The Experts below are selected from a list of 587970 Experts worldwide ranked by ideXlab platform
Minghuei Cheng - One of the best experts on this subject based on the ideXlab platform.
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the Versatility of the anterolateral thigh flap
Plastic and Reconstructive Surgery, 2009Co-Authors: Rachel Bluebondlangner, Eduardo D Rodriguez, Minghuei ChengAbstract:Summary:In the last two decades, the anterolateral thigh flap has emerged as one of the most popular reconstructive options for multiple body sites. Based on a perforator flap harvest concept, the flap encompasses the advantages of Versatility, pliability, and potential for composite tissue replacem
Andrei K. Yudin - One of the best experts on this subject based on the ideXlab platform.
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The Versatility of boron in biological target engagement
Nature Chemistry, 2017Co-Authors: Diego B. Diaz, Andrei K. YudinAbstract:Recent years have witnessed a surge of interest in targeted covalent inhibition of disease-associated proteins. Among the electrophiles used to interact with nucleophilic residues in protein structures, boron is unique for its chameleonic ability to display a range of coordination modes upon interaction with protein targets. Boron-containing molecules have been extensively used for the purposes of chemical sensing, biological probe development and drug discovery. Due to boron's empty p orbital, it can coordinate to heteroatoms such as oxygen and nitrogen. This reversible covalent mode of interaction has led to the use of boron as bait for nucleophilic residues in disease-associated proteins, culminating in the approval of new therapeutics that work by covalent mechanisms. Our analysis of a wide range of covalent inhibitors with electrophilic groups suggests that boron is a unique electrophile in its chameleonic ability to engage protein targets. Here we review boron's interactions with a range of protein side-chain residues and reveal that boron's properties are nuanced and arise from its uncommon coordination preferences. These mechanistic and structural insights should serve as a guide for the development of selective boron-based bioactive molecules.
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the Versatility of boron in biological target engagement
Nature Chemistry, 2017Co-Authors: Diego B. Diaz, Andrei K. YudinAbstract:Boron-containing molecules have been extensively used for the purposes of chemical sensing, biological probe development and drug discovery. Due to boron's empty p orbital, it can coordinate to heteroatoms such as oxygen and nitrogen. This reversible covalent mode of interaction has led to the use of boron as bait for nucleophilic residues in disease-associated proteins, culminating in the approval of new therapeutics that work by covalent mechanisms. Our analysis of a wide range of covalent inhibitors with electrophilic groups suggests that boron is a unique electrophile in its chameleonic ability to engage protein targets. Here we review boron's interactions with a range of protein side-chain residues and reveal that boron's properties are nuanced and arise from its uncommon coordination preferences. These mechanistic and structural insights should serve as a guide for the development of selective boron-based bioactive molecules.
Rachel Bluebondlangner - One of the best experts on this subject based on the ideXlab platform.
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the Versatility of the anterolateral thigh flap
Plastic and Reconstructive Surgery, 2009Co-Authors: Rachel Bluebondlangner, Eduardo D Rodriguez, Minghuei ChengAbstract:Summary:In the last two decades, the anterolateral thigh flap has emerged as one of the most popular reconstructive options for multiple body sites. Based on a perforator flap harvest concept, the flap encompasses the advantages of Versatility, pliability, and potential for composite tissue replacem
Diego B. Diaz - One of the best experts on this subject based on the ideXlab platform.
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The Versatility of boron in biological target engagement
Nature Chemistry, 2017Co-Authors: Diego B. Diaz, Andrei K. YudinAbstract:Recent years have witnessed a surge of interest in targeted covalent inhibition of disease-associated proteins. Among the electrophiles used to interact with nucleophilic residues in protein structures, boron is unique for its chameleonic ability to display a range of coordination modes upon interaction with protein targets. Boron-containing molecules have been extensively used for the purposes of chemical sensing, biological probe development and drug discovery. Due to boron's empty p orbital, it can coordinate to heteroatoms such as oxygen and nitrogen. This reversible covalent mode of interaction has led to the use of boron as bait for nucleophilic residues in disease-associated proteins, culminating in the approval of new therapeutics that work by covalent mechanisms. Our analysis of a wide range of covalent inhibitors with electrophilic groups suggests that boron is a unique electrophile in its chameleonic ability to engage protein targets. Here we review boron's interactions with a range of protein side-chain residues and reveal that boron's properties are nuanced and arise from its uncommon coordination preferences. These mechanistic and structural insights should serve as a guide for the development of selective boron-based bioactive molecules.
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the Versatility of boron in biological target engagement
Nature Chemistry, 2017Co-Authors: Diego B. Diaz, Andrei K. YudinAbstract:Boron-containing molecules have been extensively used for the purposes of chemical sensing, biological probe development and drug discovery. Due to boron's empty p orbital, it can coordinate to heteroatoms such as oxygen and nitrogen. This reversible covalent mode of interaction has led to the use of boron as bait for nucleophilic residues in disease-associated proteins, culminating in the approval of new therapeutics that work by covalent mechanisms. Our analysis of a wide range of covalent inhibitors with electrophilic groups suggests that boron is a unique electrophile in its chameleonic ability to engage protein targets. Here we review boron's interactions with a range of protein side-chain residues and reveal that boron's properties are nuanced and arise from its uncommon coordination preferences. These mechanistic and structural insights should serve as a guide for the development of selective boron-based bioactive molecules.
George E. Higgins - One of the best experts on this subject based on the ideXlab platform.
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Social Learning, Self-Control, and Offending Specialization and Versatility among Friends
American Journal of Criminal Justice, 2019Co-Authors: John H. Boman, Thomas J. Mowen, George E. HigginsAbstract:While it is generally understood that people tend not to specialize in specific types of deviance, less is understood about offending specialization and Versatility in the context of friendships. Using a large sample of persons nested within friendship pairs, this study’s goal is to explore how self-control and social learning theories contribute to an explanation for specialization and Versatility in offending among friends. We estimate a series of multilevel, dyadic, mixed-effects models which regress offending Versatility onto measures of perceptual peer Versatility, self-reported peer Versatility, attitudinal self-control, behavioral self-control, and demographic controls. Results indicate that higher amounts of perceptual peer Versatility and peer self-reported Versatility are both related to increases in Versatility among friends. Lower levels of the target respondent’s attitudinal and behavioral self-control are also related to higher amounts of offending Versatility. However, the peer’s self-control shares no relationship with offending Versatility – a point which both supports and fails to support self-control theory’s expectations about how peer effects should operate. Learning and self-control perspectives both appear to explain offending Versatility among friends. However, self-control theory’s propositions about how peer effects should operate are contradictory. The concept of opportunity may help remediate this inconsistency in Gottfredson and Hirschi’s theory.
