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Berry J Kline – One of the best experts on this subject based on the ideXlab platform.

  • temperature ph and Agitation Rate as dissolution test discriminators of zofenopril calcium tablets
    Journal of Pharmaceutical and Biomedical Analysis, 1994
    Co-Authors: Ruben Lozano, John M Joseph, Berry J Kline
    Abstract:

    Abstract Comparative in vitro dissolution studies were performed on several tablet batches of zofenopril calcium, an ACE inhibitor, to determine if they could be differentiated on the basis of their release Rates. The samples included six batches produced at Site I and one batch produced at Site 2. Using regular dissolution conditions (USP paddle method at a 50-rpm Agitation speed in phosphate buffer, pH 7.5, at 37°C), release Rates of all the tablet batches were similar. By independently altering one of the dissolution test parameters, either a lower pH or a slower Agitation Rate, discrimination between the Site I and Site 2 tablets was enhanced. Discrimination was only slightly enhanced when a lower dissolution medium temperature was used. Tablets made from different polymorphs of zofenopril calcium could not be differentiated by their dissolution profiles, even with the more discriminating conditions. The dissolution profiles of certain other zofenopril calcium tablets (including film-coated vs uncoated tablets, and tablets made with micronized vs unmicronized drug particles) were indistinguishable using a 50-rpm Agitation Rate, but they could be clearly differentiated using a 40-rpm Agitation Rate.

  • Temperature, pH and Agitation Rate as dissolution test discriminators of zofenopril calcium tablets
    Journal of pharmaceutical and biomedical analysis, 1994
    Co-Authors: Ruben Lozano, John M Joseph, Berry J Kline
    Abstract:

    Abstract Comparative in vitro dissolution studies were performed on several tablet batches of zofenopril calcium, an ACE inhibitor, to determine if they could be differentiated on the basis of their release Rates. The samples included six batches produced at Site I and one batch produced at Site 2. Using regular dissolution conditions (USP paddle method at a 50-rpm Agitation speed in phosphate buffer, pH 7.5, at 37°C), release Rates of all the tablet batches were similar. By independently altering one of the dissolution test parameters, either a lower pH or a slower Agitation Rate, discrimination between the Site I and Site 2 tablets was enhanced. Discrimination was only slightly enhanced when a lower dissolution medium temperature was used. Tablets made from different polymorphs of zofenopril calcium could not be differentiated by their dissolution profiles, even with the more discriminating conditions. The dissolution profiles of certain other zofenopril calcium tablets (including film-coated vs uncoated tablets, and tablets made with micronized vs unmicronized drug particles) were indistinguishable using a 50-rpm Agitation Rate, but they could be clearly differentiated using a 40-rpm Agitation Rate.

Lew Christopher – One of the best experts on this subject based on the ideXlab platform.

  • Effect of cultivation pH and Agitation Rate on growth and xylanase production by Aspergillus oryzae in spent sulphite liquor
    Journal of Industrial Microbiology & Biotechnology, 2008
    Co-Authors: Zawadi A. Chipeta, James C. Du Preez, Lew Christopher
    Abstract:

    The effects of cultivation pH and Agitation Rate on growth and extracellular xylanase production by Aspergillus oryzae NRRL 3485 were investigated in bioreactor cultures using spent sulphite liquor (SSL) and oats spelts xylan as respective carbon substRates. Xylanase production by this fungus was greatly affected by the culture pH, with pH 7.5 resulting in a high extracellular xylanase activity in the SSL-based medium as well as in a complex medium with xylan as carbon substRate. This effect, therefore, was not solely due to growth inhibition at the lower pH values by the acetic acid in the SSL. The xylanase activity in the SSL medium peaked at 199 U ml^−1 at pH 7.5 with a corresponding maximum specific growth Rate of 0.39 h^−1. By contrast, the maximum extracellular β-xylosidase activity pf 0.36 U ml^−1 was recorded at pH 4.0. Three low molemolecular weight xylanase isozymes were secreted at all pH values within the range of pH 4–8, whereas cellulase activity on both carbon substRates was negligible. Impeller tip velocities within the range of 1.56–3.12 m s^−1 had no marked effect, either on the xylanase activity, or on the maximum volumetric Rate of xylanase production. These results also demonstRated that SSL constituted a suitable carbon feedstock as well as inducer for xylanase production in aerobic submerged culture by this strain of A. oryzae .

  • Effect of cultivation pH and Agitation Rate on growth and xylanase production by Aspergillus oryzae in spent sulphite liquor
    Journal of industrial microbiology & biotechnology, 2008
    Co-Authors: Zawadi A. Chipeta, James C. Du Preez, Lew Christopher
    Abstract:

    The effects of cultivation pH and Agitation Rate on growth and extracellular xylanase production by Aspergillus oryzae NRRL 3485 were investigated in bioreactor cultures using spent sulphite liquor (SSL) and oats spelts xylan as respective carbon substRates. Xylanase production by this fungus was greatly affected by the culture pH, with pH 7.5 resulting in a high extracellular xylanase activity in the SSL-based medium as well as in a complex medium with xylan as carbon substRate. This effect, therefore, was not solely due to growth inhibition at the lower pH values by the acetic acid in the SSL. The xylanase activity in the SSL medium peaked at 199 U ml−1 at pH 7.5 with a corresponding maximum specific growth Rate of 0.39 h−1. By contrast, the maximum extracellular β-xylosidase activity pf 0.36 U ml−1 was recorded at pH 4.0. Three low molemolecular weight xylanase isozymes were secreted at all pH values within the range of pH 4–8, whereas cellulase activity on both carbon substRates was negligible. Impeller tip velocities within the range of 1.56–3.12 m s−1 had no marked effect, either on the xylanase activity, or on the maximum volumetric Rate of xylanase production. These results also demonstRated that SSL constituted a suitable carbon feedstock as well as inducer for xylanase production in aerobic submerged culture by this strain of A. oryzae.

Ruben Lozano – One of the best experts on this subject based on the ideXlab platform.

  • temperature ph and Agitation Rate as dissolution test discriminators of zofenopril calcium tablets
    Journal of Pharmaceutical and Biomedical Analysis, 1994
    Co-Authors: Ruben Lozano, John M Joseph, Berry J Kline
    Abstract:

    Abstract Comparative in vitro dissolution studies were performed on several tablet batches of zofenopril calcium, an ACE inhibitor, to determine if they could be differentiated on the basis of their release Rates. The samples included six batches produced at Site I and one batch produced at Site 2. Using regular dissolution conditions (USP paddle method at a 50-rpm Agitation speed in phosphate buffer, pH 7.5, at 37°C), release Rates of all the tablet batches were similar. By independently altering one of the dissolution test parameters, either a lower pH or a slower Agitation Rate, discrimination between the Site I and Site 2 tablets was enhanced. Discrimination was only slightly enhanced when a lower dissolution medium temperature was used. Tablets made from different polymorphs of zofenopril calcium could not be differentiated by their dissolution profiles, even with the more discriminating conditions. The dissolution profiles of certain other zofenopril calcium tablets (including film-coated vs uncoated tablets, and tablets made with micronized vs unmicronized drug particles) were indistinguishable using a 50-rpm Agitation Rate, but they could be clearly differentiated using a 40-rpm Agitation Rate.

  • Temperature, pH and Agitation Rate as dissolution test discriminators of zofenopril calcium tablets
    Journal of pharmaceutical and biomedical analysis, 1994
    Co-Authors: Ruben Lozano, John M Joseph, Berry J Kline
    Abstract:

    Abstract Comparative in vitro dissolution studies were performed on several tablet batches of zofenopril calcium, an ACE inhibitor, to determine if they could be differentiated on the basis of their release Rates. The samples included six batches produced at Site I and one batch produced at Site 2. Using regular dissolution conditions (USP paddle method at a 50-rpm Agitation speed in phosphate buffer, pH 7.5, at 37°C), release Rates of all the tablet batches were similar. By independently altering one of the dissolution test parameters, either a lower pH or a slower Agitation Rate, discrimination between the Site I and Site 2 tablets was enhanced. Discrimination was only slightly enhanced when a lower dissolution medium temperature was used. Tablets made from different polymorphs of zofenopril calcium could not be differentiated by their dissolution profiles, even with the more discriminating conditions. The dissolution profiles of certain other zofenopril calcium tablets (including film-coated vs uncoated tablets, and tablets made with micronized vs unmicronized drug particles) were indistinguishable using a 50-rpm Agitation Rate, but they could be clearly differentiated using a 40-rpm Agitation Rate.

Zawadi A. Chipeta – One of the best experts on this subject based on the ideXlab platform.

  • Effect of cultivation pH and Agitation Rate on growth and xylanase production by Aspergillus oryzae in spent sulphite liquor
    Journal of Industrial Microbiology & Biotechnology, 2008
    Co-Authors: Zawadi A. Chipeta, James C. Du Preez, Lew Christopher
    Abstract:

    The effects of cultivation pH and Agitation Rate on growth and extracellular xylanase production by Aspergillus oryzae NRRL 3485 were investigated in bioreactor cultures using spent sulphite liquor (SSL) and oats spelts xylan as respective carbon substRates. Xylanase production by this fungus was greatly affected by the culture pH, with pH 7.5 resulting in a high extracellular xylanase activity in the SSL-based medium as well as in a complex medium with xylan as carbon substRate. This effect, therefore, was not solely due to growth inhibition at the lower pH values by the acetic acid in the SSL. The xylanase activity in the SSL medium peaked at 199 U ml^−1 at pH 7.5 with a corresponding maximum specific growth Rate of 0.39 h^−1. By contrast, the maximum extracellular β-xylosidase activity pf 0.36 U ml^−1 was recorded at pH 4.0. Three low molecular weight xylanase isozymes were secreted at all pH values within the range of pH 4–8, whereas cellulase activity on both carbon substRates was negligible. Impeller tip velocities within the range of 1.56–3.12 m s^−1 had no marked effect, either on the xylanase activity, or on the maximum volumetric Rate of xylanase production. These results also demonstRated that SSL constituted a suitable carbon feedstock as well as inducer for xylanase production in aerobic submerged culture by this strain of A. oryzae .

  • Effect of cultivation pH and Agitation Rate on growth and xylanase production by Aspergillus oryzae in spent sulphite liquor
    Journal of industrial microbiology & biotechnology, 2008
    Co-Authors: Zawadi A. Chipeta, James C. Du Preez, Lew Christopher
    Abstract:

    The effects of cultivation pH and Agitation Rate on growth and extracellular xylanase production by Aspergillus oryzae NRRL 3485 were investigated in bioreactor cultures using spent sulphite liquor (SSL) and oats spelts xylan as respective carbon substRates. Xylanase production by this fungus was greatly affected by the culture pH, with pH 7.5 resulting in a high extracellular xylanase activity in the SSL-based medium as well as in a complex medium with xylan as carbon substRate. This effect, therefore, was not solely due to growth inhibition at the lower pH values by the acetic acid in the SSL. The xylanase activity in the SSL medium peaked at 199 U ml−1 at pH 7.5 with a corresponding maximum specific growth Rate of 0.39 h−1. By contrast, the maximum extracellular β-xylosidase activity pf 0.36 U ml−1 was recorded at pH 4.0. Three low molecular weight xylanase isozymes were secreted at all pH values within the range of pH 4–8, whereas cellulase activity on both carbon substRates was negligible. Impeller tip velocities within the range of 1.56–3.12 m s−1 had no marked effect, either on the xylanase activity, or on the maximum volumetric Rate of xylanase production. These results also demonstRated that SSL constituted a suitable carbon feedstock as well as inducer for xylanase production in aerobic submerged culture by this strain of A. oryzae.

John M Joseph – One of the best experts on this subject based on the ideXlab platform.

  • temperature ph and Agitation Rate as dissolution test discriminators of zofenopril calcium tablets
    Journal of Pharmaceutical and Biomedical Analysis, 1994
    Co-Authors: Ruben Lozano, John M Joseph, Berry J Kline
    Abstract:

    Abstract Comparative in vitro dissolution studies were performed on several tablet batches of zofenopril calcium, an ACE inhibitor, to determine if they could be differentiated on the basis of their release Rates. The samples included six batches produced at Site I and one batch produced at Site 2. Using regular dissolution conditions (USP paddle method at a 50-rpm Agitation speed in phosphate buffer, pH 7.5, at 37°C), release Rates of all the tablet batches were similar. By independently altering one of the dissolution test parameters, either a lower pH or a slower Agitation Rate, discrimination between the Site I and Site 2 tablets was enhanced. Discrimination was only slightly enhanced when a lower dissolution medium temperature was used. Tablets made from different polymorphs of zofenopril calcium could not be differentiated by their dissolution profiles, even with the more discriminating conditions. The dissolution profiles of certain other zofenopril calcium tablets (including film-coated vs uncoated tablets, and tablets made with micronized vs unmicronized drug particles) were indistinguishable using a 50-rpm Agitation Rate, but they could be clearly differentiated using a 40-rpm Agitation Rate.

  • Temperature, pH and Agitation Rate as dissolution test discriminators of zofenopril calcium tablets
    Journal of pharmaceutical and biomedical analysis, 1994
    Co-Authors: Ruben Lozano, John M Joseph, Berry J Kline
    Abstract:

    Abstract Comparative in vitro dissolution studies were performed on several tablet batches of zofenopril calcium, an ACE inhibitor, to determine if they could be differentiated on the basis of their release Rates. The samples included six batches produced at Site I and one batch produced at Site 2. Using regular dissolution conditions (USP paddle method at a 50-rpm Agitation speed in phosphate buffer, pH 7.5, at 37°C), release Rates of all the tablet batches were similar. By independently altering one of the dissolution test parameters, either a lower pH or a slower Agitation Rate, discrimination between the Site I and Site 2 tablets was enhanced. Discrimination was only slightly enhanced when a lower dissolution medium temperature was used. Tablets made from different polymorphs of zofenopril calcium could not be differentiated by their dissolution profiles, even with the more discriminating conditions. The dissolution profiles of certain other zofenopril calcium tablets (including film-coated vs uncoated tablets, and tablets made with micronized vs unmicronized drug particles) were indistinguishable using a 50-rpm Agitation Rate, but they could be clearly differentiated using a 40-rpm Agitation Rate.