aerosol particle behavior, in vivo deposition, and therapeutic clinical response.
