Aflatoxin B1 - Explore the Science & Experts | ideXlab

Scan Science and Technology

Contact Leading Edge Experts & Companies

Aflatoxin B1

The Experts below are selected from a list of 174 Experts worldwide ranked by ideXlab platform

Alberto Ritieni – 1st expert on this subject based on the ideXlab platform

  • Toxicity of Aflatoxin B1 towards the vitamin D receptor (VDR)
    Food and Chemical Toxicology, 2015
    Co-Authors: Paola Costanzo, Antonello Santini, Luigi Fattore, Ettore Novellino, Alberto Ritieni

    Abstract:

    This research describes an unexpected toxicity of the Aflatoxin B1 towards the vitamin D receptors. Rickets is a childhood disease, and calcium deficiency is the aetiological cause in Africa, being primarily associated with nutritional problems; in this research the contribution of Aflatoxin B1 exposure during the early months of life is an interesting factor to deepen in order to prevent liver damages or the development of rickets. The results show that the expression of vitamin D receptor in osteosarcoma cell line SAOS-2 is significantly down-modulated by exposure to Aflatoxin B1. This seems to suggest that Aflatoxin B1, toxic towards the vitamin D receptor, interferes with the actions of the vitamin D on calcium binding gene expression in the kidney and intestine. Experimental data indicate a 58% and 86% decrease if the cells are exposed to 5 ng/mL and 50 ng/mL of Aflatoxin B1, respectively. These results seem to indicate that natural occurrence of the Aflatoxin B1 and allelic variant of vitamin D receptor on (F allele) increase the risk of developing rickets of African children.

Paola Costanzo – 2nd expert on this subject based on the ideXlab platform

  • Toxicity of Aflatoxin B1 towards the vitamin D receptor (VDR)
    Food and Chemical Toxicology, 2015
    Co-Authors: Paola Costanzo, Antonello Santini, Luigi Fattore, Ettore Novellino, Alberto Ritieni

    Abstract:

    This research describes an unexpected toxicity of the Aflatoxin B1 towards the vitamin D receptors. Rickets is a childhood disease, and calcium deficiency is the aetiological cause in Africa, being primarily associated with nutritional problems; in this research the contribution of Aflatoxin B1 exposure during the early months of life is an interesting factor to deepen in order to prevent liver damages or the development of rickets. The results show that the expression of vitamin D receptor in osteosarcoma cell line SAOS-2 is significantly down-modulated by exposure to Aflatoxin B1. This seems to suggest that Aflatoxin B1, toxic towards the vitamin D receptor, interferes with the actions of the vitamin D on calcium binding gene expression in the kidney and intestine. Experimental data indicate a 58% and 86% decrease if the cells are exposed to 5 ng/mL and 50 ng/mL of Aflatoxin B1, respectively. These results seem to indicate that natural occurrence of the Aflatoxin B1 and allelic variant of vitamin D receptor on (F allele) increase the risk of developing rickets of African children.

Ettore Novellino – 3rd expert on this subject based on the ideXlab platform

  • Toxicity of Aflatoxin B1 towards the vitamin D receptor (VDR)
    Food and Chemical Toxicology, 2015
    Co-Authors: Paola Costanzo, Antonello Santini, Luigi Fattore, Ettore Novellino, Alberto Ritieni

    Abstract:

    This research describes an unexpected toxicity of the Aflatoxin B1 towards the vitamin D receptors. Rickets is a childhood disease, and calcium deficiency is the aetiological cause in Africa, being primarily associated with nutritional problems; in this research the contribution of Aflatoxin B1 exposure during the early months of life is an interesting factor to deepen in order to prevent liver damages or the development of rickets. The results show that the expression of vitamin D receptor in osteosarcoma cell line SAOS-2 is significantly down-modulated by exposure to Aflatoxin B1. This seems to suggest that Aflatoxin B1, toxic towards the vitamin D receptor, interferes with the actions of the vitamin D on calcium binding gene expression in the kidney and intestine. Experimental data indicate a 58% and 86% decrease if the cells are exposed to 5 ng/mL and 50 ng/mL of Aflatoxin B1, respectively. These results seem to indicate that natural occurrence of the Aflatoxin B1 and allelic variant of vitamin D receptor on (F allele) increase the risk of developing rickets of African children.