The Experts below are selected from a list of 174 Experts worldwide ranked by ideXlab platform
Alberto Ritieni - One of the best experts on this subject based on the ideXlab platform.
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Toxicity of Aflatoxin B1 towards the vitamin D receptor (VDR)
Food and Chemical Toxicology, 2015Co-Authors: Paola Costanzo, Luigi Fattore, Antonello Santini, Ettore Novellino, Alberto RitieniAbstract:This research describes an unexpected toxicity of the Aflatoxin B1 towards the vitamin D receptors. Rickets is a childhood disease, and calcium deficiency is the aetiological cause in Africa, being primarily associated with nutritional problems; in this research the contribution of Aflatoxin B1 exposure during the early months of life is an interesting factor to deepen in order to prevent liver damages or the development of rickets. The results show that the expression of vitamin D receptor in osteosarcoma cell line SAOS-2 is significantly down-modulated by exposure to Aflatoxin B1. This seems to suggest that Aflatoxin B1, toxic towards the vitamin D receptor, interferes with the actions of the vitamin D on calcium binding gene expression in the kidney and intestine. Experimental data indicate a 58% and 86% decrease if the cells are exposed to 5 ng/mL and 50 ng/mL of Aflatoxin B1, respectively. These results seem to indicate that natural occurrence of the Aflatoxin B1 and allelic variant of vitamin D receptor on (F allele) increase the risk of developing rickets of African children.
Paola Costanzo - One of the best experts on this subject based on the ideXlab platform.
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Toxicity of Aflatoxin B1 towards the vitamin D receptor (VDR)
Food and Chemical Toxicology, 2015Co-Authors: Paola Costanzo, Luigi Fattore, Antonello Santini, Ettore Novellino, Alberto RitieniAbstract:This research describes an unexpected toxicity of the Aflatoxin B1 towards the vitamin D receptors. Rickets is a childhood disease, and calcium deficiency is the aetiological cause in Africa, being primarily associated with nutritional problems; in this research the contribution of Aflatoxin B1 exposure during the early months of life is an interesting factor to deepen in order to prevent liver damages or the development of rickets. The results show that the expression of vitamin D receptor in osteosarcoma cell line SAOS-2 is significantly down-modulated by exposure to Aflatoxin B1. This seems to suggest that Aflatoxin B1, toxic towards the vitamin D receptor, interferes with the actions of the vitamin D on calcium binding gene expression in the kidney and intestine. Experimental data indicate a 58% and 86% decrease if the cells are exposed to 5 ng/mL and 50 ng/mL of Aflatoxin B1, respectively. These results seem to indicate that natural occurrence of the Aflatoxin B1 and allelic variant of vitamin D receptor on (F allele) increase the risk of developing rickets of African children.
Luigi Fattore - One of the best experts on this subject based on the ideXlab platform.
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Toxicity of Aflatoxin B1 towards the vitamin D receptor (VDR)
Food and Chemical Toxicology, 2015Co-Authors: Paola Costanzo, Luigi Fattore, Antonello Santini, Ettore Novellino, Alberto RitieniAbstract:This research describes an unexpected toxicity of the Aflatoxin B1 towards the vitamin D receptors. Rickets is a childhood disease, and calcium deficiency is the aetiological cause in Africa, being primarily associated with nutritional problems; in this research the contribution of Aflatoxin B1 exposure during the early months of life is an interesting factor to deepen in order to prevent liver damages or the development of rickets. The results show that the expression of vitamin D receptor in osteosarcoma cell line SAOS-2 is significantly down-modulated by exposure to Aflatoxin B1. This seems to suggest that Aflatoxin B1, toxic towards the vitamin D receptor, interferes with the actions of the vitamin D on calcium binding gene expression in the kidney and intestine. Experimental data indicate a 58% and 86% decrease if the cells are exposed to 5 ng/mL and 50 ng/mL of Aflatoxin B1, respectively. These results seem to indicate that natural occurrence of the Aflatoxin B1 and allelic variant of vitamin D receptor on (F allele) increase the risk of developing rickets of African children.
Ettore Novellino - One of the best experts on this subject based on the ideXlab platform.
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Toxicity of Aflatoxin B1 towards the vitamin D receptor (VDR)
Food and Chemical Toxicology, 2015Co-Authors: Paola Costanzo, Luigi Fattore, Antonello Santini, Ettore Novellino, Alberto RitieniAbstract:This research describes an unexpected toxicity of the Aflatoxin B1 towards the vitamin D receptors. Rickets is a childhood disease, and calcium deficiency is the aetiological cause in Africa, being primarily associated with nutritional problems; in this research the contribution of Aflatoxin B1 exposure during the early months of life is an interesting factor to deepen in order to prevent liver damages or the development of rickets. The results show that the expression of vitamin D receptor in osteosarcoma cell line SAOS-2 is significantly down-modulated by exposure to Aflatoxin B1. This seems to suggest that Aflatoxin B1, toxic towards the vitamin D receptor, interferes with the actions of the vitamin D on calcium binding gene expression in the kidney and intestine. Experimental data indicate a 58% and 86% decrease if the cells are exposed to 5 ng/mL and 50 ng/mL of Aflatoxin B1, respectively. These results seem to indicate that natural occurrence of the Aflatoxin B1 and allelic variant of vitamin D receptor on (F allele) increase the risk of developing rickets of African children.
Antonello Santini - One of the best experts on this subject based on the ideXlab platform.
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Toxicity of Aflatoxin B1 towards the vitamin D receptor (VDR)
Food and Chemical Toxicology, 2015Co-Authors: Paola Costanzo, Luigi Fattore, Antonello Santini, Ettore Novellino, Alberto RitieniAbstract:This research describes an unexpected toxicity of the Aflatoxin B1 towards the vitamin D receptors. Rickets is a childhood disease, and calcium deficiency is the aetiological cause in Africa, being primarily associated with nutritional problems; in this research the contribution of Aflatoxin B1 exposure during the early months of life is an interesting factor to deepen in order to prevent liver damages or the development of rickets. The results show that the expression of vitamin D receptor in osteosarcoma cell line SAOS-2 is significantly down-modulated by exposure to Aflatoxin B1. This seems to suggest that Aflatoxin B1, toxic towards the vitamin D receptor, interferes with the actions of the vitamin D on calcium binding gene expression in the kidney and intestine. Experimental data indicate a 58% and 86% decrease if the cells are exposed to 5 ng/mL and 50 ng/mL of Aflatoxin B1, respectively. These results seem to indicate that natural occurrence of the Aflatoxin B1 and allelic variant of vitamin D receptor on (F allele) increase the risk of developing rickets of African children.
